PEGylation of HPMA-based block copolymers enhances tumor accumulation in vivo: A quantitative study using radiolabeling and positron emission tomography

Journal of Controlled Release

Volumn 172, Issue 1, 2013, Pages 77-85

  Allmeroth, Mareli ^a   Moderegger, Dorothea ^a   Gündel, Daniel ^c   Buchholz, Hans Georg ^b   Mohr, Nicole ^a   Koynov, Kaloian ^d   Rösch, Frank ^a   Thews, Oliver ^c   Zentel, Rudolf ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^c MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^d MAX PLANCK INSTITUTE FOR POLYMER RESEARCH   (Germany)

Author keywords

Fluorine 18 labeling; HPMA; PEG; PET; Structure property relationships; Walker 256 mammary carcinoma

Indexed keywords

CONTROLLED RADICAL POLYMERIZATION; DEGREE OF POLYMERIZATION; FLUORINE-18; HPMA; HYDROPHILIC/HYDROPHOBIC; MAMMARY CARCINOMA; SMALL ANIMAL POSITRON EMISSION TOMOGRAPHIES; STRUCTURE PROPERTY RELATIONSHIPS;

AGGREGATES; BLOCK COPOLYMERS; CHAINS; DRUG THERAPY; HYDROPHILICITY; POLYETHYLENE OXIDES; POLYETHYLENE TEREPHTHALATES; POLYMERIZATION; POLYMERS; POSITRON EMISSION TOMOGRAPHY; TUMORS;

POLYETHYLENE GLYCOLS;

COPOLYMER; DIOXANE; MACROGOL; N (2 HYDROXYPROPYL)METHACRYLAMIDE; TRIETHYLAMINE; TYRAMINE;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; ARTICLE; BLOOD; BREAST CARCINOMA; HEART; IN VIVO STUDY; ISOTOPE LABELING; KIDNEY; KIDNEY CLEARANCE; LUNG; MUSCLE; NONHUMAN; ORGAN DISTRIBUTION; POLYMERIZATION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE STUDY; RAT; SMALL INTESTINE; SPLEEN;

FLUORINE-18 LABELING; HPMA; PEG; PET; STRUCTURE-PROPERTY RELATIONSHIPS; WALKER 256 MAMMARY CARCINOMA;

ANIMALS; FLUORINE RADIOISOTOPES; MALE; MAMMARY NEOPLASMS, ANIMAL; METHACRYLATES; MICELLES; POLYETHYLENE GLYCOLS; POSITRON-EMISSION TOMOGRAPHY; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

EID: 84883550358     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.07.027     Document Type: Article

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