Review of the safety and efficacy of vitamin A supplementation in the treatment of children with severe acute malnutrition

Nutrition Journal

Volumn 12, Issue 1, 2013, Pages

  Iannotti, Lora L ^a   Trehan, Indi ^a,b,c   Manary, Mark J ^a,b,c,d  

^a WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MALAWI   (Malawi)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

GRADE; Severe acute malnutrition; Systematic review; Vitamin A supplementation

Indexed keywords

RETINOL;

AGE DISTRIBUTION; ARTICLE; BLOOD OXYGEN TENSION; CHILDHOOD DISEASE; DIARRHEA; DISEASE SEVERITY; DRUG EFFICACY; DRUG MEGADOSE; DRUG SAFETY; EMBASE; HUMAN; KWASHIORKOR; LOW DRUG DOSE; MALNUTRITION; MARASMUS; MEASLES; MEDICAL LITERATURE; MEDICAL RESEARCH; MEDLINE; META ANALYSIS; MORBIDITY; OBSERVATIONAL STUDY; PRACTICE GUIDELINE; QUALITY CONTROL; RESPIRATORY TRACT INFECTION; RETINOL DEFICIENCY; SAMPLE SIZE; SEVERE ACUTE MALNUTRITION; SHIGELLOSIS; SIDE EFFECT; SYSTEMATIC REVIEW; TREATMENT INDICATION; TREATMENT OUTCOME; VITAMIN SUPPLEMENTATION; WORLD HEALTH ORGANIZATION;

CHILD; CHILD NUTRITION DISORDERS; DIETARY SUPPLEMENTS; DYSENTERY, BACILLARY; EVIDENCE-BASED MEDICINE; HUMANS; INDIVIDUALIZED MEDICINE; MALNUTRITION; MEASLES; PRACTICE GUIDELINES AS TOPIC; SEVERITY OF ILLNESS INDEX; VITAMIN A; VITAMIN A DEFICIENCY; WORLD HEALTH ORGANIZATION;

EID: 84883676177     PISSN: None     EISSN: 14752891     Source Type: Journal    
DOI: 10.1186/1475-2891-12-125     Document Type: Article

References (45)

1. Maternal and child undernutrition: global and regional exposures and health consequences. Black RE, Allen LH, Bhutta ZA, Caulfield LE, De Onis M, Ezzati M, Mathers C, Rivera J, Lancet 2008 371 243 260 10.1016/S0140-6736(07) 61690-0 18207566
2. Extent of vitamin A deficiency among preschool children and women of reproductive age. West KP Jr, J Nutr 2002 132 2857S 2866S 12221262 (Pubitemid 35013209)
3. UNICEF, The State of the World's Children 2012 New York: United Nations Children's Fund 2012 24072976
4. WHO, Management of severe malnutrition: a manual for physicians and other senior health workers Geneva: World Health Organization 1999
5. Ashworth A, Khanum S, Jackson A, CS, Guidelines for the inpatient treatment of severely malnourished children Geneva: World Health Organization 2003
6. The acute and chronic toxic effects of vitamin A. Penniston KL, Tanumihardjo SA, CS, Am J Clin Nutr 2006 83 191 201 16469975 (Pubitemid 44713178)
7. Vitamin A supplementation: implications for morbidity and mortality in children. Villamor E, Fawzi WW, J Infect Dis 2000 182 122 133 10.1086/315921 10944494
8. Grading quality of evidence and strength of recommendations. Atkins D, Best D, Briss PA, Eccles M, Falck-Ytter Y, Flottorp S, Guyatt GH, Harbour RT, Haugh MC, Henry D, et al. BMJ 2004 328 1490 15205295
9. GRADE guidelines: 8. Rating the quality of evidence - indirectness. Guyatt GH, Oxman AD, Kunz R, Woodcock J, Brozek J, Helfand M, Alonso-Coello P, Falck-Ytter Y, Jaeschke R, Vist G, J Clin Epidemiol 2011 64 1303 1310 10.1016/j.jclinepi.2011.04.014 21802903
10. GRADE guidelines: 7. Rating the quality of evidence - inconsistency. Guyatt GH, Oxman AD, Kunz R, Woodcock J, Brozek J, Helfand M, Alonso-Coello P, Glasziou P, Jaeschke R, Akl EA, J Clin Epidemiol 2011 64 1294 1302 10.1016/j.jclinepi.2011.03.017 21803546
11. GRADE guidelines 6. Rating the quality of evidence - imprecision. Guyatt GH, Oxman AD, Kunz R, Brozek J, Alonso-Coello P, Rind D, Devereaux PJ, Montori VM, Freyschuss B, Vist G, J Clin Epidemiol 2011 64 1283 1293 10.1016/j.jclinepi.2011.01.012 21839614
12. GRADE guidelines: 4. Rating the quality of evidence - study limitations (risk of bias). Guyatt GH, Oxman AD, Vist G, Kunz R, Brozek J, Alonso-Coello P, Montori V, Akl EA, Djulbegovic B, Falck-Ytter Y, J Clin Epidemiol 2011 64 407 415 10.1016/j.jclinepi.2010.07.017 21247734
13. Impact of vitamin A supplementation on infant and childhood mortality. Imdad A, Yakoob MY, Sudfeld C, Haider BA, Black RE, Bhutta ZA, BMC Publ Health 2011 11 Suppl 3 20
14. Antioxidant status in children with protein-energy malnutrition (PEM) living in Cairo, Egypt. Ashour MN, Salem SI, El-Gadban HM, Elwan NM, Basu TK, Eur J Clin Nutr 1999 53 669 673 10.1038/sj.ejcn.1600830 10477255 (Pubitemid 29396574)
15. Serum retinol concentrations in hospitalized severe protein-energy malnourished children. De Fatima Costa Caminha M, Da Silva Diniz A, Falbo AR, De Arruda IK, Serva VB, De Albuquerque LL, De Freitas Lola MM, Ebrahim GJ, J Trop Pediatr 2008 54 248 252 10.1093/tropej/fmn018 18385151
16. Vitamin A deficiency and protein-energy malnutrition in a sample of pre-school age children in the Kivu Province in Zaire. Donnen P, Brasseur D, Dramaix M, Vertongen F, Ngoy B, Zihindula M, Hennart P, Eur J Clin Nutr 1996 50 456 461 8862482 (Pubitemid 26246077)
17. Breast feeding and vitamin A deficiency among children attending a diarrhoea treatment centre in Bangladesh: a case-control study. Mahalanabis D, BMJ 1991 303 493 496 10.1136/bmj.303.6801.493 1912858
18. Predictors of serum retinol in children with shigellosis. Mitra AK, Alvarez JO, Wahed MA, Fuchs GJ, Stephensen CB, Am J Clin Nutr 1998 68 1088 1094 9808227 (Pubitemid 28493971)
19. Efficacy of a high-dose in addition to daily low-dose vitamin A in children suffering from severe acute malnutrition with other illnesses. Sattar S, Ahmed T, Rasul CH, Saha D, Salam MA, Hossain MI, PloS ONE 2012 7 33112 10.1371/journal.pone.0033112 22479361
20. Vitamin A supplementation but not deworming improves growth of malnourished preschool children in eastern Zaire. Donnen P, Brasseur D, Dramaix M, Vertongen F, Zihindula M, Muhamiriza M, Hennart P, J Nutr 1998 128 1320 1327 9687551 (Pubitemid 28361424)
21. A randomized, controlled trial of vitamin A in children with severe measles. Hussey GD, Klein M, N Engl J Med 1990 323 160 164 10.1056/ NEJM199007193230304 2194128 (Pubitemid 20219944)
22. Vitamin A supplementation reduces measles morbidity in young African children: a randomized, placebo-controlled, double-blind trial. Coutsoudis A, Broughton M, Coovadia HM, Am J Clin Nutr 1991 54 890 895 1951162 (Pubitemid 21899012)
23. Vitamin A supplementation fails to reduce incidence of acute respiratory illness and diarrhea in preschool-age Indonesian children. Dibley MJ, Sadjimin T, Kjolhede CL, Moulton LH, J Nutr 1996 126 434 442 8632216 (Pubitemid 26055773)
24. Randomised, double blind, placebo controlled clinical trial of efficacy of vitamin A treatment in non-measles childhood pneumonia. Nacul LC, Kirkwood BR, Arthur P, Morris SS, Magalhaes M, Fink MC, BMJ 1997 315 505 510 10.1136/bmj.315.7107.505 9329303 (Pubitemid 27359100)
25. High dose vitamin A supplementation in the course of pneumonia in Vietnamese children. Si NV, Grytter C, Vy NN, Hue NB, Pedersen FK, Acta Paediatr 1997 86 1052 1055 10.1111/j.1651-2227.1997.tb14805.x 9350882 (Pubitemid 27443708)
26. Randomized placebo-controlled clinical trial of the effect of a single high dose or daily low doses of vitamin A on the morbidity of hospitalized, malnourished children. Donnen P, Dramaix M, Brasseur D, Bitwe R, Vertongen F, Hennart P, Am J Clin Nutr 1998 68 1254 1260 9846855 (Pubitemid 28550957)
27. Single dose vitamin A treatment in acute shigellosis in Bangladesh children: randomised double blind controlled trial. Hossain S, Biswas R, Kabir I, Sarker S, Dibley M, Fuchs G, Mahalanabis D, BMJ 1998 316 422 426 10.1136/bmj.316.7129.422 9492664 (Pubitemid 28121294)
28. Adverse effects of high-dose vitamin A supplements in children hospitalized with pneumonia. Stephensen CB, Franchi LM, Hernandez H, Campos M, Gilman RH, Alvarez JO, Pediatrics 1998 101 3 9606245
29. Double-blind, randomized, controlled trial of zinc or vitamin A supplementation in young children with acute diarrhoea. Faruque AS, Mahalanabis D, Haque SS, Fuchs GJ, Habte D, Acta Paediatr 1999 88 154 160 10.1111/j.1651-2227.1999.tb01074.x 10102147 (Pubitemid 29124317)
30. A randomized, double-blind, placebo-controlled clinical trial of vitamin A in Mozambican children hospitalized with nonmeasles acute lower respiratory tract infections. Julien MR, Gomes A, Varandas L, Rodrigues P, Malveiro F, Aguiar P, Kolsteren P, Stuyft P, Hildebrand K, Labadarios D, Ferrinho P, Trop Med Int Health 1999 4 794 800 10.1046/j.1365-3156.1999.00493.x 10632986 (Pubitemid 30041032)
31. Vitamin A supplements and diarrheal and respiratory tract infections among children in Dar es Salaam, Tanzania. Fawzi WW, Mbise R, Spiegelman D, Fataki M, Hertzmark E, Ndossi G, J Pediatr 2000 137 660 667 10.1067/mpd.2000. 110136 11060532
32. Randomized, double-blind, placebo-controlled clinical trial of the efficacy of treatment with zinc or vitamin A in infants and young children with severe acute lower respiratory infection. Mahalanabis D, Lahiri M, Paul D, Gupta S, Gupta A, Wahed MA, Khaled MA, Am J Clin Nutr 2004 79 430 436 14985218 (Pubitemid 41115587)
33. Effect of daily low dose of vitamin A compared with single high dose on morbidity and mortality of hospitalized mainly malnourished children in Senegal: a randomized controlled clinical trial. Donnen P, Sylla A, Dramaix M, Sall G, Kuakuvi N, Hennart P, Eur J Clin Nutr 2007 61 1393 1399 10.1038/sj.ejcn.1602671 17299466 (Pubitemid 350245913)
34. Correlation of serum vitamin A and its transport protein (RBP) in malnourished and vitamin A deficient children. Jain MK, Mehta NJ, Fonseca M, Pai NV, J Postgrad Med 1990 36 119 123 2102908
35. Effects of acute inflammation on plasma retinol, retinol-binding protein, and its mRNA in the liver and kidneys of vitamin A-sufficient rats. Rosales FJ, Ritter SJ, Zolfaghari R, Smith JE, Ross AC, J Lipid Res 1996 37 962 971 8725149 (Pubitemid 26182330)
36. Abnormal T-cell subset proportions in vitamin-A-deficient children. Semba RD, Ward BJ, Griffin DE, Scott AL, Natadisastra G, West KP Jr, Sommer A, Muhilal, Lancet 1993 341 5 8 10.1016/0140-6736(93)92478-C 8093291 (Pubitemid 23007591)
37. Childhood mortality after a high dose of vitamin A in a high risk population. Daulaire NM, Starbuck ES, Houston RM, Church MS, Stukel TA, Pandey MR, BMJ 1992 304 207 210 10.1136/bmj.304.6821.207 1739794
38. Clinical trial of vitamin A as adjuvant treatment for lower respiratory tract infections. Kjolhede CL, Chew FJ, Gadomski AM, Marroquin DP, J Pediatr 1995 126 807 812 10.1016/S0022-3476(95)70416-7 7752011
39. Challenges in the Management of HIV-Infected Malnourished Children in Sub-Saharan Africa. Trehan I, O'Hare BA, Phiri A, Heikens GT, AIDS Research and Treatment 2012 2012 790786 22606378
40. Management of acute moderate and severe childhood malnutrition. Manary MJ, Sandige HL, BMJ 2008 337 1227 1230 10.1136/bmj.a1227
41. Antibiotics as part of the management of severe acute malnutrition. Trehan I, Goldbach HS, LaGrone LN, Meuli GJ, Wang RJ, Maleta KM, Manary MJ, N Engl J Med 2013 368 425 435 10.1056/NEJMoa1202851 23363496
42. WHO, Community-based management of severe acute malnutrition Geneva: World Health Organization, World Food Programme, United Nations System Standing Committee on Nutrition, United Nations Children's Fund 2007
43. A comparison of the uptake, metabolism and biologic effects of retinol delivered to human keratinocytes either free or bound to serum retinol-binding protein. Creek KE, St Hilaire P, Hodam JR, J Nutr 1993 123 356 361 8429387 (Pubitemid 23073251)
44. Oxidative status and DNA damage in chidren with marasmic malnutrition. Celik M, Sermatov K, Abuhandan M, Zeyrek D, Kocyigit A, Iscan A, J Clin Lab Anal 2012 26 161 166 10.1002/jcla.21505 22628231
45. Algorithms for converting estimates of child malnutrition based on the NCHS reference into estimates based on the WHO Child Growth Standards. Yang H, De Onis M, BMC Pediatr 2008 8 19 10.1186/1471-2431-8-19 18457590 (Pubitemid 351722545)