Effect of dietary sphingomyelin on absorption and fractional synthetic rate of cholesterol and serum lipid profile in humans

Lipids in Health and Disease

Volumn 12, Issue 1, 2013, Pages

  Ramprasath, Vanu R ^a   Jones, Peter J H ^a   Buckley, Donna D ^b   Woollett, Laura A ^c   Heubi, James E ^b  

^a UNIVERSITY OF MANITOBA   (Canada)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Bile; Cholesterol absorption; Fractional synthetic rate; Human; Sphingomyelin

Indexed keywords

BILE ACID; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SPHINGOMYELIN; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL; CHOLESTEROL; LIPID;

ABSORPTION; ADULT; ARTICLE; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIET SUPPLEMENTATION; DIETARY INTAKE; FEMALE; GENOTYPE; HUMAN; HUMAN EXPERIMENT; LIPID BLOOD LEVEL; MALE; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; SOLUBILIZATION; TRIACYLGLYCEROL BLOOD LEVEL; BLOOD; METABOLISM;

ADULT; BILE ACIDS AND SALTS; CHOLESTEROL; CHOLESTEROL, LDL; CHOLESTEROL, VLDL; DIETARY SUPPLEMENTS; FEMALE; HUMANS; LIPIDS; MALE; SPHINGOMYELINS; TRIGLYCERIDES;

EID: 84883562737     PISSN: None     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/1476-511X-12-125     Document Type: Article

References (38)

1. Sphingolipids: major regulators of lipid metabolism. Worgall TS, Curr Opin Clin Nutr Metab Care 2007 10 2 149 155 10.1097/MCO.0b013e328028fda3 17285002 (Pubitemid 46220306)
2. Sphingomyelin content of intestinal cell membranes regulates cholesterol absorption, Evidence for pancreatic and intestinal cell sphingomyelinase activity. Chen H, Born E, Mathur SN, Johlin FC Jr, Field FJ, Biochem J 1992 286 Pt 3 771 777 1417735
3. Sphingomyelin consumption suppresses aberrant colonic crypt foci and increases the proportion of adenomas versus adenocarcinomas in CF1 mice treated with 1,2-dimethylhydrazine: implications for dietary sphingolipids and colon carcinogenesis. Schmelz EM, Dillehay DL, Webb SK, Reiter A, Adams J, Merrill AH Jr, Cancer Res 1996 56 21 4936 4941 8895747 (Pubitemid 26374432)
4. Absorption and lipoprotein transport of sphingomyelin. Nilsson A, Duan RD, J Lipid Res 2006 47 1 154 171 16251722 (Pubitemid 43107459)
5. Sphingolipids in food and the emerging importance of sphingolipids to nutrition. Vesper H, Schmelz EM, Nikolova-Karakashian MN, Dillehay DL, Lynch DV, Merrill AH Jr, J Nutr 1999 129 7 1239 1250 10395583 (Pubitemid 29304970)
6. Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1. Kobayashi A, Takanezawa Y, Hirata T, Shimizu Y, Misasa K, Kioka N, Arai H, Ueda K, Matsuo M, J Lipid Res 2006 47 8 1791 1802 10.1194/jlr.M500546-JLR200 16702602 (Pubitemid 44222830)
7. Sphingomyelin-dependence of cholesterol efflux mediated by ABCG1. Sano O, Kobayashi A, Nagao K, Kumagai K, Kioka N, Hanada K, Ueda K, Matsuo M, J Lipid Res 2007 48 11 2377 2384 10.1194/jlr.M700139-JLR200 17761632 (Pubitemid 350058749)
8. Sphingomyelin-cholesterol interactions in biological and model membranes. Slotte JP, Chem Phys Lipids 1999 102 1-2 13 27 11001557 (Pubitemid 29438655)
9. Interactions between metabolism and intracellular distribution of cholesterol and sphingomyelin. Ridgway ND, Biochim Biophys Acta 2000 1484 2-3 129 141 10760463 (Pubitemid 30175963)
10. Plasma membranes contain half the phospholipid and 90% of the cholesterol and sphingomyelin in cultured human fibroblasts. Lange Y, Swaisgood MH, Ramos BV, Steck TL, J Biol Chem 1989 264 7 3786 3793 2917977 (Pubitemid 19072257)
11. Incorporation of cholesterol in sphingomyelin- phosphatidylcholine vesicles has profound effects on detergent-induced phase transitions. Moschetta A, Frederik PM, Portincasa P, VanBerge-Henegouwen GP, Van Erpecum KJ, J Lipid Res 2002 43 7 1046 1053 10.1194/jlr.M100355-JLR200 12091488 (Pubitemid 34760875)
12. Influence of bile salts on molecular interactions between sphingomyelin and cholesterol: relevance to bile formation and stability. van Erpecum KJ, Carey MC, Biochim Biophys Acta 1997 1345 3 269 282 10.1016/S0005-2760(97)00002-7 9150247 (Pubitemid 27171204)
13. A mutual inhibitory effect on absorption of sphingomyelin and cholesterol. Nyberg L, Duan RD, Nilsson A, J Nutr Biochem 2000 11 5 244 249 10.1016/S0955-2863(00)00069-3 10876096 (Pubitemid 30392408)
14. Egg sphingomyelin lowers the lymphatic absorption of cholesterol and alpha-tocopherol in rats. Noh SK, Koo SI, J Nutr 2003 133 11 3571 3576 14608075 (Pubitemid 37409488)
15. Dietary sphingolipids lower plasma cholesterol and triacylglycerol and prevent liver steatosis in APOE*3Leiden mice. Duivenvoorden I, Voshol PJ, Rensen PC, van Duyvenvoorde W, Romijn JA, Emeis JJ, Havekes LM, Nieuwenhuizen WF, Am J Clin Nutr 2006 84 2 312 321 16895877 (Pubitemid 44699139)
16. Dietary sphingolipids ameliorate disorders of lipid metabolism in Zucker fatty rats. Yunoki K, Renaguli M, Kinoshita M, Matsuyama H, Mawatari S, Fujino T, Kodama Y, Sugiyama M, Ohnishi M, J Agric Food Chem 2010 58 11 7030 7035 10.1021/jf100722f 20443604
17. Dietary sphingomyelin suppresses intestinal cholesterol absorption by decreasing thermodynamic activity of cholesterol monomers. Eckhardt ER, Wang DQ, Donovan JM, Carey MC, Gastroenterology 2002 122 4 948 956 10.1053/gast.2002. 32539 11910347 (Pubitemid 34267278)
18. Long term effects on human plasma lipoproteins of a formulation enriched in butter milk polar lipid. Ohlsson L, Burling H, Nilsson A, Lipids Health Dis 2009 8 44 10.1186/1476-511X-8-44 19835602
19. Effects of a sphingolipid-enriched dairy formulation on postprandial lipid concentrations. Ohlsson L, Burling H, Duan RD, Nilsson A, Eur J Clin Nutr 2010 64 11 1344 1349 10.1038/ejcn.2010.164 20808331
20. Milk sphingomyelin is more effective than egg sphingomyelin in inhibiting intestinal absorption of cholesterol and fat in rats. Noh SK, Koo SI, J Nutr 2004 134 10 2611 2616 15465755 (Pubitemid 39315261)
21. Distribution of alkaline sphingomyelinase activity in human beings and animals, Tissue and species differences. Duan RD, Hertervig E, Nyberg L, Hauge T, Sternby B, Lillienau J, Farooqi A, Nilsson A, Dig Dis Sci 1996 41 9 1801 1806 10.1007/BF02088748 8794797 (Pubitemid 26319756)
22. Alkaline sphingomyelinases and ceramidases of the gastrointestinal tract. Nilsson A, Duan RD, Chem Phys Lipids 1999 102 1-2 97 105 11001564 (Pubitemid 29438662)
23. Identification of an alkaline sphingomyelinase activity in human bile. Nyberg L, Duan RD, Axelson J, Nilsson A, Biochim Biophys Acta 1996 1300 1 42 48 10.1016/0005-2760(95)00245-6 8608160 (Pubitemid 26103898)
24. Sphingolipids in human ileostomy content after meals containing milk sphingomyelin. Ohlsson L, Hertervig E, Jonsson BA, Duan RD, Nyberg L, Svernlov R, Nilsson A, Am J Clin Nutr 2010 91 3 672 678 10.3945/ajcn.2009.28311 20071649
25. Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family. Duan RD, Bergman T, Xu N, Wu J, Cheng Y, Duan J, Nelander S, Palmberg C, Nilsson A, J Biol Chem 2003 278 40 38528 38536 10.1074/jbc.M305437200 12885774 (Pubitemid 37221748)
26. Purification and characterization of human intestinal neutral ceramidase. Ohlsson L, Palmberg C, Duan RD, Olsson M, Bergman T, Nilsson A, Biochimie 2007 89 8 950 960 10.1016/j.biochi.2007.03.009 17475390 (Pubitemid 47031431)
27. Purification of a newly identified alkaline sphingomyelinase in human bile and effects of bile salts and phosphatidylcholine on enzyme activity. Duan RD, Nilsson A, Hepatology 1997 26 4 823 830 10.1002/hep.510260403 9328299 (Pubitemid 27413643)
28. Alkaline sphingomyelinase: an old enzyme with novel implications. Duan RD, Biochim Biophys Acta 2006 1761 3 281 291 10.1016/j.bbalip.2006.03.007 16631405
29. In vitro effects of fat, FA, and cholesterol on sphingomyelin hydrolysis induced by rat intestinal alkaline sphingomyelinase. Liu JJ, Nilsson A, Duan RD, Lipids 2002 37 5 469 474 10.1007/s11745-002-0919-x 12056588 (Pubitemid 34535310)
30. Physical-chemical behavior of dietary and biliary lipids during intestinal digestion and absorption. 2. Phase analysis and aggregation states of luminal lipids during duodenal fat digestion in healthy adult human beings. Hernell O, Staggers JE, Carey MC, Biochemistry 1990 29 8 2041 2056 10.1021/bi00460a012 2328238 (Pubitemid 20085429)
31. Characterization of emulsions and lipolysis of dietary lipids in the human stomach. Armand M, Borel P, Dubois C, Senft M, Peyrot J, Salducci J, Lafont H, Lairon D, Am J Physiol 1994 266 3 Pt 1 372 G381 8166277
32. Separation of micelles and vesicles within lumenal aspirates from healthy humans: solubilization of cholesterol after a meal. Yao L, Heubi JE, Buckley DD, Fierra H, Setchell KD, Granholm NA, Tso P, Hui DY, Woollett LA, J Lipid Res 2002 43 4 654 660 11907149
33. A simple method for the isolation and purification of total lipides from animal tissues. Folch J, Lees M, Sloane Stanley GH, J Biol Chem 1957 226 1 497 509 13428781
34. Assessment of percent cholesterol absorption in humans with stable isotopes. Bosner MS, Ostlund RE Jr, Osofisan O, Grosklos J, Fritschle C, Lange LG, J Lipid Res 1993 34 6 1047 1053 8354952 (Pubitemid 23182702)
35. Effect of ursodeoxycholic acid on cholesterol absorption and metabolism in humans. Woollett LA, Buckley DD, Yao L, Jones PJ, Granholm NA, Tolley EA, Heubi JE, J Lipid Res 2003 44 5 935 942 10.1194/jlr.M200478-JLR200 12611908 (Pubitemid 37279654)
36. Human cholesterol synthesis measurement using deuterated water, Theoretical and procedural considerations. Jones PJ, Leitch CA, Li ZC, Connor WE, Arterioscler Thromb 1993 13 2 247 253 10.1161/01.ATV.13.2.247 8381301 (Pubitemid 23056798)
37. Restriction isotyping of human apolipoprotein A-IV: rapid typing of known isoforms and detection of a new isoform that deletes a conserved repeat. Hixson JE, Powers PK, J Lipid Res 1991 32 9 1529 1535 1684380
38. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. Hixson JE, Vernier DT, J Lipid Res 1990 31 3 545 548 2341813 (Pubitemid 20107994)