Quantification of islet loss and graft functionality during immune rejection by 3-tesla MRI in a rat model

Transplantation

Volumn 96, Issue 5, 2013, Pages 438-444

  Borot, Sophie ^a,b   Crowe, Lindsey A ^a   Parnaud, Géraldine ^a   Ris, Frédéric ^a   Meier, Raphael ^a   Giovannoni, Laurianne ^a   Müller, Yannick D ^a   Lacotte, Stéphanie ^a   Morel, Philippe ^a   Toso, Christian ^a   Bosco, Domenico ^a   Vallee, Jean Paul ^a   Berney, Thierry ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b UNIVERSITÉ DE FRANCHE COMTÉ   (France)

Author keywords

Islet graft monitoring; Magnetic resonance imaging; Rat islet transplantation; Superparamagnetic iron oxide nanoparticles; Xenograft.

Indexed keywords

FERUCARBOTRAN; LYMPHOCYTE ANTIBODY; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE;

ALLOGRAFT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DIAGNOSTIC ACCURACY; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GRAFT RECIPIENT; GRAFT REJECTION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPERGLYCEMIA; IMMUNOSUPPRESSIVE TREATMENT; ISOGRAFT; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; PANCREAS ISLET; PANCREAS ISLET TRANSPLANTATION; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; RAT; SENSITIVITY AND SPECIFICITY; SIGNAL DETECTION;

ANIMALS; ANTILYMPHOCYTE SERUM; GRAFT REJECTION; IMMUNOSUPPRESSION; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MAGNETIC RESONANCE IMAGING; MAGNETITE NANOPARTICLES; MALE; RATS; RATS, INBRED BN; RATS, INBRED LEW;

EID: 84883558853     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e31829b080f     Document Type: Article

References (31)

1. Shapiro AM, Ricordi C, Hering BJ, et al. International trial of the Edmonton protocol for islet transplantation. N Engl J Med 2006; 355: 1318
2. Bellin MD, Barton FB, Heitman A, et al. Potent induction immunotherapy promotes long-term insulin independence after islet transplantation in type 1 diabetes. Am J Transplant 2012; 12: 1576
3. Barton FB, Rickels MR, Alejandro R, et al. Improvement in outcomes of clinical islet transplantation: 1999Y2010. Diabetes Care 2012; 35: 1436
4. Gruessner AC, Sutherland DE, Gruessner RW. Long-termoutcome after pancreas transplantation. Curr Opin Organ Transplant 2012; 17: 100
5. Roelen DL, Huurman VA, Hilbrands R, et al. Relevance of cytotoxic alloreactivity under different immunosuppressive regimens in clinical islet cell transplantation. Clin Exp Immunol 2009; 156: 141
6. Huurman VA, Velthuis JH, Hilbrands R, et al. Allograft-specific cytokine profiles associate with clinical outcome after islet cell transplantation. Am J Transplant 2009; 9: 382
7. Huurman VA, Hilbrands R, Pinkse GG, et al. Cellular islet autoimmunity associates with clinical outcome of islet cell transplantation. PloS One 2008; 3: e2435
8. Bellin MD, Sutherland DE, Beilman GJ, et al. Similar islet function in islet allotransplant and autotransplant recipients, despite lower islet mass in autotransplants. Transplantation 2011; 91: 367
9. Niclauss N, Bosco D, Morel P, et al. Rapamycin impairs proliferation of transplanted islet beta cells. Transplantation 2011; 91: 714
10. Berney T, Toso C. Monitoring of the islet graft. Diabetes Metab 2006; 32: 503
11. Ferrari-Lacraz S, Berney T, Morel P, et al. Low risk of anti-human leukocyte antigen antibody sensitization after combined kidney and islet transplantation. Transplantation 2008; 86: 357
12. Bosi E, Braghi S, Maffi P, et al. Autoantibody response to islet transplantation in type 1 diabetes. Diabetes 2001; 50: 2464
13. Kessler L, Parissiadis A, Bayle F, et al. Evidence for humoral rejection of a pancreatic islet graft and rescue with rituximab and IV immunoglobulin therapy. Am J Transplant 2009; 9: 1961
14. Lacotte S, Berney T, Shapiro AJ, et al. Immune monitoring of pancreatic islet graft: towards a better understanding, detection and treatment of harmful events. Expert Opin Biol Ther 2011; 11: 55
15. Toso C, Isse K, Demetris AJ, et al. Histologic graft assessment after clinical islet transplantation. Transplantation 2009; 88: 1286
16. Jirak D, Kriz J, Herynek V, et al. MRI of transplanted pancreatic islets. Magn Reson Med 2004; 52: 1228
17. Ris F, Lepetit-Coiffe M, Meda P, et al. Assessment of human islet labeling with clinical grade iron nanoparticles prior to transplantation for graft monitoring by MRI. Cell Transplant 2010; 19: 1573
18. Malosio ML, Esposito A, Poletti A, et al. Improving the procedure for detection of intrahepatic transplanted islets by magnetic resonance imaging. Am J Transplant 2009; 9: 2372
19. Toso C, Vallee JP, Morel P, et al. Clinical magnetic resonance imaging of pancreatic islet grafts after iron nanoparticle labeling. Am J Transplant 2008; 8: 701
20. Crowe LA, Ris F, Nielles-Vallespin S, et al. A novel method for quantitative monitoring of transplanted islets of langerhans by positive contrast magnetic resonance imaging. Am J Transplant 2011; 11: 1158
21. Kriz J, Jirak D, Girman P, et al. Magnetic resonance imaging of pancreatic islets in tolerance and rejection. Transplantation 2005; 80: 1596
22. Evgenov NV, Medarova Z, Pratt J, et al. In vivo imaging of immune rejection in transplanted pancreatic islets. Diabetes 2006; 55: 2419
23. Kriz J, Jirak D, Berkova Z, et al. Detection of pancreatic islet allograft impairment in advance of functional failure using magnetic resonance imaging. Transpl Int 2012; 25: 250
24. Saudek F, Jirak D, Girman P, et al. Magnetic resonance imaging of pancreatic islets transplanted into the liver in humans. Transplantation 2010; 90: 1602
25. Eriksson O, Eich T, Sundin A, et al. Positron emission tomography in clinical islet transplantation. Am J Transplant 2009; 9: 2816
26. Kim JH, Jin SM, Oh SH, et al. Counting small hypointense spots confounds the quantification of functional islet mass based on islet MRI. Am J Transplant 2012; 12: 1303
27. Zacharovova K, Berkova Z, Jirak D, et al. Processing of superparamagnetic iron contrast agent ferucarbotran in transplanted pancreatic islets. Contrast Media Mol Imaging 2012; 7: 485
28. Evgenov NV, Pratt J, Pantazopoulos P, et al. Effects of glucose toxicity and islet purity on in vivo magnetic resonance imaging of transplanted pancreatic islets. Transplantation 2008; 85: 1091
29. Ricordi C, Lacy PE, Finke EH, et al. Automated method for isolation of human pancreatic islets. Diabetes 1988; 37: 413
30. Bucher P, Mathe Z, Morel P, et al. Assessment of a novel twocomponent enzyme preparation for human islet isolation and transplantation. Transplantation 2005; 79: 91
31. Pepper AR, Gall C, Mazzuca DM, et al. Diabetic rats and mice are resistant to porcine and human insulin: flawed experimental models for testing islet xenografts. Xenotransplantation 2009; 16: 502.