Design and synthesis of α-ketoamides as cathepsin s inhibitors with potential applications against tumor invasion and angiogenesis

Journal of Medicinal Chemistry

Volumn 53, Issue 11, 2010, Pages 4545-4549

  Chen, Jo Chun ^a   Uang, Biing Jiun ^a   Lyu, Ping Chiang ^a   Chang, Jang Yang ^b   Liu, Ko Jiunn ^b   Kuo, Ching Chuan ^b   Hsieh, Hsing Pang ^b   Wang, Hsin Chieh ^a   Cheng, Chao Sheng ^a   Chang, Yi Hsun ^b   Chang, Margaret Dah Tsyr ^a   Chang, Wun Shaing Wayne ^b   Lin, Chun Cheng ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA KETOAMIDE; CATHEPSIN S; CATHEPSIN S INHIBITOR; UNCLASSIFIED DRUG;

ANGIOGENESIS; ARTICLE; CANCER CELL; CANCER INVASION; CELL MIGRATION; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; LUNG ADENOCARCINOMA; METASTASIS; NEOPLASM; PROTON NUCLEAR MAGNETIC RESONANCE; TUMOR GROWTH;

AMIDES; CATHEPSINS; CELL LINE, TUMOR; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; NEOPLASM INVASIVENESS; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; PROTEASE INHIBITORS; PROTEIN CONFORMATION;

EID: 77953211174     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100089e     Document Type: Article

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