Increased bladder activity is associated with elevated oxidative stress markers and proinflammatory cytokines in a rat model of atherosclerosis-induced chronic bladder ischemia

Neurourology and Urodynamics

Volumn 31, Issue 1, 2012, Pages 185-189

  Nomiya, Masanori ^a,b   Sagawa, Koji ^a   Yazaki, Junji ^a   Takahashi, Norio ^a   Kushida, Nobuhiro ^a   Haga, Nobuhiro ^a   Aikawa, Ken ^a   Matsui, Takahiro ^c   Oka, Michiko ^c   Fukui, Tomomi ^c   Andersson, Karl Erik ^b   Yamaguchi, Osamu ^a  

^a FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

^c NIPPON SHINYAKU CO LTD   (Japan)

Author keywords

atherosclerosis; chronic bladder ischemia; detrusor overactivity; oxidative stress; proinflammatory cytokines

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; CXCL1 CHEMOKINE; INTERLEUKIN 6; INTERLEUKIN 8; MALONALDEHYDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; BLADDER DISEASE; BLADDER FUNCTION; BLADDER WALL; BODY WEIGHT; CHOLESTEROL DIET; CHRONIC BLADDER ISCHEMIA; CHRONIC DISEASE; CONTROLLED STUDY; CYSTOMETRY; ENDOTHELIUM INJURY; HISTOPATHOLOGY; ILIAC ARTERY; INTIMA; KIDNEY FIBROSIS; MALE; MICTURITION; NONHUMAN; ORGAN WEIGHT; PRESSURE; RAT; UPREGULATION;

ANIMALS; ATHEROSCLEROSIS; BIOLOGICAL MARKERS; CHRONIC DISEASE; CYTOKINES; DEOXYGUANOSINE; DISEASE MODELS, ANIMAL; ILIAC ARTERY; ISCHEMIA; MALE; MALONDIALDEHYDE; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; UP-REGULATION; URINARY BLADDER; URINARY BLADDER, OVERACTIVE; URINATION; URODYNAMICS;

EID: 84856208773     PISSN: 07332467     EISSN: 15206777     Source Type: Journal    
DOI: 10.1002/nau.21191     Document Type: Article

References (31)

1. Irwin DE, Milsom I, Hunskaar S, et al. Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: Results of the EPIC study. Eur Urol 2006; 50: 1306-14; discussion 14-5.
2. Chapple CR, Wein AJ, Abrams P, et al. Lower urinary tract symptoms revisited: A broader clinical perspective. Eur Urol 2008; 54: 563-9.
3. Yamaguchi O, Aikawa K, Shishido K, et al. Place of overactive bladder in male lower urinary tract symptoms. World J Urol 2009; 27: 723-8.
4. Andersson KE,. Storage and voiding symptoms: Pathophysiologic aspects. Urology 2003; 62: 3-10.
5. Andersson KE, de Groat WC, McVary KT, et al. Tadalafil for the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia: Pathophysiology and mechanism(s) of action. Neurourol Urodyn 2011; 30: 292-301.
6. Kaplan SA,. Male pelvic health: A urological call to arms. J Urol 2006; 176: 2351-2.
7. Ponholzer A, Temml C, Wehrberger C, et al. The association between vascular risk factors and lower urinary tract symptoms in both sexes. Eur Urol 2006; 50: 581-6.
8. Pinggera GM, Mitterberger M, Steiner E, et al. Association of lower urinary tract symptoms and chronic ischaemia of the lower urinary tract in elderly women and men: Assessment using colour Doppler ultrasonography. BJU Int 2008; 102: 470-4.
9. Pinggera GM, Mitterberger M, Pallwein L, et al. alpha-Blockers improve chronic ischaemia of the lower urinary tract in patients with lower urinary tract symptoms. BJU Int 2008; 101: 319-24.
10. Azadzoi KM, Tarcan T, Siroky MB, et al. Atherosclerosis-induced chronic ischemia causes bladder fibrosis and non-compliance in the rabbit. J Urol 1999; 161: 1626-35.
11. Yoshida M, Masunaga K, Nagata T, et al. The effects of chronic hyperlipidemia on bladder function in myocardial infarction-prone Watanabe heritable hyperlipidemic (WHHLMI) rabbits. Neurourol Urodyn 2010; 29: 1350-4.
12. Azadzoi KM, Tarcan T, Kozlowski R, et al. Overactivity and structural changes in the chronically ischemic bladder. J Urol 1999; 162: 1768-78.
13. Azadzoi KM, Shinde VM, Tarcan T, et al. Increased leukotriene and prostaglandin release, and overactivity in the chronically ischemic bladder. J Urol 2003; 169: 1885-91.
14. Azadzoi KM, Heim VK, Tarcan T, et al. Alteration of urothelial-mediated tone in the ischemic bladder: Role of eicosanoids. Neurourol Urodyn 2004; 23: 258-64.
15. Azadzoi KM, Yalla SV, Siroky MB,. Oxidative stress and neurodegeneration in the ischemic overactive bladder. J Urol 2007; 178: 710-5.
16. Azadzoi KM, Radisavljevic ZM, Golabek T, et al. Oxidative modification of mitochondrial integrity and nerve fiber density in the ischemic overactive bladder. J Urol 2010; 183: 362-9.
17. Lin AT, Chen MT, Yang CH, et al. Blood flow of the urinary bladder: Effects of outlet obstruction and correlation with bioenergetic metabolism. Neurourol Urodyn 1995; 14: 285-92.
18. Radu F, Leggett RE, Schuler C, et al. The effect of in vitro ischemia/reperfusion on contraction, free fatty acid content, phospholipid content, and malondialdehyde levels of the rabbit urinary bladder. Mol Cell Biochem 2011; 346: 179-86.
19. Oka M, Fukui T, Ueda M, et al. Suppression of bladder oxidative stress and inflammation by a phytotherapeutic agent in a rat model of partial bladder outlet obstruction. J Urol 2009; 182: 382-90.
20. Nomiya M, Yamaguchi O, Andersson KE, et al. The effect of atherosclerosis-induced chronic bladder ischemia on bladder function on the rat. Neurourol Urodyn 2011; In press. Published online in Wiley Online Library (wileyonlinelibrary.com). DOI: 10.1002/nau.21073
21. Rahman NU, Phonsombat S, Bochinski D, et al. An animal model to study lower urinary tract symptoms and erectile dysfunction: The hyperlipidaemic rat. BJU Int 2007; 100: 658-63.
22. Son H, Lee SL, Park WH, et al. New unstable bladder model in hypercholesterolemia rats. Urology 2007; 69: 186-90.
23. Lin WY, Chen CS, Wu SB, et al. Oxidative stress biomarkers in urine and plasma of rabbits with partial bladder outlet obstruction. BJU Int 2010; 107: 1839-43.
24. Sayre LM, Smith MA, Perry G,. Chemistry and biochemistry of oxidative stress in neurodegenerative disease. Curr Med Chem 2001; 8: 721-38.
25. Chien CT, Yu HJ, Lin TB, et al. Substance P via NK1 receptor facilitates hyperactive bladder afferent signaling via action of ROS. Am J Physiol Renal Physiol 2003; 284: F840-51.
26. Lin WY, Levin RM, Chichester P, et al. Effects of L-arginine and L-NAME on chronic partial bladder outlet obstruction in rabbit. Am J Physiol Regul Integr Comp Physiol 2007; 293: R2390-9.
27. Ah MK, Johnson GK, Kaldahl WB, et al. The effect of smoking on the response to periodontal therapy. J Clin Periodontol 1994; 21: 91-7.
28. Cherubini A, Ruggiero C, Polidori MC, et al. Potential markers of oxidative stress in stroke. Free Radic Biol Med 2005; 39: 841-52.
29. Masuda H, Kawano K, Matsuoka Y, et al. Interactions between inducible nitric oxide synthase and cyclooxygenase-2 in response to ischaemia-reperfusion of rabbit bladder. BJU Int 2010; 106: 716-22.
30. Jang J, Park EY, Seo SI, et al. Effects of intravesical instillation of cyclooxygenase-2 inhibitor on the expression of inducible nitric oxide synthase and nerve growth factor in cyclophosphamide-induced overactive bladder. BJU Int 2006; 98: 435-9.
31. Lee T, Andersson KE, Streng T, et al. Simultaneous registration of intraabdominal and intravesical pressures during cystometry in conscious rats - Effects of bladder outlet obstruction and intravesical PGE2. Neurourol Urodyn 2008; 27: 88-95.