Exploring smooth muscle phenotype and function in a bioreactor model of abdominal aortic aneurysm

Journal of Translational Medicine

Volumn 11, Issue 1, 2013, Pages

  Riches, Kirsten ^a,b   Angelini, Timothy G ^a   Mudhar, Gurprit S ^a   Kaye, Jean ^a   Clark, Emily ^b   Bailey, Marc A ^b,d   Sohrabi, Soroush ^a,d   Korossis, Sotirios ^c   Walker, Peter G ^b   Scott, D Julian A ^a,b,d   Porter, Karen E ^a,b  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d LEEDS GENERAL INFIRMARY   (United Kingdom)

Author keywords

Abdominal aortic aneurysm; Apoptosis; Bioreactor; Human; MMP 2; Morphology; Porcine; Proliferation; Senescence; Smooth muscle cell

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BETA GALACTOSIDASE; CASPASE 3; COLLAGENASE; ELASTASE; GELATINASE A;

ABDOMINAL AORTA ANEURYSM; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOREACTOR; CAROTID ARTERY; CELL AGING; CELL COUNT; CELL FUNCTION; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; ENZYME ASSAY; ENZYME RELEASE; EX VIVO STUDY; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; MUSCLE FUNCTION; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; SAPHENOUS VEIN; SMOOTH MUSCLE FIBER; SWINE; ZYMOGRAPHY;

ANIMALS; AORTIC ANEURYSM, ABDOMINAL; APOPTOSIS; BIOREACTORS; CAROTID ARTERIES; CELL AGING; CELL COUNT; CELL PROLIFERATION; CELL SHAPE; COLLAGENASES; HUMANS; MALE; MATRIX METALLOPROTEINASES; MODELS, BIOLOGICAL; MUSCLE, SMOOTH; MUSCLE, SMOOTH, VASCULAR; PANCREATIC ELASTASE; PHENOTYPE; SUS SCROFA;

EID: 84883670311     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-11-208     Document Type: Article

References (45)

1. Filardo G, Powell JT, Martinez MA, Ballard DJ. Surgery for small asymptomatic abdominal aortic aneurysms. Cochrane Database Syst Rev 2012, 3:CD001835.
2. Nordon IM, Hinchliffe RJ, Loftus IM, Thompson MM. Pathophysiology and epidemiology of abdominal aortic aneurysms. Nat Rev Cardiol 2011, 8:92-102.
3. McCormick ML, Gavrila D, Weintraub NL. Role of oxidative stress in the pathogenesis of abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol 2007, 27:461-469.
4. Owens GK, Kumar MS, Wamhoff BR. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev 2004, 84:767-801.
5. Henderson EL, Geng YJ, Sukhova GK, Whittemore AD, Knox J, Libby P. Death of smooth muscle cells and expression of mediators of apoptosis by T lymphocytes in human abdominal aortic aneurysms. Circulation 1999, 99:96-104.
6. Ailawadi G, Moehle CW, Pei H, Walton SP, Yang Z, Kron IL, Lau CL, Owens GK. Smooth muscle phenotypic modulation is an early event in aortic aneurysms. J Thorac Cardiovasc Surg 2009, 138:1392-1399.
7. Davis V, Persidskaia R, Baca-Regen L, Itoh Y, Nagase H, Persidsky Y, Ghorpade A, Baxter BT. Matrix metalloproteinase-2 production and its binding to the matrix are increased in abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol 1998, 18:1625-1633.
8. Longo GM, Xiong W, Greiner TC, Zhao Y, Fiotti N, Baxter BT. Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms. J Clin Invest 2002, 110:625-632.
9. Curci JA, Liao S, Huffman MD, Shapiro SD, Thompson RW. Expression and localization of macrophage elastase (matrix metalloproteinase-12) in abdominal aortic aneurysms. J Clin Invest 1998, 102:1900-1910.
10. Cafueri G, Parodi F, Pistorio A, Bertolotto M, Ventura F, Gambini C, Bianco P, Dallegri F, Pistoia V, Pezzolo A, et al. Endothelial and smooth muscle cells from abdominal aortic aneurysm have increased oxidative stress and telomere attrition. PLoS One 2012, 7:e35312.
11. Gacchina C, Brothers T, Ramamurthi A. Evaluating smooth muscle cells from CaCl2-induced rat aortal expansions as a surrogate culture model for study of elastogenic induction of human aneurysmal cells. Tissue Eng Part A 2011, 17:1945-1958.
12. Liao S, Curci JA, Kelley BJ, Sicard GA, Thompson RW. Accelerated replicative senescence of medial smooth muscle cells derived from abdominal aortic aneurysms compared to the adjacent inferior mesenteric artery. J Surg Res 2000, 92:85-95.
13. Goodall S, Crowther M, Hemingway DM, Bell PR, Thompson MM. Ubiquitous elevation of matrix metalloproteinase-2 expression in the vasculature of patients with abdominal aneurysms. Circulation 2001, 104:304-309.
14. Trollope A, Moxon JV, Moran CS, Golledge J. Animal models of abdominal aortic aneurysm and their role in furthering management of human disease. Cardiovasc Pathol 2011, 20:114-123.
15. Allaire E, Muscatelli-Groux B, Mandet C, Guinault AM, Bruneval P, Desgranges P, Clowes A, Melliere D, Becquemin JP. Paracrine effect of vascular smooth muscle cells in the prevention of aortic aneurysm formation. J Vasc Surg 2002, 36:1018-1026.
16. Allaire E, Muscatelli-Groux B, Guinault AM, Pages C, Goussard A, Mandet C, Bruneval P, Melliere D, Becquemin JP. Vascular smooth muscle cell endovascular therapy stabilizes already developed aneurysms in a model of aortic injury elicited by inflammation and proteolysis. Ann Surg 2004, 239:417-427.
17. Hynecek RL, DeRubertis BG, Trocciola SM, Zhang H, Prince MR, Ennis TL, Kent KC, Faries PL. The creation of an infrarenal aneurysm within the native abdominal aorta of swine. Surgery 2007, 142:143-149.
18. Yazdani SK, Berry JL. Development of an in vitro system to assess stent-induced smooth muscle cell proliferation: a feasibility study. J Vasc Interv Radiol 2009, 20:101-106.
19. Touroo JS, Williams SK. A tissue-engineered aneurysm model for evaluation of endovascular devices. J Biomed Mater Res A 2012, 100:3189-3196.
20. Porter KE, Nydahl S, Dunlop P, Varty K, Thrush AJ, London NJ. The development of an in vitro flow model of human saphenous vein graft intimal hyperplasia. Cardiovasc Res 1996, 31:607-614.
21. Porter KE, Varty K, Jones L, Bell PR, London NJ. Human saphenous vein organ culture: a useful model of intimal hyperplasia?. Eur J Vasc Endovasc Surg 1996, 11:48-58.
22. Porter KE, Naik J, Turner NA, Dickinson T, Thompson MM, London NJ. Simvastatin inhibits human saphenous vein neointima formation via inhibition of smooth muscle cell proliferation and migration. J Vasc Surg 2002, 36:150-157.
23. Madi HA, Riches K, Warburton P, O'Regan DJ, Turner NA, Porter KE. Inherent differences in morphology, proliferation, and migration in saphenous vein smooth muscle cells cultured from nondiabetic and type 2 diabetic patients. Am J Physiol Cell Physiol 2009, 297:C1307-C1317.
24. Hao H, Gabbiani G, Bochaton-Piallat ML. Arterial smooth muscle cell heterogeneity: implications for atherosclerosis and restenosis development. Arterioscler Thromb Vasc Biol 2003, 23:1510-1520.
25. Sanz-Gonzalez SM, Poch E, Perez-Roger I, Diez-Juan A, Ivorra C, Andres V. Control of vascular smooth muscle cell growth by cyclin-dependent kinase inhibitory proteins and its implication in cardiovascular disease. Front Biosci 2000, 5:D619-D628.
26. Dai J, Michineau S, Franck G, Desgranges P, Becquemin JP, Gervais M, Allaire E. Long term stabilization of expanding aortic aneurysms by a short course of cyclosporine A through transforming growth factor-beta induction. PLoS One 2011, 6:e28903.
27. Lopez-Candales A, Holmes DR, Liao S, Scott MJ, Wickline SA, Thompson RW. Decreased vascular smooth muscle cell density in medial degeneration of human abdominal aortic aneurysms. Am J Pathol 1997, 150:993-1007.
28. Patel MI, Ghosh P, Melrose J, Appleberg M. Smooth muscle cell migration and proliferation is enhanced in abdominal aortic aneurysms. Aust N Z J Surg 1996, 66:305-308.
29. Al-Shawaf E, Naylor J, Taylor H, Riches K, Milligan CJ, O'Regan D, Porter KE, Li J, Beech DJ. Short-term stimulation of calcium-permeable transient receptor potential canonical 5-containing channels by oxidized phospholipids. Arterioscler Thromb Vasc Biol 2010, 30:1453-1459.
30. Maqbool A, Turner NA, Galloway S, Riches K, O'Regan DJ, Porter KE. The-1562C/T MMP-9 promoter polymorphism does not predict MMP-9 expression levels or invasive capacity in saphenous vein smooth muscle cells cultured from different patients. Atherosclerosis 2009, 207:458-465.
31. Turner NA, Ho S, Warburton P, O'Regan DJ, Porter KE. Smooth muscle cells cultured from human saphenous vein exhibit increased proliferation, invasion, and mitogen-activated protein kinase activation in vitro compared with paired internal mammary artery cells. J Vasc Surg 2007, 45:1022-1028.
32. Lacolley P, Regnault V, Nicoletti A, Li Z, Michel JB. The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple roles. Cardiovasc Res 2012, 95:194-204.
33. Kotsis V, Stabouli S, Karafillis I, Nilsson P. Early vascular aging and the role of central blood pressure. J Hypertens 2011, 29:1847-1853.
34. Atturu G, Brouilette S, Samani NJ, London NJ, Sayers RD, Bown MJ. Short leukocyte telomere length is associated with abdominal aortic aneurysm (AAA). Eur J Vasc Endovasc Surg 2010, 39:559-564.
35. Orlandi A, Bochaton-Piallat ML, Gabbiani G, Spagnoli LG. Aging, smooth muscle cells and vascular pathobiology: implications for atherosclerosis. Atherosclerosis 2006, 188:221-230.
36. Kazi M, Zhu C, Roy J, Paulsson-Berne G, Hamsten A, Swedenborg J, Hedin U, Eriksson P. Difference in matrix-degrading protease expression and activity between thrombus-free and thrombus-covered wall of abdominal aortic aneurysm. Arterioscler Thromb Vasc Biol 2005, 25:1341-1346.
37. Irizarry E, Newman KM, Gandhi RH, Nackman GB, Halpern V, Wishner S, Scholes JV, Tilson MD. Demonstration of interstitial collagenase in abdominal aortic aneurysm disease. J Surg Res 1993, 54:571-574.
38. Thompson M, Cockerill G. Matrix metalloproteinase-2: the forgotten enzyme in aneurysm pathogenesis. Ann N Y Acad Sci 2006, 1085:170-174.
39. Crowther M, Goodall S, Jones JL, Bell PR, Thompson MM. Increased matrix metalloproteinase 2 expression in vascular smooth muscle cells cultured from abdominal aortic aneurysms. J Vasc Surg 2000, 32:575-583.
40. Freestone T, Turner RJ, Coady A, Higman DJ, Greenhalgh RM, Powell JT. Inflammation and matrix metalloproteinases in the enlarging abdominal aortic aneurysm. Arterioscler Thromb Vasc Biol 1995, 15:1145-1151.
41. Mortality results for randomised controlled trial of early elective surgery or ultrasonographic surveillance for small abdominal aortic aneurysms: the UK small aneurysm trial participants. Lancet 1998, 352:1649-1655.
42. Petersen E, Gineitis A, Wagberg F, Angquist KA. Activity of matrix metalloproteinase-2 and-9 in abdominal aortic aneurysms: relation to size and rupture. Eur J Vasc Endovasc Surg 2000, 20:457-461.
43. Papalambros E, Sigala F, Georgopoulos S, Menekakos C, Giatromanolaki A, Bastounis E, Sivridis E. Immunohistochemical expression of metalloproteinases MMP-2 and MMP-9 in abdominal aortic aneurysms: correlation with symptoms and aortic diameter. Int J Mol Med 2003, 12:965-968.
44. Multicentre Aneurysm Screening Study Group Multicentre aneurysm screening study (MASS): cost effectiveness analysis of screening for abdominal aortic aneurysms based on four year results from randomised controlled trial. BMJ 2002, 325:1135. Multicentre Aneurysm Screening Study Group.
45. Thompson SG, Ashton HA, Gao L, Scott RA. Screening men for abdominal aortic aneurysm: 10 year mortality and cost effectiveness results from the randomised multicentre aneurysm screening study. BMJ 2009, 338:b2307.