Structure-based discovery of antagonists for GluN3-containing N-methyl-d-aspartate receptors

Neuropharmacology

Volumn 75, Issue , 2013, Pages 324-336

  Kvist, Trine ^a   Greenwood, Jeremy R ^b   Hansen, Kasper B ^c   Traynelis, Stephen F ^c   Bräuner Osborne, Hans ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b SCHRÖDINGER INC   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antagonist; GluN3 subunit; NMDA receptor; Selectivity; Virtual screening; Xenopus oocyte electrophysiology

Indexed keywords

2 HYDROXY 5 [[4 (PYRIDIN 3 YL)THIAZOL 2 YL]AMINO]BENZOIC ACID; 4 (2,4 DICHLOROBENZOYL) 1H PYRROLE 2 CARBOXYLIC ACID; 6 HYDROXY [1,2,5]OXADIAZOLO[3,4 B]PYRAZIN 5(4H)ONE; GLYCINE BINDING GLUN3 RECEPTOR SUBUNIT ANTAGONIST; GLYCINE RECEPTOR ANTAGONIST; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RECOMBINANT DIHETEROMERIC GLUN1 RECEPTOR; RECOMBINANT DIHETEROMERIC GLUN3 RECEPTOR; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG BINDING SITE; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; ELECTROPHYSIOLOGY; IC 50; LIGAND BINDING; MATHEMATICAL MODEL; MEDIAN EFFECTIVE CONCENTRATION; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; PRIORITY JOURNAL; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION; XENOPUS;

4-(2,4-DICHLOROBENZOYL)-1H-PYRROLE-2-CARBOXYLIC ACID; 6-CYANO-7-NITROQUINOXALINE-2,3-DIONE; 6-HYDROXY-[1,2,5]OXADIAZOLO[3,4-B]PYRAZIN-5(4H)-ONE; AMPA; ANTAGONIST; CNQX; DCKA; DICHLOROKYNURENIC ACID; GLUN3 SUBUNIT; IGLUR; IONOTROPIC GLUTAMATE RECEPTOR; LBD; LIGAND-BINDING DOMAIN; N-METHYL-D-ASPARTATE; NMDA; NMDA RECEPTOR; SELECTIVITY; TEVC; TK13; TK30; TK80; TWO-ELECTRODE VOLTAGE-CLAMP; VIRTUAL SCREENING; XENOPUS OOCYTE ELECTROPHYSIOLOGY; [2-HYDROXY-5-((4-(PYRIDIN-3-YL)THIAZOL-2-YL)AMINO]BENZOIC ACID; Α-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID;

ANIMALS; BINDING SITES; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; EXCITATORY AMINO ACID ANTAGONISTS; GLYCINE; INHIBITORY CONCENTRATION 50; MEMBRANE POTENTIALS; MODELS, MOLECULAR; OOCYTES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RECEPTORS, N-METHYL-D-ASPARTATE; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

EID: 84883775690     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2013.08.003     Document Type: Article

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