Hsp60 chaperonin acts as barrier to pharmacologically induced oxidative stress mediated apoptosis in tumor cells with differential stress response

Drug Target Insights

Volumn 2013, Issue 7, 2013, Pages 35-51

  Sarangi, Upasana ^a   Singh, Manish Kumar ^b   Abhijnya, Kanugovi Vijaya Vittal ^a   Prasanna Anjaneya Reddy, Lebaka ^a   Siva Prasad, Adabagni ^a   Pitke, Vikrant Vinay ^a   Paithankar, Khanderao ^a   Subbarao Sreedhar, Amere ^a  

^a CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

^b JIWAJI UNIVERSITY   (India)

Author keywords

Hsp60; Mitochondria; Oxidative stress; Rotenone; Tumor cells

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CHAPERONIN 60; HYDROGEN PEROXIDE; PROTEIN BAX; REACTIVE OXYGEN METABOLITE; ROTENONE; SHORT HAIRPIN RNA; TANESPIMYCIN;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL PROTECTION; CELLULAR DISTRIBUTION; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; CYTOPLASM; GENE ACTIVITY; GENE LOCATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MITOCHONDRION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PHARMACOLOGICAL BLOCKING; RAT;

EID: 84883609143     PISSN: None     EISSN: 11773928     Source Type: Journal    
DOI: 10.4137/DTI.S12513     Document Type: Article

References (45)

1. Cheng MY, Hartl FU, Horwich AL. The mitochondrial chaperonin hsp60 is required for its own assembly. Nature. 1990;348(6300):455-458.
2. Chun JN, Choi B, Lee KW, et al. Cytosolic Hsp60 is involved in the NF-kappaB-dependent survival of cancer cells via IKK regulation. PLoS ONE. 2010;5(3):e9422.
3. Chandra D, Choy G, Tang DG. Cytosolic accumulation of HSP60 during apoptosis with or without apparent mitochondrial release: evidence that its pro-apoptotic or pro-survival functions involve differential interactions with caspase-3. J Biol Chem. 2007;282(43):31289-31301.
4. Cappello F, Conway de Macario E, Marasà L, Zummo G, Macario AJ. Hsp60 expression, new locations, functions and perspectives for cancer diagnosis and therapy. Cancer Biol Ther. 2008;7(6):801-809.
5. Sreedhar AS, Csermely P. Heat shock proteins in the regulation of apoptosis: new strategies in tumor therapy: a comprehensive review. Pharmacol Ther. 2004;101(3):227-257.
6. Martinou JC, Youle RJ. Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. Dev Cell. 2011;21(1):91-101.
7. Rohlena J, Dong LF, Neuzil J. Targeting the mitochondrial electron transport chain complexes for the induction of apoptosis and cancer treatment. Curr Pharm Biotechnol. 2013;14(3):377-389.
8. Fulda S, Gorman AM, Hori O, Samali A. Cellular stress responses: cell survival and cell death. Int J Cell Biol. 2010;2010:1-23.
9. Barja G. Mitochondrial oxygen radical generation and leak: sites of production in states 4 and 3, organ specifcity, and relation to aging and longevity. J Bioenerg Biomembr. 1999;31(4):347-366.
10. Sreedhar AS, Pardhasaradhi BV, Khar A, Srinivas UK. A cross talk between cellular signalling and cellular redox state during heat-induced apoptosis in a rat histiocytoma. Free Radic Biol Med. 2002;32(3):221-227.
11. Madrigal-Matute J, Fernandez-Garcia CE, Gomez-Guerrero C, et al. HSP90 inhibition by 17-DMAG attenuates oxidative stress in experimental atherosclerosis. Cardiovasc Res. 2012;95(1):116-123.
12. Arrigo AP, Virot S, Chaufour S, Firdaus W, Kretz-Remy C, Diaz-Latoud C. Hsp27 consolidates intracellular redox homeostasis by upholding glutathi-one in its reduced form and by decreasing iron intracellular levels. Antioxid Redox Signal. 2005;7(3-4):414-422.
13. Kalmar B, Greensmith L. Induction of heat shock proteins for protection against oxidative stress. Adv Drug Deliv Rev. 2009;61(4):310-318.
14. Barrett MJ, Alones V, Wang KX, Phan L, Swerdlow RH. Mitochondria-derived oxidative stress induces a heat shock protein response. J Neurosci Res. 2004;78(3):420-429.
15. Hollander JM, Lin KM, Scott BT, Dillmann WH. Over expression of PHGPX and HSP60/10 protects against ischemia/reoxygenation injury. Free Radic Biol Med. 2003;35(7):742-7451.
16. Lee YH, Govinda B, Kim JC, et al. Oxidative stress resistance through blocking Hsp60 translocation followed by SAPK/JNK inhibition in aged human diploid fibroblasts. Cell Biochem Funct. 2009;27(1):35-39.
17. Singh MP, Reddy MM, Mathur N, Saxena DK, Chowdhuri DK. Induction of hsp70, hsp60, hsp83 and hsp26 and oxidative stress markers in benzene, toluene and xylene exposed Drosophila melanogaster: role of ROS generation. Toxicol Appl Pharmacol. 2009;235(2):226-243.
18. Kaetsu A, Fukushima T, Inoue S, Lim H, Moriyama M. Role of heat shock protein 60 (HSP60) on paraquat intoxication. J Appl Toxicol. 2001;21(5): 425-430.
19. Cabiscol E, Tamarit J, Ros J. Oxidative stress in bacteria and protein damage by reactive oxygen species. Int Microbiol. 2000;3(1):3-8.
20. Cabiscol E, Bellí G, Tamarit J, Echave P, Herrero E, Ros J. Mitochondrial Hsp60, resistance to oxidative stress, and the labile iron pool are closely connected in Saccharomyces cerevisiae. J Biol Chem. 2002;277(46):44531-44538.
21. Uccelletti D, Farina F, Pinton P, et al. The Golgi Ca2+-ATPase KlPmr1p function is required for oxidative stress response by controlling the expression of the heat-shock element HSP60 in Kluyveromyces lactis. Mol Biol Cell. 2005;16(10):4636-4647.
22. Merendino AM, Bucchieri F, Campanella C, et al. Hsp60 is actively secreted by human tumor cells. PLoS ONE. 2010;5(2):e9247.
23. Ghosh JC, Siegelin MD, Dohi T, Altieri DC. Heat shock protein 60 regulation of the mitochondrial permeability transition pore in tumor cells. Cancer Res. 2010;70(22):8988-8993.
24. Ghosh JC, Dohi T, Kang BH, Altieri DC. Hsp60 regulation of tumor cell apoptosis. J Biol Chem. 2008;283(8):5188-5194.
25. Itoh H, Komatsuda A, Ohtani H, et al. Mammalian HSP60 is quickly sorted into the mitochondria under conditions of dehydration. Eur J Biochem. 2002;269(23):5931-5938.
26. Campanella C, Bucchieri F, Ardizzone NM, et al. Upon oxidative stress, the antiapoptotic Hsp60/procaspase-3 complex persists in mucoepidermoid carcinoma cells. Eur J Histochem. 2008;52(4):221-228.
27. Gupta S, Knowlton AA. HSP60, Bax, apoptosis and the heart. J Cell Mol Med. 2005;9(1):1-58.
28. Shan YX, Liu TJ, Su HF, Samsamshariat A, Mestril R, Wang PH. Hsp10 and Hsp60 modulate Bcl-2 family and mitochondria apoptosis signaling induced by doxorubicin in cardiac muscle cells. J Mol Cell Cardiol. 2003;35(9):1135-1143.
29. Vishal C, Kumar JU, Swamy CVB, et al. Repercussion of mitochondria deformity induced by anti-Hsp90 drug 17 AAG in human tumor cells. Drug Target Insights. 2011;5:11-32.
30. Taiyab A, Srinivas UK, Sreedhar AS. 17-(Allylamino)-17-demethoxygeldanamycin combination with diferuloylmethane selectively targets mitogen kinase pathway in a human neuroblastoma cell line. J Cancer Ther. 2010;1:197-204.
31. Sreedhar AS, Pardhasaradhi BV, Begum Z, Khar A, Srinivas UK. Lack of heat shock response triggers programmed cell death in a rat histiocytic cell line. FEBS Lett. 1999;456(2):339-342.
32. Li N, Ragheb K, Lawler G, et al. Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. J Biol Chem. 2003;278(10):8516-8925.
33. Vayssier-Taussat M, Kreps SE, Adrie C, Dall'Ava J, Christiani D, Polla BS. Mitochondrial membrane potential: a novel biomarker of oxidative environmental stress. Environ Health Perspect. 2002;110(3):301-305.
34. Turrens JF. Superoxide production by the mitochondrial respiratory chain. Biosci Rep. 1997;17(1):3-8.
35. Infanger DW, Sharma RV, Davisson RL. NADPH oxidases of the brain: distribution, regulation, and function. Antioxid Redox Signal. 2006;8(9-10): 1583-1596.
36. Suski JM, Lebiedzinska M, Bonora M, Pinton P, Duszynski J, Wieckowski MR. Relation between mitochondrial membrane potential and ROS formation. Methods Mol Biol. 2012;810:183-205.
37. Voos W, Röttgers K. Molecular chaperones as essential mediators of mitochondrial biogenesis. Biochim Biophys Acta. 2002;1592(1):51-62.
38. Bie AS, Palmfeldt J, Hansen J, et al. A cell model to study different degrees of Hsp60 defciency in HEK293 cells. Cell Stress Chaperones. 2011;16(6):633-640.
39. Ban HS, Shimizu K, Minegishi H, Nakamura H. Identification of HSP60 as a primary target of o-carboranylphenoxyacetanilide, an HIF-1alpha inhibitor. J Am Chem Soc. 2010;132(34):11870-11871.
40. Tsai YP, Teng SC, Wu KJ. Direct regulation of HSP60 expression by c-MYC induces transformation. FEBS Lett. 2008;582(29):4083-4088.
41. Isenberg JS, Klaunig JE. Role of the mitochondrial membrane permeability transition (MPT) in rotenone-induced apoptosis in liver cells. Toxicol Sci. 2000;53(2):340-351.
42. Li YY, Lu S, Li K, et al. Down-regulation of HSP60 expression by RNAI increases lipopolysaccharide- and cerulein-induced damages on isolated rat pancreatic tissues. Cell Stress Chaperones. 2010;15(6):965-975.
43. Samali A, Cotter TG. Heat shock proteins increase resistance to apoptosis. Exp Cell Res. 1996;223(1):163-170.
44. Beere HM. "The stress of dying": the role of heat shock proteins in the regulation of apoptosis. J Cell Sci. 2004;117(Pt 13):2641-2651.
45. Orr AL, Li S, Wang CE, et al. N-terminal mutant Huntington associates with mitochondria and impairs mitochondrial trafficking. J Neurosci. 2008;28(11):2783-2792.