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Volumn 123, Issue 9, 2013, Pages 4050-4062

A feed-forward spinal cord glycinergic neural circuit gates mechanical allodynia

Author keywords

[No Author keywords available]

Indexed keywords

6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; AMYLOID BETA PROTEIN; BICUCULLINE; CAPSAICIN; GLYCINE; GLYCINE RECEPTOR; PROTEIN KINASE C GAMMA; STRYCHNINE;

EID: 84883515305     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI70026     Document Type: Article
Times cited : (222)

References (65)
  • 1
    • 0013851199 scopus 로고
    • Pain mechanisms: A new theory
    • Melzack R, Wall PD. Pain mechanisms: a new theory. Science. 1965;150(3699):971-979.
    • (1965) Science , vol.150 , Issue.3699 , pp. 971-979
    • Melzack, R.1    Wall, P.D.2
  • 2
    • 67349202612 scopus 로고    scopus 로고
    • Models and mechanisms of hyperalgesia and allodynia
    • Sandkuhler J. Models and mechanisms of hyperalgesia and allodynia. Physiol Rev. 2009;89(2):707-758.
    • (2009) Physiol Rev , vol.89 , Issue.2 , pp. 707-758
    • Sandkuhler, J.1
  • 3
    • 78650517458 scopus 로고    scopus 로고
    • Neuronal circuitry for pain processing in the dorsal horn
    • Todd AJ. Neuronal circuitry for pain processing in the dorsal horn. Nat Rev Neurosci. 2010;11(12):823-836.
    • (2010) Nat Rev Neurosci , vol.11 , Issue.12 , pp. 823-836
    • Todd, A.J.1
  • 4
    • 84856741217 scopus 로고    scopus 로고
    • Fast synaptic inhibition in spinal sensory processing and pain control
    • Zeilhofer HU, Wildner H, Yevenes GE. Fast synaptic inhibition in spinal sensory processing and pain control. Physiol Rev. 2012;92(1):193-235.
    • (2012) Physiol Rev , vol.92 , Issue.1 , pp. 193-235
    • Zeilhofer, H.U.1    Wildner, H.2    Yevenes, G.E.3
  • 5
    • 77954615594 scopus 로고    scopus 로고
    • Synaptic pathways and inhibitory gates in the spinal cord dorsal horn
    • Takazawa T, MacDermott AB. Synaptic pathways and inhibitory gates in the spinal cord dorsal horn. Ann N Y Acad Sci. 2010;1198:153-158.
    • (2010) Ann N Y Acad Sci , vol.1198 , pp. 153-158
    • Takazawa, T.1    MacDermott, A.B.2
  • 6
    • 32544460671 scopus 로고    scopus 로고
    • Disinhibition opens the gate to pathological pain signaling in superficial neurokinin 1 receptor-expressing neurons in rat spinal cord
    • DOI 10.1523/JNEUROSCI.4584-05.2006
    • Torsney C, MacDermott AB. Disinhibition opens the gate to pathological pain signaling in superficial neurokinin 1 receptor-expressing neurons in rat spinal cord. J Neurosci. 2006;26(6):1833-1843. (Pubitemid 43236996)
    • (2006) Journal of Neuroscience , vol.26 , Issue.6 , pp. 1833-1843
    • Torsney, C.1    MacDermott, A.B.2
  • 7
    • 17644396711 scopus 로고    scopus 로고
    • Modular organization of excitatory circuits between neurons of the spinal superficial dorsal horn (laminae I and II)
    • DOI 10.1523/JNEUROSCI.0102-05.2005
    • Lu Y, Perl ER. Modular organization of excitatory circuits between neurons of the spinal superficial dorsal horn (laminae I and II). J Neurosci. 2005;25(15):3900-3907. (Pubitemid 40570423)
    • (2005) Journal of Neuroscience , vol.25 , Issue.15 , pp. 3900-3907
    • Lu, Y.1    Perl, E.R.2
  • 8
    • 0141646406 scopus 로고    scopus 로고
    • A specific inhibitory pathway between substantia gelatinosa neurons receiving direct C-fiber input
    • Lu Y, Perl ER. A specific inhibitory pathway between substantia gelatinosa neurons receiving direct C-fiber input. J Neurosci. 2003;23(25):8752-8758. (Pubitemid 37176656)
    • (2003) Journal of Neuroscience , vol.23 , Issue.25 , pp. 8752-8758
    • Lu, Y.1    Perl, E.R.2
  • 9
    • 0022981156 scopus 로고
    • Central projections of identified, unmyelinated (C) afferent fibers innervating mammalian skin
    • Sugiura Y, Lee CL, Perl ER. Central projections of identified, unmyelinated (C) afferent fibers innervating mammalian skin. Science. 1986;234(4774):358-361. (Pubitemid 17181384)
    • (1986) Science , vol.234 , Issue.4774 , pp. 358-361
    • Sugiura, Y.1    Lee, C.L.2    Perl, E.R.3
  • 10
    • 84455178983 scopus 로고    scopus 로고
    • The functional organization of cutaneous low-threshold mechanosensory neurons
    • Li L, et al. The functional organization of cutaneous low-threshold mechanosensory neurons. Cell. 2011;147(7):1615-1627.
    • (2011) Cell , vol.147 , Issue.7 , pp. 1615-1627
    • Li, L.1
  • 11
    • 70349845440 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of pain
    • Basbaum AI, Bautista DM, Scherrer G, Julius D. Cellular and molecular mechanisms of pain. Cell. 2009;139(2):267-284.
    • (2009) Cell , vol.139 , Issue.2 , pp. 267-284
    • Basbaum, A.I.1    Bautista, D.M.2    Scherrer, G.3    Julius, D.4
  • 12
    • 0142151031 scopus 로고    scopus 로고
    • Lack of Evidence for Sprouting of Abeta Afferents into the Superficial Laminas of the Spinal Cord Dorsal Horn after Nerve Section
    • Hughes DI, Scott DT, Todd AJ, Riddell JS. Lack of evidence for sprouting of Abeta afferents into the superficial laminas of the spinal cord dorsal horn after nerve section. J Neurosci. 2003;23(29):9491-9499. (Pubitemid 37352049)
    • (2003) Journal of Neuroscience , vol.23 , Issue.29 , pp. 9491-9499
    • Hughes, D.I.1    Scott, D.T.2    Todd, A.J.3    Riddell, J.S.4
  • 13
    • 0024602581 scopus 로고
    • Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: Effects of modulatory receptor systems and excitatory amino acid antagonists
    • DOI 10.1016/0304-3959(89)90160-7
    • Yaksh TL. Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists. Pain. 1989;37(1):111-123. (Pubitemid 19095624)
    • (1989) Pain , vol.37 , Issue.1 , pp. 111-123
    • Yaksh, T.L.1
  • 15
    • 40049085287 scopus 로고    scopus 로고
    • Spread of excitation across modality borders in spinal dorsal horn of neuropathic rats
    • Schoffnegger D, Ruscheweyh R, Sandkuhler J. Spread of excitation across modality borders in spinal dorsal horn of neuropathic rats. Pain. 2008;135(3):300-310.
    • (2008) Pain , vol.135 , Issue.3 , pp. 300-310
    • Schoffnegger, D.1    Ruscheweyh, R.2    Sandkuhler, J.3
  • 16
    • 36549088202 scopus 로고    scopus 로고
    • Transformation of the output of spinal lamina I neurons after nerve injury and microglia stimulation underlying neuropathic pain
    • Keller AF, Beggs S, Salter MW, De Koninck Y. Transformation of the output of spinal lamina I neurons after nerve injury and microglia stimulation underlying neuropathic pain. Mol Pain. 2007;3:27.
    • (2007) Mol Pain , vol.3 , pp. 27
    • Keller, A.F.1    Beggs, S.2    Salter, M.W.3    De Koninck, Y.4
  • 17
    • 42549170053 scopus 로고    scopus 로고
    • Glycine inhibitory dysfunction turns touch into pain through PKCgamma interneurons
    • Miraucourt LS, Dallel R, Voisin DL. Glycine inhibitory dysfunction turns touch into pain through PKCgamma interneurons. PLoS One. 2007;2(11):e1116.
    • (2007) PLoS One , vol.2 , Issue.11
    • Miraucourt, L.S.1    Dallel, R.2    Voisin, D.L.3
  • 18
    • 61449241737 scopus 로고    scopus 로고
    • Glycine inhibitory dysfunction induces a selectively dynamic, morphine-resistant, and neurokinin 1 receptor-independent mechanical allodynia
    • Miraucourt LS, Moisset X, Dallel R, Voisin DL. Glycine inhibitory dysfunction induces a selectively dynamic, morphine-resistant, and neurokinin 1 receptor-independent mechanical allodynia. J Neurosci. 2009;29(8):2519-2527.
    • (2009) J Neurosci , vol.29 , Issue.8 , pp. 2519-2527
    • Miraucourt, L.S.1    Moisset, X.2    Dallel, R.3    Voisin, D.L.4
  • 19
    • 58849154669 scopus 로고    scopus 로고
    • Low-threshold primary afferent drive onto GABAergic interneurons in the superficial dorsal horn of the mouse
    • Daniele CA, MacDermott AB. Low-threshold primary afferent drive onto GABAergic interneurons in the superficial dorsal horn of the mouse. J Neurosci. 2009;29(3):686-695.
    • (2009) J Neurosci , vol.29 , Issue.3 , pp. 686-695
    • Daniele, C.A.1    MacDermott, A.B.2
  • 20
    • 79956150521 scopus 로고    scopus 로고
    • Glycine inhibitory dysfunction turns touch into pain through astrocyte-derived D-serine
    • Miraucourt LS, Peirs C, Dallel R, Voisin DL. Glycine inhibitory dysfunction turns touch into pain through astrocyte-derived D-serine. Pain. 2011;152(6):1340-1348.
    • (2011) Pain , vol.152 , Issue.6 , pp. 1340-1348
    • Miraucourt, L.S.1    Peirs, C.2    Dallel, R.3    Voisin, D.L.4
  • 21
    • 0030881680 scopus 로고    scopus 로고
    • Preserved acute pain and reduced neuropathic pain in mice lacking PKCgamma
    • DOI 10.1126/science.278.5336.279
    • Malmberg AB, Chen C, Tonegawa S, Basbaum AI. Preserved acute pain and reduced neuropathic pain in mice lacking PKCgamma. Science. 1997;278(5336):279- 283. (Pubitemid 27450873)
    • (1997) Science , vol.278 , Issue.5336 , pp. 279-283
    • Malmberg, A.B.1    Chen, C.2    Tonegawa, S.3    Basbaum, A.I.4
  • 22
    • 51149102303 scopus 로고    scopus 로고
    • Innocuous, not noxious, input activates PKCgamma interneurons of the spinal dorsal horn via myelinated afferent fibers
    • Neumann S, Braz JM, Skinner K, Llewellyn-Smith IJ, Basbaum AI. Innocuous, not noxious, input activates PKCgamma interneurons of the spinal dorsal horn via myelinated afferent fibers. J Neurosci. 2008;28(32):7936-7944.
    • (2008) J Neurosci , vol.28 , Issue.32 , pp. 7936-7944
    • Neumann, S.1    Braz, J.M.2    Skinner, K.3    Llewellyn-Smith, I.J.4    Basbaum, A.I.5
  • 23
    • 0033606406 scopus 로고    scopus 로고
    • The types of neuron which contain protein kinase C gamma in rat spinal cord
    • DOI 10.1016/S0006-8993(99)01500-0, PII S0006899399015000
    • Polgar E, Fowler JH, McGill MM, Todd AJ. The types of neuron which contain protein kinase C gamma in rat spinal cord. Brain Res. 1999;833(1):71-80. (Pubitemid 29336146)
    • (1999) Brain Research , vol.833 , Issue.1 , pp. 71-80
    • Polgar, E.1    Fowler, J.H.2    McGill, M.M.3    Todd, A.J.4
  • 24
    • 0036554701 scopus 로고    scopus 로고
    • Correlations between neuronal morphology and electro-physiological features in the rodent superficial dorsal horn
    • DOI 10.1113/jphysiol.2001.012890
    • Grudt TJ, Perl ER. Correlations between neuronal morphology and electrophysiological features in the rodent superficial dorsal horn. J Physiol. 2002;540(pt 1):189-207. (Pubitemid 35174995)
    • (2002) Journal of Physiology , vol.540 , Issue.1 , pp. 189-207
    • Grudt, T.J.1    Perl, E.R.2
  • 25
    • 77957914572 scopus 로고    scopus 로고
    • Populations of inhibitory and excitatory interneurons in lamina II of the adult rat spinal dorsal horn revealed by a combined electrophysiological and anatomical approach
    • Yasaka T, Tiong SY, Hughes DI, Riddell JS, Todd AJ. Populations of inhibitory and excitatory interneurons in lamina II of the adult rat spinal dorsal horn revealed by a combined electrophysiological and anatomical approach. Pain. 2010;151(2):475-488.
    • (2010) Pain , vol.151 , Issue.2 , pp. 475-488
    • Yasaka, T.1    Tiong, S.Y.2    Hughes, D.I.3    Riddell, J.S.4    Todd, A.J.5
  • 26
    • 77954511622 scopus 로고    scopus 로고
    • Inhibitory neurones of the spinal substantia gelatinosa mediate interaction of signals from primary afferents
    • Zheng J, Lu Y, Perl ER. Inhibitory neurones of the spinal substantia gelatinosa mediate interaction of signals from primary afferents. J Physiol. 2010;588(pt 12):2065-2075.
    • (2010) J Physiol , vol.588 , Issue.PART 12 , pp. 2065-2075
    • Zheng, J.1    Lu, Y.2    Perl, E.R.3
  • 27
    • 0030833052 scopus 로고    scopus 로고
    • Relationship of substance P to afferent characteristics of dorsal root ganglion neurones in guinea-pig
    • Lawson SN, Crepps BA, Perl ER. Relationship of substance P to afferent characteristics of dorsal root ganglion neurones in guinea-pig. J Physiol. 1997;505(pt 1):177-191. (Pubitemid 27504291)
    • (1997) Journal of Physiology , vol.505 , Issue.1 , pp. 177-191
    • Lawson, S.N.1    Crepps, B.A.2    Perl, E.R.3
  • 28
    • 0020052002 scopus 로고
    • Primary afferent units from the hairy skin of the rat hind limb
    • DOI 10.1016/0006-8993(82)90768-5
    • Lynn B, Carpenter SE. Primary afferent units from the hairy skin of the rat hind limb. Brain Res. 1982;238(1):29-43. (Pubitemid 12158434)
    • (1982) Brain Research , vol.238 , Issue.1 , pp. 29-43
    • Lynn, B.1    Carpenter, S.E.2
  • 29
    • 84865648815 scopus 로고    scopus 로고
    • Morphological, neurochemical and electrophysiological features of parvalbumin-expressing cells: A likely source of axo-axonic inputs in the mouse spinal dorsal horn
    • Hughes DI, et al. Morphological, neurochemical and electrophysiological features of parvalbumin-expressing cells: a likely source of axo-axonic inputs in the mouse spinal dorsal horn. J Physiol. 2012;590(pt 16):3927-3951.
    • (2012) J Physiol , vol.590 , Issue.PART 16 , pp. 3927-3951
    • Hughes, D.I.1
  • 30
    • 57049187026 scopus 로고    scopus 로고
    • Spinal cord injury-induced attenuation of GABAergic inhibition in spinal dorsal horn circuits is associated with down-regulation of the chloride transporter KCC2 in rat
    • Lu Y, Zheng J, Xiong L, Zimmermann M, Yang J. Spinal cord injury-induced attenuation of GABAergic inhibition in spinal dorsal horn circuits is associated with down-regulation of the chloride transporter KCC2 in rat. J Physiol. 2008;586(pt 23):5701-5715.
    • (2008) J Physiol , vol.586 , Issue.PART 23 , pp. 5701-5715
    • Lu, Y.1    Zheng, J.2    Xiong, L.3    Zimmermann, M.4    Yang, J.5
  • 31
    • 34347250846 scopus 로고    scopus 로고
    • Selective action of noradrenaline and serotonin on neurones of the spinal superficial dorsal horn in the rat
    • DOI 10.1113/jphysiol.2007.131565
    • Lu Y, Perl ER. Selective action of noradrenaline and serotonin on neurones of the spinal superficial dorsal horn in the rat. J Physiol. 2007;582(pt 1):127-136. (Pubitemid 46993566)
    • (2007) Journal of Physiology , vol.582 , Issue.1 , pp. 127-136
    • Lu, Y.1    Perl, E.R.2
  • 32
    • 66949160335 scopus 로고    scopus 로고
    • Morphological and neurochemical organization of the spinal dorsal horn
    • Basbaum AI, Bushnell MC, eds. Oxford, United Kingdom: Elsevier
    • Ribeiro-da-Silva A, De Koninck Y. Morphological and neurochemical organization of the spinal dorsal horn. In: Basbaum AI, Bushnell MC, eds. Science of Pain. Oxford, United Kingdom: Elsevier; 2009:279-310.
    • (2009) Science of Pain , pp. 279-310
    • Ribeiro-da-Silva, A.1    De Koninck, Y.2
  • 33
    • 34548742876 scopus 로고    scopus 로고
    • Moving from an averaged to specific view of spinal cord pain processing circuits
    • DOI 10.1152/jn.00581.2007
    • Graham BA, Brichta AM, Callister RJ. Moving from an averaged to specific view of spinal cord pain processing circuits. J Neurophysiol. 2007;98(3):1057-1063. (Pubitemid 47435862)
    • (2007) Journal of Neurophysiology , vol.98 , Issue.3 , pp. 1057-1063
    • Graham, B.A.1    Brichta, A.M.2    Callister, R.J.3
  • 34
    • 70350323716 scopus 로고    scopus 로고
    • Mrgprd-expressing polymodal nociceptive neurons innervate most known classes of substantia gelatinosa neurons
    • Wang H, Zylka MJ. Mrgprd-expressing polymodal nociceptive neurons innervate most known classes of substantia gelatinosa neurons. J Neurosci. 2009;29(42):13202-13209.
    • (2009) J Neurosci , vol.29 , Issue.42 , pp. 13202-13209
    • Wang, H.1    Zylka, M.J.2
  • 35
    • 72749093557 scopus 로고    scopus 로고
    • Effects of sciatic nerve axotomy on excitatory synaptic transmission in rat substantia gelatinosa
    • Chen Y, Balasubramanyan S, Lai AY, Todd KG, Smith PA. Effects of sciatic nerve axotomy on excitatory synaptic transmission in rat substantia gelatinosa. J Neurophysiol. 2009;102(6):3203-3215.
    • (2009) J Neurophysiol , vol.102 , Issue.6 , pp. 3203-3215
    • Chen, Y.1    Balasubramanyan, S.2    Lai, A.Y.3    Todd, K.G.4    Smith, P.A.5
  • 36
    • 84894157329 scopus 로고    scopus 로고
    • Properties of spinal lamina III GABAergic neurons in naive and in neuropathic mice
    • published online ahead of print March 7, 2013 doi: 10.1002/j.1532-2149. 2013.00294.x
    • Gassner M, Leitner J, Gruber-Schoffnegger D, Forsthuber L, Sandkuhler J. Properties of spinal lamina III GABAergic neurons in naive and in neuropathic mice [published online ahead of print March 7, 2013]. Eur J Pain. doi: 10.1002/j.1532-2149.2013.00294.x.
    • Eur J Pain
    • Gassner, M.1    Leitner, J.2    Gruber-Schoffnegger, D.3    Forsthuber, L.4    Sandkuhler, J.5
  • 37
    • 11344251617 scopus 로고    scopus 로고
    • Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd
    • DOI 10.1016/j.neuron.2004.12.015, PII S0896627304008037
    • Zylka MJ, Rice FL, Anderson DJ. Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd. Neuron. 2005;45(1):17-25. (Pubitemid 40075346)
    • (2005) Neuron , vol.45 , Issue.1 , pp. 17-25
    • Zylka, M.J.1    Rice, F.L.2    Anderson, D.J.3
  • 38
    • 0034126330 scopus 로고    scopus 로고
    • Long-term intrathecal administration of glycine prevents mechanical hyperalgesia in a rat model of neuropathic pain
    • Huang W, Simpson RK. Long-term intrathecal administration of glycine prevents mechanical hyperalgesia in a rat model of neuropathic pain. Neurol Res. 2000;22(2):160-164. (Pubitemid 30180794)
    • (2000) Neurological Research , vol.22 , Issue.2 , pp. 160-164
    • Huang, W.1    Simpson Jr., R.K.2
  • 39
    • 0031656553 scopus 로고    scopus 로고
    • Milacemide, a glycine pro-drug, inhibits strychnine-allodynia without affecting normal nociception in the rat
    • DOI 10.1016/S0304-3959(98)00086-4, PII S0304395998000864
    • Khandwala H, Loomis CW. Milacemide, a glycine pro-drug, inhibits strychnine-allodynia without affecting normal nociception in the rat. Pain. 1998;77(1):87-95. (Pubitemid 28398838)
    • (1998) Pain , vol.77 , Issue.1 , pp. 87-95
    • Khandwala, H.1    Loomis, C.W.2
  • 40
    • 0029954954 scopus 로고    scopus 로고
    • Reduction in the mechanonociceptive response by intrathecal administration of glycine and related compounds
    • DOI 10.1007/BF02532399
    • Simpson RK Jr, Gondo M, Robertson CS, Goodman JC. Reduction in the mechanonociceptive response by intrathecal administration of glycine and related compounds. Neurochem Res. 1996;21(10):1221-1226. (Pubitemid 26357274)
    • (1996) Neurochemical Research , vol.21 , Issue.10 , pp. 1221-1226
    • Simpson Jr., R.K.1    Gondo, M.2    Robertson, C.S.3    Goodman, J.C.4
  • 41
    • 0027979339 scopus 로고
    • Morphine insensitive allodynia is produced by intrathecal strychnine in the lightly anesthetized rat
    • DOI 10.1016/0304-3959(94)90146-5
    • Sherman SE, Loomis CW. Morphine insensitive allodynia is produced by intrathecal strychnine in the lightly anesthetized rat. Pain. 1994;56(1):17-29. (Pubitemid 24037256)
    • (1994) Pain , vol.56 , Issue.1 , pp. 17-29
    • Sherman, S.E.1    Loomis, C.W.2
  • 42
    • 0029993392 scopus 로고    scopus 로고
    • Involvement of glutamate receptors in strychnine- and bicuculline-induced allodynia in conscious mice
    • Onaka M, Minami T, Nishihara I, Ito S. Involvement of glutamate receptors in strychnine- and bicuculline-induced allodynia in conscious mice. Anesthesiology. 1996;84(5):1215-1222.
    • (1996) Anesthesiology , vol.84 , Issue.5 , pp. 1215-1222
    • Onaka, M.1    Minami, T.2    Nishihara, I.3    Ito, S.4
  • 43
    • 0026555273 scopus 로고
    • Peripheral nerve injury triggers central sprouting of myelinated afferents
    • Woolf CJ, Shortland P, Coggeshall RE. Peripheral nerve injury triggers central sprouting of myelinated afferents. Nature. 1992;355(6355):75-78.
    • (1992) Nature , vol.355 , Issue.6355 , pp. 75-78
    • Woolf, C.J.1    Shortland, P.2    Coggeshall, R.E.3
  • 44
    • 0027536941 scopus 로고
    • Chronic peripheral nerve section results in a rearrangement of the central axonal arborizations of axotomized A beta primary afferent neurons in the rat spinal cord
    • Shortland P, Woolf CJ. Chronic peripheral nerve section results in a rearrangement of the central axonal arborizations of axotomized A beta primary afferent neurons in the rat spinal cord. J Comp Neurol. 1993;330(1):65-82. (Pubitemid 23095314)
    • (1993) Journal of Comparative Neurology , vol.330 , Issue.1 , pp. 65-82
    • Shortland, P.1    Woolf, C.J.2
  • 45
    • 0028236466 scopus 로고
    • Central sprouting and functional plasticity of regenerated primary afferents
    • Koerber HR, Mirnics K, Brown PB, Mendell LM. Central sprouting and functional plasticity of regenerated primary afferents. J Neurosci. 1994;14(6):3655-3671. (Pubitemid 24174114)
    • (1994) Journal of Neuroscience , vol.14 , Issue.6 , pp. 3655-3671
    • Koerber, H.R.1    Mirnics, K.2    Brown, P.B.3    Mendell, L.M.4
  • 46
    • 0033015345 scopus 로고    scopus 로고
    • Ultrastructural analysis of ectopic synaptic boutons arising from peripherally regenerated primary afferent fibers
    • Koerber HR, Mirnics K, Kavookjian AM, Light AR. Ultrastructural analysis of ectopic synaptic boutons arising from peripherally regenerated primary afferent fibers. J Neurophysiol. 1999;81(4):1636-1644. (Pubitemid 29262496)
    • (1999) Journal of Neurophysiology , vol.81 , Issue.4 , pp. 1636-1644
    • Koerber, H.R.1    Mirnics, K.2    Kavookjian, A.M.3    Light, A.R.4
  • 47
    • 0033550724 scopus 로고    scopus 로고
    • Myelinated afferents sprout into lamina II of L3-5 dorsal horn following chronic constriction nerve injury in rats
    • DOI 10.1016/S0006-8993(98)01291-8, PII S0006899398012918
    • Nakamura S, Myers RR. Myelinated afferents sprout into lamina II of L3-5 dorsal horn following chronic constriction nerve injury in rats. Brain Res. 1999;818(2):285-290. (Pubitemid 29229942)
    • (1999) Brain Research , vol.818 , Issue.2 , pp. 285-290
    • Nakamura, S.-I.1    Myers, R.R.2
  • 48
    • 0033535120 scopus 로고    scopus 로고
    • Increased uptake and transport of cholera toxin B-subunit in dorsal root ganglion neurons after peripheral axotomy: Possible implications for sensory sprouting
    • DOI 10.1002/(SICI)1096-9861(19990208)404:2<143::AI
    • Tong YG, Wang HF, Ju G, Grant G, Hokfelt T, Zhang X. Increased uptake and transport of cholera toxin B-subunit in dorsal root ganglion neurons after peripheral axotomy: possible implications for sensory sprouting. J Comp Neurol. 1999;404(2):143-158. (Pubitemid 29086541)
    • (1999) Journal of Comparative Neurology , vol.404 , Issue.2 , pp. 143-158
    • Tong, Y.-G.1    Wang, H.F.2    Ju, G.3    Grant, G.4    Hokfelt, T.5    Zhang, X.6
  • 50
    • 77954738979 scopus 로고    scopus 로고
    • Glycinergic and GABAergic tonic inhibition fine tune inhibitory control in regionally distinct subpopulations of dorsal horn neurons
    • Takazawa T, MacDermott AB. Glycinergic and GABAergic tonic inhibition fine tune inhibitory control in regionally distinct subpopulations of dorsal horn neurons. J Physiol. 2010;588(pt 14):2571-2587.
    • (2010) J Physiol , vol.588 , Issue.PART 14 , pp. 2571-2587
    • Takazawa, T.1    MacDermott, A.B.2
  • 53
    • 45549090676 scopus 로고    scopus 로고
    • Cytokine mechanisms of central sensitization: Distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord
    • Kawasaki Y, Zhang L, Cheng JK, Ji RR. Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord. J Neurosci. 2008;28(20):5189-5194.
    • (2008) J Neurosci , vol.28 , Issue.20 , pp. 5189-5194
    • Kawasaki, Y.1    Zhang, L.2    Cheng, J.K.3    Ji, R.R.4
  • 54
    • 0035887592 scopus 로고    scopus 로고
    • Region-specific developmental specialization of GABA-glycine cosynapses in laminas I-II of the rat spinal dorsal horn
    • Keller AF, Coull JA, Chery N, Poisbeau P, De Koninck Y. Region-specific developmental specialization of GABA-glycine cosynapses in laminas I-II of the rat spinal dorsal horn. J Neurosci. 2001;21(20):7871-7880. (Pubitemid 32952746)
    • (2001) Journal of Neuroscience , vol.21 , Issue.20 , pp. 7871-7880
    • Keller, A.F.1    Coull, J.A.M.2    Chery, N.3    Poisbeau, P.4    De Koninck, Y.5
  • 55
    • 34249655521 scopus 로고    scopus 로고
    • Cell-type-specific excitatory and inhibitory circuits involving primary afferents in the substantia gelatinosa of the rat spinal dorsal horn in vitro
    • DOI 10.1113/jphysiol.2006.123919
    • Yasaka T, et al. Cell-type-specific excitatory and inhibitory circuits involving primary afferents in the substantia gelatinosa of the rat spinal dorsal horn in vitro. J Physiol. 2007;581(pt 2):603-618. (Pubitemid 46831759)
    • (2007) Journal of Physiology , vol.581 , Issue.2 , pp. 603-618
    • Yasaka, T.1    Kato, G.2    Furue, H.3    Rashid, M.H.4    Sonohata, M.5    Tamae, A.6    Murata, Y.7    Masuko, S.8    Yoshimura, M.9
  • 57
    • 84861447770 scopus 로고    scopus 로고
    • TRPV1 in GABAergic interneurons mediates neuropathic mechanical allodynia and disinhibition of the nociceptive circuitry in the spinal cord
    • Kim YH, et al. TRPV1 in GABAergic interneurons mediates neuropathic mechanical allodynia and disinhibition of the nociceptive circuitry in the spinal cord. Neuron. 2012;74(4):640-647.
    • (2012) Neuron , vol.74 , Issue.4 , pp. 640-647
    • Kim, Y.H.1
  • 58
    • 0033174498 scopus 로고    scopus 로고
    • From the gate to the neuromatrix
    • Melzack R. From the gate to the neuromatrix. Pain. 1999;(suppl 6):S121-S126.
    • (1999) Pain , Issue.SUPPL. 6
    • Melzack, R.1
  • 59
    • 63449123821 scopus 로고    scopus 로고
    • The gate theory, then and now
    • Merskey H, Loeser J, Dubner R, eds. H. Seattle, Washington, USA: IASP Press
    • Cervero F. The gate theory, then and now. In: Merskey H, Loeser J, Dubner R, eds. The Paths of Pain: 1975-2005. H. Seattle, Washington, USA: IASP Press; 2005:21-41.
    • (2005) The Paths of Pain: 1975-2005 , pp. 21-41
    • Cervero, F.1
  • 60
    • 0014609028 scopus 로고
    • Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli
    • Bessou P, Perl ER. Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli. J Neurophysiol. 1969;32(6):1025-1043.
    • (1969) J Neurophysiol , vol.32 , Issue.6 , pp. 1025-1043
    • Bessou, P.1    Perl, E.R.2
  • 61
    • 33845737742 scopus 로고    scopus 로고
    • Ideas about pain, a historical view
    • DOI 10.1038/nrn2042, PII NRN2042
    • Perl ER. Ideas about pain, a historical view. Nat Rev Neurosci. 2007;8(1):71-80. (Pubitemid 46012000)
    • (2007) Nature Reviews Neuroscience , vol.8 , Issue.1 , pp. 71-80
    • Perl, E.R.1
  • 62
    • 34547184022 scopus 로고    scopus 로고
    • Nociceptors - noxious stimulus detectors
    • Woolf CJ, Ma Q. Nociceptors - noxious stimulus detectors. Neuron. 2007;55(3):353-364.
    • (2007) Neuron , vol.55 , Issue.3 , pp. 353-364
    • Woolf, C.J.1    Ma, Q.2
  • 63
    • 0027416836 scopus 로고
    • Blind patch-clamp recordings from substantia gelatinosa neurons in adult rat spinal cord slices: Pharmacological properties of synaptic currents
    • DOI 10.1016/0306-4522(93)90216-3
    • Yoshimura M, Nishi S. Blind patch-clamp recordings from substantia gelatinosa neurons in adult rat spinal cord slices: pharmacological properties of synaptic currents. Neuroscience. 1993;53(2):519-526. (Pubitemid 23101336)
    • (1993) Neuroscience , vol.53 , Issue.2 , pp. 519-526
    • Yoshimura, M.1    Nishi, S.2
  • 64
    • 0028104634 scopus 로고
    • Adenosine inhibition of synaptic transmission in the substantia gelatinosa
    • Li J, Perl ER. Adenosine inhibition of synaptic transmission in the substantia gelatinosa. J Neurophysiol. 1994;72(4):1611-1621. (Pubitemid 24325090)
    • (1994) Journal of Neurophysiology , vol.72 , Issue.4 , pp. 1611-1621
    • Li, J.1    Perl, E.R.2
  • 65
    • 0026727999 scopus 로고
    • An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat
    • Kim SH, Chung JM. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain. 1992;50(3):355-363.
    • (1992) Pain , vol.50 , Issue.3 , pp. 355-363
    • Kim, S.H.1    Chung, J.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.