Outcome effectiveness of the severe sepsis resuscitation bundle with addition of lactate clearance as a bundle item: A multi-national evaluation

Critical Care

Volumn 15, Issue 5, 2011, Pages

  Nguyen, H Bryant ^a,b   Kuan, Win S ^c   Batech, Michael ^a   Shrikhande, Pinak ^d   Mahadevan, Malcolm ^c   Li, Chih Huang ^e,f   Ray, Sumit ^g   Dengel, Anna ^b  

^a LOMA LINDA UNIVERSITY   (United States)

^b LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL UNIVERSITY HEALTH SYSTEM   (Singapore)

^d FORTIS HOSPITAL   (India)

^e CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^f CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^g SIR GANGA RAM HOSPITAL   (India)

Author keywords

[No Author keywords available]

Indexed keywords

LACTIC ACID;

ADULT; AGED; ARTICLE; ASIA; CENTRAL VENOUS PRESSURE; CONTROLLED STUDY; DISEASE SEVERITY; EMERGENCY WARD; FEMALE; FLUID THERAPY; GENERAL CONDITION IMPROVEMENT; HEALTH CARE QUALITY; HEALTH PROGRAM; HUMAN; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; MORTALITY; OUTCOME ASSESSMENT; OXYGEN SATURATION; PRACTICE GUIDELINE; PRIORITY JOURNAL; RESUSCITATION; SEPSIS; SURVIVING SEPSIS CAMPAIGN RESUSCITATION BUNDLE; TERTIARY HEALTH CARE; METABOLIC CLEARANCE RATE; METHODOLOGY; MIDDLE AGED; PROSPECTIVE STUDY; STATISTICS; TREATMENT OUTCOME;

AGED; ASIA; FEMALE; GUIDELINE ADHERENCE; HUMANS; LACTIC ACID; MALE; METABOLIC CLEARANCE RATE; MIDDLE AGED; PRACTICE GUIDELINES AS TOPIC; PROSPECTIVE STUDIES; RESUSCITATION; SEPSIS; TREATMENT OUTCOME;

EID: 80053341456     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc10469     Document Type: Article

References (33)

1. Dombrovskiy VY, Martin AA, Sunderram J, Paz HL. Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003. Crit Care Med 2007, 35:1244-1250. 10.1097/01.CCM.0000261890.41311.E9, 17414736.
2. Harrison DA, Welch CA, Eddleston JM. The epidemiology of severe sepsis in England, Wales and Northern Ireland, 1996 to 2004: secondary analysis of a high quality clinical database, the ICNARC Case Mix Programme Database. Crit Care 2006, 10:R42. 10.1186/cc4854, 1550902, 16542492.
3. Shen HN, Lu CL, Yang HH. Epidemiologic trend of severe sepsis in Taiwan from 1997 through 2006. Chest 2010, 138:298-304. 10.1378/chest.09-2205, 20363844.
4. Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, Reinhart K, Angus DC, Brun-Buisson C, Beale R, Calandra T, Dhainaut JF, Gerlach H, Harvey M, Marini JJ, Marshall J, Ranieri M, Ramsay G, Sevransky J, Thompson BT, Townsend S, Vender JS, Zimmerman JL, Vincent JL. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008, 36:296-327. 10.1097/01.CCM.0000298158.12101.41, 18158437.
5. Ferrer R, Artigas A, Levy MM, Blanco J, Gonzalez-Diaz G, Garnacho-Montero J, Ibanez J, Palencia E, Quintana M, de la Torre-Prados MV. Improvement in process of care and outcome after a multicenter severe sepsis educational program in Spain. JAMA 2008, 299:2294-2303. 10.1001/jama.299.19.2294, 18492971.
6. Levy MM, Dellinger RP, Townsend SR, Linde-Zwirble WT, Marshall JC, Bion J, Schorr C, Artigas A, Ramsay G, Beale R, Parker MM, Gerlach H, Reinhart K, Silva E, Harvey M, Regan S, Angus DC. The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Crit Care Med 2010, 38:367-374. 10.1097/CCM.0b013e3181cb0cdc, 20035219.
7. Suarez D, Ferrer R, Artigas A, Azkarate I, Garnacho-Montero J, Goma G, Levy MM, Ruiz JC. Cost-effectiveness of the Surviving Sepsis Campaign protocol for severe sepsis: a prospective nation-wide study in Spain. Intensive Care Med 2011, 37:444-452. 10.1007/s00134-010-2102-3, 21152895.
8. Jansen TC, van Bommel J, Bakker J. Blood lactate monitoring in critically ill patients: a systematic health technology assessment. Crit Care Med 2009, 37:2827-2839. 10.1097/CCM.0b013e3181a98899, 19707124.
9. Mikkelsen ME, Miltiades AN, Gaieski DF, Goyal M, Fuchs BD, Shah CV, Bellamy SL, Christie JD. Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock. Crit Care Med 2009, 37:1670-1677. 10.1097/CCM.0b013e31819fcf68, 19325467.
10. Okorie ON, Dellinger P. Lactate: biomarker and potential therapeutic target. Crit Care Clin 2011, 27:299-326. 10.1016/j.ccc.2010.12.013, 21440203.
11. Bakker J, Gris P, Coffernils M, Kahn RJ, Vincent JL. Serial blood lactate levels can predict the development of multiple organ failure following septic shock. Am J Surg 1996, 171:221-226. 10.1016/S0002-9610(97)89552-9, 8619454.
12. Nguyen HB, Rivers EP, Knoblich BP, Jacobsen G, Muzzin A, Ressler JA, Tomlanovich MC. Early lactate clearance is associated with improved outcome in severe sepsis and septic shock. Crit Care Med 2004, 32:1637-1642. 10.1097/01.CCM.0000132904.35713.A7, 15286537.
13. Arnold RC, Shapiro NI, Jones AE, Schorr C, Pope J, Casner E, Parrillo JE, Dellinger RP, Trzeciak S. Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis. Shock 2009, 32:35-39. 10.1097/SHK.0b013e3181971d47, 19533847.
14. Sepsis Bundle. Surviving Sepsis Campaign and Institute for Healthcare Improvement. , http://wwwihiorg/IHI/Topics/CriticalCare/Sepsis
15. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001, 345:1368-1377. 10.1056/NEJMoa010307, 11794169.
16. Nguyen HB, Corbett SW, Steele R, Banta J, Clark RT, Hayes SR, Edwards J, Cho T, Wittlake WA. Implementation of a bundle of quality indicators for the early management of severe sepsis and septic shock is associated with decreased mortality. Crit Care Med 2007, 35:1105-1112. 10.1097/01.CCM.0000259463.33848.3D, 17334251.
17. Girardis M, Rinaldi L, Donno L, Marietta M, Codeluppi M, Marchegiano P, Venturelli C. Effects on management and outcome of severe sepsis and septic shock patients admitted to the intensive care unit after implementation of a sepsis program: a pilot study. Crit Care 2009, 13:R143. 10.1186/cc8029, 2784353, 19728879.
18. Castellanos-Ortega A, Suberviola B, Garcia-Astudillo LA, Holanda MS, Ortiz F, Llorca J, Delgado-Rodriguez M. Impact of the Surviving Sepsis Campaign protocols on hospital length of stay and mortality in septic shock patients: results of a three-year follow-up quasi-experimental study. Crit Care Med 2010, 38:1036-1043. 10.1097/CCM.0b013e3181d455b6, 20154597.
19. Coba V, Whitmill M, Mooney R, Horst HM, Brandt MM, Digiovine B, Mlynarek M, McLellan B, Boleski G, Yang J, Conway W, Jordon J. Resuscitation bundle compliance in severe sepsis and septic shock: improves survival, is better late than never. J Intensive Care Med 2011,
20. Mikkelsen ME, Gaieski DF, Goyal M, Miltiades AN, Munson JC, Pines JM, Fuchs BD, Shah CV, Bellamy SL, Christie JD. Factors associated with nonadherence to early goal-directed therapy in the ED. Chest 2010, 138:551-558. 10.1378/chest.09-2210, 2939882, 20173053.
21. Marik PE, Baram M, Vahid B. Does central venous pressure predict fluid responsiveness? A systematic review of the literature and the tale of seven mares. Chest 2008, 134:172-178. 10.1378/chest.07-2331, 18628220.
22. van Beest PA, Hofstra JJ, Schultz MJ, Boerma EC, Spronk PE, Kuiper MA. The incidence of low venous oxygen saturation on admission to the intensive care unit: a multi-center observational study in The Netherlands. Crit Care 2008, 12:R33. 10.1186/cc6811, 2447553, 18318895.
23. Pope JV, Jones AE, Gaieski DF, Arnold RC, Trzeciak S, Shapiro NI. Multicenter study of central venous oxygen saturation (ScvO2) as a predictor of mortality in patients with sepsis. Ann Emerg Med 2010, 55:40-46. e41, 10.1016/j.annemergmed.2009.08.014, 2828585, 19854541.
24. Gunn SR, Fink MP, Wallace B. Equipment review: the success of early goal-directed therapy for septic shock prompts evaluation of current approaches for monitoring the adequacy of resuscitation. Crit Care 2005, 9:349-359. 10.1186/cc3725, 1269450, 16137384.
25. Coen D, Vaccaro A, Cazzaniga M, Cortellaro F, Monti G, Tombini V. Toward a noninvasive approach to early goal-directed therapy. Chest 2011, 139:726-727. 10.1378/chest.10-2632, 21362666.
26. Jones AE, Shapiro NI, Trzeciak S, Arnold RC, Claremont HA, Kline JA. Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA 2010, 303:739-746. 10.1001/jama.2010.158, 2918907, 20179283.
27. Jansen TC, van Bommel J, Schoonderbeek FJ, Sleeswijk Visser SJ, van der Klooster JM, Lima AP, Willemsen SP, Bakker J. Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial. Am J Respir Crit Care Med 2010, 182:752-761. 10.1164/rccm.200912-1918OC, 20463176.
28. Siegel JH, Fabian M, Smith JA, Kingston EP, Steele KA, Wells MR, Kaplan LJ. Oxygen debt criteria quantify the effectiveness of early partial resuscitation after hypovolemic hemorrhagic shock. J Trauma 2003, 54:862-880; discussion 880. 10.1097/01.TA.0000066186.97206.39, 12777899.
29. Barbee RW, Reynolds PS, Ward KR. Assessing shock resuscitation strategies by oxygen debt repayment. Shock 2010, 33:113-122. 10.1097/SHK.0b013e3181b8569d, 20081495.
30. Sakr Y, Dubois MJ, De Backer D, Creteur J, Vincent JL. Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock. Crit Care Med 2004, 32:1825-1831. 10.1097/01.CCM.0000138558.16257.3F, 15343008.
31. Ranucci M, Isgro G, Carlucci C, De La Torre T, Enginoli S, Frigiola A. Central venous oxygen saturation and blood lactate levels during cardiopulmonary bypass are associated with outcome after pediatric cardiac surgery. Crit Care 2010, 14:R149. 2945132, 20684758.
32. Sauneuf B, Charbonneau P. Lactate clearance and central venous oxygen saturation in early sepsis. JAMA 2010, 303:2031. author reply 2031-2032.
33. Ho BC, Bellomo R, McGain F, Jones D, Naka T, Wan L, Braitberg G. The incidence and outcome of septic shock patients in the absence of early-goal directed therapy. Crit Care 2006, 10:R80. 10.1186/cc4918, 1550929, 16704743.