메뉴 건너뛰기




Volumn 14, Issue 1, 2013, Pages

Stem cells isolated from adipose tissue of obese patients show changes in their transcriptomic profile that indicate loss in stemcellness and increased commitment to an adipocyte-like phenotype

Author keywords

Cardiovascular risk factors; Human adipose derived stem cells; Inflammatory genes; Subcutaneous adipose tissue; Transcriptome

Indexed keywords

SMAD3 PROTEIN;

EID: 84883787660     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-14-625     Document Type: Article
Times cited : (116)

References (57)
  • 6
    • 15044364921 scopus 로고    scopus 로고
    • Comparison of gene expression in intra-abdominal and subcutaneous fat: a study of men with morbid obesity and nonobese men using microarray and proteomics
    • Von Eyben FE, Kroustrup JP, Larsen JF, Celis J. Comparison of gene expression in intra-abdominal and subcutaneous fat: a study of men with morbid obesity and nonobese men using microarray and proteomics. Ann N Y Acad Sci 2004, 1030:508-536.
    • (2004) Ann N Y Acad Sci , vol.1030 , pp. 508-536
    • Von Eyben, F.E.1    Kroustrup, J.P.2    Larsen, J.F.3    Celis, J.4
  • 9
    • 24944489239 scopus 로고    scopus 로고
    • Microarray profiling of isolated abdominal subcutaneous adipocytes from obese vs non-obese Pima Indians: increased expression of inflammation-related genes
    • 10.1007/s00125-005-1867-3, 1409820, 16059715
    • Lee YH, Nair S, Rousseau E, Allison DB, Page GP, Tataranni PA, Bogardus C, Permana PA. Microarray profiling of isolated abdominal subcutaneous adipocytes from obese vs non-obese Pima Indians: increased expression of inflammation-related genes. Diabetologia 2005, 48:1776-1783. 10.1007/s00125-005-1867-3, 1409820, 16059715.
    • (2005) Diabetologia , vol.48 , pp. 1776-1783
    • Lee, Y.H.1    Nair, S.2    Rousseau, E.3    Allison, D.B.4    Page, G.P.5    Tataranni, P.A.6    Bogardus, C.7    Permana, P.A.8
  • 11
    • 24944588778 scopus 로고    scopus 로고
    • Increased expression of inflammation-related genes in cultured preadipocytes/stromal vascular cells from obese compared with non-obese Pima Indians
    • 10.1007/s00125-005-1868-2, 1409821, 16034612
    • Nair S, Lee YH, Rousseau E, Cam M, Tataranni PA, Baier LJ, Bogardus C, Permana PA. Increased expression of inflammation-related genes in cultured preadipocytes/stromal vascular cells from obese compared with non-obese Pima Indians. Diabetologia 2005, 48:1784-1788. 10.1007/s00125-005-1868-2, 1409821, 16034612.
    • (2005) Diabetologia , vol.48 , pp. 1784-1788
    • Nair, S.1    Lee, Y.H.2    Rousseau, E.3    Cam, M.4    Tataranni, P.A.5    Baier, L.J.6    Bogardus, C.7    Permana, P.A.8
  • 12
    • 82655181516 scopus 로고    scopus 로고
    • Obesity short-circuits stemness gene network in human adipose multipotent stem cells
    • 10.1096/fj.10-171439, 21846837
    • Roldan M, Macias-Gonzalez M, Garcia R, Tinahones FJ, Martin M. Obesity short-circuits stemness gene network in human adipose multipotent stem cells. FASEB J 2011, 25:4111-4126. 10.1096/fj.10-171439, 21846837.
    • (2011) FASEB J , vol.25 , pp. 4111-4126
    • Roldan, M.1    Macias-Gonzalez, M.2    Garcia, R.3    Tinahones, F.J.4    Martin, M.5
  • 14
    • 74049140758 scopus 로고    scopus 로고
    • Phenotypes of stem cells from diverse origin
    • Tarnok A, Ulrich H, Bocsi J. Phenotypes of stem cells from diverse origin. Cytometry A 2010, 77:6-10.
    • (2010) Cytometry A , vol.77 , pp. 6-10
    • Tarnok, A.1    Ulrich, H.2    Bocsi, J.3
  • 16
    • 0038664242 scopus 로고    scopus 로고
    • Molecular and cellular characterisation of highly purified stromal stem cells derived from human bone marrow
    • 10.1242/jcs.00369, 12665563
    • Gronthos S, Zannettino AC, Hay SJ, Shi S, Graves SE, Kortesidis A, Simmons PJ. Molecular and cellular characterisation of highly purified stromal stem cells derived from human bone marrow. J Cell Sci 2003, 116:1827-1835. 10.1242/jcs.00369, 12665563.
    • (2003) J Cell Sci , vol.116 , pp. 1827-1835
    • Gronthos, S.1    Zannettino, A.C.2    Hay, S.J.3    Shi, S.4    Graves, S.E.5    Kortesidis, A.6    Simmons, P.J.7
  • 18
    • 80055119713 scopus 로고    scopus 로고
    • Mesenchymal stem cells from adipose tissue which have been differentiated into chondrocytes in three-dimensional culture express lubricin
    • Musumeci G, Lo Furno D, Loreto C, Giuffrida R, Caggia S, Leonardi R, Cardile V. Mesenchymal stem cells from adipose tissue which have been differentiated into chondrocytes in three-dimensional culture express lubricin. Exp Biol Med (Maywood) 2011, 236:1333-1341.
    • (2011) Exp Biol Med (Maywood) , vol.236 , pp. 1333-1341
    • Musumeci, G.1    Lo Furno, D.2    Loreto, C.3    Giuffrida, R.4    Caggia, S.5    Leonardi, R.6    Cardile, V.7
  • 20
    • 31444441967 scopus 로고    scopus 로고
    • Hox genes: a continuation of embryonic patterning?
    • 10.1016/j.tig.2005.11.004, 16325300
    • Morgan R. Hox genes: a continuation of embryonic patterning?. Trends Genet 2006, 22:67-69. 10.1016/j.tig.2005.11.004, 16325300.
    • (2006) Trends Genet , vol.22 , pp. 67-69
    • Morgan, R.1
  • 21
    • 33646271627 scopus 로고    scopus 로고
    • Evidence for a role of developmental genes in the origin of obesity and body fat distribution
    • 10.1073/pnas.0601752103, 1458940, 16617105
    • Gesta S, Bluher M, Yamamoto Y, Norris AW, Berndt J, Kralisch S, Boucher J, Lewis C, Kahn CR. Evidence for a role of developmental genes in the origin of obesity and body fat distribution. Proc Natl Acad Sci USA 2006, 103:6676-6681. 10.1073/pnas.0601752103, 1458940, 16617105.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 6676-6681
    • Gesta, S.1    Bluher, M.2    Yamamoto, Y.3    Norris, A.W.4    Berndt, J.5    Kralisch, S.6    Boucher, J.7    Lewis, C.8    Kahn, C.R.9
  • 22
    • 80955136605 scopus 로고    scopus 로고
    • Adipose stem cells originate from perivascular cells
    • 10.1042/BC20110033, 21679159
    • Cai X, Lin Y, Hauschka PV, Grottkau BE. Adipose stem cells originate from perivascular cells. Biol Cell 2011, 103:435-447. 10.1042/BC20110033, 21679159.
    • (2011) Biol Cell , vol.103 , pp. 435-447
    • Cai, X.1    Lin, Y.2    Hauschka, P.V.3    Grottkau, B.E.4
  • 23
    • 33749502961 scopus 로고    scopus 로고
    • Cytokines and hematopoietic stem cell mobilization
    • 10.1002/jcb.21043, 16888804
    • Nervi B, Link DC, DiPersio JF. Cytokines and hematopoietic stem cell mobilization. J Cell Biochem 2006, 99:690-705. 10.1002/jcb.21043, 16888804.
    • (2006) J Cell Biochem , vol.99 , pp. 690-705
    • Nervi, B.1    Link, D.C.2    DiPersio, J.F.3
  • 25
    • 68349148199 scopus 로고    scopus 로고
    • Association of waist circumference, traditional cardiovascular risk factors, and stromal-derived factor-1 in adolescents
    • 10.1111/j.1399-5448.2008.00486.x, 19076302
    • Jung C, Fischer N, Fritzenwanger M, Pernow J, Brehm BR, Figulla HR. Association of waist circumference, traditional cardiovascular risk factors, and stromal-derived factor-1 in adolescents. Pediatr Diabetes 2009, 10:329-335. 10.1111/j.1399-5448.2008.00486.x, 19076302.
    • (2009) Pediatr Diabetes , vol.10 , pp. 329-335
    • Jung, C.1    Fischer, N.2    Fritzenwanger, M.3    Pernow, J.4    Brehm, B.R.5    Figulla, H.R.6
  • 26
    • 0037453716 scopus 로고    scopus 로고
    • Modulation of Rho GTPase signaling regulates a switch between adipogenesis and myogenesis
    • 10.1016/S0092-8674(03)00271-X, 12705864
    • Sordella R, Jiang W, Chen GC, Curto M, Settleman J. Modulation of Rho GTPase signaling regulates a switch between adipogenesis and myogenesis. Cell 2003, 113:147-158. 10.1016/S0092-8674(03)00271-X, 12705864.
    • (2003) Cell , vol.113 , pp. 147-158
    • Sordella, R.1    Jiang, W.2    Chen, G.C.3    Curto, M.4    Settleman, J.5
  • 27
    • 0037470230 scopus 로고    scopus 로고
    • Basic helix-loop-helix transcription factor epicardin/capsulin/Pod-1 suppresses differentiation by negative regulation of transcription
    • 10.1074/jbc.M212248200, 12493738
    • Funato N, Ohyama K, Kuroda T, Nakamura M. Basic helix-loop-helix transcription factor epicardin/capsulin/Pod-1 suppresses differentiation by negative regulation of transcription. J Biol Chem 2003, 278:7486-7493. 10.1074/jbc.M212248200, 12493738.
    • (2003) J Biol Chem , vol.278 , pp. 7486-7493
    • Funato, N.1    Ohyama, K.2    Kuroda, T.3    Nakamura, M.4
  • 28
    • 34347205271 scopus 로고    scopus 로고
    • Cranial muscle defects of Pitx2 mutants result from specification defects in the first branchial arch
    • 10.1073/pnas.0701122104, 1851590, 17384148
    • Shih HP, Gross MK, Kioussi C. Cranial muscle defects of Pitx2 mutants result from specification defects in the first branchial arch. Proc Natl Acad Sci USA 2007, 104:5907-5912. 10.1073/pnas.0701122104, 1851590, 17384148.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 5907-5912
    • Shih, H.P.1    Gross, M.K.2    Kioussi, C.3
  • 29
    • 79958183374 scopus 로고    scopus 로고
    • The gp130 receptor cytokine family: regulators of adipocyte development and function
    • 10.2174/138161211795164202, 3119891, 21375496
    • White UA, Stephens JM. The gp130 receptor cytokine family: regulators of adipocyte development and function. Curr Pharm Des 2011, 17:340-346. 10.2174/138161211795164202, 3119891, 21375496.
    • (2011) Curr Pharm Des , vol.17 , pp. 340-346
    • White, U.A.1    Stephens, J.M.2
  • 30
    • 17344381882 scopus 로고    scopus 로고
    • TR1, a new member of the tumor necrosis factor receptor superfamily, induces fibroblast proliferation and inhibits osteoclastogenesis and bone resorption
    • Kwon BS, Wang S, Udagawa N, Haridas V, Lee ZH, Kim KK, Oh KO, Greene J, Li Y, Su J, et al. TR1, a new member of the tumor necrosis factor receptor superfamily, induces fibroblast proliferation and inhibits osteoclastogenesis and bone resorption. FASEB J 1998, 12:845-854.
    • (1998) FASEB J , vol.12 , pp. 845-854
    • Kwon, B.S.1    Wang, S.2    Udagawa, N.3    Haridas, V.4    Lee, Z.H.5    Kim, K.K.6    Oh, K.O.7    Greene, J.8    Li, Y.9    Su, J.10
  • 31
    • 36249015353 scopus 로고    scopus 로고
    • Expression and regulation of osteoprotegerin in adipose tissue
    • 10.3349/ymj.2007.48.5.765, 2628141, 17963332
    • An JJ, Han DH, Kim DM, Kim SH, Rhee Y, Lee EJ, Lim SK. Expression and regulation of osteoprotegerin in adipose tissue. Yonsei Med J 2007, 48:765-772. 10.3349/ymj.2007.48.5.765, 2628141, 17963332.
    • (2007) Yonsei Med J , vol.48 , pp. 765-772
    • An, J.J.1    Han, D.H.2    Kim, D.M.3    Kim, S.H.4    Rhee, Y.5    Lee, E.J.6    Lim, S.K.7
  • 32
    • 0035094860 scopus 로고    scopus 로고
    • Associations of serum osteoprotegerin levels with diabetes, stroke, bone density, fractures, and mortality in elderly women
    • 10.1210/jc.86.2.631, 11158021
    • Browner WS, Lui LY, Cummings SR. Associations of serum osteoprotegerin levels with diabetes, stroke, bone density, fractures, and mortality in elderly women. J Clin Endocrinol Metab 2001, 86:631-637. 10.1210/jc.86.2.631, 11158021.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 631-637
    • Browner, W.S.1    Lui, L.Y.2    Cummings, S.R.3
  • 33
    • 84860344707 scopus 로고    scopus 로고
    • Down-regulation of type I Runx2 mediated by dexamethasone is required for 3T3-L1 adipogenesis
    • 10.1210/me.2011-1287, 22422618
    • Zhang YY, Li X, Qian SW, Guo L, Huang HY, He Q, Liu Y, Ma CG, Tang QQ. Down-regulation of type I Runx2 mediated by dexamethasone is required for 3T3-L1 adipogenesis. Mol Endocrinol 2012, 26:798-808. 10.1210/me.2011-1287, 22422618.
    • (2012) Mol Endocrinol , vol.26 , pp. 798-808
    • Zhang, Y.Y.1    Li, X.2    Qian, S.W.3    Guo, L.4    Huang, H.Y.5    He, Q.6    Liu, Y.7    Ma, C.G.8    Tang, Q.Q.9
  • 34
    • 78649828932 scopus 로고    scopus 로고
    • Obesity-mediated inflammatory microenvironment stimulates osteoclastogenesis and bone loss in mice
    • 10.1016/j.exger.2010.09.014, 2998554, 20923699
    • Halade GV, El Jamali A, Williams PJ, Fajardo RJ, Fernandes G. Obesity-mediated inflammatory microenvironment stimulates osteoclastogenesis and bone loss in mice. Exp Gerontol 2011, 46:43-52. 10.1016/j.exger.2010.09.014, 2998554, 20923699.
    • (2011) Exp Gerontol , vol.46 , pp. 43-52
    • Halade, G.V.1    El Jamali, A.2    Williams, P.J.3    Fajardo, R.J.4    Fernandes, G.5
  • 36
    • 77954349282 scopus 로고    scopus 로고
    • Adipose tissue remodeling in pathophysiology of obesity
    • 10.1097/MCO.0b013e32833aabef, 3235038, 20531178
    • Lee MJ, Wu Y, Fried SK. Adipose tissue remodeling in pathophysiology of obesity. Curr Opin Clin Nutr Metab Care 2010, 13:371-376. 10.1097/MCO.0b013e32833aabef, 3235038, 20531178.
    • (2010) Curr Opin Clin Nutr Metab Care , vol.13 , pp. 371-376
    • Lee, M.J.1    Wu, Y.2    Fried, S.K.3
  • 37
    • 41549097235 scopus 로고    scopus 로고
    • Characterization of human mesenchymal stem cell secretome at early steps of adipocyte and osteoblast differentiation
    • 10.1186/1471-2199-9-26, 2279142, 18302751
    • Chiellini C, Cochet O, Negroni L, Samson M, Poggi M, Ailhaud G, Alessi MC, Dani C, Amri EZ. Characterization of human mesenchymal stem cell secretome at early steps of adipocyte and osteoblast differentiation. BMC Mol Biol 2008, 9:26. 10.1186/1471-2199-9-26, 2279142, 18302751.
    • (2008) BMC Mol Biol , vol.9 , pp. 26
    • Chiellini, C.1    Cochet, O.2    Negroni, L.3    Samson, M.4    Poggi, M.5    Ailhaud, G.6    Alessi, M.C.7    Dani, C.8    Amri, E.Z.9
  • 38
    • 0348015841 scopus 로고    scopus 로고
    • The effect of hyaluronan on osteoblast proliferation and differentiation in rat calvarial-derived cell cultures
    • Huang L, Cheng YY, Koo PL, Lee KM, Qin L, Cheng JC, Kumta SM. The effect of hyaluronan on osteoblast proliferation and differentiation in rat calvarial-derived cell cultures. J Biomed Mater Res A 2003, 66:880-884.
    • (2003) J Biomed Mater Res A , vol.66 , pp. 880-884
    • Huang, L.1    Cheng, Y.Y.2    Koo, P.L.3    Lee, K.M.4    Qin, L.5    Cheng, J.C.6    Kumta, S.M.7
  • 39
    • 33746281978 scopus 로고    scopus 로고
    • Gene expression, synthesis and degradation of hyaluronan during differentiation of 3T3-L1 adipocytes
    • 10.1016/j.abb.2006.05.010, 16824481
    • Allingham PG, Brownlee GR, Harper GS, Pho M, Nilsson SK, Brown TJ. Gene expression, synthesis and degradation of hyaluronan during differentiation of 3T3-L1 adipocytes. Arch Biochem Biophys 2006, 452:83-91. 10.1016/j.abb.2006.05.010, 16824481.
    • (2006) Arch Biochem Biophys , vol.452 , pp. 83-91
    • Allingham, P.G.1    Brownlee, G.R.2    Harper, G.S.3    Pho, M.4    Nilsson, S.K.5    Brown, T.J.6
  • 40
    • 34447552373 scopus 로고    scopus 로고
    • Role of versican and hyaluronan in the differentiation of 3T3-L1 cells into preadipocytes and mature adipocytes
    • 10.1016/j.matbio.2007.04.002, 17513099
    • Zizola CF, Julianelli V, Bertolesi G, Yanagishita M, Calvo JC. Role of versican and hyaluronan in the differentiation of 3T3-L1 cells into preadipocytes and mature adipocytes. Matrix Biol 2007, 26:419-430. 10.1016/j.matbio.2007.04.002, 17513099.
    • (2007) Matrix Biol , vol.26 , pp. 419-430
    • Zizola, C.F.1    Julianelli, V.2    Bertolesi, G.3    Yanagishita, M.4    Calvo, J.C.5
  • 41
    • 0347985272 scopus 로고    scopus 로고
    • Obesity-induced inflammatory changes in adipose tissue
    • 297006, 14679172
    • Wellen KE, Hotamisligil GS. Obesity-induced inflammatory changes in adipose tissue. J Clin Invest 2003, 112:1785-1788. 297006, 14679172.
    • (2003) J Clin Invest , vol.112 , pp. 1785-1788
    • Wellen, K.E.1    Hotamisligil, G.S.2
  • 42
    • 33846201363 scopus 로고    scopus 로고
    • Release of interleukins and other inflammatory cytokines by human adipose tissue is enhanced in obesity and primarily due to the nonfat cells
    • Fain JN. Release of interleukins and other inflammatory cytokines by human adipose tissue is enhanced in obesity and primarily due to the nonfat cells. Vitam Horm 2006, 74:443-477.
    • (2006) Vitam Horm , vol.74 , pp. 443-477
    • Fain, J.N.1
  • 43
  • 45
    • 83055181305 scopus 로고    scopus 로고
    • LOX-1 and obesity
    • 10.1007/s10557-011-6335-3, 21881850
    • Yan M, Mehta JL, Hu C. LOX-1 and obesity. Cardiovasc Drugs Ther 2011, 25:469-476. 10.1007/s10557-011-6335-3, 21881850.
    • (2011) Cardiovasc Drugs Ther , vol.25 , pp. 469-476
    • Yan, M.1    Mehta, J.L.2    Hu, C.3
  • 46
    • 23644455127 scopus 로고    scopus 로고
    • PPARgamma regulates adipocyte cholesterol metabolism via oxidized LDL receptor 1
    • 10.1172/JCI24130, 1172230, 16007265
    • Chui PC, Guan HP, Lehrke M, Lazar MA. PPARgamma regulates adipocyte cholesterol metabolism via oxidized LDL receptor 1. J Clin Invest 2005, 115:2244-2256. 10.1172/JCI24130, 1172230, 16007265.
    • (2005) J Clin Invest , vol.115 , pp. 2244-2256
    • Chui, P.C.1    Guan, H.P.2    Lehrke, M.3    Lazar, M.A.4
  • 47
    • 38749118269 scopus 로고    scopus 로고
    • The lectin-like oxidized low-density-lipoprotein receptor: a pro-inflammatory factor in vascular disease
    • 10.1042/BJ20071196, 18092947
    • Dunn S, Vohra RS, Murphy JE, Homer-Vanniasinkam S, Walker JH, Ponnambalam S. The lectin-like oxidized low-density-lipoprotein receptor: a pro-inflammatory factor in vascular disease. Biochem J 2008, 409:349-355. 10.1042/BJ20071196, 18092947.
    • (2008) Biochem J , vol.409 , pp. 349-355
    • Dunn, S.1    Vohra, R.S.2    Murphy, J.E.3    Homer-Vanniasinkam, S.4    Walker, J.H.5    Ponnambalam, S.6
  • 48
    • 73649097539 scopus 로고    scopus 로고
    • Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death
    • 10.1111/j.1742-4658.2009.07411.x, 19878313
    • Lin Y, Hupp TR, Stevens C. Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death. FEBS J 2010, 277:48-57. 10.1111/j.1742-4658.2009.07411.x, 19878313.
    • (2010) FEBS J , vol.277 , pp. 48-57
    • Lin, Y.1    Hupp, T.R.2    Stevens, C.3
  • 50
    • 0038322020 scopus 로고    scopus 로고
    • Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function
    • 10.1074/jbc.M212259200, 12524424
    • Choy L, Derynck R. Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function. J Biol Chem 2003, 278:9609-9619. 10.1074/jbc.M212259200, 12524424.
    • (2003) J Biol Chem , vol.278 , pp. 9609-9619
    • Choy, L.1    Derynck, R.2
  • 51
    • 65549109680 scopus 로고    scopus 로고
    • Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss
    • 10.1016/j.jacc.2008.12.068, 19460605
    • Lavie CJ, Milani RV, Ventura HO. Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss. J Am Coll Cardiol 2009, 53:1925-1932. 10.1016/j.jacc.2008.12.068, 19460605.
    • (2009) J Am Coll Cardiol , vol.53 , pp. 1925-1932
    • Lavie, C.J.1    Milani, R.V.2    Ventura, H.O.3
  • 52
    • 79958814620 scopus 로고    scopus 로고
    • Adiposopathy is " sick fat" a cardiovascular disease?
    • 10.1016/j.jacc.2011.02.038, 21679848
    • Bays HE. Adiposopathy is " sick fat" a cardiovascular disease?. J Am Coll Cardiol 2011, 57:2461-2473. 10.1016/j.jacc.2011.02.038, 21679848.
    • (2011) J Am Coll Cardiol , vol.57 , pp. 2461-2473
    • Bays, H.E.1
  • 54
    • 0036081355 scopus 로고    scopus 로고
    • Gene expression omnibus: NCBI gene expression and hybridization array data repository
    • 10.1093/nar/30.1.207, 99122, 11752295
    • Edgar R, Domrachev M, Lash AE. Gene expression omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res 2002, 30:207-210. 10.1093/nar/30.1.207, 99122, 11752295.
    • (2002) Nucleic Acids Res , vol.30 , pp. 207-210
    • Edgar, R.1    Domrachev, M.2    Lash, A.E.3
  • 55
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: a practical and powerful approach to multiple testing
    • Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser B Methodol 1995, 57:289-300.
    • (1995) J R Stat Soc Ser B Methodol , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 56
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method
    • 10.1006/meth.2001.1262, 11846609
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 2001, 25:402-408. 10.1006/meth.2001.1262, 11846609.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 57
    • 80054936460 scopus 로고    scopus 로고
    • Tissue factor regulates microvessel formation and stabilization by induction of chemokine (C-C motif) ligand 2 expression
    • 10.1161/ATVBAHA.111.233536, 21868706
    • Arderiu G, Pena E, Aledo R, Juan-Babot O, Badimon L. Tissue factor regulates microvessel formation and stabilization by induction of chemokine (C-C motif) ligand 2 expression. Arterioscler Thromb Vasc Biol 2011, 31:2607-2615. 10.1161/ATVBAHA.111.233536, 21868706.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 2607-2615
    • Arderiu, G.1    Pena, E.2    Aledo, R.3    Juan-Babot, O.4    Badimon, L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.