Valproic acid increases expression of neuronal stem/progenitor cell in spinal cord injury

Journal of Korean Neurosurgical Society

Volumn 54, Issue 1, 2013, Pages 8-13

  Bang, Woo Seok ^a   Kim, Kyoung Tae ^a   Cho, Dae Chul ^a   Kim, Hye Jeong ^a   Sung, Joo Kyung ^a  

^a Kyungpook National University Hospital   (South Korea)

Author keywords

Nestin; Neural stem progenitor cell; SOX2; Spinal cord injury; Valproic acid

Indexed keywords

NESTIN; TRANSCRIPTION FACTOR SOX2; VALPROIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; EPENDYMA; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NEURAL STEM CELL; NONHUMAN; PROTEIN EXPRESSION; RAT; SPINAL CORD INJURY; WESTERN BLOTTING; WHITE MATTER;

EID: 84883691978     PISSN: 20053711     EISSN: 15987876     Source Type: Journal    
DOI: 10.3340/jkns.2013.54.1.8     Document Type: Article

References (35)

1. Balentine JD: Pathology of experimental spinal cord trauma. I. The necrotic lesion as a function of vascular injury. Lab Invest:39 236-253, 1978
2. Balentine JD: Pathology of experimental spinal cord trauma. II. Ultrastructure of axons and myelin. Lab Invest: 39 254-266, 1978.
3. Basso DM, Beattie MS, Bresnahan JC: Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp Neurol: 139 244-256, 1996
4. Brederlau A, Correia AS, Anisimov SV, Elmi M, Paul GRoybon L et al, Transplantation of human embryonic stem cell-derived cells to a rat model of Parkinson's disease: effect of in vitro differentiation on graft survival and teratoma formation. Stem Cells: 241433-1440, 2006
5. Brüstle O, Jones KN, Learish RD, Karram K, Choudhary KWiestler OD, et al, Embryonic stem cell-derived glial precursors: a source of myelinating transplants. Science: 285754-756, 1999
6. Bug G, Gül H, Schwarz K, Pfeifer H, Kampfmann MZheng X, et al, Valproic acid stimulates proliferation and self-renewal of hematopoietic stem cells. Cancer Res: 652537-2541, 2005
7. Chen PS, Peng GS, Li G, Yang S, Wu XWang CC, et al, Valproate protects dopaminergic neurons in midbrain neuron/glia cultures by stimulating the release of neurotrophic factors from astrocytes. Mol Psychiatry: 11 1116-1125, 2006
8. Chuang DM, Leng Y, Marinova Z, Kim HJ, Chiu CT: Multiple roles of HDAC inhibition in neurodegenerative conditions. Trends Neurosci: 32591-601, 2009
9. Dash PK, Orsi SA, Zhang M, Grill RJ, Pati SZhao J, et al,Valproate administered after traumatic brain injury provides neuroprotection and improves cognitive function in rats. PLoS One 5: e11383, 2010
10. Feng HL, Leng Y, Ma CH, Zhang J, Ren M, Chuang DM: Combined lithium and valproate treatment delays disease onset, reduces neurologi cal deficits and prolongs survival in an amyotrophic lateral sclerosmouse model. Neuroscience 155: 567-572, 2008
11. Gage FH, Coates PW, Palmer TD, Kuhn HG, Fisher LJSuhonen JO, et al, Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain. Proc Natl Acad Sci U S A 92: 11879-11883, 1995
12. Go HS, Kim KC, Choi CS, Jeon SJ, Kwon KJ, Han SH, et al, Prenatal exposure to valproic acid increases the neural progenitor cell pool and induces macrocephaly in rat brain via a mechanism involving the GSK3β/β-catenin pathway. Neuropharmacology. 63: 1028-1041, 2012
13. Gorio A, Gokmen N, Erbayraktar S, Yilmaz O, Madaschi L, Cichetti C, et al, Recombinant human erythropoietin counteracts secondary injury and markedly enhances neurological recovery from experimental spinal cord trauma. Proc Natl Acad Sci U S A. 99: 9450-9455, 2002
14. Imitola J, Raddassi K, Park KI, Mueller FJ, Nieto M, Teng Y.D, et al, Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway. Proc Natl Acad Sci U S A. 101: 18117-18122, 2004
15. Inoue T, Kawaguchi S, Kurisu K: Spontaneous regeneration of the pyramidal tract after transection in young rats. Neurosci Lett. 247: 151-154, 1998
16. Iseda T, Nishio T, Kawaguchi S, Yamanoto M, Kawasaki T, Wakisaka S: Spontaneous regeneration of the corticospinal tract after transection in young rats: a key role of reactive astrocytes in making favorable and unfavorable conditions for regeneration. Neuroscience. 126: 365-374, 2004
17. Johansson CB, Momma S, Clarke DL, Risling M, Lendahl U, Frisén J., Identification of a neural stem cell in the adult mammalian central nervous system. Cell. 96: 25-34, 1999
18. Keirstead HS, Nistor G, Bernal G, Totoiu M, Cloutier F, Sharp K, et al, Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury. J Neurosci. 25: 4694-4705, 2005
19. Kikukawa S, Kawaguchi S, Mizoguchi A, Ide C, Koshinaga M: Regeneration of dorsal column axons after spinal cord injury in young rats. Neurosci Lett. 249: 135-138, 1998
20. Kim HJ, Rowe M, Ren M, Hong JS, Chen PS, Chuang DM: Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. J Pharmacol Exp Ther. 321: 892-901, 2007
21. Lee H, Shamy GA, Elkabetz Y, Schofield CM, Harrsion NL, Panagiotakos G, et al, Directed differentiation and transplantation of human embryonic stem cell-derived motoneurons. Stem Cells. 25: 1931-1939, 2007
22. Lee HJ, Wu J, Chung J, Wrathall JR: SOX2 expression is upregulated in adult spinal cord after contusion injury in both oligodendrocyte lineage and ependymal cells. J Neurosci Res. 91: 196-210, 2013
23. Lee SM, Yune TY, Kim SJ, Park DW, Lee YK, Kim YC, et al, Minocycline reduces cell death and improves functional recovery after traumatic spinal cord injury in the rat. J Neurotrauma. 20: 1017-1027, 2003
24. Li S, Strittmatter SM: Delayed systemic Nogo-66 receptor antagonist promotes recovery from spinal cord injury. J Neurosci. 23: 4219-4227, 2003
25. Maurer MH, Brömme JO, Feldmann RE Jr, Järve A, Sabouri F Bürgers HF, et al, Glycogen synthase kinase 3beta (GSK3beta) regulates differentiation and proliferation in neural stem cells from the rat subventricular zone. J Proteome Res. 6: 1198-1208, 2007
26. Nistor GI, Totoiu MO, Haque N, Carpenter MK, Keirstead HS: Human embryonic stem cells differentiate into oligodendrocytes in high purity and myelinate after spinal cord transplantation. Glia. 49: 385-396, 2005
27. Qing H, He G, Ly PT, Fox CJ, Staufenbiel MCai F, et al, Valproic acid inhibits Abeta production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models. J Exp Med 205: 27812789, 2008
28. Ren M, Leng Y, Jeong M, Leeds PR, Chuang DM: Valproic acid reduces brain damage induced by transient focal cerebral ischemia in rats: potential roles of histone deacetylase inhibition and heat shock protein induction. J Neurochem. 89: 1358-1367, 2004
29. Rowland JW, Hawryluk GW, Kwon B, Fehlings MG: Current status of acute spinal cord injury pathophysiology and emerging therapies: promise on the horizon. Neurosurg Focus. 25: E2, 2008.
30. Shibuya S, Miyamoto O, Auer RN, Itano T, Mori S, Norimatsu H: Embryonic intermediate filament, nestin, expression following traumatic spinal cord injury in adult rats. Neuroscience. 114: 905-916, 2002
31. Sinn DI, Kim SJ, Chu K, Jung KH, Lee ST Song EC, et al, Valproic acid-mediated neuroprotection in intracerebral hemorrhage via histone deacetylase inhibition and transcriptional activation. Neurobiol Dis. 26: 464-472, 2007
32. Sugai F, Yamamoto Y, Miyaguchi K, Zhou Z, Sumi HH, amasaki T, et al, Benefit of valproic acid in suppressing disease progression of ALS model mice. Eur J Neurosci: 20 3179-3183, 2004
33. Sumner CJ, Huynh TN, Markowitz JA, Perhac JS, Hill BCoovert DD, et al, Valproic acid increases SMN levels in spinal muscular atrophy patient cells. Ann Neurol: 54647-654, 2003
34. Wang Z, Leng Y, Tsai LK, Leeds P, Chuang DM: Valproic acid attenuates blood-brain barrier disruption in a rat model of transient focal cerebral ischemia: the roles of HDAC and MMP-9 inhibition. J Cereb Blood Flow Metab: 3152-57, 2011
35. Yu SH, Cho DC, Kim KT, Nam KH, Cho HJ, Sung JK: The neuroprotective effect of treatment of valproic Acid in acute spinal cord injury. J Korean Neurosurg Soc: 51191-198, 2012