Adaptive optics imaging of geographic atrophy

Investigative Ophthalmology and Visual Science

Volumn 54, Issue 5, 2013, Pages 3673-3680

  Gocho, Kiyoko ^a   Sarda, Valérie ^a   Falah, Sabrina ^a   Sahel, José Alain ^a   Sennlaub, Florian ^b   Benchaboune, Mustapha ^a   Ullern, Martine ^a   Paques, Michel ^a  

^a CENTRE HOSPITALIER NATIONAL D OPHTALMOLOGIE DES QUINZE VINGTS   (France)

^b INSERM   (France)

Author keywords

Adaptive optics; Geographic atrophy; Infrared imaging; Retinal pigment epithelium

Indexed keywords

ADAPTIVE OPTICS; ADULT; AGED; ARTICLE; AUTOFLUORESCENCE IMAGING; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; EYE FUNDUS; FEMALE; FLUORESCENCE IMAGING; FOLLOW UP; FUNDUS CAMERA; GEOGRAPHIC ATROPHY; HUMAN; ILLUMINATION; IMAGE PROCESSING; MALE; NEAR INFRARED REFLECTANCE SPECTROSCOPY; OBSERVATIONAL STUDY; OPTICAL COHERENCE TOMOGRAPHY; OPTICAL COHERENCE TOMOGRAPHY DEVICE; OPTICS; PRIORITY JOURNAL; RETINAL PIGMENT EPITHELIUM; SCANNING LASER OPHTHALMOSCOPE; SCANNING LASER OPHTHALMOSCOPY; TIME LAPSE IMAGING; VISUAL ACUITY; CONTROLLED CLINICAL TRIAL; DISEASE COURSE; INFRARED IMAGING; METHODOLOGY; MIDDLE AGED; NEAR INFRARED SPECTROSCOPY; OPHTHALMOSCOPY; PATHOLOGY; PATHOPHYSIOLOGY; PIGMENT EPITHELIUM; VERY ELDERLY;

ADAPTIVE OPTICS; GEOGRAPHIC ATROPHY; INFRARED IMAGING; RETINAL PIGMENT EPITHELIUM;

AGED; AGED, 80 AND OVER; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; FUNDUS OCULI; GEOGRAPHIC ATROPHY; HUMANS; MALE; MIDDLE AGED; OPHTHALMOSCOPY; RETINAL PIGMENT EPITHELIUM; SPECTROSCOPY, NEAR-INFRARED; TIME-LAPSE IMAGING;

EID: 84883593012     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.12-10672     Document Type: Article

References (26)

1. Augood CA, Vingerling JR, de Jong PT, et al. Prevalence of age-related maculopathy in older Europeans: the European Eye Study (EUREYE). Arch Ophthalmol. 2006;124:529–535.
2. Klein R, Chou CF, Klein BE, Zhang X, Meuer SM, Saaddine JB. Prevalence of age-related macular degeneration in the US population. Arch Ophthalmol. 2011;129:75–80.
3. Haines JL, Hauser MA, Schmidt S, et al. Complement factor H variant increases the risk of age-related macular degeneration. Science. 2005;308:419–421.
4. Sarks SH. Ageing and degeneration in the macular region: a clinico-pathological study. Br J Ophthalmol. 1976;60:324–341.
5. Penfold PL, Killingsworth MC, Sarks SH. Senile macular degeneration. The involvement of giant cells in atrophy of the retinal pigment epithelium. Invest Ophthalmol Vis Sci. 1986;27:364–371.
6. Sarks JP, Sarks SH, Killingsworth MC. Evolution of geographic atrophy of the retinal pigment epithelium. Eye (Lond). 1988;2: 552–577.
7. Cherepanoff S, McMenamin P, Gillies MC, Kettle E, Sarks SH. Bruch’s membrane and choroidal macrophages in early and advanced age-related macular degeneration. Br J Ophthalmol. 2010;94:918–925.
8. Curcio CA, Medeiros NE, Millican CL. The Alabama Age-Related Macular Degeneration Grading System for donor eyes. Invest Ophthalmol Vis Sci. 1998;39:1085–1096.
9. Liang J, Williams DR, Miller DT. Supernormal vision and high-resolution retinal imaging through adaptive optics. J Opt Soc Am. 1997;14:2884–2892.
10. Querques G, Massamba N, Guigui B, et al. In vivo evaluation of photoreceptor mosaic in early onset large colloid drusen using adaptive optics. Acta Ophthalmol. 2012;90:e327–328.
11. Godara P, Siebe C, Rha J, Michaelides M, Carroll J. Assessing the photoreceptor mosaic over drusen using adaptive optics and SD-OCT. Ophthalmic Surg Lasers Imaging. 2010;41:41:S104–108.
12. Boretsky A, Khan F, Burnett G, et al. In vivo imaging of photoreceptor disruption associated with age-related macular degeneration: A pilot study. Lasers Surg Med. 2012;44:603– 610.
13. Viard C, Nakashima K, Lamory B, Paques M, Levecq X, Chateau N. Imaging microscopic structures in pathological retinas using a flood-illumination adaptive optics retinal camera. Proc SPIE. 2011;7885:488–509.
14. Goldsmith NT. Deep focus: a digital image processing technique to produce improved focal depth in light microscopy. Image Anal Stereol. 2000;19:163–167.
15. Morgan JI, Dubra A, Wolfe R, Merigan WH, Williams DR. In vivo autofluorescence imaging of the human and macaque retinal pigment epithelial cell mosaic. Invest Ophthalmol Vis Sci. 2009;50:1350–1359.
16. Roorda A, Zhang Y, Duncan JL. High-resolution in vivo imaging of the RPE mosaic in eyes with retinal disease. Invest Ophthalmol Vis Sci. 2007;48:2297–2303.
17. Sunness JS, Bressler NM, Tian Y, Alexander J, Applegate CA. Measuring geographic atrophy in advanced age-related macular degeneration. Invest Ophthalmol Vis Sci. 1999;40:1761– 1769.
18. Choudhry N, Giani A, Miller JW. Fundus autofluorescence in geographic atrophy: a review. Semin Ophthalmol. 2010;25: 206–213.
19. Schmitz-Valckenberg S, Fleckenstein M, Scholl HP, Holz FG. Fundus autofluorescence and progression of age-related macular degeneration. Surv Ophthalmol. 2009;54:96–117.
20. Göbel AP, Fleckenstein M, Schmitz-Valckenberg S, Brinkmann CK, Holz FG. Imaging geographic atrophy in age-related macular degeneration. Ophthalmologica. 2011;226:182– 190.
21. Holz FG, Bindewald-Wittich A, Fleckenstein M, et al. Progression of geographic atrophy and impact of fundus autofluorescence patterns in age-related macular degeneration. Am J Ophthalmol. 2007;143:463–472.
22. Weinberger AW, Lappas A, Kirschkamp T, et al. Fundus near infrared fluorescence correlates with fundus near infrared reflectance. Invest Ophthalmol Vis Sci. 2006;47:3098–3108.
23. Keilhauer CN, Delori FC. Near-infrared autofluorescence imaging of the fundus: visualization of ocular melanin. Invest Ophthalmol Vis Sci. 2006;47:3556–3564.
24. Kellner U, Kellner S, Weinitz S. Fundus autofluorescence (488 nm) and near-infrared autofluorescence (787 nm) visualize different retinal pigment epithelium alterations in patients with age-related macular degeneration. Retina. 2010;30:6– 15.
25. Schmitz-Valckenberg S, Lara D, Nizari S, et al. Localisation and significance of in vivo near-infrared autofluorescent signal in retinal imaging. Br J Ophthalmol. 2011;95:1134–1139.
26. Paques M, Simonutti M, Augustin S, Goupille O, El Mathari B, Sahel JA. In vivo observation of the locomotion of microglial cells in the retina. Glia. 2010;58:1663–1668.