Challenges in the Management of HIV-Infected Malnourished Children in Sub-Saharan Africa

AIDS Research and Treatment

Volumn 2012, Issue , 2012, Pages

  Trehan, Indi ^a,b   O'Hare, Bernadette A ^a   Phiri, Ajib ^a   Heikens, Geert Tom ^a  

^a UNIVERSITY OF MALAWI   (Malawi)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84873037896     PISSN: 20901240     EISSN: 20901259     Source Type: Journal    
DOI: 10.1155/2012/790786     Document Type: Review

References (74)

1. Kerac M., McGrath M., Grijalva-Eternod C., Management of Acute Malnutrition in Infants (MAMI) project. 2009 Oxford, UK Emergency Nutrition Network
2. Black R. E., Morris S. S., Bryce J., Where and why are 10 million children dying every year? Lancet 2003 361 9376 2226 2234 2-s2.0-0038128166 10.1016/S0140-6736(03)13779-8 (Pubitemid 36782560)
3. Hesseling A. C., Westra A. E., Werschkull H., Donald P. R., Beyers N., Hussey G. D., El-Sadr W., Schaaf H. S., Outcome of HIV infected children with culture confirmed tuberculosis. Archives of Disease in Childhood 2005 90 11 1171 1174 2-s2.0-27644595160 10.1136/adc.2004.070466 (Pubitemid 41565280)
4. WHO, Management of severe malnutrition: a manual for physicians and other senior health workers. 1999 Geneva, Switzerland World Health Organization
5. Ashworth A., Khanum S., Jackson A., Schofield C., Guidelines for the Inpatient Treatment of Severely Malnourished Children 2003 Geneva, Switzerland World Health Organization
6. WHO, Severe malnutrition: report of a consultation to review current literature. 2005 Geneva, Switzerland World Health Organization
7. Heikens G. T., Bunn J., Amadi B., Manary M., Chhagan M., Berkley J. A., Rollins N., Kelly P., Adamczick C., Maitland K., Tomkins A., Case management of HIV-infected severely malnourished children: challenges in the area of highest prevalence. The Lancet 2008 371 9620 1305 1307 2-s2.0-41749117073 10.1016/S0140-6736(08)60565-6 (Pubitemid 351491320)
8. Collins S., Dent N., Binns P., Bahwere P., Sadler K., Hallam A., Management of severe acute malnutrition in children. Lancet 2006 368 9551 1992 2000 2-s2.0-33751402365 10.1016/S0140-6736(06)69443-9 (Pubitemid 44821358)
9. Manary M. J., Sandige H. L., Management of acute moderate and severe childhood malnutrition. British Medical Journal 2008 337 a2180 2-s2.0-58149263501 10.1136/bmj.a2180
10. WHO, WFP, UNSCN, UNICEF, Community-based management of severe acute malnutrition. 2007 World Health Organization, World Food Programme, United Nations System Standing Committee on Nutrition and United Nations Children's Fund
11. Ndekha M. J., Manary M. J., Ashorn P., Briend A., Home-based therapy with ready-to-use therapeutic food is of benefit to malnourished, HIV-infected Malawian children. Acta Paediatrica 2005 94 2 222 225 2-s2.0-14844313772 10.1080/08035250410022503 (Pubitemid 40343699)
12. WHO, World health statistics 2011. 2011 Geneva, Switzerland World Health Organization
13. UNICEF, The state of the world's children 2011. 2011 United Nations Children's Fund
14. WHO, Major causes of death in neonates and children under five: African region-2008 (revised). 2011, http://www.who.int/child-adolescent-health/media/ CAH-death-u5-neonates-afro-2008.pdf
15. Harries A. D., Zachariah R., Corbett E. L., Lawn S. D., Santos-Filho E. T., Chimzizi R., Harrington M., Maher D., Williams B. G., De Cock K. M., The HIV-associated tuberculosis epidemic-when will we act? The Lancet 2010 375 9729 1906 1919 2-s2.0-77952880349 10.1016/S0140-6736(10)60409-6
16. Donald P. R., Marais B. J., Barry C. E., Age and the epidemiology and pathogenesis of tuberculosis. The Lancet 2010 375 9729 1852 1854 2-s2.0-77952742208 10.1016/S0140-6736(10)60580-6
17. Hesseling A. C., Cotton M. F., Jennings T., Whitelaw A., Johnson L. F., Eley B., Roux P., Godfrey-Faussett P., Schaaf H. S., High incidence of tuberculosis among HIV-infected infants: evidence from a South African population-based study highlights the need for improved tuberculosis control strategies. Clinical Infectious Diseases 2009 48 1 108 114 2-s2.0-57749120563 10.1086/595012
18. Maartens G., Wilkinson R. J., Tuberculosis. Lancet 2007 370 9604 2030 2043 2-s2.0-36849092820 10.1016/S0140-6736(07)61262-8 (Pubitemid 350236315)
19. Magadi M. A., m.magadi@city.ac.uk Household and community HIV/AIDS status and child malnutrition in sub-Saharan Africa: evidence from the demographic and health surveys. Social Science and Medicine 2011 73 3 436 446 10.1016/j.socscimed.2011.05.042
20. Braun M., Kabue M. M., McCollum E. D., Ahmed S., Kim M., Aertker L., Chirwa M., Eliya M., Mofolo I., Hoffman I., Kazembe P. N., Van Der Horst C., Kline M. W., Hosseinipour M. C., mina-hosseinipour@med.unc.edu Inadequate coordination of maternal and infant HIV services detrimentally affects early infant diagnosis outcomes in lilongwe, Malawi. Journal of Acquired Immune Deficiency Syndromes 2011 56 5 e122 e128 10.1097/QAI.0b013e31820a7f2f
21. UNAIDS, Global plan towards the elimination of new HIV infections among children by 2015 and keeping their mothers alive 2011-;2015. 2011 Geneva, Switzerland Joint United Nations Programme on HIV/AIDS
22. Schouten E. J., eschouten@msh.org Jahn A., Midiani D., Makombe S. D., Mnthambala A., Chirwa Z., Harries A. D., Van Oosterhout J. J., Meguid T., Ben-Smith A., Zachariah R., Lynen L., Zolfo M., Van Damme W., Gilks C. F., Atun R., Shawa M., Chimbwandira F., Prevention of mother-to-child transmission of HIV and the health-related Millennium Development Goals: time for a public health approach. The Lancet 2011 378 9787 282 284 10.1016/S0140-6736(10)62303-3
23. Zachariah R., zachariah@internet.lu Bemelmans M., Akesson A., Gomani P., Phiri K., Isake B., Van Den Akker T., Philips M., Mwale A., Gausi F., Kwanjana J., Harries A. D., Reduced tuberculosis case notification associated with scaling up antiretroviral treatment in rural Malawi. International Journal of Tuberculosis and Lung Disease 2011 15 7 933 937 10.5588/ijtld.10.0666
24. Bunn J., Thindwa M., Kerac M., Features associated with underlying HIV infection in severe acute childhood malnutrition: a cross sectional study. Malawi Medical Journal 2009 21 3 108 112 2-s2.0-70350103031
25. Jackson A. A., Golden M. H. N., Weatherall D. J., Ledingham J. G. G., Warrell D. A., Severe malnutrition. Oxford Textbook of Medicine 1987 Oxford, UK Oxford University Press 12 28
26. Heikens G. T., How can we improve the care of severely malnourished children in Africa? PLoS Medicine 2007 4 2 e45 2-s2.0-33847657600 10.1371/journal.pmed.0040045.t001 (Pubitemid 46354426)
27. Hughes S. M., Amadi B., Mwiya M., Nkamba H., Mulundu G., Tomkins A., Goldblatt D., CD4 counts decline despite nutritional recovery in HIV-infected zambian children with severe malnutrition. Pediatrics 2009 123 2 e347 e351 2-s2.0-61549090602 10.1542/peds.2008-1316
28. Fergusson P., Tomkins A., HIV prevalence and mortality among children undergoing treatment for severe acute malnutrition in sub-Saharan Africa: a systematic review and meta-analysis. Transactions of the Royal Society of Tropical Medicine and Hygiene 2009 103 6 541 548 2-s2.0-67349208150 10.1016/j.trstmh.2008.10.029
29. WHO, Guidelines for an integrated approach to the nutritional care of HIV-infected children (6 months-14 years). 2009 Geneva, Switzerland World Health Organization
30. Heikens G. T., Rehabilitation of Sick Malnourished Children: Environment, Requirements, Prognosis and Feasibility 2003 Amsterdam, The Netherlands Rozenberg Publishers
31. De Maayer T., tim.demaayer@wits.ac.za Saloojee H., Clinical outcomes of severe malnutrition in a high tuberculosis and HIV setting. Archives of Disease in Childhood 2011 96 6 560 564 10.1136/adc.2010.205039
32. Kessler L., Daley H., Malenga G., Graham S., The impact of the human immunodeficiency virus type 1 on the management of severe malnutrition in Malawi. Annals of Tropical Paediatrics 2000 20 1 50 56 2-s2.0-0034105695 10.1080/02724930092075 (Pubitemid 30171229)
33. Amadi B., Mwiya M., Musuku J., Watuka A., Sianongo S., Ayoub A., Kelly P., Effect of nitazoxanide on morbidity and mortality in Zambian children with cryptosporidiosis: a randomised controlled trial. Lancet 2002 360 9343 1375 1380 2-s2.0-0037010366 10.1016/S0140-6736(02)11401-2 (Pubitemid 35341302)
34. Ferrand R. A., Bandason T., Musvaire P., Larke N., Nathoo K., Mujuru H., Ndhlovu C. E., Munyati S., Cowan F. M., Gibb D. M., Corbett E. L., Causes of acute hospitalization in adolescence: burden and spectrum of HIV-related morbidity in a country with an early-onset and severe HIV epidemic: a prospective survey. PLoS Medicine 2010 7 2 2-s2.0-77449111194 10.1371/journal.pmed.1000178 e1000178
35. Kerac M., Bunn J., Seal A., Thindwa M., Tomkins A., Sadler K., Bahwere P., Collins S., Probiotics and prebiotics for severe acute malnutrition (PRONUT study): a double-blind efficacy randomised controlled trial in Malawi. The Lancet 2009 374 9684 136 144 2-s2.0-67649849676 10.1016/S0140-6736(09)60884-9
36. Bunn J., Kerac M., Excess mortality risk associated with HIV in a large Malawian Nutritional Rehabilitation Unit. Malawi Medical Journal 2007 19 2 95
37. Bronzan R. N., Taylor T. E., Mwenechanya J., Tembo M., Kayira K., Bwanaisa L., Njobvu A., Kondowe W., Chalira C., Walsh A. L., Phiri A., Wilson L. K., Molyneux M. E., Graham S. M., Bacteremia in Malawian children with severe malaria: prevalence, etiology, HIV coinfection, and outcome. Journal of Infectious Diseases 2007 195 6 895 904 2-s2.0-33847621655 10.1086/511437 (Pubitemid 46363936)
38. Maitland K., Berkley J. A., Shebbe M., Peshu N., English M., Newton C. R. J. C., Children with severe malnutrition: can those at highest risk of death be identified with the WHO protocol? PLoS Medicine 2006 3 12, article e500 2431 2439 2-s2.0-33845863653 10.1371/journal.pmed.0030500 (Pubitemid 46026458)
39. Babirekere-Iriso E., Musoke P., Kekitiinwa A., Bacteraemia in severely malnourished children in an HIV-endemic setting. Annals of Tropical Paediatrics 2006 26 4 319 328 2-s2.0-34447337727 10.1179/146532806X152845 (Pubitemid 47054669)
40. WHO, IUATLD, Guidance for national tuberculosis and HIV programmes on the management of tuberculosis in HIV-infected children: recommendations for a public health approach. 2010 Paris, france World Health Organization and International Union Against Tuberculosis and Lung Disease
41. Madhi S. A., Petersen K., Madhi A., Khoosal M., Klugman K. P., Increased disease burden and antibiotic resistance of bacteria causing severe community-acquired lower respiratory tract infections in human immunodeficiency virus type 1-infected children. Clinical Infectious Diseases 2000 31 1 170 176 2-s2.0-0034456878 10.1086/313925 (Pubitemid 32268959)
42. Zar H. J., Hanslo D., Hussey G., The impact of HIV infection and trimethoprim-sulphamethoxazole prophylaxis on bacterial isolates from children with community-acquired pneumonia in South Africa. Journal of Tropical Pediatrics 2003 49 2 78 83 2-s2.0-0037395948 10.1093/tropej/49.2.78 (Pubitemid 36503733)
43. Everett D. B., Dean.Everett@liverpool.ac.uk Mukaka M., Denis B., Gordon S. B., Carrol E. D., van Oosterhout J. J., Molyneux E. M., Molyneux M., French N., Heyderman R. S., Ten years of surveillance for invasive streptococcus pneumoniae during the era of antiretroviral scale-up and cotrimoxazole prophylaxis in Malawi. PLoS ONE 2011 6 3 10.1371/journal.pone.0017765 e17765
44. Jahoor F., Abramson S., Heird W. C., The protein metabolic response to HIV infection in young children. American Journal of Clinical Nutrition 2003 78 1 182 189 2-s2.0-0038168707 (Pubitemid 39655264)
45. Melchior J. C., Salmon D., Rigaud D., Leport C., Bouvet E., Detruchis P., Vilde J. L., Vachon F., Coulaud J. P., Apfelbaum M., Resting energy expenditure is increased in stable, malnourished HIV-infected patients. American Journal of Clinical Nutrition 1991 53 2 437 441 2-s2.0-0025856369 (Pubitemid 121000851)
46. Fergusson P., Tomkins A., Kerac M., Improving survival of children with severe acute malnutrition in HIV-prevalent settings. International Health 2009 1 1 10 16 2-s2.0-71549130129 10.1016/j.inhe.2009.03.001
47. Kerac M., Akahane K., Blencowe H., Inpatient feeding for children with complicated severe acute malnutrition: audit of ready-to-use food vs. F100 milk in transition phase. Proceedings of the 11th Commonwealth Association of Paediatric Gastroenterology and Nutrition Congress 2011 London, UK
48. Bandsma R. H. J., Mendel M., Spoelstra M. N., Reijngoud D. J., Boer T., Stellaard F., Brabin B., Schellekens R., Senga E., Tom Heikens G., Mechanisms behind decreased endogenous glucose production in malnourished children. Pediatric Research 2010 68 5 423 428 2-s2.0-77958510968 10.1203/PDR. 0b013e3181f2b959
49. Bandsma R. H. J., Spoelstra M. N., Mari A., Mendel M., van Rheenen P. F., Senga E., van Dijk T., Heikens G. T., Impaired glucose absorption in children with severe malnutrition. Journal of Pediatrics 2011 158 2 282.e1 287.e1 2-s2.0-77956494378 10.1016/j.jpeds.2010.07.048
50. Amadi B., Kelly P., Mwiya M., Mulwazi E., Sianongo S., Changwe F., Thomson M., Hachungula J., Watuka A., Walker-Smith J., Chintu C., Intestinal and systemic infection, HIV, and mortality in Zambian children with persistent diarrhea and malnutrition. Journal of Pediatric Gastroenterology and Nutrition 2001 32 5 550 554 2-s2.0-0034952351 10.1097/00005176-200105000-00011 (Pubitemid 32601806)
51. Heikens G. T., Schofield W. N., Dawson S., The kingston project-II. The effects of high energy supplement and metronidazole on malnourished children rehabilitated in the community: anthropometry. European Journal of Clinical Nutrition 1993 47 3 160 173 2-s2.0-0027529266 (Pubitemid 23099686)
52. Brent A. J., Oundo J. O., Mwangi I., Ochola L., Lowe B., Berkley J. A., Salmonella bacteremia in Kenyan children. Pediatric Infectious Disease Journal 2006 25 3 230 236 2-s2.0-33644931395 10.1097/01.inf.0000202066.02212.ff (Pubitemid 43379063)
53. Chhagan M. K., Kauchali S., Comorbidities and mortality among children hospitalized with diarrheal disease in an area of high prevalence of human immunodeficiency virus infection. Pediatric Infectious Disease Journal 2006 25 4 333 338 2-s2.0-33645552817 10.1097/01.inf.0000207400.93627.4c
54. Glennie S. J., Williams N. A., Heyderman R. S., Mucosal immunity in resource-limited setting: is the battle ground different? Trends in Microbiology 2010 18 11 487 493 2-s2.0-77958165100 10.1016/j.tim.2010.08.002
55. Akech S. O., Karisa J., Nakamya P., Boga M., Maitland K., Phase II trial of isotonic fluid resuscitation in Kenyan children with severe malnutrition and hypovolaemia. BMC Pediatrics 2010 10, article 71 2-s2.0-77957315184 10.1186/1471-2431-10-71
56. Andresen E., Rollins N. C., Sturm A. W., Conana N., Greiner T., Bacterial contamination and over-dilution of commercial infant formula prepared by HIV-Infected mothers in a Prevention of Mother-to-Child Transmission (PMTCT) programme, South Africa. Journal of Tropical Pediatrics 2007 53 6 409 414 2-s2.0-37849044225 10.1093/tropej/fmm059
57. Callens S. F. J., Shabani N., Lusiama J., Lelo P., Kitetele F., Colebunders R., Gizlice Z., Edmonds A., Van Rie A., Behets F., Mortality and associated factors after initiation of pediatric antiretroviral treatment in the democratic republic of the congo. Pediatric Infectious Disease Journal 2009 28 1 35 40 2-s2.0-66149148223 10.1097/INF.0b013e318184eeb9
58. Naidoo R., Rennert W., Lung A., Naidoo K., McKerrow N., The influence of nutritional status on the response to HAART in HIV-infected children in South Africa. Pediatric Infectious Disease Journal 2010 29 6 511 513 2-s2.0-77953150629 10.1097/INF.0b013e3181d1e989
59. Taye B., Shiferaw S., Enquselassie F., The impact of malnutrition in survival of HIV infected children after initiation of antiretroviral treatment (ART). Ethiopian Medical Journal 2010 48 1 1 10 2-s2.0-77955084909
60. Kim M. H., Cox C., Dave A., Prompt initiation of ART with therapeutic food is associated with improved outcomes in HIV-infected Malawian children with malnutrition. Journal of Acquired Immune Deficiency Syndromes 2012 59 2 173 176
61. Sutcliffe C. G., csutclif@jhsph.edu van Dijk J. H., janneke.vandijk@miam. org.zm Munsanje B., bornface.munsanje@miam.org.zm Hamangaba F., francis.hamangaba@miam.org.zm Sinywimaanzi P., pamela.sinywimaanzi@miam.org.zm Thuma P. E., phil.thuma@macharesearch.org Moss W. J., wmoss@jhsph.edu Weight and height z-scores improve after initiating ART among HIV-infected children in rural Zambia: a cohort study. BMC Infectious Diseases 2011 11, article 54 10.1186/1471-2334-11-54
62. Heikens G. T., Schofield W. N., Dawson S. M., Waterlow J. C., Long-stay versus short-stay hospital treatment of children suffering from severe protein-energy malnutrition. European Journal of Clinical Nutrition 1994 48 12 873 882 2-s2.0-0028596995
63. Prendergast A., Bwakura-Dangarembizi M. F., Cook A. D., Hospitalization for severe malnutrition among HIV-infected children starting antiretroviral therapy. AIDS 2011 25 7 951 956
64. Wang M. E., Castillo M. E., Montano S. M., Zunt J. R., Immune reconstitution inflammatory syndrome in human immunodeficiency virus-infected children in Peru. Pediatric Infectious Disease Journal 2009 28 10 900 903 2-s2.0-70349664779 10.1097/INF.0b013e3181a4b7fa
65. Yotebieng M., Van Rie A., Moultrie H., Cole S. R., Adimora A., Behets F., Meyers T., Effect on mortality and virological response of delaying antiretroviral therapy initiation in children receiving tuberculosis treatment. Journal of Acquired Immune Deficiency Syndromes 2010 24 9 1341 1349 2-s2.0-77952897265 10.1097/QAD.0b013e328339e576
66. Madebo T., Lindtjorn B., Aukrust P., Berge R. K., Circulating antioxidants and lipid peroxidation products in untreated tuberculosis patients in Ethiopia. American Journal of Clinical Nutrition 2003 78 1 117 122 2-s2.0-0037493478 (Pubitemid 39655256)
67. Wood R., When to start antiretroviral therapy in children with TB? Expert Review of Anti-Infective Therapy 2010 8 10 1101 1104 2-s2.0-77958187072 10.1586/eri.10.103
68. Pollock L., Else L., Poerksen G., Molyneux E., Moons P., Walker S., Fraser W., Back D., Khoo S., Pharmacokinetics of nevirapine in HIV-infected children with and without malnutrition receiving divided adult fixed-dose combination tablets. Journal of Antimicrobial Chemotherapy 2009 64 6 1251 1259 2-s2.0-76249122103 10.1093/jac/dkp358
69. Health, Clinical Management of HIV in Children and Adults 2011 1st Lilongwe, Malawi Malawi Ministry of Health
70. Verhagen L. M., Warris A., Van Soolingen D., de Groot R., Hermans P. W. M., Human immunodeficiency virus and tuberculosis coinfection in children: challenges in diagnosis and treatment. Pediatric Infectious Disease Journal 2010 29 10 e63 e70 2-s2.0-77957266889 10.1097/INF.0b013e3181ee23ae
71. Newton S. M., Brent A. J., Anderson S., Whittaker E., Kampmann B., Paediatric tuberculosis. The Lancet Infectious Diseases 2008 8 8 498 510 2-s2.0-47349106620 10.1016/S1473-3099(08)70182-8 (Pubitemid 352001412)
72. Swaminathan S., Rekha B., Pediatric tuberculosis: global overview and challenges. Clinical Infectious Diseases 2010 50 suplement 3 S184 S194 2-s2.0-77951771653 10.1086/651490
73. Nicol M. P., mark.nicol@uct.ac.za Workman L., Isaacs W., Munro J., Black F., Eley B., Boehme C. C., Zemanay W., Zar H. J., Accuracy of the Xpert MTB/RIF test for the diagnosis of pulmonary tuberculosis in children admitted to hospital in Cape Town, South Africa: a descriptive study. The Lancet Infectious Diseases 2011 11 11 819 824 10.1016/S1473-3099(11)70167-0
74. WHO, WHO endorses new rapid tuberculosis test. 2011, http://www.who.int/ mediacentre/news/releases/2010/tb-test-20101208/en/index.html