Novel pirfenidone analogues: Synthesis of pyridin-2-ones for the treatment of pulmonary fibrosis

Archiv der Pharmazie

Volumn 339, Issue 8, 2006, Pages 429-436

  Ammar, Yousry A ^a   Ismail, Magda M F ^b   El Sehrawi, Hend M ^b   Noaman, Eman ^c   Bayomi, Ashraf H ^b   Shawer, Taghreed Z ^b  

^a Al Azhar University   (Egypt)

^b Al Azhar University   (Egypt)

^c NATIONAL CENTER FOR RADIATION RESEARCH AND TECHNOLOGY   (Egypt)

Author keywords

2 Pyridone; Antifibrotic activity; Bicyclic pyridone; Synthesis

Indexed keywords

1 (4 FLUORO ETHOXYPHENYL) 4,6 DIMETHYL 2 OXO 1,2 DIHYDROPYRIDINE 3 CARBONITRILE; 2 CYANO N(4-FLUORO ETHOXYPHENYL)ACETAMIDE DERIVATIVE; 3 AMINO 7 (4 FLUORO ETHOXYPHENYL) 6 OXO 4 PHENYL 6,7 DIHYDRO 1H PYRAZOLO[3,4 B]PYRIDINE 5 CARBONITRILE; 4 [2 (DIMETHYLAMINO)VINYL] 1 (4 FLUOROPHENYL) 6 METHYL 2 OXO 1,2 DIHYDROPYRIDINE 3 CARBONITRILE; 4 METHYL 2 OXO 6 PHENYL 1,2 DIHYDROPYRIDINE 3 CARBONITRILE; 8 (4 ETHOXYPHENYL) 4 IMINO 7 OXO 3,5 DIPHENYL 2 THIOXO ,2,3,4,7,8 HEXAHYDRO PYRIDO[2,3 D]PYRIMIDINE 6 CARBONITRILE; 8 (4 FLUORO ETHOXYPHENYL) 2 METHYL 4,7 DIOXO 5 PHENYL 3,4,7,8 TETRAHYDRO PYRIDO[2,3 D]PYRIMIDINE 6 CARBONITRILE; 8 AMINO 2 (4 ETHOXYPHENYL) 3 METHYL 1 OXO 6 PHENYL 1,2 DIHYDROISOQUINOLINE 7 CARBONITRILE; 8 AMINO 2 (4 FLUOROPHENYL) 6 (4 METHOXYPHENYL) 3 METHYL 1 OXO 1,2 DIHYDROISOQUINOLINE 7 CARBONITRITE; ANTIFIBROTIC AGENT; ETHYL N 3,5 DICYANO 1 (4-FLUORO ETHOXYPHENYL) 6 OXO 4 PHENYL 1,6 DIHYDROPYRIDIN 2 YL FORMIMIDATE DERIVATIVE; HYDROXYPROLINE; L ARYL 2 OXO L,2 DIHYDROPYRIDINE 3 CARBONITRILE; PIRFENIDONE; PYRAZOLO[3,4B]PYRIDINE 5 CARBONITRILES; PYRIDINE 2 ONE; PYRIDO[2,3 D]PYRIMIDINE 6 CARBONITRILE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; LUNG FIBROSIS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ADMINISTRATION, ORAL; ALANINE TRANSAMINASE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPARTATE AMINOTRANSFERASES; BLEOMYCIN; BRONCHOALVEOLAR LAVAGE FLUID; CREATININE; DIHYDROPYRIDINES; DISEASE MODELS, ANIMAL; HYDROXYPROLINE; INTUBATION, INTRATRACHEAL; L-LACTATE DEHYDROGENASE; LUNG; MALE; MOLECULAR STRUCTURE; PULMONARY FIBROSIS; PYRIDONES; RATS; TIME FACTORS; UREA;

EID: 33748252630     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.200600017     Document Type: Article

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