In vivo autofluorescence imaging of the human and macaque retinal pigment epithelial cell mosaic

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 3, 2009, Pages 1350-1359

  Morgan, Jessica I W ^a   Dubra, Alfredo ^a   Wolfe, Robert ^a   Merigan, William H ^a   Williams, David R ^a  

^a UNIVERSITY OF ROCHESTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DENSITY; CELL SIZE; CELLULAR DISTRIBUTION; FEMALE; HUMAN; IMAGE ANALYSIS; IN VIVO STUDY; MACACA; MALE; NONHUMAN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINAL PIGMENT EPITHELIAL CELL; SCANNING LASER OPHTHALMOSCOPY; ANIMAL; CELL COUNT; CHEMISTRY; CYTOLOGY; FLUORESCENCE; METHODOLOGY; OPHTHALMOSCOPE; OPHTHALMOSCOPY; RETINA CONE;

LIPOFUSCIN;

ADULT; ANIMALS; CELL COUNT; FEMALE; FLUORESCENCE; HUMANS; LIPOFUSCIN; MACACA FASCICULARIS; MACACA NEMESTRINA; MALE; OPHTHALMOSCOPES; OPHTHALMOSCOPY; RETINAL CONE PHOTORECEPTOR CELLS; RETINAL PIGMENT EPITHELIUM;

EID: 62649152376     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.08-2618     Document Type: Article

References (48)

1. Strauss O. The retinal pigment epithelium in visual function. Physiol Rev. 2005;85(3):845-881.
2. Gao H, Hollyfield JG. Aging of the human retina: Differential loss of neurons and retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 1992;33(1):1-17.
3. Watzke RC, Soldevilla JD, Trune DR. Morphometric analysis of human retinal pigment epithelium: correlation with age and location. Curr Eye Res. 1993;12(2):133-142.
4. Panda-Jonas S, Jonas JB, Jakobczyk-Zmija M. Retinal pigment epithelial cell count, distribution, and correlations in normal human eyes. Am J Ophthalmol. 1996;121:181-189.
5. Harman AM, Fleming PA, Hoskins RV, Moore SR. Development and aging of cell topography in the human retinal pigment epithelium. Invest Ophthalmol Vis Sci. 1997;38(10):2016-2026.
6. Del Priore LV, Kuo Y-H, Tazel TH. Age-related changes in human RPE cell density and apoptosis proportion in situ. Invest Ophthalmol Vis Sci. 2002;43:3312-3318.
7. Leung IY-F, Sandstrom MM, Zucker CL, et al. Nutritional manipulation of primate retinas, II: Effects of age, n-3 fatty acids, lutein, and zeaxanthin on retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2004;45(9):3244-3256.
8. Maguire AM, Simonelli F, Pierce EA, et al. Safety and Efficacy of gene transfer for Leber's congenital amaurosis. N Engl J Med. 2008;358:2240-2248.
9. Liang J, Williams DR, Miller DT. Supernormal vision and high-resolution retinal imaging through adaptive optics. J Opt Soc Am A. 1997;14(11):2884-2892.
10. Hofer H, Chen L, Yoon GY, et al. Improvement in retinal image quality with dynamic correction of the eye's aberrations. Opt Express. 2001;8(11):631-643.
11. Roorda A, Williams DR. The arrangement of the three cone classes in the living human eye. Nature (Lond). 1999;397:520-522.
12. Roorda A, Romero-Borja F, Donnelly WJ III, et al. Adaptive optics scanning laser ophthalmoscopy. Opt Express. 2002;10(9):405-412.
13. Hermann B, Fernandez EJ, Unterhuber A, et al. Adaptive-optics ultrahigh-resolution optical coherence tomography. Opt Lett. 2004;29(18):2142-2144.
14. Carroll J, Neitz M, Hofer H, et al. Functional photoreceptor loss revealed with adaptive optics: an alternate cause for color blindness. Proc Natl Acad Sci U S A. 2004;101(22):8461-8466.
15. Wolfing JI, Chung M, Carroll J, et al. High-resolution retinal imaging of cone-rod dystrophy. Ophthalmology. 2006;113:1014-1019.
16. Choi SS, Doble N, Hardy JL, et al. In vivo imaging of the photoreceptor mosaic in retinal dystrophies and correlations with visual function. Invest Ophthalmol Vis Sci. 2006;47:2080-2092.
17. Roorda A, Zhang Y, Duncan JL. High-resolution in vivo imaging of the RPE mosaic in eyes with retinal disease. Invest Ophthalmol Vis Sci. 2007;48(5):2297-2303.
18. Radu RA, Mata NL, Nusinowitz S, et al. Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration. Proc Natl Acad Sci U S A. 2003; 100(8):4742-4747.
19. Feeneyburns L, Hilderbrand ES, Eldridge S. Aging human RPE: morphometric analysis of macular, equatorial, and peripheral cells. Invest Ophthalmol Vis Sci. 1984;25(2):195-200.
20. Eldred GE, Katz ML. Fluorophores of the human retinal pigment epithelium: separation and spectral characterization. Exp Eye Res. 1988;47:71-86.
21. Sparrow JR, Fishkin N, Zhou J, et al. A2E, a byproduct of the visual cycle. Vision Res. 2003;43:2983-2990.
22. Fishkin NE, Sparrow JR, Allikmets R, Nakanishi K. Isolation and characterization of a retinal pigment epithelial cell fluorophore: an all-trans-retinal dimer conjugate. Proc Natl Acad Sci U S A. 2005; 102(20):7091-7096.
23. von Ruckmann A, Fitzke FW, Bird AC. Distribution of fundus autofluorescence with a scanning laser ophthalmoscope. Br J Ophthalmol. 1995;79:407-412.
24. Delori FC. Spectrophotometer for noninvasive measurement of intrinsic fluorescence and reflectance of the ocular fundus. Appl Opt. 1994;33(31):7439-7452.
25. Delori FC, Dorey CK, Staurenghi G, et al. In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics. Invest Ophthalmol Vis Sci. 1995;36(3):718-729.
26. von Ruckmann A, Fitzke FW, Bird AC. Fundus autofluorescence in age-related macular disease imaged with a laser scanning ophthalmoscope. Invest Ophthalmol Vis Sci. 1997;38:478-486.
27. Lois N, Halfyard AS, Bird AC, Fitzke FW. Quantitative evaluation of fundus autofluorescence imaged "in vivo" in eyes with retinal disease. Br J Ophthalmol. 2000;84:741-745.
28. Delori FC, Goger DG, Dorey CK. Age-related accumulation and spatial distribution of lipofuscin in RPE of normal subjects. Invest Ophthalmol Vis Sci. 2001;42(8):1855-1866.
29. Holz FG, Bellman C, Staudt S, et al. Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2001;42(5):1051-1056.
30. Lois N, Halfyard AS, Bird AC, et al. Fundus autofluorescence in Stargardt macular dystrophy-fundus flavimaculatus. Am J Ophthalmol. 2004;138(1):55-63.
31. Bindewald A, Jorzik JJ, Loesch A, et al. Visualization of retinal pigment epithelial cells in vivo using digital high-resolution confocal scanning laser ophthalmoscopy. Am J Ophthalmol. 2004; 137(3):556-558.
32. Wing GL, Blanchard GC, Weiter JJ. The topography and age relationship of lipofuscin concentration in the retinal pigment epithelium. Invest Ophthalmol Vis Sci. 1978;17(7):601-607.
33. Gray DC, Merigan W, Wolfing JI, et al. In vivo fluorescence imaging of primate retinal ganglion cells and retinal pigment epithelial cells. Opt Express. 2006;14:7144-7158.
34. Metha AB, Crane AM, Rylander HGI, et al. Maintaining the cornea and the general physiological environment in visual neurophysiology experiments. J Neurosci Methods. 2001;109:153-166.
35. Wyszecki G, Stiles WS. Color Science: Concepts and Methods, Quantitative Data and Formulae. 2nd ed. New York: John Wiley & Sons; 1982.
36. ANSI. American National Standard for Safe Use of Lasers. ANSI publication no. Z136.1-2007. Orlando, FL: Laser Institute of America; 2007.
37. Li KY, Roorda A. Automated identification of cone photoreceptors in adaptive optics retinal images. J Opt Soc Am A. 2007;24(5): 1358-1363.
38. Baraas RC, Carroll J, Gunther KL, et al. Adaptive optics retinal imaging reveals S-cone dystrophy in tritan color-vision deficiency. J Opt Soc America A. 2007;24(5):1438-1447.
39. Galli-Resta L, Novelli E, Kryger Z, et al. Modelling the mosaic organization of rod and cone photoreceptors with a minimalspacing rule. Eur J Neurosci. 1999;11:1461-1469.
40. Coletta NJ, Williams DR. Psychophysical estimate of extrafoveal cone spacing. J Opt Soc Am A. 1987;4(8):1503-1513.
41. Taylor BN, Kuyatt CE. Guidelines for Evaluating and Expressing the Uncertainty of NIST Measurement Results. Washington, DC: U.S. Department of Commerce, Technology Administration NIo-SaT, ed., 1994; v. NIST Technical Note 1297.
42. Burns SA, He JC, Delori F. Do the cones see light scattered from the deep retinal layers. Vision Sci. 1997;1:94-7.
43. Prieto PM, McLellan JS, Burns SA. Investigating the light absorption in a single pass through the photoreceptor layer by means of the lipofuscin fluorescence. Vision Res. 2005;45(15):1957-1965.
44. Curcio CA, Sloan KR. Packing geometry of human cone photoreceptors: variation with eccentricity and evidence for local anisotropy. Vis Neurosci. 1992;9:169-180.
45. Burke JM, Hjelmeland LM. Mosaicism of the retinal pigment epithelium: seeing the small picture. Mol Interv. 2005;5(4):241-249.
46. Bindewald-Wittich A, Han M, Schmitz-Valckenberg S, et al. Twophoton-excited fluorescence imaging of human PRE cells with a femtosceond Ti:Sapphire laser. Invest Ophthalmol Vis Sci. 2006; 47:4553-4557.
47. Snodderly DM, Sandstrom MM, Leung IY-F, et al. Retinal pigment epithelial cell distribution in central retina of rhesus monkeys. Invest Ophthalmol Vis Sci. 2002;43:2815-2818.
48. Morgan JIW, Hunter JJ, Masella B, et al. Light-induced retinal changes observed using high-resolution autofluorescence imaging of the retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2008;49:3715-3729.