A pilot trial assessing urinary gene expression profiling with an mRNA array for diabetic nephropathy

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Zheng, Min ^a   Lv, Lin Li ^a   Cao, Yu Han ^a   Liu, Hong ^a   Ni, Jie ^a   Dai, Hou Yong ^a   Liu, Dan ^a   Lei, Xiang Dong ^b   Liu, Bi Cheng ^a  

^a MEDICAL SCHOOL OF SOUTHEAST UNIVERSITY   (China)

^b CT Bioscience   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ACTININ 4; CONNECTIVE TISSUE GROWTH FACTOR; DIPEPTIDYL CARBOXYPEPTIDASE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; NOTCH3 RECEPTOR; PLASMINOGEN ACTIVATOR INHIBITOR 1; SYNAPTOPODIN; TISSUE INHIBITOR OF METALLOPROTEINASE 4; TRANSCRIPTION FACTOR TWIST;

ACE GENE; ADULT; AGED; ALPHA ACTININ 4 GENE; ARTICLE; CDH1 GENE; CDH2 GENE; CLINICAL ARTICLE; COLLAGEN TYPE 4ALPHA GENE; CONTROLLED STUDY; CTGF GENE; DIABETIC NEPHROPATHY; DISEASE COURSE; FAT1 GENE; FEMALE; GENE; GENE EXPRESSION PROFILING; GENE TARGETING; GENETIC ASSOCIATION; GLOMERULUS FILTRATION RATE; HIGH THROUGHPUT SEQUENCING; HUMAN; MALE; MCP 1 GENE; MICROARRAY ANALYSIS; NOTCH3 GENE; PAI 1 GENE; PATHOPHYSIOLOGY; PILOT STUDY; REAL TIME POLYMERASE CHAIN REACTION; RENAL SYSTEM PARAMETERS; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SYNAPTOPODIN GENE; TIMP 1 GENE; TWIST GENE; URINARY CELL PELLET; URINE SEDIMENT;

ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; DIABETIC NEPHROPATHIES; FEMALE; GENE EXPRESSION PROFILING; HUMANS; MALE; MASS SCREENING; MICROARRAY ANALYSIS; MIDDLE AGED; PILOT PROJECTS; REPRODUCIBILITY OF RESULTS; RNA, MESSENGER; SENSITIVITY AND SPECIFICITY;

EID: 84862093969     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0034824     Document Type: Article

References (24)

1. Atkins RC, Zimmet P, (2010) World Kidney Day 2010: diabetic kidney disease-act now or pay later. Am J Kidney Dis 55: 205-8.
2. Chang SS, (2008) Albuminuria and diabetic nephropathy. Pediatr Endocrinol Rev 5 (Suppl 4): 974-9.
3. Macisaac RJ, Jerums G, (2011) Diabetic kidney disease with and without albuminuria. Curr Opin Nephrol Hypertens 20: 246-57.
4. Navarro-Gonzalez JF, Mora-Fernandez C, Muros de Fuentes M, Garcia-Perez J, (2011) Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy. Nat Rev Nephrol 7: 327-40.
5. Li MX, Liu BC, (2007) Epithelial to mesenchymal transition in the progression of tubulointerstitial fibrosis. Chin Med J (Engl) 120: 1925-30.
6. Tesch GH, Lim AK, (2011) Recent insights into diabetic renal injury from the db/db mouse model of type 2 diabetic nephropathy. Am J Physiol Renal Physiol 300: F301-10.
7. Menzel S, Moeller MJ, (2011) Role of the podocyte in proteinuria. Pediatr Nephrol 26: 1775-80.
8. Muthukumar T, Dadhania D, Ding R, Snopkowski C, Naqvi R, et al. (2005) Messenger RNA for FOXP3 in the urine of renal-allograft recipients. N Engl J Med 353: 2342-51.
9. Wang G, Lai FM, Lai KB, Chow KM, Kwan CH, et al. (2008) Urinary mRNA expression of ACE and ACE2 in human type 2 diabetic nephropathy. Diabetologia 51: 1062-7.
10. Zheng M, Lv LL, Ni J, Ni HF, Li Q, et al. (2011) Urinary podocyte-associated mRNA profile in various stages of diabetic nephropathy. PLoS One 6: e20431.
11. Zheng M, Lv LL, Cao YH, Zhang JD, Wu M, et al. (2011) Urinary mRNA markers of epithelial-mesenchymal transition correlate with progression of diabetic nephropathy. Clin Endocrinol (Oxf). [Epub ahead of print].
12. Roepman P, (2010) The future of diagnostic gene-expression microarrays: bridging the gap between bench and bedside. Bioanalysis 2: 249-62.
13. Svensson K, Granberg M, Karlsson L, Neubauerova V, Forsman M, et al. (2009) A real-time PCR array for hierarchical identification of Francisella isolates. PLoS One 4: e8360.
14. Munshi R, Johnson A, Siew ED, Ikizler TA, Ware LB, et al. (2011) MCP-1 gene activation marks acute kidney injury. J Am Soc Nephrol 22: 165-75.
15. Rodder S, Scherer A, Korner M, Marti HP, (2011) A subset of metzincins and related genes constitutes a marker of human solid organ fibrosis. Virchows Arch 458: 487-96.
16. Wu CC, Chen JS, Huang CF, Chen CC, Lu KC, et al. (2011) Approaching biomarkers of membranous nephropathy from a murine model to human disease. J Biomed Biotechnol 581928.
17. Petermann AT, Krofft R, Blonski M, Hiromura K, Vaughn M, et al. (2003) Podocytes that detach in experimental membranous nephropathy are viable. Kidney Int 64: 1222-31.
18. Vogelmann SU, Nelson WJ, Myers BD, Lemley KV, (2003) Urinary excretion of viable podocytes in health and renal disease. Am J Physiol Renal Physiol 285: F40-8.
19. Tam FW, Riser BL, Meeran K, Rambow J, Pusey CD, et al. (2009) Urinary monocyte chemoattractant protein-1 (MCP-1) and connective tissue growth factor (CCN2) as prognostic markers for progression of diabetic nephropathy. Cytokine 47: 37-42.
20. Huang Y, Border WA, Yu L, Zhang J, Lawrence DA, et al. (2008) A PAI-1 mutant, PAI-1R, slows progression of diabetic nephropathy. J Am Soc Nephrol 19: 329-38.
21. Chawla T, Sharma D, Singh A, (2010) Role of the renin angiotensin system in diabetic nephropathy. World J Diabetes 1: 141-5.
22. Liu Y, (2010) New insights into epithelial-mesenchymal transition in kidney fibrosis. J Am Soc Nephrol 21: 212-22.
23. National Kidney Foundation (2007) KDOQI Clinical Practice Guidelines and Clinical Practice Recommendations for Diabetes and Chronic Kidney Disease. Am J Kidney Dis 49: S12-154.
24. Ma YC, Zuo L, Chen JH, Luo Q, Yu XQ, et al. (2006) Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease. J Am Soc Nephrol 17: 2937-44.