Protective effect of a β3-adrenoceptor agonist on bladder function in a rat model of chronic bladder ischemia

European Urology

Volumn 64, Issue 4, 2013, Pages 664-671

  Sawada, Norifumi ^a,b   Nomiya, Masanori ^c   Hood, Brandy ^b   Koslov, David ^b   Zarifpour, Mona ^b   Andersson, Karl Erik ^b  

^a UNIVERSITY OF YAMANASHI   (Japan)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

^c FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Arterial endothelial injury; Atherosclerosis; Cholesterol diet; Cystometry; Detrusor overactivity; Mirabegron

Indexed keywords

CARBACHOL; COLLAGEN; MIRABEGRON; POTASSIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER CAPACITY; BLADDER DISEASE; BLADDER DYSFUNCTION; BLADDER FUNCTION; CHOLESTEROL DIET; CHRONIC BLADDER ISCHEMIA; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; ELECTROSTIMULATION; ENDOTHELIUM INJURY; HISTOLOGY; ILIAC ARTERY; IN VITRO STUDY; ISCHEMIA; MALE; MICTURITION; NEOINTIMA; NONHUMAN; PRIORITY JOURNAL; RAT; URODYNAMICS;

ARTERIAL ENDOTHELIAL INJURY; ATHEROSCLEROSIS; CHOLESTEROL DIET; CYSTOMETRY; DETRUSOR OVERACTIVITY; MIRABEGRON;

ACETANILIDES; ADRENERGIC BETA-3 RECEPTOR AGONISTS; ANIMALS; CHOLESTEROL, DIETARY; CHRONIC DISEASE; COLLAGEN; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ILIAC ARTERY; ISCHEMIA; MALE; NEOINTIMA; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, BETA-3; THIAZOLES; TIME FACTORS; URINARY BLADDER; URINARY BLADDER, OVERACTIVE; URINATION; URODYNAMICS; VASCULAR SYSTEM INJURIES;

EID: 84883781954     PISSN: 03022838     EISSN: 18737560     Source Type: Journal    
DOI: 10.1016/j.eururo.2013.06.043     Document Type: Article

References (29)

1. E.A. Gormley, D.J. Lightner, K.L. Burgio American Urological Association; Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction Diagnosis and treatment of overactive bladder (non-neurogenic) in adults: AUA/SUFU guideline J Urol 188 Suppl 2012 2455 2463
2. M.G. Lucas, R.J.L. Bosch, and F.C. Burkhard EAU guidelines on assessment and nonsurgical management of urinary incontinence Eur Urol 62 2012 1130 1142
3. P. Madhuvrata, J.D. Cody, G. Ellis, G.P. Herbison, and E.J. Hay-Smith Which anticholinergic drug for overactive bladder symptoms in adults Cochrane Database Syst Rev 2012 CD005429
4. 3- adrenoceptor agonists in the treatment of the overactive bladder. J Urol. In press. http://dx.doi.org/10.1016/j.juro.2013.02.104.
5. V.W. Nitti, S. Auerbach, N. Martin, A. Calhoun, M. Lee, and S. Herschorn Results of a randomized phase III trial of mirabegron in patients with overactive bladder J Urol 189 2013 1388 1395
6. Chapple CR, Dvorak V, Radziszewski P, et al., Dragon Investigator Group. A phase II dose-ranging study of mirabegron in patients with overactive bladder. Int Urogynecol J. In press. http://dx.doi.org/10.1007/s00192-013-2042-x.
7. Chapple CR, Amarenco G, López Aramburu MA, et al., BLOSSOM Investigator Group. A proof-of-concept study: mirabegron, a new therapy for overactive bladder. Neurourol Urodyn. In press. http://dx.doi.org/10.1002/nau. 22373
8. C.R. Chapple, S.A. Kaplan, and D. Mitcheson Randomized double-blind, active-controlled phase 3 study to assess 12-month safety and efficacy of mirabegron, a β3-adrenoceptor agonist, in overactive bladder Eur Urol 63 2013 296 305
9. V. Khullar, G. Amarenco, and J.C. Angulo Efficacy and tolerability of mirabegron, a β3-adrenoceptor agonist, in patients with overactive bladder: results from a randomised European-Australian phase 3 trial Eur Urol 63 2013 283 295
10. A. Ponholzer, C. Temml, C. Wehrberger, M. Marszalek, and S. Madersbacher The association between vascular risk factors and lower urinary tract symptoms in both sexes Eur Urol 50 2006 581 586
11. G.M. Pinggera, M. Mitterberger, and E. Steiner Association of lower urinary tract symptoms and chronic ischaemia of the lower urinary tract in elderly women and men: assessment using colour Doppler ultrasonography BJU Int 102 2008 470 474
12. Uzun H, Ciçek Y, Kocaman SA, Durakoǧlugil ME, Zorba OU. Increased pulse-wave velocity and carotid intima-media thickness in patients with lower urinary tract symptoms. Scand J Urol. http://dx.doi.org/10.3109/ 21681805.2013.780185
13. M. Nomiya, O. Yamaguchi, and K.E. Andersson The effect of atherosclerosis-induced chronic bladder ischemia on bladder function in the rat Neurourol Urodyn 31 2012 195 200
14. M. Nomiya, K. Sagawa, and J. Yazaki Increased bladder activity is associated with elevated oxidative stress markers and proinflammatory cytokines in a rat model of atherosclerosis-induced chronic bladder ischemia Neurourol Urodyn 31 2012 185 189
15. K.E. Andersson Pathways for relaxation of detrusor smooth muscle Adv Exp Med Biol 462 1999 241 252
16. H. Uchida, K. Shishido, M. Nomiya, and O. Yamaguchi Involvement of cyclic AMP-dependent and -independent mechanisms in the relaxation of rat detrusor muscle via beta-adrenoceptors Eur J Pharmacol 518 2005 195 202
17. E.P. Frazier, S.L. Peters, A.S. Braverman, M.R. Ruggieri Sr., and M.C. Michel Signal transduction underlying the control of urinary bladder smooth muscle tone by muscarinic receptors and beta-adrenoceptors Naunyn Schmiedebergs Arch Pharmacol 377 2008 449 462
18. G.V. Petkov Role of potassium ion channels in detrusor smooth muscle function and dysfunction Nat Rev Urol 9 2012 30 40
19. D. Pinsky, M. Oz, and H. Liao Restoration of the cAMP second messenger pathway enhances cardiac preservation for transplantation in a heterotopic rat model J Clin Invest 92 1993 2994 3002
20. T. Minor, S. Akbar, and R. Tolba Preservation of livers from non-heart-beating donors: modulation of cAMP signal and organ viability by glucagon Transplant Proc 31 1999 1068
21. M. Riera, J. Torras, and J.M. Cruzado The enhancement of endogenous cAMP with pituitary adenylate cyclase-activating polypeptide protects rat kidney against ischemia through the modulation of inflammatory response Transplantation 72 2001 1217 1223
22. J.E. Greenland, and A.F. Brading The effect of bladder outflow obstruction on detrusor blood flow changes during the voiding cycle in conscious pigs J Urol 165 2001 245 248
23. J.E. Greenland, J.J. Hvistendahl, and H. Andersen The effect of bladder outlet obstruction on tissue oxygen tension and blood flow in the pig bladder BJU Int 85 2000 1109 1114
24. W.C. Cole, C.D. McPherson, and D. Sontag ATP-regulated K+ channels protect the myocardium against ischemia/reperfusion damage Circulation Res 69 1991 571 581
25. W. Xu, Y. Liu, and S. Wang Cytoprotective role of Ca2+- activated K+ channels in the cardiac inner mitochondrial membrane Science 298 2002 1029 1033
26. L. Chmielewska, and D. Malinska Cytoprotective action of the potassium channel opener NS1619 under conditions of disrupted calcium homeostasis Pharmacol Rep 63 2011 176 183
27. T. Takasu, M. Ukai, and S. Sato Effect of (R)-2-(2-aminothiazol-4-yl)- 4′-{2-[(2-hydroxy-2-phenylethyl)amino]ethyl} acetanilide (YM178), a novel selective beta3-adrenoceptor agonist, on bladder function J Pharmacol Exp Ther 321 2007 642 647
28. J.I. Gillespie, S. Palea, V. Guilloteau, M. Guerard, P. Lluel, and C. Korstanje Modulation of non-voiding activity by the muscarinergic antagonist tolterodine and the β(3)-adrenoceptor agonistmirabegron in conscious rats with partial outflow obstruction BJU Int 110 2012 E132 E142
29. N. Aizawa, Y. Homma, and Y. Igawa Effects of mirabegron, a novel beta3-adrenoceptor agonist, on primary bladder afferent activity and bladder microcontractions in rats compared with the effects of oxybutynin Eur Urol 62 2012 1165 1173