Effect of daily low dose of vitamin A compared with single high dose on morbidity and mortality of hospitalized mainly malnourished children in senegal: A randomized controlled clinical trial

European Journal of Clinical Nutrition

Volumn 61, Issue 12, 2007, Pages 1393-1399

  Donnen, P ^a   Sylla, A ^b   Dramaix, M ^a   Sall, G ^b   Kuakuvi, N ^b   Hennart, P ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b Centre Hospitalier Universitaire Aristide Le Dantec de Dakar   (Senegal)

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO; RETINOL PALMITATE;

ADOLESCENT; ARTICLE; CHILD; CHILDHOOD MORTALITY; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CONVALESCENCE; DIARRHEA; DISEASE DURATION; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MEGADOSE; EDEMA; FEMALE; FOLLOW UP; HAZARD RATIO; HIGH RISK PATIENT; HOSPITAL ADMISSION; HOSPITAL DISCHARGE; HOSPITAL INFECTION; HOSPITALIZATION; HOSPITALIZED CHILD; HUMAN; INCIDENCE; INFANT; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MALNUTRITION; MORBIDITY; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT DISEASE; RETINOL DEFICIENCY; SENEGAL; SINGLE DRUG DOSE; SURVIVAL; VITAMIN SUPPLEMENTATION;

ADOLESCENT; CHILD; CHILD NUTRITION DISORDERS; CHILD, PRESCHOOL; CONFIDENCE INTERVALS; CROSS INFECTION; DIARRHEA; DIETARY SUPPLEMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; EDEMA; FEMALE; HOSPITAL MORTALITY; HOSPITALIZATION; HUMANS; INFANT; INFANT, NEWBORN; MALE; MORBIDITY; ODDS RATIO; PROTEIN-ENERGY MALNUTRITION; RESPIRATORY TRACT INFECTIONS; SENEGAL; SURVIVAL ANALYSIS; VITAMIN A; VITAMIN A DEFICIENCY;

EID: 37049019485     PISSN: 09543007     EISSN: 14765640     Source Type: Journal    
DOI: 10.1038/sj.ejcn.1602671     Document Type: Article

References (29)

1. Barclay AJG, Foster A, Sommer A (1987). Vitamin A supplements and mortality related to measles: A randomised clinical trial. BMJ 294, 294-296.
2. Beau J-P, Garenne M, Diop B, Briend A, Diop Mar I (1987). Diarrhoea and nutritional status as risk factors of child mortality in a Dakar hospital (Senegal). J Trop Pediatr 33, 4-9.
3. Bresee J, Fischer M, Dowell S, Johnston BD, Biggs VM, Levine RS et al. (1996). Vitamin A therapy for children with respiratory syncytial virus infection: A multicenter trial in the United States. Pediatr Infect Dis J 15, 777-782.
4. Coutsoudis A, Broughton M, Coovadia HM (1991). Vitamin A supplementation reduces measles morbidity in young African children: A randomized, placebo-controlled, double-blind trial. Am J Clin Nutr 54, 890-895.
5. Dewan V, Patwari AK, Jain M, Dewan N (1995). A randomised controlled trial of vitamin A supplementation in acute diarrhea. Indian Pediatr 32, 21-25.
6. Dibley MJ, Goldsby JB, Staehling NW, Trowbridge FL (1987). Development of normalized curves for the international growth reference: Historical and technical considerations. Am J Clin Nutr 46, 736-748.
7. Donnen Ph, Dramaix M, Brasseur D, Bitwe R, Vertongen F, Hennart Ph (1998). Randomized placebo-controlled clinical trial of the effect of a single high dose or daily low doses of vitamin A supplementation on morbidity of hospitalized malnourished children. Am J Clin Nutr 68, 1254-1260.
8. Ellison JB (1932). Intensive vitamin A therapy in measles. BMJ 2, 708-711.
9. Faruque ASG, Mahalanabis D, Haque SS, Fuchs GJ, Habte D (1999). Double-blind, randomised, controlled trial of zinc or vitamin A supplementation in young children with acute diarrhoea. Acta Paediatr 88, 154-160.
10. Fawzi WW, Mbise RL, Fataki MR, Herrera MG, Kawau F, Hertzmark E et al. (1998). Vitamin A supplementation and severity of pneumonia in children admitted to the hospital in Dar es Salaam, Tanzania. Am J Clin Nutr 68, 187-192.
11. Fawzi WW, Mbise R, Spiegelman D, Fataki M, Hertzmark E, Ndossi G (2000). Vitamin A supplements and diarrheal and respiratory tract infections among children in Dar es Salaam, Tanzania. J Pediatr 137, 660-667.
12. Friedman A, Meidovsky A, Leitner G, Sklan D (1991). Decreased resistance and immune response to Escherichia coli infection in chicks with low or high intakes of vitamin A. J Nutr 121, 395-400.
13. Henning B, Stewart K, Zaman K, Alam AN, Brown KH, Black RE (1992). Lack of therapeutic efficacy of vitamin A for non-cholera, watery diarrhea in Bangladeshi children. Eur J Clin Nutr 46, 437-443.
14. Hossain S, Biswas R, Kabir I, Sarker S, Dibley M, Fuchs G et al. (1998). Single dose vitamin A treatment in acute shigellosis in Bangladeshi children: Randomised double-blind controlled trial. BMJ 316, 422-426.
15. Hussey GD, Klein M (1990). A randomized, controlled trial of vitamin A in children with severe measles. N Engl J Med 323, 160-164.
16. Ingenbleek Y, Van Den Schrieck HG, De Nayer P, De Visscher M (1975). The role of retinol-binding-protein in protein-calorie malnutrition. Metabolism 24, 633-641.
17. Julien MR, Gomes A, Varandas L, Rodrigues P, Malveiro F, Aguiar P et al. (1999). A randomised, double-blind, placebo-controlled clinical trial of vitamin A in Mozambican children hospitalised with non-measles acute lower respiratory tract infections. Trop Med Int Health 4 794-800.
18. Kjolhede CL, Chew FJ, Gadomski AM, Marroquin DP (1995). Clinical trial of vitamin A as adjuvant treatment for lower respiratory tract infections. J Pediatr 126, 807-812.
19. Mahalabanis D, Lahiri M, Paul D, Gupta S, Gupta A, Wahed MA et al. (2004). Randomized, double-blind, placebo-controlled clinical trial of the efficacy of treatment with zinc or vitamin A in infants and young children with acute lower respiratory infection. Am J Clin Nutr 79, 430-436.
20. McNally L, Tomkins A (2001). A review of the evidence for the benefits and safety of adding vitamin A to the treatment of six common health problems in children. Bull WHO 22, 295-310.
21. Nacul LC, Kirkwood BR, Arthur P, Morris SS, Magalhaes M, Fink MCDS (1997). Randomised, double-blind, placebo-controlled clinical trial of the efficacy of vitamin A treatment in non-measles chilhood pneumonia. Br Med J 315, 505-510.
22. Ross DA (2002). Recommendations for vitamin A supplementation. J Nutr 131, 2902S-2906S.
23. Si NV, Grytter C, Vy NNT, Hue NB, Pedersen FK (1997). High-dose vitamin A supplementation in the course of pneumoniae in Vietnamese children. Acta Pediatr 86, 1052-1055.
24. Sommer A, West KP (1996). Vitamin A deficiency: Health, Survival and Vision. Oxford University Press: New York, NY.
25. Stephensen C, Franchi L, Hernandez H, Campos M, Gilman R, Alvarez J (1998). Adverse effects of high-dose vitamin A supplements in children hospitalised with pneumonia. Pediatrics 101, E3.
26. Vanderpas J, Vertongen F (1985). Erythrocyte vitamin E is oxidized at a lower peroxide concentration in neonates than in adults. Blood 66, 1272-1277.
27. Villamor E, Fawzi WW (2000). Vitamin A supplementation: Implications for morbidity and mortality in children. J Infect Dis 182, S122-S133.
28. Villamor E, Fawzi WW (2005). Effects of vitamin A supplementation on immune responses and correlation with clinical outcomes. Clin Microbiol Rev 18, 446-464.
29. Yurdakok K, Ozmert E, Yalçin SS, Laleli Y (2000). Vitamin A supplementation in acute diarrhoea. J Pediatr Gastroenterol Nutr 31, 234-237.