2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces microglial nitric oxide production and subsequent rat primary cortical neuron apoptosis through p38/JNK MAPK pathway

Toxicology

Volumn 312, Issue 1, 2013, Pages 132-141

  Li, Yuanye ^a   Chen, Gang ^a   Zhao, Jianya ^a   Nie, Xiaoke ^a   Wan, Chunhua ^a   Liu, Jiao ^a   Duan, Zhiqing ^a   Xu, Guangfei ^a  

^a NANTONG UNIVERSITY   (China)

Author keywords

2,3,7,8 Tetrachlorodibenzo p dioxin (TCDD); Inducible nitric oxide synthase (iNOS); Microglia; Neuron; Nitric oxide (NO); P38 JNK MAPK

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; INDUCIBLE NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN CELL; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; EMBRYO; ENZYME ACTIVATION; MICROGLIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UPREGULATION;

2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN; 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD); C-JUN N-TERMINAL KINASE; CENTRAL NERVOUS SYSTEM; CNS; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENOS; ERK; EXTRACELLULAR SIGNAL-REGULATED KINASE; IL-6; INDUCIBLE NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE (INOS); INOS; INTERLEUKIN-6; IROS; JNK; MAPK; MICROGLIA; MITOGEN-ACTIVATED PROTEIN KINASE; NEURON; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NITRIC OXIDE (NO); NITRIC OXIDE SYNTHASE; NNOS; NO; NOS; O(2)(*-); ONOO(-); P38 MAPK; P38 MITOGEN-ACTIVATED PROTEIN KINASE; P38/JNK MAPK; PERIPHERAL NERVOUS SYSTEM; PEROXYNITRITE; PNS; REACTIVE NITROGEN SPECIES; REACTIVE OXIDE SPECIES; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTION-POLYMERASE CHAIN REACTION; RNS; ROS; RT-PCR; SUPEROXIDE RADICAL; TCDD; TNF-Α; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALS; ANTHRACENES; APOPTOSIS; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; IMIDAZOLES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; MICROGLIA; NITRIC OXIDE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; TETRACHLORODIBENZODIOXIN;

EID: 84883701906     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2013.08.008     Document Type: Article

References (36)

1. Ahn S.K., Hong S., Park Y.M., Choi J.Y., Lee W.T., Park K.A., Lee J.E. Protective effects of agmatine on lipopolysaccharide-injured microglia and inducible nitric oxide synthase activity. Life Sci. 2012, 91:1345-1350.
2. Ajizian S.J., English B.K., Meals E.A. Specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and interferon-gamma. J. Infect. Dis. 1999, 179:939-944.
3. Bellavance M.A., Rivest S. The neuroendocrine control of the innate immune system in health and brain diseases. Immunol. Rev. 2012, 248:36-55.
4. Butterfield D.A., Reed T., Sultana R. Roles of 3-nitrotyrosine- and 4-hydroxynonenal-modified brain proteins in the progression and pathogenesis of Alzheimer's disease. Free Radic. Res. 2011, 45:59-72.
5. Chang L., Karin M. Mammalian MAP kinase signalling cascades. Nature 2001, 410:37-40.
6. Cheepsunthorn P., Radov L., Menzies S., Reid J., Connor J.R. Characterization of a novel brain-derived microglial cell line isolated from neonatal rat brain. Glia 2001, 35:53-62.
7. Collins L.L., Williamson M.A., Thompson B.D., Dever D.P., Gasiewicz T.A., Opanashuk L.A. 2,3,7,8-Tetracholorodibenzo-p-dioxin exposure disrupts granule neuron precursor maturation in the developing mouse cerebellum. Toxicol. Sci. 2008, 103:125-136.
8. Dawson V.L., Dawson T.M. Nitric oxide in neurodegeneration. Prog. Brain Res. 1998, 118:215-229.
9. Garrington T.P., Johnson G.L. Organization and regulation of mitogen-activated protein kinase signaling pathways. Curr. Opin. Cell Biol. 1999, 11:211-218.
10. Griess P. Bemerkungen zu der Abhandlung der HH. Weselky und Benedikt Ueber einige Azoverbindungen. Ber. Dtsch. Chem. Ges. 1879, 12:426-428.
11. Hossain A., Tsuchiya S., Minegishi M., Osada M., Ikawa S., Tezuka F.A., Kaji M., Konno T., Watanabe M., Kikuchi H. The Ah receptor is not involved in 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated apoptosis in human leukemic T cell lines. J. Biol. Chem. 1998, 273:19853-19858.
12. Knott A.B., Bossy-Wetzel E. Nitric oxide in health and disease of the nervous system. Antioxid. Redox Signal. 2009, 11:541-554.
13. Kwon M.J., Jeong K.S., Choi E.J., Lee B.H. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced activation of mitogen-activated protein kinase signaling pathway in Jurkat T cells. Pharmacol. Toxicol. 2003, 93:186-190.
14. Li W., Matsumura F. Significance of the nongenomic, inflammatory pathway in mediating the toxic action of TCDD to induce rapid and long-term cellular responses in 3T3-L1 adipocytes. Biochemistry 2008, 47:13997-14008.
15. Li W., Vogel C.F., Wu D., Matsumura F. Non-genomic action of TCDD to induce inflammatory responses in HepG2 human hepatoma cells and in liver of C57BL/6J mice. Biol. Chem. 2010, 391:1205-1219.
16. Liberatore G.T., Jackson-Lewis V., Vukosavic S., Mandir A.S., Vila M., McAuliffe W.G., Dawson V.L., Dawson T.M., Przedborski S. Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease. Nat. Med. 1999, 5:1403-1409.
17. Lijia Z., Zhao S., Wang X., Wu C., Yang J. A self-propelling cycle mediated by reactive oxide species and nitric oxide exists in LPS-activated microglia. Neurochem. Int. 2012, 61:1220-1230.
18. Liu H., Xu R., Feng L., Guo W., Cao N., Qian C., Teng P., Wang L., Wu X., Sun Y., Li J., Shen Y., Xu Q. A novel chromone derivative with anti-inflammatory property via inhibition of ROS-dependent activation of TRAF6-ASK1-p38 pathway. PLoS One 2012, 7:e37168.
19. Mates J.M., Segura J.A., Alonso F.J., Marquez J. Roles of dioxins and heavy metals in cancer and neurological diseases using ROS-mediated mechanisms. Free Radic. Biol. Med. 2010, 49:1328-1341.
20. Mulero-Navarro S., Santiago-Josefat B., Pozo-Guisado E., Merino J.M., Fernandez-Salguero P.M. Down-regulation of CYP1A2 induction during the maturation of mouse cerebellar granule cells in culture: role of nitric oxide accumulation. Eur. J. Neurosci. 2003, 18:2265-2272.
21. Munoz L., Ammit A.J. Targeting p38 MAPK pathway for the treatment of Alzheimer's disease. Neuropharmacology 2010, 58:561-568.
22. Murphy S. Production of nitric oxide by glial cells: regulation and potential roles in the CNS. Glia 2000, 29:1-13.
23. Nakano H., Shindo M., Sakon S., Nishinaka S., Mihara M., Yagita H., Okumura K. Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1. Proc. Natl. Acad. Sci. U. S. A. 1998, 95:3537-3542.
24. Nathan C., Xie Q.W. Regulation of biosynthesis of nitric oxide. J. Biol. Chem. 1994, 269:13725-13728.
25. Park H.H., Kim M.J., Li Y., Park Y.N., Lee J., Lee Y.J., Kim S.G., Park H.J., Son J.K., Chang H.W., Lee E. Britanin suppresses LPS-induced nitric oxide, PGE(2) and cytokine production via NF-kappaB and MAPK inactivation in RAW 264. 7 cells. Int. Immunopharmacol. 2013, 15:296-302.
26. Park S.J., Yoon W.K., Kim H.J., Son H.Y., Cho S.W., Jeong K.S., Kim T.H., Kim S.H., Kim S.R., Ryu S.Y. 2,3,7,8-Tetrachlorodibenzo-p-dioxin activates ERK and p38 mitogen-activated protein kinases in RAW 264.7 cells. Anticancer Res. 2005, 25:2831-2836.
27. Rothwell N.J., Relton J.K. Involvement of cytokines in acute neurodegeneration in the CNS. Neurosci. Biobehav. Rev. 1993, 17:217-227.
28. Sanchez-Martin F.J., Fernandez-Salguero P.M., Merino J.M. 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces apoptosis in neural growth factor (NGF)-differentiated pheochromocytoma PC12 cells. Neurotoxicology 2010, 31:267-276.
29. Sciullo E.M., Dong B., Vogel C.F., Matsumura F. Characterization of the pattern of the nongenomic signaling pathway through which TCDD-induces early inflammatory responses in U937 human macrophages. Chemosphere 2009, 74:1531-1537.
30. Sevko A., Michels T., Vrohlings M., Umansky L., Beckhove P., Kato M., Shurin G.V., Shurin M.R., Umansky V. Antitumor effect of Paclitaxel is mediated by inhibition of myeloid-derived suppressor cells and chronic inflammation in the spontaneous melanoma model. J. Immunol. 2013, 190:2464-2471.
31. Shaked H., Hofseth L.J., Chumanevich A., Chumanevich A.A., Wang J., Wang Y., Taniguchi K., Guma M., Shenouda S., Clevers H., Harris C.C., Karin M. Chronic epithelial NF-kappaB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:14007-14012.
32. Steinert J.R., Chernova T., Forsythe I.D. Nitric oxide signaling in brain function, dysfunction, and dementia. Neuroscientist 2010, 16:435-452.
33. Thellung S., Villa V., Corsaro A., Pellistri F., Venezia V., Russo C., Aceto A., Robello M., Florio T. ERK1/2 and p38 MAP kinases control prion protein fragment 90-231-induced astrocyte proliferation and microglia activation. Glia 2007, 55:1469-1485.
34. Vallejo R., Tilley D.M., Vogel L., Benyamin R. The role of glia and the immune system in the development and maintenance of neuropathic pain. Pain Pract. 2010, 10:167-184.
35. Xu G., Li Y., Yoshimoto K., Chen G., Wan C., Iwata T., Mizusawa N., Duan Z., Liu J., Jiang J. 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced inflammatory activation is mediated by intracellular free calcium in microglial cells. Toxicology 2013, 308:158-167.
36. Yong H.Y., Koh M.S., Moon A. The p38 MAPK inhibitors for the treatment of inflammatory diseases and cancer. Expert Opin. Investig. Drugs 2009, 18:1893-1905.