Induced pluripotent stem (iPS) cells inhibit apoptosis and fibrosis in streptozotocin-induced diabetic rats

Molecular Pharmaceutics

Volumn 8, Issue 6, 2011, Pages 2350-2357

  Neel, Sarah ^a   Singla, Dinender K ^a  

^a UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

embryonic stem cells; fractional shortening; heart; induced pluripotent stem cells; type 1

Indexed keywords

ALPHA ACTIN; CASPASE 3; PANCREATIC TRANSCRIPTION FACTOR 1A; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; DIABETIC CARDIOMYOPATHY; ECHOCARDIOGRAPHY; EMBRYONIC STEM CELL; ENZYME ASSAY; HEART FUNCTION; HEART MUSCLE FIBROSIS; HEART VENTRICLE REMODELING; HISTOPATHOLOGY; HYPOTHESIS; IMMUNOHISTOCHEMISTRY; MALE; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STEM CELL TRANSPLANTATION; STREPTOZOCIN DIABETES; VASCULAR FIBROSIS;

ANIMALS; APOPTOSIS; CASPASE 3; CULTURE MEDIA, CONDITIONED; DIABETES MELLITUS, EXPERIMENTAL; FIBROSIS; INDUCED PLURIPOTENT STEM CELLS; MALE; MYOCYTES, CARDIAC; RATS; RATS, SPRAGUE-DAWLEY;

EID: 82955172969     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp2004675     Document Type: Article

References (44)

1. Aneja, A.; Tang, W. H.; Bansilal, S.; Garcia, M. J.; Farkouh, M. E. Diabetic cardiomyopathy: insights into pathogenesis, diagnostic challenges, and therapeutic options Am. J. Med. 2008, 121, 748-757
2. Angoulvant, D.; Ivanes, F.; Ferrera, R.; Matthews, P. G.; Nataf, S.; Ovize, M. Mesenchymal stem cell conditioned media attenuates in vitro and ex vivo myocardial reperfusion injury J. Heart Lung Transplant. 2011, 30, 95-102
3. Asbun, J.; Villarreal, F. J. The pathogenesis of myocardial fibrosis in the setting of diabetic cardiomyopathy J. Am. Coll. Cardiol. 2006, 47, 693-700 (Pubitemid 43243087)
4. Atkinson, M. A.; Eisenbarth, G. S. Type 1 diabetes: new perspectives on disease pathogenesis and treatment Lancet 2001, 358, 221-229 (Pubitemid 32718550)
5. Baraka, A.; AbdelGawad, H. Targeting apoptosis in the heart of streptozotocin-induced diabetic rats J. Cardiovasc. Pharmacol. Ther. 2010, 15, 175-181
6. Boudina, S.; Abel, E. D. Diabetic cardiomyopathy revisited Circulation 2007, 115, 3213-3223 (Pubitemid 47012236)
7. Boudina, S.; Abel, E. D. Diabetic cardiomyopathy, causes and effects Rev. Endocr. Metab. Disord. 2010, 11, 31-39
8. Boudoulas, K. D.; Hatzopoulos, A. K. Cardiac repair and regeneration: the Rubik's cube of cell therapy for heart disease Dis. Models Mech. 2009, 2, 344-358
9. Burlison, J. S.; Long, Q.; Fujitani, Y.; Wright, C. V.; Magnuson, M. A. Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells Dev. Biol. 2008, 316, 74-86
10. Cai, L.; Kang, Y. J. Oxidative stress and diabetic cardiomyopathy: a brief review Cardiovasc. Toxicol. 2001, 1, 181-193 (Pubitemid 37013746)
11. Clark, R. J.; McDonough, P. M.; Swanson, E.; Trost, S. U.; Suzuki, M.; Fukuda, M.; Dillmann, W. H. Diabetes and the accompanying hyperglycemia impairs cardiomyocyte calcium cycling through increased nuclear O-GlcNAcylation J. Biol. Chem. 2003, 278, 44230-44237 (Pubitemid 37377167)
12. Crisostomo, P. R.; Abarbanell, A. M.; Wang, M.; Lahm, T.; Wang, Y.; Meldrum, D. R. Embryonic stem cells attenuate myocardial dysfunction and inflammation after surgical global ischemia via paracrine actions Am. J. Physiol. 2008, 295, H1726-H1735
13. Delicado, E. G.; Torres, M.; Miras-Portugal, M. T. Glucose transporters in chromaffin cells: subcellular distribution and characterization FEBS Lett. 1988, 229, 35-39 (Pubitemid 18058745)
14. El-Seweidy, M. M.; Sadik, N. A.; Shaker, O. G. Role of sulfurous mineral water and sodium hydrosulfide as potent inhibitors of fibrosis in the heart of diabetic rats Arch. Biochem. Biophys. 2011, 506, 48-57
15. Fatma, S.; Selby, D. E.; Singla, R. D.; Singla, D. K. Factors Released from Embryonic Stem Cells Stimulate c-kit-FLK-1(+ve) Progenitor Cells and Enhance Neovascularization Antioxid. Redox Signaling 2010, 13, 1857-1865
16. Glass, C. E.; Singal, P. K.; Singla, D. K. Stem cells in the diabetic infarcted heart Heart Failure Rev. 2010, 15, 581-588
17. Guo, H. D.; Wang, H. J.; Tan, Y. Z.; Wu, J. H. Transplantation of marrow-derived cardiac stem cells carried in fibrin improves cardiac function after myocardial infarction Tissue Eng., Part A 2011, 17, 45-58
18. Hofbauer, L. C.; Brueck, C. C.; Singh, S. K.; Dobnig, H. Osteoporosis in patients with diabetes mellitus J. Bone Miner. Res. 2007, 22, 1317-1328 (Pubitemid 351339677)
19. Intengan, H. D.; Schiffrin, E. L. Vascular remodeling in hypertension: roles of apoptosis, inflammation, and fibrosis Hypertension 2001, 38, 581-587
20. Jalili, R. B.; Rezakhanlou, A. M.; Hosseini-Tabatabaei, A.; Ao, Z.; Warnock, G. L.; Ghahary, A. Fibroblast populated collagen matrix promotes islet survival and reduces the number of islets required for diabetes reversal J. Cell. Physiol. 2010, 226 (7) 1813-1819
21. Joshi, D.; Gupta, R.; Dubey, A.; Shiwalkar, A.; Pathak, P.; Gupta, R. C.; Chauthaiwale, V.; Dutt, C. TRC4186, a novel AGE-breaker, improves diabetic cardiomyopathy and nephropathy in Ob-ZSF1 model of type 2 diabetes J. Cardiovasc. Pharmacol. 2009, 54, 72-81
22. Khullar, M.; Al-Shudiefat, A. A.; Ludke, A.; Binepal, G.; Singal, P. K. Oxidative stress: a key contributor to diabetic cardiomyopathy Can. J. Physiol. Pharmacol. 2010, 88, 233-240
23. Kumar, D.; Hacker, T. A.; Buck, J.; Whitesell, L. F.; Kaji, E. H.; Douglas, P. S.; Kamp, T. J. Distinct mouse coronary anatomy and myocardial infarction consequent to ligation Coron. Artery Dis. 2005, 16, 41-44 (Pubitemid 40279597)
24. Lacotte, S.; Berney, T.; Shapiro, A. J.; Toso, C. Immune monitoring of pancreatic islet graft: towards a better understanding, detection and treatment of harmful events Expert Opin. Biol. Ther. 2011, 11, 55-66
25. Malmberg, K.; Ryden, L.; Wedel, H.; Birkeland, K.; Bootsma, A.; Dickstein, K.; Efendic, S.; Fisher, M.; Hamsten, A.; Herlitz, J.; Hildebrandt, P.; MacLeod, K.; Laakso, M.; Torp-Pedersen, C.; Waldenstrom, A. Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidity Eur. Heart J. 2005, 26, 650-661 (Pubitemid 40516876)
26. Matsumoto, S. Islet cell transplantation for Type 1 diabetes J. Diabetes 2010, 2, 16-22
27. Nelson, T. J.; Martinez-Fernandez, A.; Yamada, S.; Perez-Terzic, C.; Ikeda, Y.; Terzic, A. Repair of acute myocardial infarction by human stemness factors induced pluripotent stem cells Circulation 2009, 120, 408-416
28. Passier, R.; van Laake, L. W.; Mummery, C. L. Stem-cell-based therapy and lessons from the heart Nature 2008, 453, 322-329 (Pubitemid 351693138)
29. Shimizu, M.; Umeda, K.; Sugihara, N.; Yoshio, H.; Ino, H.; Takeda, R.; Okada, Y.; Nakanishi, I. Collagen remodelling in myocardia of patients with diabetes J. Clin. Pathol. 1993, 46, 32-36 (Pubitemid 23039583)
30. Singla, D. K. Embryonic stem cells in cardiac repair and regeneration Antioxid. Redox Signaling 2009, 11, 1857-1863
31. Singla, D. K. Stem cells in the infarcted heart J. Cardiovasc. Transl. Res. 2010, 3, 73-78
32. Singla, D. K.; Lyons, G. E.; Kamp, T. J. Transplanted embryonic stem cells following mouse myocardial infarction inhibit apoptosis and cardiac remodeling Am. J. Physiol. 2007, 293, H1308-H1314
33. Singla, D. K.; Singla, R. D.; McDonald, D. E. Factors released from embryonic stem cells inhibit apoptosis in H9c2 cells through PI3K/Akt but not ERK pathway Am. J. Physiol. 2008, 295, H907
34. Spees, J. L.; Olson, S. D.; Whitney, M. J.; Prockop, D. J. Mitochondrial transfer between cells can rescue aerobic respiration Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 1283
35. Spees, J. L.; Whitney, M. J.; Sullivan, D. E.; Lasky, J. A.; Laboy, M.; Ylostalo, J.; Prockop, D. J. Bone marrow progenitor cells contribute to repair and remodeling of the lung and heart in a rat model of progressive pulmonary hypertension FASEB J. 2008, 22, 1226-1236 (Pubitemid 351519976)
36. Tarquini, R.; Lazzeri, C.; Pala, L.; Rotella, C. M.; Gensini, G. F. The diabetic cardiomyopathy Acta Diabetol. 2011, 48, 173-181
37. Timmers, L.; Lim, S. K.; Arslan, F.; Armstrong, J. S.; Hoefer, I. E.; Doevendans, P. A.; Piek, J. J.; El Oakley, R. M.; Choo, A.; Lee, C. N.; Pasterkamp, G.; de Kleijn, D. P. Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium Stem Cell Res. 2007, 1, 129-137
38. Voulgari, C.; Papadogiannis, D.; Tentolouris, N. Diabetic cardiomyopathy: from the pathophysiology of the cardiac myocytes to current diagnosis and management strategies Vasc. Health Risk Manag. 2010, 6, 883-903
39. Wernig, M.; Meissner, A.; Foreman, R.; Brambrink, T.; Ku, M.; Hochedlinger, K.; Bernstein, B. E.; Jaenisch, R. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state Nature 2007, 448, 318-324 (Pubitemid 47080337)
40. Widyantoro, B.; Emoto, N.; Nakayama, K.; Anggrahini, D. W.; Adiarto, S.; Iwasa, N.; Yagi, K.; Miyagawa, K.; Rikitake, Y.; Suzuki, T.; Kisanuki, Y. Y.; Yanagisawa, M.; Hirata, K. Endothelial cell-derived endothelin-1 promotes cardiac fibrosis in diabetic hearts through stimulation of endothelial-to- mesenchymal transition Circulation 2010, 121, 2407-2418
41. Wild, S.; Roglic, G.; Green, A.; Sicree, R.; King, H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030 Diabetes Care 2004, 27, 1047-1053 (Pubitemid 38579764)
42. Yan, B.; Abdelli, L. S.; Singla, D. K. Transplanted Induced Pluripotent Stem Cells Improve Cardiac Function and Induce Neovascularization in the Infarcted Hearts of db/db Mice Mol. Pharmaceutics 2011, 8 (5) 1602-1610
43. Zhang, N.; Li, J.; Luo, R.; Jiang, J.; Wang, J. A. Bone marrow mesenchymal stem cells induce angiogenesis and attenuate the remodeling of diabetic cardiomyopathy Exp. Clin. Endocrinol. Diabetes 2008, 116, 104-111 (Pubitemid 351363380)
44. Zhao, M.; Barron, M. R.; Li, Z.; Koprowski, S.; Hall, C. L.; Lough, J. Making stem cells infarct avid Cell Transplant. 2010, 19, 245-250