메뉴 건너뛰기




Volumn 33, Issue 9, 2013, Pages 529-541

Overactivation of mitogen-activated protein kinase and suppression of mitofusin-2 expression are two independent events in high mobility group box 1 protein-mediated T cell immune dysfunction

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BETA ACTIN; GAMMA INTERFERON; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 2; INTERLEUKIN 4; MITOFUSIN 2; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; TRANSCRIPTION FACTOR NFAT;

EID: 84883706469     PISSN: 10799907     EISSN: 15577465     Source Type: Journal    
DOI: 10.1089/jir.2012.0054     Document Type: Article
Times cited : (6)

References (45)
  • 1
    • 0028352358 scopus 로고
    • Polymicrobial sepsis but not low-dose endotoxin infusion causes decreased splenocyte IL-2/IFN-[gamma] release while increasing IL-4/IL-10 production
    • Ayala A, Deol ZK, Lehman DL, Herdon CD, Chaudry IH. 1994. Polymicrobial sepsis but not low-dose endotoxin infusion causes decreased splenocyte IL-2/IFN-[gamma] release while increasing IL-4/IL-10 production. J Surg Res 56(6):579-585.
    • (1994) J Surg Res , vol.56 , Issue.6 , pp. 579-585
    • Ayala, A.1    Deol, Z.K.2    Lehman, D.L.3    Herdon, C.D.4    Chaudry, I.H.5
  • 2
    • 0030890234 scopus 로고    scopus 로고
    • Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3
    • Beals CR, Sheridan CM, Turck CW, Gardner P, Crabtree GR. 1997. Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3. Science 275(5308):1930-1934.
    • (1997) Science , vol.275 , Issue.5308 , pp. 1930-1934
    • Beals, C.R.1    Sheridan, C.M.2    Turck, C.W.3    Gardner, P.4    Crabtree, G.R.5
  • 3
    • 0033485261 scopus 로고    scopus 로고
    • Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation
    • Bulavin DV, Saito S, Hollander MC, Sakaguchi K, Anderson CW, et al. 1999. Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. EMBO J 18(23):6845-6854.
    • (1999) EMBO J , vol.18 , Issue.23 , pp. 6845-6854
    • Bulavin, D.V.1    Saito, S.2    Hollander, M.C.3    Sakaguchi, K.4    Anderson, C.W.5
  • 5
    • 0035282334 scopus 로고    scopus 로고
    • Mammalian MAP kinase signalling cascades
    • Chang L, Karin M. 2001. Mammalian MAP kinase signalling cascades. Nature 410(6824):37-40.
    • (2001) Nature , vol.410 , Issue.6824 , pp. 37-40
    • Chang, L.1    Karin, M.2
  • 6
    • 4444270915 scopus 로고    scopus 로고
    • Dysregulation of HSG triggers vascular proliferative disorders
    • Chen KH, Guo X, Ma D, Guo Y, Li Q, et al. 2004. Dysregulation of HSG triggers vascular proliferative disorders. Nat Cell Biol 6(9):872-883.
    • (2004) Nat Cell Biol , vol.6 , Issue.9 , pp. 872-883
    • Chen, K.H.1    Guo, X.2    Ma, D.3    Guo, Y.4    Li, Q.5
  • 7
    • 34547216984 scopus 로고    scopus 로고
    • Function and regulation in MAPK signaling pathways: Lessons learned from the yeast Saccharomyces cerevisiae
    • Chen RE, Thorner J. 2007. Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae. Biochim Biophys Acta 1773(8):1311-1340.
    • (2007) Biochim Biophys Acta , vol.1773 , Issue.8 , pp. 1311-1340
    • Chen, R.E.1    Thorner, J.2
  • 8
    • 0033931374 scopus 로고    scopus 로고
    • C-Jun NH(2)-terminal kinase inhibits targeting of the protein phosphatase calcineurin to NFATc1
    • Chow CW, Dong C, Flavell RA, Davis RJ. 2000. c-Jun NH(2)-terminal kinase inhibits targeting of the protein phosphatase calcineurin to NFATc1. Mol Cell Biol 20(14):5227-5234.
    • (2000) Mol Cell Biol , vol.20 , Issue.14 , pp. 5227-5234
    • Chow, C.W.1    Dong, C.2    Flavell, R.A.3    Davis, R.J.4
  • 9
    • 0026300729 scopus 로고
    • Extracellular signalregulated kinases: ERKs in progress
    • Cobb MH, Boulton TG, Robbins DJ. 1991. Extracellular signalregulated kinases: ERKs in progress. Cell Regul 2(12):965-978.
    • (1991) Cell Regul , vol.2 , Issue.12 , pp. 965-978
    • Cobb, M.H.1    Boulton, T.G.2    Robbins, D.J.3
  • 10
    • 38349000606 scopus 로고    scopus 로고
    • Mitofusin 2: A mitochondriashaping protein with signaling roles beyond fusion
    • de Brito OM, Scorrano L. 2008. Mitofusin 2: a mitochondriashaping protein with signaling roles beyond fusion. Antioxid Redox Signal 10(3):621-633.
    • (2008) Antioxid Redox Signal , vol.10 , Issue.3 , pp. 621-633
    • De Brito, O.M.1    Scorrano, L.2
  • 11
    • 0032080849 scopus 로고    scopus 로고
    • Inhibition of mitogen-activated protein kinase kinase blocks T cell proliferation but does not induce or prevent anergy
    • DeSilva DR, Jones EA, Favata MF, Jaffee BD, Magolda RL, et al. 1998. Inhibition of mitogen-activated protein kinase kinase blocks T cell proliferation but does not induce or prevent anergy. J Immunol 160(9):4175-4181.
    • (1998) J Immunol , vol.160 , Issue.9 , pp. 4175-4181
    • Desilva, D.R.1    Jones, E.A.2    Favata, M.F.3    Jaffee, B.D.4    Magolda, R.L.5
  • 12
    • 29744461215 scopus 로고    scopus 로고
    • The p38 mitogen-activated protein kinase regulates effector functions of primary human CD4 T cells
    • Dodeller F, Skapenko A, Kalden JR, Lipsky PE, Schulze-Koops H. 2005. The p38 mitogen-activated protein kinase regulates effector functions of primary human CD4 T cells. Eur J Immunol 35(12):3631-3642.
    • (2005) Eur J Immunol , vol.35 , Issue.12 , pp. 3631-3642
    • Dodeller, F.1    Skapenko, A.2    Kalden, J.R.3    Lipsky, P.E.4    Schulze-Koops, H.5
  • 13
    • 0032983831 scopus 로고    scopus 로고
    • T helper cell subset ratios in patients with severe sepsis
    • Ferguson NR, Galley HF, Webster NR. 1999. T helper cell subset ratios in patients with severe sepsis. Intensive Care Med 25(1):106-109.
    • (1999) Intensive Care Med , vol.25 , Issue.1 , pp. 106-109
    • Ferguson, N.R.1    Galley, H.F.2    Webster, N.R.3
  • 14
    • 0037769813 scopus 로고    scopus 로고
    • Inflammatory promoting activity of HMGB1 on human microvascular endothelial cells
    • Fiuza C, Bustin M, Talwar S, Tropea M, Gerstenberger E, et al. 2003. Inflammatory promoting activity of HMGB1 on human microvascular endothelial cells. Blood 101(7):2652-2660.
    • (2003) Blood , vol.101 , Issue.7 , pp. 2652-2660
    • Fiuza, C.1    Bustin, M.2    Talwar, S.3    Tropea, M.4    Gerstenberger, E.5
  • 15
    • 0032701390 scopus 로고    scopus 로고
    • Selective defects of T lymphocyte function in patients with lethal intraabdominal infection
    • Heidecke CD, Hensler T, Weighardt H, Zantl N, Wagner H, et al. 1999. Selective defects of T lymphocyte function in patients with lethal intraabdominal infection. Am J Surg 178(4):288-292.
    • (1999) Am J Surg , vol.178 , Issue.4 , pp. 288-292
    • Heidecke, C.D.1    Hensler, T.2    Weighardt, H.3    Zantl, N.4    Wagner, H.5
  • 16
    • 0037115421 scopus 로고    scopus 로고
    • Gadd45a protects against UV irradiation-induced skin tumors, and promotes apoptosis and stress signaling via MAPK and p53
    • Hildesheim J, Bulavin DV, Anver MR, Alvord WG, Hollander MC, et al. 2002. Gadd45a protects against UV irradiation-induced skin tumors, and promotes apoptosis and stress signaling via MAPK and p53. Cancer Res 62(24):7305-7315.
    • (2002) Cancer Res , vol.62 , Issue.24 , pp. 7305-7315
    • Hildesheim, J.1    Bulavin, D.V.2    Anver, M.R.3    Alvord, W.G.4    Hollander, M.C.5
  • 17
    • 0027428530 scopus 로고
    • Raf-1 forms a stable complex with Mek1 and activates Mek1 by serine phosphorylation
    • Huang W, Alessandrini A, Crews CM, Erikson RL. 1993. Raf-1 forms a stable complex with Mek1 and activates Mek1 by serine phosphorylation. Proc Natl Acad Sci USA 90(23):10947-10951.
    • (1993) Proc Natl Acad Sci USA , vol.90 , Issue.23 , pp. 10947-10951
    • Huang, W.1    Alessandrini, A.2    Crews, C.M.3    Erikson, R.L.4
  • 18
    • 77954175102 scopus 로고    scopus 로고
    • HMGB1, a potent proinflammatory cytokine in sepsis
    • Huang W, Tang Y, Li L. 2010. HMGB1, a potent proinflammatory cytokine in sepsis. Cytokine 51(2):119-126.
    • (2010) Cytokine , vol.51 , Issue.2 , pp. 119-126
    • Huang, W.1    Tang, Y.2    Li, L.3
  • 19
    • 0033538569 scopus 로고    scopus 로고
    • Receptor for advanced glycation end products (RAGE)-mediated neurite outgrowth and activation of NF-kappaB require the cytoplasmic domain of the receptor but different downstream signaling pathways
    • Huttunen HJ, Fages C, Rauvala H. 1999. Receptor for advanced glycation end products (RAGE)-mediated neurite outgrowth and activation of NF-kappaB require the cytoplasmic domain of the receptor but different downstream signaling pathways. J Biol Chem 274(28):19919-19924.
    • (1999) J Biol Chem , vol.274 , Issue.28 , pp. 19919-19924
    • Huttunen, H.J.1    Fages, C.2    Rauvala, H.3
  • 20
    • 0033178358 scopus 로고    scopus 로고
    • T cell responses to bacterial infection
    • Kerksiek KM, Pamer EG. 1999. T cell responses to bacterial infection. Curr Opin Immunol 11(4):400-405.
    • (1999) Curr Opin Immunol , vol.11 , Issue.4 , pp. 400-405
    • Kerksiek, K.M.1    Pamer, E.G.2
  • 21
    • 29144496853 scopus 로고    scopus 로고
    • Correlation between mRNA expression of Th1/Th2 cytokines and their specific transcription factors in human helper T-cell clones
    • Kitamura N, Kaminuma O, Mori A, Hashimoto T, Kitamura F, et al. 2005. Correlation between mRNA expression of Th1/Th2 cytokines and their specific transcription factors in human helper T-cell clones. Immunol Cell Biol 83(5):536-541.
    • (2005) Immunol Cell Biol , vol.83 , Issue.5 , pp. 536-541
    • Kitamura, N.1    Kaminuma, O.2    Mori, A.3    Hashimoto, T.4    Kitamura, F.5
  • 22
    • 77952343286 scopus 로고    scopus 로고
    • Burn trauma induces early HMGB1 release in patients: Its correlation with cytokines
    • Lantos J, Fö ldi V, Roth E, Wéber G, Bogár L, et al. 2010. Burn trauma induces early HMGB1 release in patients: its correlation with cytokines. Shock 33(6):562-567.
    • (2010) Shock , vol.33 , Issue.6 , pp. 562-567
    • Lantos, J.1    Fö Ldi, V.2    Roth, E.3    Wéber, G.4    Bogár, L.5
  • 23
    • 0036247432 scopus 로고    scopus 로고
    • T-cell activation through the antigen receptor. Part 1: Signaling components, signaling pathways, and signal integration at the T-cell antigen receptor synapse
    • Nel AE. 2002. T-cell activation through the antigen receptor. Part 1: signaling components, signaling pathways, and signal integration at the T-cell antigen receptor synapse. J Allergy Clin Immunol 109(5):758-770.
    • (2002) J Allergy Clin Immunol , vol.109 , Issue.5 , pp. 758-770
    • Nel, A.E.1
  • 24
    • 0035434019 scopus 로고    scopus 로고
    • Sepsis syndromes: Understanding the role of innate and acquired immunity
    • Oberholzer A, Oberholzer C, Moldawer LL. 2001. Sepsis syndromes: understanding the role of innate and acquired immunity. Shock 16(2):83-96.
    • (2001) Shock , vol.16 , Issue.2 , pp. 83-96
    • Oberholzer, A.1    Oberholzer, C.2    Moldawer, L.L.3
  • 25
    • 0028857787 scopus 로고
    • Major injury leads to predominance of the T helper-2 lymphocyte phenotype and diminished interleukin-12 production associated with decreased resistance to infection
    • O'Sullivan ST, Lederer JA, Horgan AF, Chin DH, Mannick JA, et al. 1995. Major injury leads to predominance of the T helper-2 lymphocyte phenotype and diminished interleukin-12 production associated with decreased resistance to infection. Ann Surg 222(4):482-490.
    • (1995) Ann Surg , vol.222 , Issue.4 , pp. 482-490
    • O'Sullivan, S.T.1    Lederer, J.A.2    Horgan, A.F.3    Chin, D.H.4    Mannick, J.A.5
  • 26
    • 0032167830 scopus 로고    scopus 로고
    • The transcription factor NFAT4 is involved in the generation and survival of T cells
    • Oukka M, Ho IC, de la Brousse FC, Hoey T, Grusby MJ, et al. 1998. The transcription factor NFAT4 is involved in the generation and survival of T cells. Immunity 9(3):295-304.
    • (1998) Immunity , vol.9 , Issue.3 , pp. 295-304
    • Oukka, M.1    Ho, I.C.2    De La Brousse, F.C.3    Hoey, T.4    Grusby, M.J.5
  • 27
    • 14644439251 scopus 로고    scopus 로고
    • Burn injury induces a change in T cell homeostasis affecting preferentially CD4+ T cells
    • Patenaude J, D'Elia M, Hamelin C, Garrel D, Bernier J. 2005. Burn injury induces a change in T cell homeostasis affecting preferentially CD4+ T cells. J Leukoc Biol 77(2):141-150.
    • (2005) J Leukoc Biol , vol.77 , Issue.2 , pp. 141-150
    • Patenaude, J.1    D'Elia, M.2    Hamelin, C.3    Garrel, D.4    Bernier, J.5
  • 28
    • 11444261016 scopus 로고    scopus 로고
    • Downregulation of NF-kappaB activity associated with alteration in proliferative response in the spleen after burn injury
    • Phan HH, Cho K, Nelson HA, Shin S, Jeong J, et al. 2005. Downregulation of NF-kappaB activity associated with alteration in proliferative response in the spleen after burn injury. Shock 23(1):73-79.
    • (2005) Shock , vol.23 , Issue.1 , pp. 73-79
    • Phan, H.H.1    Cho, K.2    Nelson, H.A.3    Shin, S.4    Jeong, J.5
  • 29
    • 0001589410 scopus 로고
    • Insulin-stimulated microtubule-associated protein kinase is phosphorylated on tyrosine and threonine in vivo
    • Ray LB, Sturgill TW. 1988. Insulin-stimulated microtubule-associated protein kinase is phosphorylated on tyrosine and threonine in vivo. Proc Natl Acad Sci USA 85(11):3753-3757.
    • (1988) Proc Natl Acad Sci USA , vol.85 , Issue.11 , pp. 3753-3757
    • Ray, L.B.1    Sturgill, T.W.2
  • 30
    • 0032525233 scopus 로고    scopus 로고
    • Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway
    • Rincón M, Enslen H, Raingeaud J, Recht M, Zapton T, et al. 1998. Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway. EMBO J 17(10): 2817-2829.
    • (1998) EMBO J , vol.17 , Issue.10 , pp. 2817-2829
    • Rincón, M.1    Enslen, H.2    Raingeaud, J.3    Recht, M.4    Zapton, T.5
  • 31
    • 0034190231 scopus 로고    scopus 로고
    • The JNK and P38 MAP kinase signaling pathways in T cell-mediated immune responses
    • Rincón M, Flavell RA, Davis RA. 2000. The JNK and P38 MAP kinase signaling pathways in T cell-mediated immune responses. Free Radic Biol Med 28(9):1328-1337.
    • (2000) Free Radic Biol Med , vol.28 , Issue.9 , pp. 1328-1337
    • Rincón, M.1    Flavell, R.A.2    Davis, R.A.3
  • 32
    • 0037902498 scopus 로고    scopus 로고
    • JNK and p38 MAP kinases in CD4+ and CD8+ T cells
    • Rincón M, Pedraza-Alva G. 2003. JNK and p38 MAP kinases in CD4+ and CD8+ T cells. Immunol Rev 192(1):131-142.
    • (2003) Immunol Rev , vol.192 , Issue.1 , pp. 131-142
    • Rincón, M.1    Pedraza-Alva, G.2
  • 34
    • 0029011218 scopus 로고
    • The MAPK signaling cascade
    • Seger R, Krebs EG. 1995. The MAPK signaling cascade. FASEB J 9(9):726-735.
    • (1995) FASEB J , vol.9 , Issue.9 , pp. 726-735
    • Seger, R.1    Krebs, E.G.2
  • 35
    • 34548170490 scopus 로고    scopus 로고
    • Mitofusin-2 is a major determinant of oxidative stress-mediated heart muscle cell apoptosis
    • Shen T, Zheng M, Cao C, Chen C, Tang J, et al. 2007. Mitofusin-2 is a major determinant of oxidative stress-mediated heart muscle cell apoptosis. J Biol Chem 282(32):23354-23361.
    • (2007) J Biol Chem , vol.282 , Issue.32 , pp. 23354-23361
    • Shen, T.1    Zheng, M.2    Cao, C.3    Chen, C.4    Tang, J.5
  • 36
    • 0034244303 scopus 로고    scopus 로고
    • Role of neutrophils in burn-induced microvascular injury in the intestine
    • Sir O, Fazal N, Choudhry MA, Goris RJ, Gamelli RL, et al. 2000. Role of neutrophils in burn-induced microvascular injury in the intestine. Shock 14(2):113-117.
    • (2000) Shock , vol.14 , Issue.2 , pp. 113-117
    • Sir, O.1    Fazal, N.2    Ma, C.3    Goris, R.J.4    Gamelli, R.L.5
  • 37
    • 0034682315 scopus 로고    scopus 로고
    • Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases
    • Taguchi A, Blood DC, del Toro G, Canet A, Lee DC, et al. 2000. Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases. Nature 405(6784):354-360.
    • (2000) Nature , vol.405 , Issue.6784 , pp. 354-360
    • Taguchi, A.1    Blood, D.C.2    Del Toro, G.3    Canet, A.4    Lee, D.C.5
  • 38
    • 0034664960 scopus 로고    scopus 로고
    • A new phosphospecific cell-based ELISA for p42/p44 mitogen-activated protein kinase (MAPK), p38 MAPK, protein kinase B and cAMP-response-element- binding protein
    • Versteeg HH, Nijhuis E, van den Brink GR, Evertzen M, Pynaert GN, et al. 2000. A new phosphospecific cell-based ELISA for p42/p44 mitogen-activated protein kinase (MAPK), p38 MAPK, protein kinase B and cAMP-response-element- binding protein. Biochem J 350(Pt 3):717-722.
    • (2000) Biochem J , vol.350 , Issue.PART 3 , pp. 717-722
    • Versteeg, H.H.1    Nijhuis, E.2    Van Den Brink, G.R.3    Evertzen, M.4    Pynaert, G.N.5
  • 39
    • 0033538467 scopus 로고    scopus 로고
    • HMG-1 as a late mediator of endotoxin lethality in mice
    • Wang H, Bloom O, Zhang M, Vishnubhakat JM, Ombrellino M, et al. 1999. HMG-1 as a late mediator of endotoxin lethality in mice. Science 285(5425):248-251.
    • (1999) Science , vol.285 , Issue.5425 , pp. 248-251
    • Wang, H.1    Bloom, O.2    Zhang, M.3    Vishnubhakat, J.M.4    Ombrellino, M.5
  • 40
    • 33845885124 scopus 로고    scopus 로고
    • High mobility group box-1 protein induces the migration and activation of human dendritic cells and acts as an alarmin
    • Yang D, Chen Q, Yang H, Tracey KJ, Bustin M, et al. 2007. High mobility group box-1 protein induces the migration and activation of human dendritic cells and acts as an alarmin. J Leukoc Biol 81(1):59-66.
    • (2007) J Leukoc Biol , vol.81 , Issue.1 , pp. 59-66
    • Yang, D.1    Chen, Q.2    Yang, H.3    Tracey, K.J.4    Bustin, M.5
  • 41
    • 54449086270 scopus 로고    scopus 로고
    • The potential role of high mobility group box 1 protein in immune dysfunction and its regulatory mechanism after major trauma
    • Yao YM, Lin HY. 2008. The potential role of high mobility group box 1 protein in immune dysfunction and its regulatory mechanism after major trauma. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 20(9):513-515.
    • (2008) Zhongguo Wei Zhong Bing Ji Jiu Yi Xue , vol.20 , Issue.9 , pp. 513-515
    • Yao, Y.M.1    Lin, H.Y.2
  • 42
    • 0035992188 scopus 로고    scopus 로고
    • High mobility group box chromosomal protein 1 (HMGB1) is an antibacterial factor produced by the human adenoid
    • Zetterström CK, Bergman T, Rynnel-Dagöö B, Erlandsson Harris H, Soder O, et al. 2002. High mobility group box chromosomal protein 1 (HMGB1) is an antibacterial factor produced by the human adenoid. Pediatr Res 52(2):148-154.
    • (2002) Pediatr Res , vol.52 , Issue.2 , pp. 148-154
    • Zetterström, C.K.1    Bergman, T.2    Rynnel-Dagöö, B.3    Erlandsson, H.H.4    Soder, O.5
  • 43
    • 54049148137 scopus 로고    scopus 로고
    • Relationship between high-mobility group box 1 protein release and T-cell suppression in rats after thermal injury
    • Zhang LT, Yao YM, Dong YQ, Dong N, Yu Y, et al. 2008. Relationship between high-mobility group box 1 protein release and T-cell suppression in rats after thermal injury. Shock 30(4):449-455.
    • (2008) Shock , vol.30 , Issue.4 , pp. 449-455
    • Zhang, L.T.1    Yao, Y.M.2    Dong, Y.Q.3    Dong, N.4    Yu, Y.5
  • 44
    • 33644976705 scopus 로고    scopus 로고
    • MAP kinases in immune responses
    • Zhang YL, Dong C. 2005. MAP kinases in immune responses. Cell Mol Immunol 2(1):20-27.
    • (2005) Cell Mol Immunol , vol.2 , Issue.1 , pp. 20-27
    • Zhang, Y.L.1    Dong, C.2
  • 45
    • 84861691555 scopus 로고    scopus 로고
    • Upregulation of mitofusin-2 protects CD4+ T cells from HMGB1-mediated immune dysfunction partly through Ca2 +-NFAT signaling pathway
    • Zhao GJ, Yao YM, Lu ZQ, Hong GL, Zhu XM, et al. 2012. Upregulation of mitofusin-2 protects CD4+ T cells from HMGB1-mediated immune dysfunction partly through Ca2 +-NFAT signaling pathway. Cytokine 59(1):79-85.
    • (2012) Cytokine , vol.59 , Issue.1 , pp. 79-85
    • Zhao, G.J.1    Yao, Y.M.2    Lu, Z.Q.3    Hong, G.L.4    Zhu, X.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.