Epiphyseal abnormalities, trabecular bone loss and articular chondrocyte hypertrophy develop in the long bones of postnatal Ext1-deficient mice

Bone

Volumn 57, Issue 1, 2013, Pages 220-231

  Sgariglia, Federica ^a   Candela, Maria Elena ^a   Huegel, Julianne ^a   Jacenko, Olena ^b   Koyama, Eiki ^a,c   Yamaguchi, Yu ^d   Pacifici, Maurizio ^a,c   Enomoto Iwamoto, Motomi ^a,c  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA SCHOOL OF VETERINARY MEDICINE   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d BURNHAM INSTITUTE   (United States)

Author keywords

Articular cartilage; Ext1; Growth plate; Heparan sulfate; Hereditary Multiple Exostoses; Long bones

Indexed keywords

COLLAGEN TYPE 10; COLLAGENASE 3; PERLECAN; TAMOXIFEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY HEIGHT; BONE GROWTH; BONE LENGTH; CARTILAGE CELL; CELL SHAPE; CELL SIZE; CONTROLLED STUDY; EPIPHYSIS DISEASE; EXT1 GENE; GENE; GENE DELETION; GENE EXPRESSION; GENE FUNCTION; GROWTH PLATE; GROWTH RETARDATION; HEREDITARY MULTIPLE EXOSTOSIS; HYPERTROPHY; LONG BONE; MOUSE; MUTANT; NONHUMAN; OSTEOARTHRITIS; OSTEOLYSIS; POSTNATAL GROWTH; PROTEIN EXPRESSION; TRABECULAR BONE;

ARTICULAR CARTILAGE; BMP; BONE MORPHOGENETIC PROTEIN; EXT1; FGF; FIBROBLAST GROWTH FACTOR; GROWTH PLATE; HEPARAN SULFATE; HEPARAN SULFATE PROTEOGLYCANS; HEREDITARY MULTIPLE EXOSTOSES; HME; HS; HSPGS; IHH; INDIAN HEDGEHOG; LONG BONES; MATRIX METALLOPROTEASE 13; MMP-13; TARTRATE-RESISTANT ACID PHOSPHATASE; TRAP; VASCULAR ENDOTHELIAL GROWTH FACTORS; VEGFS;

ANIMALS; BONE AND BONES; CARTILAGE, ARTICULAR; CHONDROCYTES; GROWTH PLATE; HYPEROSTOSIS; IMMUNOHISTOCHEMISTRY; MICE; MICE, TRANSGENIC; N-ACETYLGLUCOSAMINYLTRANSFERASES;

EID: 84883640526     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2013.08.012     Document Type: Article

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