Bisphosphonate-linked hyaluronic acid hydrogel sequesters and enzymatically releases active bone morphogenetic protein-2 for induction of osteogenic differentiation

Biomacromolecules

Volumn 14, Issue 9, 2013, Pages 3055-3063

  Hulsart Billström, Gry ^a   Yuen, Pik Kwan ^a   Marsell, Richard ^a   Hilborn, Jöns ^b   Larsson, Sune ^a   Ossipov, Dmitri ^b  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOLOGOUS BONE GRAFTING; BONE MORPHOGENETIC PROTEIN-2; BONE MORPHOGENETIC PROTEINS; BONE TISSUE REGENERATION; CHEMICAL FUNCTIONALITY; HYALURONIC ACID HYDROGELS; MESENCHYMAL STEM CELL; OSTEOGENIC DIFFERENTIATION;

BIOACTIVITY; BIOLOGICAL MATERIALS; BONE; CELL CULTURE; DEGRADATION; FLOWCHARTING; GRAFTING (CHEMICAL); HYALURONIC ACID; SCAFFOLDS (BIOLOGY);

HYDROGELS;

BISPHOSPHONIC ACID DERIVATIVE; BONE MORPHOGENETIC PROTEIN 2; GROWTH FACTOR; HYALURONIC ACID; HYDRAZONE DERIVATIVE; LIGAND;

ARTICLE; BIOLOGICAL ACTIVITY; BONE DEVELOPMENT; BONE MARROW CELL; CELL DIFFERENTIATION; CONTROLLED STUDY; CROSS LINKING; CYTOTOXICITY; DRUG RELEASE; ENCAPSULATION; ENZYMATIC DEGRADATION; ENZYME RELEASE; HYDROGEL; IN VITRO STUDY; INCUBATION TIME; MESENCHYMAL STEM CELL; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN BINDING;

ANIMALS; BIOCATALYSIS; BONE MORPHOGENETIC PROTEIN 2; CELL ADHESION; CELL DIFFERENTIATION; CELL SURVIVAL; CELLS, CULTURED; DELAYED-ACTION PREPARATIONS; DIPHOSPHONATES; HUMANS; HYALURONIC ACID; HYALURONOGLUCOSAMINIDASE; HYDROGELS; HYDROLYSIS; KINETICS; MESENCHYMAL STROMAL CELLS; OSTEOBLASTS; OSTEOGENESIS; RATS; TISSUE SCAFFOLDS;

EID: 84883786248     PISSN: 15257797     EISSN: 15264602     Source Type: Journal    
DOI: 10.1021/bm400639e     Document Type: Article

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