Differentiation-inducing activity of neomycin in cultured rat glioma cells

Neurological Research

Volumn 26, Issue 4, 2004, Pages 401-403

  Cuevas, Pedro ^a,b   Díaz González, Diana ^a   Dujovny, Manuel ^b  

^a HOSPITAL RAMÓN Y CAJAL   (Spain)

^b WAYNE STATE UNIVERSITY   (United States)

Author keywords

Brain tumor treatment; Cellular differentiation; Glial fibrillary acidic protein; Glioma C6 cells; Neomycin

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; NEOMYCIN;

ANIMAL CELL; ARTICLE; ASTROCYTE; CANCER CELL CULTURE; CARCINOGENIC ACTIVITY; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; DRUG ACTIVITY; GLIOMA CELL; NONHUMAN; PROTEIN EXPRESSION; RAT;

ANIMALS; BRAIN NEOPLASMS; CELL COUNT; CELL DIFFERENTIATION; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIOMA; IMMUNOHISTOCHEMISTRY; NEOMYCIN; PROTEIN SYNTHESIS INHIBITORS; RATS; TUMOR CELLS, CULTURED;

EID: 2942614751     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1179/016164104225016317     Document Type: Article

References (23)

1. Bauteria H, Picht T, Keb D, et al. Retinoids inhibit human glioma cell proliferation and migration in primary cell cultures but not in established cell lines. Neurosurgery 2000; 46: 419-430
2. Beere HM, Kickman JA. Differentiation: A suitable strategy for cancer chemotherapy? Anticancer Drug Des 1993; 8: 299-322
3. Dirks PB, Patel K, Hubbard SL, et al. Retinoic acid and the cyclin dependent kinase inhibitors synergistically alter proliferation and morphology of U343 astrocytoma cells. Oncogene 1997; 15: 2037-2048
4. Ebert PS, Salcman M. Differentiation therapy is potentiated by chemotherapy and hyperthermia in human and canine brain tumor cells in vitro. Neurosurgery 1994; 34: 657-664
5. Engelhard HH, Duncan HA, Dal Canto M. Molecular characterization of glioblastoma cell differentiation. Neurosurgery 1997; 41: 886-897
6. Linskey ME, Gilbert MR. Glial differentiation: A review with implications for new directions in neuro-oncology. Neurosurgery 1995; 36: 1-22
7. Samid D, Shock S, Myers CE. Selective growth arrest and phenotypic reversion of prostate cancer cells in vitro by nontoxic pharmacological concentration of phenylacetate. J Clin Invest 1993; 91: 2288-2295
8. Cuevas P, Díaz-González D, Carceller F, et al. Dual blockade of mitogen-activated protein kinases ERK-1 (p42) and ERK-2 (p44) and cyclic AMP response element binding protein (CREB) by neomycin inhibits glioma cell proliferation. Neurol Res 2003; 25: 13-16
9. Bignam, A, Dahl D, Rueger DC. Glial fibrillary acidic (GFA) protein in normal neural cells and in pathological conditions. In: Advances in cellular neurobiology. New York: Academic Press, 1980: Vol. 1, pp. 285-310
10. Bogcam-Rudloff E, Nister M, Betsholtz C, et al. Human glial fibrillary acidic protein: Complementary DNA cloning, chromosome localization, and messenger RNA expression in human glioma cell lines of various phenotypes. Cancer Res 1991; 51: 1553-1560
11. Deck JH, Eng LF. The role of GFAP in the diagnosis of CNS tumors. Acta Neuropathol 1978; 42: 183-190
12. Delpech B, Delpech A, Vidard MN. GFAP in tumors of the CNS. Br J Cancer 1978; 37: 33-40
13. Thibault A, Samid D, Cooper MR, et al. Phase I study of phenylacetate administered twice daily to patients with cancer. Cancer 1995; 75: 2932-2938
14. Rutka JT, De Armond SJ, Giblin J, et al. Effect of retinoids on the proliferation, morphology and expression of glial fibrillary acidic protein of an anaplastic astrocytoma cell line. Int J Cancer 1988; 42: 419-427
15. Rutka JT, Smith SL. Transfection of human astrocytoma cells with glial fibrillary acidic protein complementary DNA: Analysis of expression, proliferation and tumorigenicity. Cancer Res 1993; 53: 3624-3631
16. Rutka JT, Hubbard SL, Fukuyama K, et al. Effects of antisense glial fibrillary acidic protein complementary DNA on the growth, invasion and adhesion of human astrocytoma cells. Cancer Res 1994; 54: 3267-3272
17. Fearon ER, Cho KR, Nigro JM, et al. Identification of a chromosome 18q gene that is altered in colorectal cancers. Science 1990; 247: 49-56
18. Martindale. In: Reynolds JEF, eds. The extra pharmacopoeia. London: The Pharmaceutical Press, 1989: pp. 268-269
19. Safiejki-Mroczka B, Bell PB. The induction of protrusion by neomycin in human gliomal cells is correlated with a decrease followed by an increase in filamentous actin. Cell Biol Int 1995; 19: 655-674
20. Cuevas P, Díaz-González D, Dujovny M. Antiproliferative effect of neomycin in glioma cells. Neurol Res 2002; 24: 389-391
21. Cuevas P, Díaz-González D, Dujovny M. Antiproliferative action of neomycin is associated with inhibition of cyclin D1 activation in glioma cells. Neurol Res 2003; 25: 691-693
22. Hu G-F. Neomycin inhibits the angiogenic activity of fibroblast and epidermal growth factors. Biochem Biophys Res Commun 2001; 287: 870-874
23. Cuevas P, Díaz-González D, Dujovny M. Glioma cell-associated sustained activation of the transcription factor, nuclear factor-KB, was inhibited by neomycin. Neurol Res 2003; 25: 271-274