Glutathione Status and the Renal Elimination of Inorganic Mercury in the Mrp2-/- Mouse

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Bridges, Christy C ^a   Joshee, Lucy ^a   van den Heuvel, Jeroen J M W ^b   Russel, Frans G M ^b   Zalups, Rudolfs K ^a  

^a MERCER UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; INORGANIC COMPOUND; MERCURY; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 4; XENOBIOTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FVB MOUSE; KIDNEY CLEARANCE; KIDNEY PROXIMAL TUBULE; LIVER CLEARANCE; MEMBRANE TRANSPORT; MEMBRANE VESICLE; MOUSE; MOUSE STRAIN; MRP2 POSITIVE MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

ANIMALS; BIOLOGICAL TRANSPORT; CATIONS, DIVALENT; CYSTEINE; FEMALE; GENE DELETION; GLUTATHIONE; HUMANS; KIDNEY; KIDNEY TUBULES; MERCURY; MICE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS;

EID: 84883512033     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0073559     Document Type: Article

References (31)

1. Leslie EM, (2012) Arsenic-glutathione conjugate transport by the human multidrug resistance proteins (MRPs/ABCCs). J Inorg Biochem 108: 141-149.
2. Wortelboer HM, Balvers MG, Usta M, van Bladeren PJ, Cnubben NH, (2008) Glutathione-dependent interaction of heavy metal compounds with multidrug resistance proteins MRP1 and MRP2. Environ Toxicol Pharmacol 26: 102-108.
3. Cui Y, Konig J, Buchholz JK, Spring H, Leier I, et al. (1999) Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells. Mol Pharmacol 55: 929-937.
4. Dijkstra M, Havinga R, Vonk RJ, Kuipers F, (1996) Bile secretion of cadmium, silver, zinc and copper in the rat. Involvement of various transport systems. Life Sci 59: 1237-1246.
5. Carriere P, Mantha M, Champagne-Paradis S, Jumarie C, (2011) Characterization of basolateral-to-apical transepithelial transport of cadmium in intestinal TC7 cell monolayers. Biometals 24: 857-874.
6. Bridges CC, Joshee L, Zalups RK, (2008) MRP2 and the DMPS- and DMSA-mediated elimination of mercury in TR(-) and control rats exposed to thiol S-conjugates of inorganic mercury. Toxicol Sci 105: 211-220.
7. Bridges CC, Joshee L, Zalups RK, (2008) Multidrug resistance proteins and the renal elimination of inorganic mercury mediated by 2,3-dimercaptopropane-1-sulfonic acid and meso-2,3-dimercaptosuccinic acid. J Pharmacol Exp Ther 324: 383-390.
8. Sugawara N, Lai YR, Sugaware C, Arizono K, (1998) Decreased hepatobiliary secretion of inorganic mercury, its deposition and toxicity in the Eisai hyperbilirubinemic rat with no hepatic canalicular organic anion transporter. Toxicology 126: 23-31.
9. van Aubel RA, Smeets PH, Peters JG, Bindels RJ, Russel FG, (2002) The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP. J Am Soc Nephrol 13: 595-603.
10. Bridges CC, Zalups RK, (2010) Transport of inorganic mercury and methylmercury in target tissues and organs. J Toxicol Environ Health B Crit Rev 13: 385-410.
11. Zalups RK, (2000) Molecular interactions with mercury in the kidney. Pharmacol Rev 52: 113-143.
12. Li S, Thompson SA, Kavanagh TJ, Woods JS, (1996) Localization by in situ hybridization of gamma-glutamylcysteine synthetase mRNA expression in rat kidney following acute methylmercury treatment. Toxicol Appl Pharmacol 141: 59-67.
13. Li S, Thompson SA, Woods JS, (1996) Localization of gamma-glutamylcysteine synthetase mRNA expression in mouse brain following methylmercury treatment using reverse transcription in situ PCR amplification. Toxicol Appl Pharmacol 140: 180-187.
14. Woods JS, Ellis ME, (1995) Up-regulation of glutathione synthesis in rat kidney by methyl mercury. Relationship to mercury-induced oxidative stress. Biochem Pharmacol 50: 1719-1724.
15. Woods JS, Davis HA, Baer RP, (1992) Enhancement of gamma-glutamylcysteine synthetase mRNA in rat kidney by methyl mercury. Arch Biochem Biophys 296: 350-353.
16. Zalups RK, Lash LH, (1990) Effects of uninephrectomy and mercuric chloride on renal glutathione homeostasis. J Pharmacol Exp Ther 254: 962-970.
17. Chu XY, Strauss JR, Mariano MA, Li J, Newton DJ, et al. (2006) Characterization of mice lacking the multidrug resistance protein MRP2 (ABCC2). J Pharmacol Exp Ther 317: 579-589.
18. Belanger M, Westin A, Barfuss DW, (2001) Some health physics aspects of working with 203 Hg in university research. Health Phys 80: S28-30.
19. Bridges CC, Bauch C, Verrey F, Zalups RK, (2004) Mercuric conjugates of cysteine are transported by the amino acid transporter system b(0,+): implications of molecular mimicry. J Am Soc Nephrol 15: 663-673.
20. Lee HB, Blaufox MD, (1985) Blood volume in the rat. J Nucl Med 26: 72-76.
21. Fariss MW, Reed DJ, (1987) High-performance liquid chromatography of thiols and disulfides: dinitrophenol derivatives. Methods Enzymol 143: 101-109.
22. El-Sheikh AA, van den Heuvel JJ, Koenderink JB, Russel FG, (2007) Interaction of nonsteroidal anti-inflammatory drugs with multidrug resistance protein (MRP) 2/ABCC2- and MRP4/ABCC4-mediated methotrexate transport. J Pharmacol Exp Ther 320: 229-235.
23. Van Aubel RA, Koenderink JB, Peters JG, Van Os CH, Russel FG, (1999) Mechanisms and interaction of vinblastine and reduced glutathione transport in membrane vesicles by the rabbit multidrug resistance protein Mrp2 expressed in insect cells. Mol Pharmacol 56: 714-719.
24. Schaub TP, Kartenbeck J, Konig J, Spring H, Dorsam J, et al. (1999) Expression of the MRP2 gene-encoded conjugate export pump in human kidney proximal tubules and in renal cell carcinoma. J Am Soc Nephrol 10: 1159-1169.
25. Bridges CC, Joshee L, Zalups RK, (2011) MRP2 and the handling of mercuric ions in rats exposed acutely to inorganic and organic species of mercury. Toxicol Appl Pharmacol 251: 50-58.
26. Zhou SF, Wang LL, Di YM, Xue CC, Duan W, et al. (2008) Substrates and inhibitors of human multidrug resistance associated proteins and the implications in drug development. Curr Med Chem 15: 1981-2039.
27. Anzai N, Jutabha P, Enomoto A, Yokoyama H, Nonoguchi H, et al. (2005) Functional characterization of rat organic anion transporter 5 (Slc22a19) at the apical membrane of renal proximal tubules. J Pharmacol Exp Ther 315: 534-544.
28. Kwak JO, Kim HW, Oh KJ, Ko CB, Park H, et al. (2005) Characterization of mouse organic anion transporter 5 as a renal steroid sulfate transporter. J Steroid Biochem Mol Biol 97: 369-375.
29. Thiebaut F, Tsuruo T, Hamada H, Gottesman MM, Pastan I, et al. (1987) Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. Proc Natl Acad Sci U S A 84: 7735-7738.
30. Lash LH, (2009) Renal glutathione transport: Identification of carriers, physiological functions, and controversies. Biofactors 35: 500-508.
31. Franklin CC, Backos DS, Mohar I, White CC, Forman HJ, et al. (2009) Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase. Mol Aspects Med 30: 86-98.