TRPA1 ion channels in vagal afferent nerves contribute to ventilatorinduced lung injury in a rat model

General Physiology and Biophysics

Volumn 32, Issue 3, 2013, Pages 389-394

  Wang, Shenhui ^a   Shi, Pengcai ^a   Wang, Yuelan ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Acute lung injury; Induced lung injury; Neurogenic inflammation; TRPA1; Ventilator

Indexed keywords

3,4 METHYLENEDIOXYAMPHETAMINE; INTERLEUKIN 8; MYELOPEROXIDASE; N (4 ISOPROPYLPHENYL) 2 (1,2,3,6 TETRAHYDRO 1,3 DIMETHYL 2,6 DIOXO 7H PURIN 7 YL)ACETAMIDE; PROTEIN; REACTIVE OXYGEN METABOLITE; SUBSTANCE P; SUPEROXIDE DISMUTASE; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; LEUKOCYTE COUNT; NEUROGENIC INFLAMMATION; NONHUMAN; PROTEIN EXPRESSION; RAT; SENSORY NERVE; TIDAL VOLUME; VAGUS NERVE; VENTILATOR INDUCED LUNG INJURY;

AFFERENT PATHWAYS; ANIMALS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; MALE; MALONDIALDEHYDE; RATS; RATS, SPRAGUE-DAWLEY; SUBSTANCE P; SUPEROXIDE DISMUTASE; TRPC CATION CHANNELS; VAGUS NERVE; VENTILATOR-INDUCED LUNG INJURY;

EID: 84883626352     PISSN: 02315882     EISSN: 13384325     Source Type: Journal    
DOI: 10.4149//gpb-2013045     Document Type: Article

References (23)

1. Andreev Y. A., Vassilevski A. A., Kozlov S. A. (2012): Molecules to selectively target receptors for treatment of pain and neurogenic inflammation. Recent. Pat. Inflamm. Allergy. Drug. Discov. 6, 35-45 http://dx.doi.org/10.2174/ 187221312798889266
2. Brierley S. M., Castro J., Harrington A. M., Hughes P. A., Page A. J., Rychkov G. Y., Blackshaw L. A. (2011): TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity. J. Physiol. 589, 3575-3593 http://dx.doi.org/10.1113/jphysiol.2011.206789
3. Contreras M., Ansari B., Curley G., Higgins B. D., Hassett P., O'Toole D., Laffey J. G. (2012): Hypercapnic acidosis attenuates ventilation-induced lung injury by a nuclear factor-κB-dependent mechanism. Crit. Care. Med. 40, 2622-2630 http://dx.doi.org/10.1097/CCM.0b013e318258f8b4
4. Dib M., Zsengeller Z., Mitsialis A., Lu B., Craig S., Gerard C., Gerard N. P. (2009): A paradoxical protective role for the proinflammatory peptide substance P receptor (NK1R) in acute hyperoxic lung injury. Am. J. Physiol. Lung. Cell. Mol. Physiol. 297, 687-697 http://dx.doi.org/10.1152/ajplung.90509. 2008
5. Eid S. R., Crown E. D., Moore E. L., Liang H. A., Choong K. C., Dima S., Henze D. A., Kane S. A., Urban M. O. (2008): HC- 030031, a TRPA1 selective antagonist, attenuates inflammatory-and neuropathy-induced mechanical hypersensitivity. Mol. Pain 4, 1-10 http://dx.doi.org/10.1186/1744-8069-4-48
6. Gattinoni L., Caironi P., Carlesso E. (2005): How to ventilate patients with acute lung injury and acute respiratory distress syndrome. Curr. Opin. Crit. Care 11, 69-76 http://dx.doi.org/10.1097/00075198-200502000-00011
7. Hamanaka K., Jian M. Y., Weber D. S., Alvarez D. F., Townsley M. I., Al-Mehdi A. B., King J. A., Liedtke W., Parker J. C. (2007): TRPV4 initiates the acute calcium-dependent permeability increase during ventilator-induced lung injury in isolated mouse lungs. Am. J. Physiol. Lung. Cell. Mol. Physiol. 293, 923-932 http://dx.doi.org/10.1152/ajplung.00221.2007
8. Ho K. W, Ward N. J., Calkins D. J. (2012): TRPV1: a stress response protein in the central nervous system. Am. J. Neurodegener. Dis. 1, 1-14
9. Imanaka H., Shimaoka M., Matsuura N., Nishimura M., Ohta N., Kiyono H. (2001): Ventilator-induced lung injury is associated with neutrophil infiltration, macrophage activation, and TGF-beta 1 mRNA upregulation in rat lungs. Anesth. Analg. 92, 428-436 http://dx.doi.org/10.1213/00000539-200102000- 00029
10. Karzai W., Cui X., Heinicke N., Niemann C., Gerstenberger E. P., Correa R., Banks S., Mehlhorn B., Bloos F., Reinhart K., Eichacker P. Q. (2005): Neutrophil stimulation with granulocyte colony-stimulating factor worsens ventilator-induced lung injury and mortality in rats. Anesthesiology 103, 996-1005 http://dx.doi.org/10.1097/00000542-200511000-00014
11. Lionetti V., Recchia F. A., Ranieri V. M. (2005): Overview of ventilator-induced lung injury mechanisms. Curr. Opin. Crit. Care 11, 82-86 http://dx.doi.org/10.1097/00075198-200502000-00013
12. Liu D., Yan Z., Minshall R. D., Schwartz D. E., Chen Y., Hu G. (2012): Activation of calpains mediates early lung neutrophilic inflammation in ventilator-induced lung injury. Am. J. Physiol. Lung. Cell. Mol. Physiol. 302, 370-379 http://dx.doi.org/10.1152/ajplung.00349.2011
13. Nassenstein C., Kwong K., Taylor-Clark T., Kollarik M., Macglashan D. M., Braun A., (2008): Undem BJ. Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs. J. Physiol. 586, 1595-1604 http://dx.doi.org/10.1113/jphysiol.2007.148379
14. Ngiam N., Kavanagh B. P. (2012): Ventilator-induced lung injury: the role of gene activation. Curr. Opin. Crit. Care. 18, 16-22 http://dx.doi.org/10. 1097/MCC.0b013e32834e7d00
15. O'Connor T. M., O'Connell J., O'Brien D. I., Goode T., Bredin C. P., Shanahan F. (2004): The role of substance P in inflammatory disease. J. Cell. Physiol. 201, 167-180 http://dx.doi.org/10.1002/jcp.20061
16. Perez Fontan J. J. (2002): On lung nerves and neurogenic injury. Ann. Med. 34, 226-240 http://dx.doi.org/10.1080/078538902320322493
17. Pertovaara A., Koivisto A. (2011): TRPA1 ion channel in the spinal dorsal horn as a therapeutic target in central pain hypersensitivity and cutaneous neurogenic inflammation. Eur. J. Pharmacol. 666, 1-4 http://dx.doi.org/10.1016/ j.ejphar.2011.05.027
18. Ricard J. D., Dreyfuss D., Saumon G. (2001): Production of inflammatory cytokines in ventilator-induced lung injury: a reappraisal. Am. J. Respir. Crit. Care. Med. 163, 1176-1180 http://dx.doi.org/10.1164/ajrccm.163.5.2006053
19. Shimabukuro D. W., Sawa T., Gropper M. A. (2003): Injury and repair in lung and airways. Crit. Care Med. 31, 524-531 http://dx.doi.org/10.1097/01.CCM. 0000081437.06466.B3
20. Toth D. M., Szoke E., Bolcskei K., Kvell K., Bender B., Bosze Z., Szolcsanyi J., Sandor Z. (2011): Nociception, neurogenic inflammation and thermoregulation in TRPV1 knockdown transgenic mice. Cell. Mol. Life Sci. 68, 2589-2601 http://dx.doi.org/10.1007/s00018-010-0569-2
21. Uhlig S. (2002): Ventilation-induced lung injury and mechanotransduction: stretching it too far? Am. J. Physiol. Lung. Cell. Mol. Physiol. 282, 892-896
22. Vlahakis N. E., Hubmayr R. D. (2005): Cellular stress failure in ventilator-injured lungs. Am. J. Respir. Crit. Care. Med. 171, 1328-1342 http://dx.doi.org/10.1164/rccm.200408-1036SO
23. Wei H., Koivisto A., Pertovaara A. (2010): Spinal TRPA1 ion channels contribute to cutaneous neurogenic inflammation in the rat. Neurosci. Lett. 479, 253-256 http://dx.doi.org/10.1016/j.neulet.2010.05.073