Differential association of somatic and cognitive symptoms of depression and anxiety with inflammation: Findings from the netherlands study of depression and anxiety (NESDA)

Psychoneuroendocrinology

Volumn 38, Issue 9, 2013, Pages 1573-1585

  Duivis, Hester E ^a   Vogelzangs, Nicole ^b   Kupper, Nina ^a   De Jonge, Peter ^a,c   Penninx, Brenda W J H ^b  

^a TILBURG UNIVERSITY   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Anxiety symptoms; Cognitive; Cohort study; Depressive symptoms; HsCRP; IL 6; Inflammation; Somatic; TNF

Indexed keywords

ANTIDEPRESSANT AGENT; C REACTIVE PROTEIN; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ANXIETY NEUROSIS; ARTICLE; BLOOD SAMPLING; BODY MASS; CLINICAL ASSESSMENT; CLINICAL EVALUATION; COGNITIVE DEFECT; DEMOGRAPHY; DEPRESSION; DISEASE ASSOCIATION; DRUG USE; FEMALE; HEALTH STATUS; HUMAN; INFLAMMATION; LIFESTYLE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PSYCHOSOMATIC DISORDER; SEX DIFFERENCE; SOCIAL STATUS; SYMPTOMATOLOGY;

ANXIETY SYMPTOMS; COGNITIVE; COHORT STUDY; DEPRESSIVE SYMPTOMS; HSCRP; IL-6; INFLAMMATION; SOMATIC; TNF-Α;

ADOLESCENT; ADULT; AGED; ALCOHOL DRINKING; ANTI-INFLAMMATORY AGENTS; ANTIDEPRESSIVE AGENTS; ANXIETY; BIOLOGICAL MARKERS; BODY MASS INDEX; C-REACTIVE PROTEIN; COMORBIDITY; DEPRESSION; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INFLAMMATION; INTERLEUKIN-6; LIFE STYLE; MALE; MIDDLE AGED; NETHERLANDS; PRINCIPAL COMPONENT ANALYSIS; SEVERITY OF ILLNESS INDEX; SMOKING; SOCIOECONOMIC FACTORS; SYMPTOM ASSESSMENT; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 84883654709     PISSN: 03064530     EISSN: 18733360     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2013.01.002     Document Type: Article

References (68)

1. Bankier B., Barajas J., Martinez-Rumayor A., Januzzi J.L. Association between C-reactive protein and generalized anxiety disorder in stable coronary heart disease patients. Eur. Heart J. 2008, 29:2212-2217.
2. Bankier B., Barajas J., Martinez-Rumayor A., Januzzi J.L. Association between major depressive disorder and C-reactive protein levels in stable coronary heart disease patients. J. Psychosom. Res. 2009, 66:189-194.
3. Beck A.T., Epstein N., Brown G., Steer R.A. An inventory for measuring clinical anxiety: psychometric properties. J. Consult. Clin. Psychol. 1988, 56:893-897.
4. Boschloo L., Vogelzangs N., Smit J.H., van den Brink W., Veltman D.J., Beekman A.T., Penninx B.W. The performance of the Alcohol Use Disorder Identification Test (AUDIT) in detecting alcohol abuse and dependence in a population of depressed or anxious persons. J. Affect. Disord. 2010, 126:441-446.
5. Bremmer M.A., Beekman A.T., Deeg D.J., Penninx B.W., Dik M.G., Hack C.E., Hoogendijk W.J. Inflammatory markers in late-life depression: results from a population-based study. J. Affect. Disord. 2008, 106:249-255.
6. Carney R.M., Freedland K.E. Are somatic symptoms of depression better predictors of cardiac events than cognitive symptoms in coronary heart disease?. Psychosom. Med. 2012, 74:33-38.
7. Copeland W.E., Shanahan L., Worthman C., Angold A., Costello E.J. Cumulative depression episodes predict later C-reactive protein levels: a prospective analysis. Biol. Psychiatry 2012, 71:15-21.
8. Craig C.L., Marshall A.L., Sjöström M., Bauman A.E., Booth M.L., Ainsworth B.E., Pratt M., Ekelund U., Yngve A., Sallis J.F., Oja P. International physical activity questionnaire: 12-country reliability and validity. Med. Sci. Sports Exerc. 2003, 35:1381-1395.
9. Cushman M., Legault C., Barrett-Connor E., Stefanick M.L., Kessler C., Judd H.L., Sakkinen P.A., Tracy R.P. Effect of postmenopausal hormones on inflammation-sensitive proteins: the Postmenopausal Estrogen/Progestin Interventions (PEPI) Study. Circulation 1999, 100:717-722.
10. Dantzer R., O'Connor J.C., Freund G.G., Johnson R.W., Kelley K.W. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat. Rev. Neurosci. 2008, 9:46-56.
11. de Jonge P., Mangano D., Whooley M.A. Differential association of cognitive and somatic depressive symptoms with heart rate variability in patients with stable coronary heart disease: findings from the heart and soul study. Psychosom. Med. 2007, 69:735-739.
12. de Wit L.M., Fokkema M., van Straten A., Lamers F., Cuijpers P., Penninx B.W. Depressive and anxiety disorders and the association with obesity, physical, and social activities. Depress. Anxiety 2010, 27:1057-1065.
13. Dod H.S., Bhardwaj R., Sajja V., Weidner G., Hobbs G.R., Konat G.W., Manivannan S., Gharib W., Warden B.E., Nanda N.C., Beto R.J., Ornish D., Jain A.C. Effect of intensive lifestyle changes on endothelial function and on inflammatory markers of atherosclerosis. Am. J. Cardiol. 2010, 105:362-367.
14. Dowlati Y., Herrmann N., Swardfager W., Liu H., Sham L., Reim E.K., Lanctot K.L. A meta-analysis of cytokines in major depression. Biol. Psychiatry 2010, 67:446-457.
15. Duivis H.E., de Jonge P., Penninx B.W., Na B.Y., Cohen B.E., Whooley M.A. Depressive symptoms health behaviors, and subsequent inflammation in patients with coronary heart disease: prospective findings from the heart and soul study. Am. J. Psychiatry 2011, 168:913-920.
16. Duivis H.E., Kupper N., Penninx B.W., Na B., de Jonge P., Whooley M.A. Depressive symptoms and white blood cell count in coronary heart disease patients: prospective findings from the Heart and Soul Study. Psychoneuroendocrinology 2012, 10.1016/j.psyneuen.2012.07.006.
17. Eckel R.H., Grundy S.M., Zimmet P.Z. The metabolic syndrome. Lancet 2005, 365:1415-1428.
18. Elovainio M., Aalto A.M., Kivimaki M., Pirkola S., Sundvall J., Lonnqvist J., Reunanen A. Depression and C-reactive protein: population-based Health 2000 Study. Psychosom. Med. 2009, 71:423-430.
19. Ferrante A.W. Obesity-induced inflammation: a metabolic dialogue in the language of inflammation. J. Intern. Med. 2007, 262:408-414.
20. Friedman B.H. An autonomic flexibility-neurovisceral integration model of anxiety and cardiac vagal tone. Biol. Psychol. 2007, 74:185-199.
21. Gimeno D., Kivimaki M., Brunner E.J., Elovainio M., De Vogli R., Steptoe A., Kumari M., Lowe G.D., Rumley A., Marmot M.G., Ferrie J.E. Associations of C-reactive protein and interleukin-6 with cognitive symptoms of depression: 12-year follow-up of the Whitehall II study. Psychol. Med. 2009, 39:413-423.
22. Haarala A., Kähönen M., Eklund C., Jylhävä J., Koskinen T., Taittonen L., Huupponen R., Lehtimäki T., Viikari J., Raitakari O.T., Hurme M. Heart rate variability is independently associated with C-reactive protein but not with Serum amyloid A. The Cardiovascular Risk in Young Finns Study. Eur. J. Clin. Invest. 2011, 41:951-957.
23. Haensel A., Mills P.J., Nelesen R.A., Ziegler M.G., Dimsdale J.E. The relationship between heart rate variability and inflammatory markers in cardiovascular diseases. Psychoneuroendocrinology 2008, 33:1305-1312.
24. Hamer M., Molloy G.J., de Oliveira C., Demakakos P. Persistent depressive symptomatology and inflammation: to what extent do health behaviours and weight control mediate this relationship?. Brain Behav. Immun. 2009, 23:413-418.
25. Hoen P.W., Whooley M.A., Martens E.J., Na B., van Melle J.P., de Jonge P. Differential associations between specific depressive symptoms and cardiovascular prognosis in patients with stable coronary heart disease. J. Am. Coll. Cardiol. 2010, 56:838-844.
26. Hoge E.A., Brandstetter K., Moshier S., Pollack M.H., Wong K.K., Simon N.M. Broad spectrum of cytokine abnormalities in panic disorder and posttraumatic stress disorder. Depress. Anxiety 2009, 26:447-455.
27. Howren M.B., Lamkin D.M., Suls J. Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosom. Med. 2009, 71:171-186.
28. Jilma B., Dirnberger E., Loscher I., Rumplmayr A., Hildebrandt J., Eichler H.G., Kapiotis S., Wagner O.F. Menstrual cycle-associated changes in blood levels of interleukin-6, alpha1 acid glycoprotein, and C-reactive protein. J. Lab. Clin. Med. 1997, 130:69-75.
29. Kabacoff R.I., Segal D.L., Hersen M., Van Hasselt V.B. Psychometric properties and diagnostic utility of the Beck Anxiety Inventory and the state-trait anxiety inventory with older adult psychiatric outpatients. J. Anxiety Disord. 1997, 11:33-47.
30. Kendler K.S., Myers J., Prescott C.A. Sex differences in the relationship between social support and risk for major depression: a longitudinal study of opposite-sex twin pairs. Am. J. Psychiatry 2005, 162:250-256.
31. Kupper N., Widdershoven J.W., Pedersen S.S. Cognitive/affective and somatic/affective symptom dimensions of depression are associated with current and future inflammation in heart failure patients. J. Affect. Disord. 2012, 136:567-576.
32. Licht C.M., de Geus E.J., van Dyck R., Penninx B.W. Association between anxiety disorders and heart rate variability in The Netherlands Study of Depression and Anxiety (NESDA). Psychosom. Med. 2009, 71:508-518.
33. Licht C.M., de Geus E.J., van Dyck R., Penninx B.W. Longitudinal evidence for unfavorable effects of antidepressants on heart rate variability. Biol. Psychiatry 2010, 68:861-868.
34. Liukkonen T., Räsänen P., Jokelainen J., Leinonen M., Järvelin M.-R., Meyer-Rochow V.B., Timonen M. The association between anxiety and C-reactive protein (CRP) levels: results from the Northern Finland 1966 Birth Cohort Study. Eur. Psychiatry 2011, 26:363-369.
35. Luppino F.S., de Wit L.M., Bouvy P.F., Stijnen T., Cuijpers P., Penninx B.W., Zitman F.G. Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies. Arch. Gen. Psychiatry 2010, 67:220-229.
36. Maciejewski P.K., Prigerson H.G., Mazure C.M. Sex differences in event-related risk for major depression. Psychol. Med. 2001, 31:593-604.
37. McGlory G. The association of depressive symptoms and C-reactive protein and cortisol among women with acute coronary syndrome. Dissert. Abst. Int. B: Sci. Eng. 2009, 70:6816.
38. Meijer A., Conradi H.J., Bos E.H., Thombs B.D., van Melle J.P., de Jonge P. Prognostic association of depression following myocardial infarction with mortality and cardiovascular events: a meta-analysis of 25 years of research. Gen. Hosp. Psychiatry 2011, 33:203-216.
39. Miller A.H., Maletic V., Raison C.L. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol. Psychiatry 2009, 65:732-741.
40. Miller G.E., Freedland K.E., Carney R.M., Stetler C.A., Banks W.A. Pathways linking depression, adiposity, and inflammatory markers in healthy young adults. Brain Behav. Immun. 2003, 17:276-285.
41. Mykletun A., Overland S., Aarø L.E., Liabø H.-M., Stewart R. Smoking in relation to anxiety and depression: evidence from a large population survey: the HUNT study. Eur. Psychiatry 2008, 23:77-84.
42. Nabi H., Hall M., Koskenvuo M., Singh-Manoux A., Oksanen T., Suominen S., Kivimaki M., Vahtera J. Psychological and somatic symptoms of anxiety and risk of coronary heart disease: the health and social support prospective cohort study. Biol. Psychiatry 2010, 67:378-385.
43. O'Connor M.-F., Bower J.E., Cho H.J., Creswell J.D., Dimitrov S., Hamby M.E., Hoyt M.A., Martin J.L., Robles T.F., Sloan E.K., Thomas K.S., Irwin M.R. To assess, to control, to exclude: effects of biobehavioral factors on circulating inflammatory markers. Brain Behav. Immun. 2009, 23:887-897.
44. O'Donovan A., Hughes B.M., Slavich G.M., Lynch L., Cronin M.-T., O'Farrelly C., Malone K.M. Clinical anxiety, cortisol and interleukin-6: evidence for specificity in emotion-biology relationships. Brain Behav. Immun. 2010, 24:1074-1077.
45. Osman A., Hoffman J., Barrios F.X., Kopper B.A., Breitenstein J.L., Hahn S.K. Factor structure, reliability, and validity of the Beck Anxiety Inventory in adolescent psychiatric inpatients. J. Clin. Psychol. 2002, 58:443-456.
46. Patten S.B., Williams J.V., Lavorato D.H., Eliasziw M. A longitudinal community study of major depression and physical activity. Gen. Hosp. Psychiatry 2009, 31:571-575.
47. Penninx B.W., Beekman A.T., Smit J.H., Zitman F.G., Nolen W.A., Spinhoven P., Cuijpers P., de Jong P.J., van Marwijk H.W., Assendelft W.J., van der Meer K., Verhaak P., Wensing M., de Graaf R., Hoogendijk W.J., Ormel J., van Dyck R. Consortium FtNr. The Netherlands Study of Depression and Anxiety (NESDA): rationale, objectives and methods. Int. J. Methods Psychiatr. Res. 2008, 17:121-140.
48. Pitsavos C., Panagiotakos D.B., Papageorgiou C., Tsetsekou E., Soldatos C., Stefanadis C. Anxiety in relation to inflammation and coagulation markers, among healthy adults: the ATTICA Study. Atherosclerosis 2006, 185:320-326.
49. Pizzi C., Manzoli L., Mancini S., Bedetti G., Fontana F., Costa G.M. Autonomic nervous system, inflammation and preclinical carotid atherosclerosis in depressed subjects with coronary risk factors. Atherosclerosis 2010, 212:292-298.
50. Preacher K., Hayes A. Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Behav. Res. Methods 2008, 40:879-891.
51. Reichert V., Xue X., Bartscherer D., Jacobsen D., Fardellone C., Folan P., Kohn N., Talwar A., Metz C.N. A pilot study to examine the effects of smoking cessation on serum markers of inflammation in women at risk for cardiovascular disease. Chest 2009, 136:212-219.
52. Roberts C., Troop N., Connan F., Treasure J., Campbell I.C. The effects of stress on body weight: biological and psychological predictors of change in BMI. Obesity 2007, 15:3045-3055.
53. Rush A.J., Gullion C.M., Basco M.R., Jarrett R.B., Trivedi M.H. The Inventory of Depressive Symptomatology (IDS): psychometric properties. Psychol. Med. 1996, 26:477-486.
54. Samaan C.M. The macrophage at the intersection of immunity and metabolism in obesity. Diabetol. Metab. Syndr. 2011, 3:1-9.
55. Saunders J.B., Aasland O.G., Babor T.F., de la Fuente J.R., Grant M. Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO collaborative project on early detection of persons with harmful alcohol consumption-II. Addiction 1993, 88:791-804.
56. Shaffer J.A., Edmondson D., Chaplin W.F., Schwartz J.E., Shimbo D., Burg M.M., Rieckmann N., Davidson K.W. Directionality of the relationship between depressive symptom dimensions and C-reactive protein in patients with acute coronary syndromes. Psychosom. Med. 2011, 73:370-377.
57. Stewart J.C., Rand K.L., Muldoon M.F., Kamarck T.W. A prospective evaluation of the directionality of the depression-inflammation relationship. Brain Behav. Immun. 2009, 23:936-944.
58. Strine T.W., Mokdad A.H., Balluz L.S., Gonzalez O., Crider R., Berry J.T., Kroenke K. Depression and anxiety in the united states: findings from the 2006 behavioral risk factor surveillance system. Psychiatr. Serv. 2008, 59:1383-1390.
59. Stuart M.J., Baune B.T. Depression and type 2 diabetes: inflammatory mechanisms of a psychoneuroendocrine co-morbidity. Neurosci. Biobehav. Rev. 2012, 36:658-676.
60. Toprak A., Kandavar R., Toprak D., Chen W., Srinivasan S., Xu J., Anwar A., Berenson G. C-reactive protein is an independent predictor for carotid artery intima-media thickness progression in asymptomatic younger adults (from the Bogalusa Heart Study). BMC Cardiovasc. Disord. 2011, 11:78.
61. van Melle J.P., de Jonge P., Spijkerman T.A., Tijssen J.G., Ormel J., van Veldhuisen D.J., van den Brink R.H., van den Berg M.P. Prognostic association of depression following myocardial infarction with mortality and cardiovascular events: a meta-analysis. Psychosom. Med. 2004, 66:814-822.
62. Vogelzangs N., Duivis H.E., Beekman A.T.F., Kluft C., Neuteboom J., Hoogendijk W., Smit J.H., de Jonge P., Penninx B.W.J.H. Association of depressive disorders, depression characteristics and antidepressant medication with inflammation. Transl. Psychiatry 2012, 2:e79.
63. Vogelzangs N., Seldenrijk A., Beekman A.T., van Hout H.P., de Jonge P., Penninx B.W. Cardiovascular disease in persons with depressive and anxiety disorders. J. Affect. Disord. 2010, 125:241-248.
64. von Kanel R., Begre S., Abbas C.C., Saner H., Gander M.L., Schmid J.P. Inflammatory biomarkers in patients with posttraumatic stress disorder caused by myocardial infarction and the role of depressive symptoms. Neuroimmunomodulation 2010, 17:39-46.
65. Wardenaar K.J., van Veen T., Giltay E.J., den Hollander-Gijsman M., Penninx B.W., Zitman F.G. The structure and dimensionality of the Inventory of Depressive Symptomatology Self Report (IDS-SR) in patients with depressive disorders and healthy controls. J. Affect. Disord. 2010, 125:146-154.
66. WHO, 2008. WHO Collaborating Centre for Drug Statistics Methodology. http://www.whocc.no/.
67. Whooley M.A., Caska C.M., Hendrickson B.E., Rourke M.A., Ho J., Ali S. Depression and inflammation in patients with coronary heart disease: findings from the heart and soul study. Biol. Psychiatry 2007, 62:314-320.
68. Wiesbeck G.A., Kuhl H.C., Yaldizli O., Wurst F.M. Tobacco smoking and depression - results from the WHO/ISBRA study. Neuropsychobiology 2008, 57:26-31.