-
2
-
-
78149284013
-
Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer
-
Schramek, D., Leibbrandt, A., Sigl, V., Kenner, L., Pospisilik, J. A., Lee, H. J., Hanada, R., Joshi, P. A., Aliprantis, A., Glimcher, L., Pasparakis, M., Khokha, R., Ormandy, C. J., Widschwendter, M., Schett, G., and Penninger, J. M. (2010) Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer. Nature 468, 98-102
-
(2010)
Nature
, vol.468
, pp. 98-102
-
-
Schramek, D.1
Leibbrandt, A.2
Sigl, V.3
Kenner, L.4
Pospisilik, J.A.5
Lee, H.J.6
Hanada, R.7
Joshi, P.A.8
Aliprantis, A.9
Glimcher, L.10
Pasparakis, M.11
Khokha, R.12
Ormandy, C.J.13
Widschwendter, M.14
Schett, G.15
Penninger, J.M.16
-
3
-
-
77953388315
-
Progesterone induces adult mammary stem cell expansion
-
Joshi, P. A., Jackson, H. W., Beristain, A. G., Di Grappa, M. A., Mote, P. A., Clarke, C. L., Stingl, J., Waterhouse, P. D., and Khokha, R. (2010) Progesterone induces adult mammary stem cell expansion. Nature 465, 803-807
-
(2010)
Nature
, vol.465
, pp. 803-807
-
-
Joshi, P.A.1
Jackson, H.W.2
Beristain, A.G.3
Di Grappa, M.A.4
Mote, P.A.5
Clarke, C.L.6
Stingl, J.7
Waterhouse, P.D.8
Khokha, R.9
-
4
-
-
84859509821
-
Changing concepts. Menopausal hormone therapy and breast cancer
-
Chlebowski, R. T., and Anderson, G. L. (2012) Changing concepts. Menopausal hormone therapy and breast cancer. J. Natl. Cancer Inst. 104, 517-527
-
(2012)
J. Natl. Cancer Inst.
, vol.104
, pp. 517-527
-
-
Chlebowski, R.T.1
Anderson, G.L.2
-
5
-
-
0037830132
-
Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women. The women's health initiative randomized trial
-
Chlebowski, R. T., Hendrix, S. L., Langer, R. D., Stefanick, M. L., Gass, M., Lane, D., Rodabough, R. J., Gilligan, M. A., Cyr, M. G., Thomson, C. A., Khandekar, J., Petrovitch, H., and McTiernan, A. (2003) Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women. The Women's Health Initiative Randomized Trial. JAMA 289, 3243-3253
-
(2003)
JAMA
, vol.289
, pp. 3243-3253
-
-
Chlebowski, R.T.1
Hendrix, S.L.2
Langer, R.D.3
Stefanick, M.L.4
Gass, M.5
Lane, D.6
Rodabough, R.J.7
Gilligan, M.A.8
Cyr, M.G.9
Thomson, C.A.10
Khandekar, J.11
Petrovitch, H.12
McTiernan, A.13
-
6
-
-
0031906819
-
Transgenic mice carrying an imbalance in the native ratio of A to B forms of progesterone receptor exhibit developmental abnormalities in mammary glands
-
Shyamala, G., Yang, X., Silberstein, G., Barcellos-Hoff, M. H., and Dale, E. (1998) Transgenic mice carrying an imbalance in the native ratio of A to B forms of progesterone receptor exhibit developmental abnormalities in mammary glands. Proc. Natl. Acad. Sci. U.S.A. 95, 696-701
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 696-701
-
-
Shyamala, G.1
Yang, X.2
Silberstein, G.3
Barcellos-Hoff, M.H.4
Dale, E.5
-
7
-
-
0042693019
-
Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform
-
Mulac-Jericevic, B., Lydon, J. P., DeMayo, F. J., and Conneely, O. M. (2003) Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform. Proc. Natl. Acad. Sci. U.S.A. 100, 9744-9749
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 9744-9749
-
-
Mulac-Jericevic, B.1
Lydon, J.P.2
Demayo, F.J.3
Conneely, O.M.4
-
8
-
-
0029115517
-
Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities
-
Lydon, J. P., DeMayo, F. J., Funk, C. R., Mani, S. K., Hughes, A. R., Montgomery, C. A., Jr., Shyamala, G., Conneely, O. M., and O'Malley, B. W. (1995) Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities. Genes Dev. 9, 2266-2278
-
(1995)
Genes Dev.
, vol.9
, pp. 2266-2278
-
-
Lydon, J.P.1
Demayo, F.J.2
Funk, C.R.3
Mani, S.K.4
Hughes, A.R.5
Montgomery Jr., C.A.6
Shyamala, G.7
Conneely, O.M.8
O'malley, B.W.9
-
9
-
-
0025239785
-
Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B
-
Kastner, P., Krust, A., Turcotte, B., Stropp, U., Tora, L., Gronemeyer, H., and Chambon, P. (1990) Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO J. 9, 1603-1614
-
(1990)
EMBO J.
, vol.9
, pp. 1603-1614
-
-
Kastner, P.1
Krust, A.2
Turcotte, B.3
Stropp, U.4
Tora, L.5
Gronemeyer, H.6
Chambon, P.7
-
10
-
-
0033967491
-
Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome
-
Lange, C. A., Shen, T., and Horwitz, K. B. (2000) Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome. Proc. Natl. Acad. Sci. U.S.A. 97, 1032-1037
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 1032-1037
-
-
Lange, C.A.1
Shen, T.2
Horwitz, K.B.3
-
11
-
-
33845315093
-
Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone antagonist
-
Poole, A. J., Li, Y., Kim, Y., Lin, S. C., Lee, W. H., and Lee, E. Y. (2006) Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone antagonist. Science 314, 1467-1470
-
(2006)
Science
, vol.314
, pp. 1467-1470
-
-
Poole, A.J.1
Li, Y.2
Kim, Y.3
Lin, S.C.4
Lee, W.H.5
Lee, E.Y.6
-
12
-
-
10044257416
-
Phosphorylation of progesterone receptor serine 400 mediates ligand-independent transcriptional activity in response to activation of cyclin-dependent protein kinase
-
Pierson-Mullany, L. K., and Lange, C. A. (2004) Phosphorylation of progesterone receptor serine 400 mediates ligand-independent transcriptional activity in response to activation of cyclin-dependent protein kinase. Mol. Cell Biol. 24, 10542-10557
-
(2004)
Mol. Cell Biol.
, vol.24
, pp. 10542-10557
-
-
Pierson-Mullany, L.K.1
Lange, C.A.2
-
14
-
-
37349094929
-
GSK-3 targets Cdc25A for ubiquitinmediated proteolysis, and GSK-3 inactivation correlates with Cdc25A overproduction in human cancers
-
Kang, T., Wei, Y., Honaker, Y., Yamaguchi, H., Appella, E., Hung, M. C., and Piwnica-Worms, H. (2008) GSK-3 targets Cdc25A for ubiquitinmediated proteolysis, and GSK-3 inactivation correlates with Cdc25A overproduction in human cancers. Cancer Cell 13, 36-47
-
(2008)
Cancer Cell
, vol.13
, pp. 36-47
-
-
Kang, T.1
Wei, Y.2
Honaker, Y.3
Yamaguchi, H.4
Appella, E.5
Hung, M.C.6
Piwnica-Worms, H.7
-
15
-
-
0035967897
-
Regulation of GSK-3.Acellular multiprocessor
-
Harwood, A. J. (2001) Regulation of GSK-3.Acellular multiprocessor. Cell 105, 821-824
-
(2001)
Cell
, vol.105
, pp. 821-824
-
-
Harwood, A.J.1
-
16
-
-
65449189828
-
Tuning the activation threshold of a kinase network by nested feedback loops
-
Justman, Q. A., Serber, Z., Ferrell, J. E., Jr., El-Samad, H., and Shokat, K. M. (2009) Tuning the activation threshold of a kinase network by nested feedback loops. Science 324, 509-512
-
(2009)
Science
, vol.324
, pp. 509-512
-
-
Justman, Q.A.1
Serber, Z.2
Ferrell Jr., J.E.3
El-Samad, H.4
Shokat, K.M.5
-
17
-
-
84866322681
-
Evolutionary pathways in BRCA1-associated breast tumors
-
Martins, F. C., De, S., Almendro, V., Gönen, M., Park, S. Y., Blum, J. L., Herlihy, W., Ethington, G., Schnitt, S. J., Tung, N., Garber, J. E., Fetten, K., Michor, F., and Polyak, K. (2012) Evolutionary pathways in BRCA1-associated breast tumors. Cancer Discov. 2, 503-511
-
(2012)
Cancer Discov.
, vol.2
, pp. 503-511
-
-
Martins, F.C.1
De, S.2
Almendro, V.3
Gönen, M.4
Park, S.Y.5
Blum, J.L.6
Herlihy, W.7
Ethington, G.8
Schnitt, S.J.9
Tung, N.10
Garber, J.E.11
Fetten, K.12
Michor, F.13
Polyak, K.14
-
18
-
-
40449130327
-
Oncogene-mediated inhibition of glycogen synthase kinase 3 impairs degradation of prolactin receptor
-
Plotnikov, A., Li, Y., Tran, T. H., Tang, W., Palazzo, J. P., Rui, H., and Fuchs, S. Y. (2008) Oncogene-mediated inhibition of glycogen synthase kinase 3 impairs degradation of prolactin receptor. Cancer Res. 68, 1354-1361
-
(2008)
Cancer Res.
, vol.68
, pp. 1354-1361
-
-
Plotnikov, A.1
Li, Y.2
Tran, T.H.3
Tang, W.4
Palazzo, J.P.5
Rui, H.6
Fuchs, S.Y.7
-
19
-
-
41649119043
-
Progesterone receptor rapid signaling mediates serine 345 phosphorylation and tethering to specificity protein 1 transcription factors
-
Faivre, E. J., Daniel, A. R., Hillard, C. J., and Lange, C. A. (2008) Progesterone receptor rapid signaling mediates serine 345 phosphorylation and tethering to specificity protein 1 transcription factors. Mol. Endocrinol. 22, 823-837
-
(2008)
Mol. Endocrinol.
, vol.22
, pp. 823-837
-
-
Faivre, E.J.1
Daniel, A.R.2
Hillard, C.J.3
Lange, C.A.4
-
20
-
-
36849096094
-
Phosphorylation-dependent antagonism of sumoylation derepresses progesterone receptor action in breast cancer cells
-
Daniel, A. R., Faivre, E. J., and Lange, C. A. (2007) Phosphorylation-dependent antagonism of sumoylation derepresses progesterone receptor action in breast cancer cells. Mol. Endocrinol. 21, 2890-2906
-
(2007)
Mol. Endocrinol.
, vol.21
, pp. 2890-2906
-
-
Daniel, A.R.1
Faivre, E.J.2
Lange, C.A.3
-
21
-
-
70350543566
-
Specific involvement of glycogen synthase kinase-3 in the function and activity of sex steroid hormone receptors reveals the complexity of their regulation
-
Grisouard, J., and Mayer, D. (2009) Specific involvement of glycogen synthase kinase-3 in the function and activity of sex steroid hormone receptors reveals the complexity of their regulation. J. Steroid Biochem. Mol. Biol. 117, 87-92
-
(2009)
J. Steroid Biochem. Mol. Biol.
, vol.117
, pp. 87-92
-
-
Grisouard, J.1
Mayer, D.2
-
22
-
-
25444468111
-
Glycogen synthase kinase-3 interacts with and phosphorylates estrogen receptor and is involved in the regulation of receptor activity
-
Medunjanin, S., Hermani, A., De Servi, B., Grisouard, J., Rincke, G., and Mayer, D. (2005) Glycogen synthase kinase-3 interacts with and phosphorylates estrogen receptor and is involved in the regulation of receptor activity. J. Biol. Chem. 280, 33006-33014
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 33006-33014
-
-
Medunjanin, S.1
Hermani, A.2
De Servi, B.3
Grisouard, J.4
Rincke, G.5
Mayer, D.6
-
23
-
-
77954823170
-
Glycogen synthase kinase-3 plays a central role in mediating glucocorticoidinduced apoptosis
-
Spokoini, R., Kfir-Erenfeld, S., Yefenof, E., and Sionov, R. V. (2010) Glycogen synthase kinase-3 plays a central role in mediating glucocorticoidinduced apoptosis. Mol. Endocrinol. 24, 1136-1150
-
(2010)
Mol. Endocrinol.
, vol.24
, pp. 1136-1150
-
-
Spokoini, R.1
Kfir-Erenfeld, S.2
Yefenof, E.3
Sionov, R.V.4
-
24
-
-
2442487857
-
Glycogen synthase kinase-3 is involved in the phosphorylation and suppression of androgen receptor activity
-
Salas, T. R., Kim, J., Vakar-Lopez, F., Sabichi, A. L., Troncoso, P., Jenster, G., Kikuchi, A., Chen, S. Y., Shemshedini, L., Suraokar, M., Logothetis, C. J., DiGiovanni, J., Lippman, S. M., and Menter, D. G. (2004) Glycogen synthase kinase-3 is involved in the phosphorylation and suppression of androgen receptor activity. J. Biol. Chem. 279, 19191-19200
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 19191-19200
-
-
Salas, T.R.1
Kim, J.2
Vakar-Lopez, F.3
Sabichi, A.L.4
Troncoso, P.5
Jenster, G.6
Kikuchi, A.7
Chen, S.Y.8
Shemshedini, L.9
Suraokar, M.10
Logothetis, C.J.11
Digiovanni, J.12
Lippman, S.M.13
Menter, D.G.14
-
25
-
-
77649259667
-
Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland
-
Beleut, M., Rajaram, R. D., Caikovski, M., Ayyanan, A., Germano, D., Choi, Y., Schneider, P., and Brisken, C. (2010) Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland. Proc. Natl. Acad. Sci. U.S.A. 107, 2989-2994
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 2989-2994
-
-
Beleut, M.1
Rajaram, R.D.2
Caikovski, M.3
Ayyanan, A.4
Germano, D.5
Choi, Y.6
Schneider, P.7
Brisken, C.8
-
26
-
-
84864352040
-
Progesterone and estrogen receptors segregate into different cell subpopulations in the normal human breast
-
Hilton, H. N., Graham, J. D., Kantimm, S., Santucci, N., Cloosterman, D., Huschtscha, L. I., Mote, P. A., and Clarke, C. L. (2012) Progesterone and estrogen receptors segregate into different cell subpopulations in the normal human breast. Mol. Cell Endocrinol. 361, 191-201
-
(2012)
Mol. Cell Endocrinol.
, vol.361
, pp. 191-201
-
-
Hilton, H.N.1
Graham, J.D.2
Kantimm, S.3
Santucci, N.4
Cloosterman, D.5
Huschtscha, L.I.6
Mote, P.A.7
Clarke, C.L.8
-
27
-
-
35948971359
-
Progesterone receptor regulates Bcl-2 gene expression through direct binding to its promoter region in uterine leiomyoma cells
-
Yin, P., Lin, Z., Cheng, Y. H., Marsh, E. E., Utsunomiya, H., Ishikawa, H., Xue, Q., Reierstad, S., Innes, J., Thung, S., Kim, J. J., Xu, E., and Bulun, S. E. (2007) Progesterone receptor regulates Bcl-2 gene expression through direct binding to its promoter region in uterine leiomyoma cells. J. Clin. Endocrinol. Metab. 92, 4459-4466
-
(2007)
J. Clin. Endocrinol. Metab.
, vol.92
, pp. 4459-4466
-
-
Yin, P.1
Lin, Z.2
Cheng, Y.H.3
Marsh, E.E.4
Utsunomiya, H.5
Ishikawa, H.6
Xue, Q.7
Reierstad, S.8
Innes, J.9
Thung, S.10
Kim, J.J.11
Xu, E.12
Bulun, S.E.13
-
28
-
-
34547425975
-
Growth factor signaling pathways modulate BRCA1 repression of estrogen receptor activity
-
Ma, Y., Hu, C., Riegel, A. T., Fan, S., and Rosen, E. M. (2007) Growth factor signaling pathways modulate BRCA1 repression of estrogen receptor activity. Mol. Endocrinol. 21, 1905-1923
-
(2007)
Mol. Endocrinol.
, vol.21
, pp. 1905-1923
-
-
Ma, Y.1
Hu, C.2
Riegel, A.T.3
Fan, S.4
Rosen, E.M.5
-
29
-
-
57749115897
-
Negative regulation of AKT activation by BRCA1
-
Xiang, T., Ohashi, A., Huang, Y., Pandita, T. K., Ludwig, T., Powell, S. N., and Yang, Q. (2008) Negative Regulation of AKT Activation by BRCA1. Cancer Res. 68, 10040-10044
-
(2008)
Cancer Res.
, vol.68
, pp. 10040-10044
-
-
Xiang, T.1
Ohashi, A.2
Huang, Y.3
Pandita, T.K.4
Ludwig, T.5
Powell, S.N.6
Yang, Q.7
-
30
-
-
0029587224
-
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
-
Cross, D. A., Alessi, D. R., Cohen, P., Andjelkovich, M., and Hemmings, B. A. (1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378, 785-789
-
(1995)
Nature
, vol.378
, pp. 785-789
-
-
Cross, D.A.1
Alessi, D.R.2
Cohen, P.3
Andjelkovich, M.4
Hemmings, B.A.5
|