Product analysis and inhibition studies of a causative asn to ser variant of 4-hydroxyphenylpyruvate dioxygenase suggest a simple route to the treatment of Hawkinsinuria

Biochemistry

Volumn 49, Issue 33, 2010, Pages 7218-7226

  Brownlee, June M ^a   Heinz, Brian ^a   Bates, Judith ^a   Moran, Graham R ^a  

^a UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4-HYDROXYPHENYLPYRUVATE DIOXYGENASE; AUTOSOMAL DOMINANTS; BINDING MECHANISMS; CARBOXYMETHYL; CELLULAR THIOLS; EARLY LIFE; HISTORY OF USE; HOMOGENTISATE; METABOLIC ACIDOSIS; MICHAEL ADDITIONS; PRODUCT ANALYSIS; PROPANOIC ACID; SIGNIFICANT IMPACTS; STREPTOMYCES AVERMITILIS; TRIFLUOROMETHYL; WILD TYPES; WILD-TYPE ENZYMES;

ACIDS; ADDITION REACTIONS; AMINO ACIDS; ENCODING (SYMBOLS); ENZYME INHIBITION; ENZYMES; GENE ENCODING; PHOSPHATASES; RATE CONSTANTS;

DIAGNOSIS;

2 [2 NITRO 4 (TRIFLUOROMETHYL)BENZOYL] 1,3 CYCLOHEXANEDIONE; 4 HYDROXYPHENYLPYRUVATE DIOXYGENASE; ACETIC ACID DERIVATIVE; AMINO ACID; ASPARAGINE; ENZYME VARIANT; HAWKINSIN; HOMOGENTISIC ACID; OXYGENASE INHIBITOR; SERINE; THIOL; UNCLASSIFIED DRUG; CYCLOHEXANONE DERIVATIVE; NITISINONE; NITROBENZOIC ACID DERIVATIVE; QUINOLACETIC ACID; QUINONE DERIVATIVE;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; DRUG PROTEIN BINDING; ENZYME ACTIVITY; ENZYME PURIFICATION; ENZYME STABILITY; GENE MUTATION; GENETIC CONSERVATION; HAWKINSINURIA; METABOLIC ACIDOSIS; MICHAEL ADDITION; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; WILD TYPE; AMINO ACID SEQUENCE; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; ENZYMOLOGY; ESCHERICHIA COLI; GENE EXPRESSION; GENETICS; HUMAN; INFANT; ISOLATION AND PURIFICATION; METABOLIC DISORDER; METABOLISM; MOLECULAR GENETICS; MUTATION; RAT; SEQUENCE ALIGNMENT; STREPTOMYCES;

4-HYDROXYPHENYLPYRUVATE DIOXYGENASE; AMINO ACID SEQUENCE; ANIMALS; CYCLOHEXANONES; ESCHERICHIA COLI; GENE EXPRESSION; HUMANS; INFANT; METABOLIC DISEASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; NITROBENZOATES; QUINONES; RATS; SEQUENCE ALIGNMENT; STREPTOMYCES;

RATTUS; STREPTOMYCES AVERMITILIS;

EID: 77955687869     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi1008112     Document Type: Article

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