Inversion of enantioselectivity of a mononuclear non-heme iron(II)-dependent hydroxylase by tuning the interplay of metal-center geometry and protein structure

Angewandte Chemie - International Edition

Volumn 52, Issue 37, 2013, Pages 9677-9681

  Pratter, Sarah M ^a   Konstantinovics, Cornelia ^a   Di Giuro, Cristiana M L ^a   Leitner, Erich ^a   Kumar, Devesh ^b   De Visser, Sam P ^c   Grogan, Gideon ^d   Straganz, Grit D ^a  

^a GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

^b BABASAHEB BHIMRAO AMBEDKAR UNIVERSITY   (India)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

^d UNIVERSITY OF YORK   (United Kingdom)

Author keywords

asymmetric catalysis; hydroxylation; metalloenzymes; non heme iron; protein design

Indexed keywords

ASYMMETRIC CATALYSIS; HYDROXYLASES; IRON CENTERS; METAL CENTERS; METALLOENZYMES; PROTEIN DESIGN; PROTEIN STRUCTURES; SUBSTRATE LIGANDS;

ENANTIOSELECTIVITY; HYDROXYLATION; PORPHYRINS;

PROTEINS;

IRON; MIXED FUNCTION OXIDASE;

ARTICLE; ASYMMETRIC CATALYSIS; BIOCATALYSIS; CHEMISTRY; HYDROXYLATION; KINETICS; METABOLISM; METALLOENZYMES; NON-HEME IRON; PROTEIN DESIGN; PROTEIN TERTIARY STRUCTURE; STEREOISOMERISM; X RAY CRYSTALLOGRAPHY;

ASYMMETRIC CATALYSIS; HYDROXYLATION; METALLOENZYMES; NON-HEME IRON; PROTEIN DESIGN;

BIOCATALYSIS; CRYSTALLOGRAPHY, X-RAY; HYDROXYLATION; IRON; KINETICS; MIXED FUNCTION OXYGENASES; PROTEIN STRUCTURE, TERTIARY; STEREOISOMERISM;

EID: 84883548416     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201304633     Document Type: Article

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