Synthesis, pharmacophores, and mechanism study of pyridin-2(1H)-one derivatives as regulators of translation initiation factor 3A

Archiv der Pharmazie

Volumn 346, Issue 9, 2013, Pages 654-666

  Zhu, Weixing ^a   Shen, Jie ^a   Li, Qianbin ^a   Pei, Qi ^a   Chen, Jun ^a   Chen, Zhuo ^a   Liu, Zhaoqian ^a   Hu, Gaoyun ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Eukaryotic translation initiation factor 3, subunit A (eIF3a); Fibrosis; Lung cancer; Pyridin 2(1H) one; Regulators

Indexed keywords

1 PHENYL 5 [(2 TOLYLAMINO) METHYL] PYRIDIN 2(1H) ONE; 1 PHENYL 5 [(PHENYLAMINO) METHYL] PYRIDIN 2(1H) ONE; 1 PHENYL 5[(3 TOLYLAMINO) METHYL] PYRIDIN 2(1H) ONE; 1 PHENYL 5[(4 TOLYLAMINO) METHYL] PYRIDIN 2(1H) ONE; 1(3 FLUOROPHENYL) 5 [(PHENYLAMINO) METHYL] PYRIDIN 2(1H) ONE; 1(3 FLUOROPHENYL) 5[(3 TOLYLAMINO) METHYL] PYRIDIN 2(1H) ONE; 1(3 FLUOROPHENYL) 5[(4 METHOXYPHENYLAMINO) METHYL) PYRIDIN 2(1H) ONE; 1(3 FLUOROPHENYL) 5[(4 TOLYLAMINO) METHYL] PYRIDIN 2(1H) ONE; 1(4 METHOXYPHENYL) 5[(2 TOLYLAMINO) METHYL] PYRIDIN 2(1H) ONE; 1(4 METHOXYPHENYL) 5[(3 TOLYLAMINO) METHYL] PYRIDIN 2(1H) ONE; 1(4 METHOXYPHENYL) 5[(4 METHOXYPHENYLAMINO) METHYL] PYRIDINE 2(1H) ONE; 1(4 METHOXYPHENYL) 5[(PHENYLAMINO) METHYL] PYRIDIN 2(1H) ONE; 5 [(4 ACETYLPHENYLAMINO) METHYL] 1(3 FLUOROPHENYL) PYRIDIN 2(1H) ONE; 5 [(4 CHLOROPHENYLAMINO) METHYL] 1(3 FLUOROPHENYL) PYRIDIN 2(1H) ONE; 5[(4 ACETYLPHENYLAMINO) METHYL] 1 PHENYLPYRIDIN 2(1H) ONE; 5[(4 ACETYLPHENYLAMINO) METHYL] 1(4 METHOXYPHENYL) PYRIDIN 2(1H) ONE; 5[(4 CHLOROPHENYLAMINO) METHYL] 1 PHENYLPYRIDIN 2(1H) ONE; 5[(4 CHLOROPHENYLAMINO) METHYL] 1(4 METHOXYPHENYL) PYRIDIN 2(1H) ONE; 5[(4 METHOXYPHENYLAMINO) METHYL] 1 PHENYLPYRIDIN 2(1H) ONE; ANTIFIBROTIC AGENT; ANTINEOPLASTIC AGENT; CISPLATIN; INITIATION FACTOR 3; INITIATION FACTOR 3A; MIMOSINE; MOLECULAR SCAFFOLD; PYRIDIN 2(1H) ONE DERIVATIVE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL VIABILITY; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; FIBROSIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MOUSE; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; TRANSLATION REGULATION; WESTERN BLOTTING;

EUKARYOTIC TRANSLATION INITIATION FACTOR 3, SUBUNIT A (EIF3A); FIBROSIS; LUNG CANCER; PYRIDIN-2(1H)-ONE; REGULATORS;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG DESIGN; EUKARYOTIC INITIATION FACTOR-3; FIBROBLASTS; FIBROSIS; HUMANS; INHIBITORY CONCENTRATION 50; LUNG NEOPLASMS; MICE; NIH 3T3 CELLS; PYRIDONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84883679095     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.201300138     Document Type: Article

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