Discovery of 4-amino-2-(thio)phenol derivatives as novel protein kinase and angiogenesis inhibitors for the treatment of cancer: Synthesis and biological evaluation. Part II

European Journal of Medicinal Chemistry

Volumn 69, Issue , 2013, Pages 191-200

  Xu, Fuming ^a   Zhang, Lei ^a   Jia, Yuping ^b   Wang, Xuejian ^a   Li, Xiaoguang ^a   Wen, Qingli ^c   Zhang, Yingjie ^a   Xu, Wenfang ^a  

^a SHANDONG UNIVERSITY   (China)

^b Shandong Institute of Pharmaceutical Industry   (China)

^c WEIFANG MEDICAL UNIVERSITY   (China)

Author keywords

ABL; AKT; HUVECs; Protein kinase; Rat thoracic aorta rings

Indexed keywords

4 AMINO 2 (THIO)PHENOL; ABELSON KINASE; ANGIOGENESIS INHIBITOR; N [3 [(1,3,4 THIADIAZOL 2 YL)THIO] 4 HYDROXYPHENYL] 4 NITROBENZAMIDE; N [3 [(1,3,4 THIADIAZOL 2 YL)THIO] 4 HYDROXYPHENYL] 4 NITROBENZENESULFONAMIDE; N [3 [(1H 1,2,4 TRIAZOL 5 YL)THIO] 4 HYDROXYPHENYL] 2,4,6 TRIISOPROPYLBENZENESULFONAMIDE; N [3 [(1H 1,2,4 TRIAZOL 5 YL)THIO] 4 HYDROXYPHENYL] 2,4,6 TRIMETHYLBENZENESULFONAMIDE; N [3 [(1H 1,2,4 TRIAZOL 5 YL)THIO] 4 HYDROXYPHENYL] 2,6 DICHLOROBENZENESULFONAMIDE; N [3 [(1H 1,2,4 TRIAZOL 5 YL)THIO] 4 HYDROXYPHENYL] 4 CHLOROBENZENESULFONAMIDE; N [3 [(1H 1,2,4 TRIAZOL 5 YL)THIO] 4 HYDROXYPHENYL] 4 METHOXYBENZENESULFONAMIDE; N [3 [(1H 1,2,4 TRIAZOL 5 YL)THIO] 4 HYDROXYPHENYL] 4 METHYLBENZENESULFONAMIDE; N [3 [(1H 1,2,4 TRIAZOL 5 YL)THIO] 4 HYDROXYPHENYL] 4 NITROBENZAMIDE; N [3 [(1H 1,2,4 TRIAZOL 5 YL)THIO] 4 HYDROXYPHENYL] 4 NITROBENZENESULFONAMIDE; N [3 [(1H 1,2,4 TRIAZOL 5 YL)THIO] 4 HYDROXYPHENYL] NAPHTHALENE 1 SULFONAMIDE; N [3 [(1H 1,2,4 TRIAZOL 5 YL)THIO] 4 HYDROXYPHENYL]METHANESULFONAMIDE; N [3 [(1H 1,2,4 TRIAZOL 5 YL)THIO] 4 HYDROXYPHENYL]NAPHTHALENE 2 SULFONAMIDE; N [3 [(7H PURIN 6 YL)THIO] 4 HYDROXYPHENYL] 4 NITROBENZAMIDE; N [3 [(7H PURIN 6 YL)THIO] 4 HYDROXYPHENYL] 4 NITROBENZENESULFONAMIDE; N [4 HYDROXY 3 [(1 METHYL 1H TETRAZOL 5 YL)THIO]PHENYL] 4 NITROBENZAMIDE; N [4 HYDROXY 3 [(1 METHYL 1H TETRAZOL 5 YL)THIO]PHENYL] 4 NITROBENZENESULFONAMIDE; N [4 HYDROXY 3 [(5 METHYL 1,3,4 THIADIAZOL 2 YL)THIO]PHENYL] 4 NITROBENZAMIDE; N [4 HYDROXY 3 [(5 METHYL 1,3,4 THIADIAZOL 2 YL)THIO]PHENYL] 4 NITROBENZENESULFONAMIDE; PAZOPANIB; PHENOL DERIVATIVE; PROTEIN KINASE B; PROTEIN KINASE INHIBITOR; STAUROSPORINE; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ARTICLE; CANCER THERAPY; CONTROLLED STUDY; DRUG DESIGN; DRUG DEVELOPMENT; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; IC 50; IN VITRO STUDY; MALE; MOLECULAR DOCKING; NONHUMAN; RAT; THORACIC AORTA; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR RING;

ABL; AKT; FHRYIUWAZBCUGX-UHFFFAOYSA-N; HUVECS; PROTEIN KINASE; RAT THORACIC AORTA RINGS;

ANGIOGENESIS INHIBITORS; ANIMALS; AORTA, THORACIC; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MALE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NEOPLASMS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-ABL; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; TRIAZOLES; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84883648930     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.07.056     Document Type: Article

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