Lipopolysaccharide Enhances Mouse Lung Tumorigenesis: A Model for Inflammation-Driven Lung Cancer

Veterinary Pathology

Volumn 50, Issue 5, 2013, Pages 895-902

  Melkamu, T ^a   Qian, X ^b   Upadhyaya, P ^b   O'Sullivan, M G ^a,b   Kassie, F ^a,b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

4 (methylnitrosamino) 1 (3 pyridyl) 1 butanone; animal model; lipopolysaccharide; lung tumor; macrophage

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; 4-(N-METHYL-N-NITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE; LIPOPOLYSACCHARIDE; NITROSAMINE;

4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE; ANIMAL; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DRUG EFFECT; IMMUNOHISTOCHEMISTRY; INTRANASAL DRUG ADMINISTRATION; LUNG TUMOR; MACROPHAGE; MOUSE; PATHOPHYSIOLOGY; STATISTICAL MODEL; WESTERN BLOTTING;

4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE; ANIMAL MODEL; LIPOPOLYSACCHARIDE; LUNG TUMOR; MACROPHAGE;

ADMINISTRATION, INTRANASAL; ANIMALS; BLOTTING, WESTERN; CARCINOGENESIS; DISEASE MODELS, ANIMAL; IMMUNOHISTOCHEMISTRY; LINEAR MODELS; LIPOPOLYSACCHARIDES; LUNG NEOPLASMS; MICE; NITROSAMINES;

EID: 84883616429     PISSN: 03009858     EISSN: 15442217     Source Type: Journal    
DOI: 10.1177/0300985813476061     Document Type: Article

References (38)

1. Basseres DS,Ebbs A,Levantini E, et al.Requirement of the NF-kappaB subunit p65/RelA for K-Ras-induced lung tumorigenesis.Cancer Res. 2010;70 (9): 3537-3546.
2. Bauer AK,Malkinson AM,Kleeberger SR.Susceptibility to neoplastic and non-neoplastic pulmonary diseases in mice: genetic similarities.Am J Physiol Lung Cell Mol Physiol. 2004;287 (4): L685-L703.
3. Bollrath J,Greten FR.IKK/NF-kappaB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis.EMBO Rep. 2009;10 (12): 1314-1319.
4. Brown J,Wang H,Hajishengallis GN, et al.TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk.J Dent Res. 2011;90 (4): 417-427.
5. Chen ZB,Liu C,Chen FQ, et al.Effects of tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) on the activation of ERK1/2 MAP kinases and the proliferation of human mammary epithelial cells.Environ Toxicol Pharmacol. 2006;22 (3): 283-291.
6. Colotta F,Allavena P,Sica A, et al.Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability.Carcinogenesis. 2009;30 (7): 1073-1081.
7. Dagne A,Melkamu T,Schutten MM, et al.Enhanced inhibition of lung adenocarcinoma by combinatorial treatment with indole-3-carbinol and silibinin in A/J mice.Carcinogenesis. 2011;32 (4): 561-567.
8. Ehlting C,Ronkina N,Böhmer O, et al.Distinct functions of the mitogen-activated protein kinase-activated protein (MAPKAP) kinases MK2 and MK3: MK2 mediates lipopolysaccharide-induced signal transducers and activators of transcription 3 (STAT3) activation by preventing negative regulatory effects of MK3.J Biol Chem. 2011;286 (52): 24113-24124.
9. Guha M,Mackman N.LPS induction of gene expression in human monocytes.Cell Signal. 2001;13 (2): 85-94.
10. Halappanavar S,Russell M,Stampfli MR, et al.Induction of the interleukin 6/ signal transducer and activator of transcription pathway in the lungs of mice sub-chronically exposed to mainstream tobacco smoke.BMC Med Genomics. 2009;2:56.
11. Hasday JD,Bascom R,Costa JJ, et al.Bacterial endotoxin is an active component of cigarette smoke.Chest. 1999;115 (3): 829-835.
12. Hecht SS,Lin D,Castonguay A.Effects of α-deuterium substitution on the mutagenicity of 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK).Carcinogenesis. 1983;4:305-310.
13. Ho YS,Chen CH,Wang YJ, et al.Tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces cell proliferation in normal human bronchial epithelial cells through NFkappaB activation and cyclin D1 up-regulation.Toxicol Appl Pharmacol. 2005;205 (2): 133-148.
14. Hussain SP,Harris CC.Inflammation and cancer: an ancient link with novel potentials.Int J Cancer. 2007;121 (11): 2373-2380.
15. Jemal A,Bray F,Center MM, et al.Global cancer statistics.CA Cancer J Clin. 2011;61 (2): 69-90.
16. Kennedy SM,Christiani DC,Eisen EA, et al.Cotton dust and endotoxin exposure-response relationships in cotton textile workers.Am Rev Respir Dis. 1987;135 (1): 194-200.
17. Keohavong P,Kahkonen B,Kinchington E, et al.K-ras mutations in lung tumors from NNK-treated mice with lipopolysaccharide-elicited lung inflammation.Anticancer Res. 2011;31 (9): 2877-2882.
18. Larsson L,Pehrson C,Dechen T, et al.Microbiological components in mainstream and sidestream cigarette smoke.Tob Induc Dis. 2012;10 (1): 13.
19. Lee H,Herrmann A,Deng JH, et al.Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors.Cancer Cell. 2009;15 (4): 283-293.
20. Malkinson AM,You M.The intronic structure of cancer-related genes regulates susceptibility to cancer.Mol Carcinog. 1994;10 (2): 61-65.
21. Mannino DM,Aguayo SM,Petty TL, et al.Low lung function and incident lung cancer in the United States: data from the First National Health and Nutrition Examination Survey follow-up.Arch Intern Med. 2003;163 (12): 1475-1480.
22. Mantovani A,Allavena P,Sica A, et al.Cancer-related inflammation.Nature. 2008;454 (7203): 436-444.
23. Martinez FO,Sica A,Mantovani A, et al.Macrophage activation and polarization.Front Biosci. 2008;13:453-461.
24. Moghaddam SJ,Ochoa CE,Sethi S, et al.Nontypeable Haemophilus influenzae in chronic obstructive pulmonary disease and lung cancer.Int J Chron Obstruct Pulmon Dis. 2011;6:113-123.
25. Nikitin AY,Alcaraz A,Anver MR, et al.Classification of proliferative pulmonary lesions of the mouse: recommendations of the mouse models of human cancers consortium.Cancer Res. 2004;64 (7): 2307-2316.
26. Ock CY,Kim EH,Hong H, et al.Prevention of colitis-associated colorectal cancer with 8-hydroxydeoxyguanosine.Cancer Prev Res. 2011;4 (9): 1507-1521.
27. Ojaniemi M,Glumoff V,Harju K, et al.Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages.Eur J Immunol. 2003;33 (3): 597-605.
28. Qian X,Melkamu T,Upadhyaya P, et al.Indole-3-carbinol inhibited tobacco smoke carcinogen-induced lung adenocarcinoma in A/J mice when administered during the postinitiation or progression phase of lung tumorigenesis.Cancer Lett. 2011;311 (1): 57-65.
29. Schwartz DA,Thorne PS,Yagla SJ, et al.The role of endotoxin in grain dust-induced lung disease.Am J Respir Crit Care Med. 1995;152 (2): 603-608.
30. Sethi S,Maloney J,Grove L, et al.Airway Inflammation and bronchial bacterial colonization in chronic obstructive pulmonary disease.Am J Respir Crit Care Med. 2006;173 (9): 991-998.
31. Tsurutani J,Castillo SS,Brognard J, et al.Tobacco components stimulate Akt-dependent proliferation and NFkappaB-dependent survival in lung cancer cells.Carcinogenesis. 2005;26 (7): 1182-1195.
32. Turato G,Di Stefano A,Maestrelli P, et al.Effect of smoking cessation on airway inflammation in chronic bronchitis.Am J Respir Crit Care Med. 1995;152 (4 pt 1): 1262-1267.
33. Vernooy JH,Dentener MA,van Suylen RJ, et al.Long term intratracheal lipopolysaccharide exposure in mice results in chronic lung inflammation and persistent pathology.Am J Respir Cell Mol Biol. 2002;26 (1): 152-159.
34. Wisnivesky JP,Yankelevitz D,Henschke CI.Stage of lung cancer in relation to its size, part 2: evidence.Chest. 2005;127 (4): 1136-1139.
35. Wright JL,Lawson LM,Pare PD, et al.Morphology of peripheral airways in current smokers and ex-smokers.Am Rev Respir Dis. 1983;127 (4): 474-477.
36. Wu YL,Kou YR,Ou HL, et al.Glucosamine regulation of LPS-mediated inflammation in human bronchial epithelial cells.Eur J Pharmacol. 2010;635 ((1-3)): 219-226.
37. Yang F,Chen H,Xiang J, et al.Relationship between tumor size and disease stage in non-small cell lung cancer.BMC Cancer. 2010;10:474.
38. Zaynagetdinov R,Sherrill TP,Polosukhin VV, et al.A critical role for macrophages in promotion of urethane-induced lung carcinogenesis.J Immunol. 2011;187 (11): 5703-5711.