Mast cell FcεRI density and function dissociate from dependence on soluble IgE concentration at very low and very high IgE concentrations

Journal of Asthma

Volumn 50, Issue 2, 2013, Pages 117-121

  Krohn, Inge Kortekaas ^a   Lund, Gitte ^b   Frandsen, Pernille Munk ^a   Schiotz, Peter Oluf ^a   Dahl, Ronald ^c   Hoffmann, Hans Jürgen ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b ALK ABELLÓ   (Denmark)

^c AARHUS UNIVERSITY   (Denmark)

Author keywords

CD63; Derp2; Histamine; IgE receptor; IL 4; PGD2; Recombinant human IgE

Indexed keywords

CD63 ANTIGEN; FC EPSILON RECEPTOR I; FC RECEPTOR; HISTAMINE; IMMUNOGLOBULIN E; INTERLEUKIN 4; PROSTAGLANDIN D2; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; EFFECTOR CELL; HISTAMINE RELEASE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MAST CELL DEGRANULATION; OUTCOME ASSESSMENT; PROSTAGLANDIN SYNTHESIS;

ANTIGENS, CD63; ANTIGENS, DERMATOPHAGOIDES; CELL DEGRANULATION; HISTAMINE RELEASE; HUMANS; HYPERSENSITIVITY; IMMUNOGLOBULIN E; LEUKOCYTES, MONONUCLEAR; MAST CELLS; PROSTAGLANDIN D2; RECEPTORS, IGG; STATISTICS, NONPARAMETRIC;

EID: 84873668291     PISSN: 02770903     EISSN: 15324303     Source Type: Journal    
DOI: 10.3109/02770903.2012.752504     Document Type: Article

References (13)

1. Siraganian RP. Mast cell signal transduction from the high-affinity IgE receptor. Curr Opin Immunol 2003 Dec; 15(6):639-646
2. Rivera J, Gilfillan AM. Molecular regulation of mast cell activation. J Allergy Clin Immunol 2006 Jun; 117(6):1214-1225
3. Saini SS, Klion AD, Holland SM, Hamilton RG, Bochner BS, Macglashan DW. The relationship between serum IgE and surface levels of FcepsilonR on human leukocytes in various diseases: Correlation of expression with FcepsilonRI on basophils but not on monocytes or eosinophils. J Allergy Clin Immunol 2000 Sep; 106(3): 514-520
4. Beck LA, Marcotte GV, MacGlashan D, Togias A, Saini S. Omalizumab-induced reductions in mast cell Fce psilon RI expression and function. J Allergy Clin Immunol 2004 Sep; 114(3):527-530
5. Gomez G, Jogie-Brahim S, Shima M, Schwartz LB. Omalizumab reverses the phenotypic and functional effects of IgE-enhanced Fc epsilonRI on human skin mast cells. J Immunol 2007 Jul 15; 179(2):1353-1361
6. Christensen LH, Holm J, Lund G, Riise E, Lund K. Several distinct properties of the IgE repertoire determine effector cell degranulation in response to allergen challenge. J Allergy Clin Immunol 2008 Aug; 122(2):298-304
7. Lorentz A, Wilke M, Sellge G, Worthmann H, Klempnauer J, Manns MP, Bischoff SC. IL-4-induced priming of human intestinal mast cells for enhanced survival and Th2 cytokine generation is reversible and associated with increased activity of ERK1/2 and c-Fos. J Immunol 2005 Jun 1; 174(11):6751-6756
8. Holm M, Andersen HB, Hetland TE, Dahl C, Hoffmann HJ, Junker S, Schiøtz PO. Sevenweek culture of functional humanmast cells from buffy coat preparations. J ImmunolMethods 2008 Jul 31; 336(2):213-221
9. Andersen HB, Holm M, Hetland TE, Dahl C, Junker S, Schiøtz PO, Hoffmann HJ. Comparison of short term in vitro cultured human mast cells from different progenitors-peripheral blood-derived progenitors generate highly mature and functional mast cells. J Immunol Methods 2008 May 16; 336(2):166-174
10. Hoffmann HJ, Frandsen PM, Christensen LH, Schiøtz PO, Dahl R. Cultured human mast cells are heterogeneous for expression of the high-affinity IgE receptor Fc?RI. Int Arch Allergy Immunol 2012; 157(3):246-250
11. Johansson SGO, Nopp A, Oman H, Ankerst J, Cardell LO, Grönneberg R, Matsols H, Rudblad S, Strand V, Stålenheim G. The size of the disease relevant IgE antibody fraction in relation to 'total-IgE' predicts the efficacy of anti-IgE (Xolair) treatment. Allergy 2009 Oct; 64(10):1472-1477
12. Skov PS, Mosbech H, Norn S, Weeke B. Sensitive glass microfibrebased histamine analysis for allergy testing in washed blood cells. Results compared with conventional leukocyte histamine release assay. Allergy 1985 Apr; 40(3):213-218
13. Bousquet J, Rabe K, Humbert M, Chung KF, Berger W, Fox H, Ayre G, Chen H, Thomas K, Blogg M, Holgate S. Predicting and evaluating response to omalizumab in patients with severe allergic asthma. Respir Med 2007 Jul; 101(7):1483-1492.