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Volumn 26, Issue 4, 2013, Pages 445-455

Osteoporosis: From bone biology to individual treatment decision;Osteoporose: Da biologia óssea à decisão terapêutica individual

Author keywords

Bone and bones; Bone remodeling; Bone resorption; Osteoblasts; Osteoclasts; Osteoporosis epidemiology; Osteoporosis therapy

Indexed keywords

ALENDRONIC ACID; BA 058; BETA CATENIN; CALCITONIN; CALCITRIOL; CALCIUM SENSING RECEPTOR; CATHEPSIN K; COLLAGEN TYPE 1; DENOSUMAB; GHRELIN; GLUCAGON LIKE PEPTIDE 1; GLUCOCORTICOID; IBANDRONIC ACID; ODANACATIB; PARATHYROID HORMONE; PARATHYROID HORMONE[1-34]; PLACEBO; RALOXIFENE; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; RISEDRONIC ACID; SCLEROSTIN; STRONTIUM RANELATE; UNCLASSIFIED DRUG; ZOLEDRONIC ACID;

EID: 84883504134     PISSN: 0870399X     EISSN: 16460758     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (11)

References (103)
  • 1
    • 84883512248 scopus 로고    scopus 로고
    • on behalf of WHO, WHO Scientific Group on the Assessment of Osteoporosis at the Primary Health Care Level meeting, Summary Meeting Report, Brussels, Belgium, 5-7 May 2004. WHO 2007. [Accessed 2013 Jun 02]. Disponível em
    • Khaltaev N, Pfleger BA, on behalf of WHO, WHO Scientific Group on the Assessment of Osteoporosis at the Primary Health Care Level meeting, Summary Meeting Report, Brussels, Belgium, 5-7 May 2004. WHO 2007. [Accessed 2013 Jun 02]. Disponível em: http://www.who.int/chp/topics/Osteoporosis.pdf.
    • Khaltaev, N.1    Pfleger, B.A.2
  • 3
    • 73349131143 scopus 로고    scopus 로고
    • A epidemiologia e o impacto sócio-económico das fracturas da extremidade proximal do fémur, uma reflexão sobre o padrão actual de tratamento da osteoporose grave
    • Branco JC, Felicíssimo P, Monteiro J. A epidemiologia e o impacto sócio-económico das fracturas da extremidade proximal do fémur, uma reflexão sobre o padrão actual de tratamento da osteoporose grave. Acta Reumatol Port. 2009;34:475-85.
    • (2009) Acta Reumatol Port , vol.34 , pp. 475-485
    • Branco, J.C.1    Felicíssimo, P.2    Monteiro, J.3
  • 4
    • 31944443249 scopus 로고    scopus 로고
    • Osteoporosis: A still increasing prevalence
    • Reginster JY, Burlet N. Osteoporosis: a still increasing prevalence. Bone. 2006;38:S4-9.
    • (2006) Bone , vol.38
    • Reginster, J.Y.1    Burlet, N.2
  • 6
    • 84883542403 scopus 로고    scopus 로고
    • Osteoporosis
    • In: Newman AB, Cauley JA, editors, Amsterdam: Springer
    • Cauley JA, Newman AB. Osteoporosis. In: Newman AB, Cauley JA, editors. The Epidemiology of Aging. Amsterdam: Springer; 2012. p. 499-522.
    • (2012) The Epidemiology of Aging , pp. 499-522
    • Cauley, J.A.1    Newman, A.B.2
  • 7
    • 54249097380 scopus 로고    scopus 로고
    • Long-term survival and fracture risk after hip fracture: A 22-year follow-up in women
    • von Friesendorff M, Besjakov J, Akesson K. Long-term survival and fracture risk after hip fracture: a 22-year follow-up in women. J Bone Miner Res. 2008;23:1832-41.
    • (2008) J Bone Miner Res , vol.23 , pp. 1832-1841
    • von Friesendorff, M.1    Besjakov, J.2    Akesson, K.3
  • 8
    • 21644444684 scopus 로고    scopus 로고
    • Risk of wrist fracture in women is heritable and is influenced by genes that are largely independent of those influencing BMD
    • Andrew T, Antioniades L, Scurrah KJ, MacGregor AJ, Spector TD. Risk of wrist fracture in women is heritable and is influenced by genes that are largely independent of those influencing BMD. J Bone Miner Res. 2005;20:67-74.
    • (2005) J Bone Miner Res , vol.20 , pp. 67-74
    • Andrew, T.1    Antioniades, L.2    Scurrah, K.J.3    Macgregor, A.J.4    Spector, T.D.5
  • 9
    • 0033550968 scopus 로고    scopus 로고
    • Mortality after all major types of osteoporotic fracture in men and women: An observational study
    • Center JR, Center JR, Nguyen TV, Schneider D, Sambrook PN, Eisman JA. Mortality after all major types of osteoporotic fracture in men and women: an observational study. Lancet. 1999;353:878-82.
    • (1999) Lancet , vol.353 , pp. 878-882
    • Center, J.R.1    Center, J.R.2    Nguyen, T.V.3    Schneider, D.4    Sambrook, P.N.5    Eisman, J.A.6
  • 10
    • 0027222768 scopus 로고
    • Consensus development conference (1993): Diagnosis, prophylaxis and treatment of osteoporosis
    • Christiansen C. Consensus development conference (1993): Diagnosis, prophylaxis and treatment of osteoporosis. Am J Med. 1993;94:646-50.
    • (1993) Am J Med , vol.94 , pp. 646-650
    • Christiansen, C.1
  • 11
    • 0028188829 scopus 로고
    • Report of a WHO Study Group
    • Assessment of fracture risk and its application to screening for postmenopausal osteoporosis
    • Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group. World Health Organ Tech Rep Ser. 1994;843:1-129.
    • (1994) World Health Organ Tech Rep Ser , vol.843 , pp. 1-129
  • 13
    • 0942268144 scopus 로고    scopus 로고
    • Fracture incidence and association with bone mineral density in elderly men and women: The Rotterdam Study
    • Schuit SC, van der Klift M, Weel AE, de Laet CE, Burger H, Seeman E, et al. Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study. Bone. 2004;34:195-202.
    • (2004) Bone , vol.34 , pp. 195-202
    • Schuit, S.C.1    van der Klift, M.2    Weel, A.E.3    de Laet, C.E.4    Burger, H.5    Seeman, E.6
  • 15
    • 78651493109 scopus 로고    scopus 로고
    • Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: A need for international reference standards
    • Vasikaran S, Eastell R, Bruyère O, Foldes AJ, Garnero P, Griesmacher A, et al. Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards. Osteoporos Int. 2011;22:391-420.
    • (2011) Osteoporos Int , vol.22 , pp. 391-420
    • Vasikaran, S.1    Eastell, R.2    Bruyère, O.3    Foldes, A.J.4    Garnero, P.5    Griesmacher, A.6
  • 16
    • 79953751008 scopus 로고    scopus 로고
    • Osteoporosis: Now and the future
    • Rachner TD, Khosla S, Hofbauer LC. Osteoporosis: now and the future. Lancet. 2011;377:1276-87.
    • (2011) Lancet , vol.377 , pp. 1276-1287
    • Rachner, T.D.1    Khosla, S.2    Hofbauer, L.C.3
  • 17
    • 0036606093 scopus 로고    scopus 로고
    • Diagnosis of osteoporosis and assessment of fracture risk
    • Kanis JA. Diagnosis of osteoporosis and assessment of fracture risk. Lancet. 2002;359:1929-36.
    • (2002) Lancet , vol.359 , pp. 1929-1936
    • Kanis, J.A.1
  • 18
    • 0031745604 scopus 로고    scopus 로고
    • Design of NORA, the National Osteoporosis Risk Assessment Program: A longitudinal US registry of postmenopausal women
    • Siris E, Miller P, Barrett-Connor E, Abbott T, Sherwood L, Berger M. Design of NORA, the National Osteoporosis Risk Assessment Program: a longitudinal US registry of postmenopausal women. Osteoporos Int.1998;8:S62-9.
    • (1998) Osteoporos Int , vol.8
    • Siris, E.1    Miller, P.2    Barrett-Connor, E.3    Abbott, T.4    Sherwood, L.5    Berger, M.6
  • 19
    • 78649326406 scopus 로고    scopus 로고
    • Impact of treatments for postmenopausal osteoporosis (Bisphophonates, Parathyroid Hormone, Strontium Ranelate and Denosumab) on bone quality: A systematic review
    • Gallacher SJ, Dixon T. Impact of treatments for postmenopausal osteoporosis (Bisphophonates, Parathyroid Hormone, Strontium Ranelate and Denosumab) on bone quality: a systematic review. Calcif Tissue Int. 2010;87:469-84.
    • (2010) Calcif Tissue Int , vol.87 , pp. 469-484
    • Gallacher, S.J.1    Dixon, T.2
  • 20
    • 43049175471 scopus 로고    scopus 로고
    • FRAX and the assessment of fracture probability in men and women from the UK
    • Kanis JA, Johnell O, Oden A, Johansson H, McCloskey E. FRAX and the assessment of fracture probability in men and women from the UK. Osteoporos Int. 2008;19:385-97.
    • (2008) Osteoporos Int , vol.19 , pp. 385-397
    • Kanis, J.A.1    Johnell, O.2    Oden, A.3    Johansson, H.4    McCloskey, E.5
  • 21
  • 22
    • 79960418936 scopus 로고    scopus 로고
    • Clinical risk factors for osteoporosis in Ireland and the UK: A comparison of Frax and QFractures Scores
    • Cummins NM, Poku EK, Towler MR, O'Driscoll OM, Ralston SH. Clinical risk factors for osteoporosis in Ireland and the UK: a comparison of Frax and QFractures Scores. Calcif Tissue Int. 2011;89:172-7.
    • (2011) Calcif Tissue Int , vol.89 , pp. 172-177
    • Cummins, N.M.1    Poku, E.K.2    Towler, M.R.3    O'Driscoll, O.M.4    Ralston, S.H.5
  • 23
    • 77953383192 scopus 로고    scopus 로고
    • Early impairment of trabecular microarchitecture assessed with HR-pQCT in patients with stage II-IV Chronic Kidney Disease
    • Baccheta J, Boutroy S, Vilayphiou N, Juillard L, Guebre-Egziabher F, Rognant N, et al. Early impairment of trabecular microarchitecture assessed with HR-pQCT in patients with stage II-IV Chronic Kidney Disease. J Bone Miner Res. 2010;25:849-57.
    • (2010) J Bone Miner Res , vol.25 , pp. 849-857
    • Baccheta, J.1    Boutroy, S.2    Vilayphiou, N.3    Juillard, L.4    Guebre-Egziabher, F.5    Rognant, N.6
  • 24
    • 50849132537 scopus 로고    scopus 로고
    • Chronic Kidney disease and bone fracture: A growing concern
    • Nickolas TL, Leonard MB, Shane E. Chronic Kidney disease and bone fracture: a growing concern. Kidney Int. 2008;74:721-31.
    • (2008) Kidney Int , vol.74 , pp. 721-731
    • Nickolas, T.L.1    Leonard, M.B.2    Shane, E.3
  • 25
    • 0026642505 scopus 로고
    • Determinants of total body and regional bone mineral density in normal postmenopausal women-a key role for fat mass
    • Reid IR, Ames R, Evans MC, Sharpe S, Gamble G, France JT, et al. Determinants of total body and regional bone mineral density in normal postmenopausal women-a key role for fat mass. J Clin Endocrinol Metab. 1992;75:45-51.
    • (1992) J Clin Endocrinol Metab , vol.75 , pp. 45-51
    • Reid, I.R.1    Ames, R.2    Evans, M.C.3    Sharpe, S.4    Gamble, G.5    France, J.T.6
  • 28
    • 37548998960 scopus 로고    scopus 로고
    • Correlation of Obesity and Osteoporosis: Effect of Fat Mass on the Determination of Osteoporosis
    • Zhao LJ, Jiang H, Papasian CJ, Maulik D, Drees B, Hamilton J, et al. Correlation of Obesity and Osteoporosis: Effect of Fat Mass on the Determination of Osteoporosis. J Bone Miner Res. 2008;23:17-29.
    • (2008) J Bone Miner Res , vol.23 , pp. 17-29
    • Zhao, L.J.1    Jiang, H.2    Papasian, C.J.3    Maulik, D.4    Drees, B.5    Hamilton, J.6
  • 29
    • 84867222853 scopus 로고    scopus 로고
    • Low osteocalcin/collagen type I bone gene expression ratio is associated with hip fragility fractures
    • Rodrigues AM, Caetano-Lopes J, Vale AC, Vidal B, Lopes A, Aleixo I, et al. Low osteocalcin/collagen type I bone gene expression ratio is associated with hip fragility fractures. Bone. 2012;51:981-9.
    • (2012) Bone , vol.51 , pp. 981-989
    • Rodrigues, A.M.1    Caetano-Lopes, J.2    Vale, A.C.3    Vidal, B.4    Lopes, A.5    Aleixo, I.6
  • 32
    • 84878348235 scopus 로고    scopus 로고
    • Wnt signalling in bone formation and its therapeutic potential for bone diseases
    • Kim JH, Liu X, Wang J, Chen X, Zhang H, Kim SH, et al. Wnt signalling in bone formation and its therapeutic potential for bone diseases. Ther Adv Musculoskel Dis. 2013;5:13-31.
    • (2013) Ther Adv Musculoskel Dis , vol.5 , pp. 13-31
    • Kim, J.H.1    Liu, X.2    Wang, J.3    Chen, X.4    Zhang, H.5    Kim, S.H.6
  • 33
    • 79951820514 scopus 로고    scopus 로고
    • Upregulation of inflammatory genes and downregulation of sclerostin gene expression are key elements in the early phase of fragility fracture healing
    • Caetano-Lopes J, Lopes A, Rodrigues A, Fernandes D, Perpetuo IP, Monjardino T, et al. Upregulation of inflammatory genes and downregulation of sclerostin gene expression are key elements in the early phase of fragility fracture healing. Plos One. 2011;6:e16947.
    • (2011) Plos One , vol.6
    • Caetano-Lopes, J.1    Lopes, A.2    Rodrigues, A.3    Fernandes, D.4    Perpetuo, I.P.5    Monjardino, T.6
  • 34
    • 0034455103 scopus 로고    scopus 로고
    • Birth and death of bone cells: Basic regulatory, mechanisms and implications for the pathogenesis and treatment of osteoporosis
    • Manolagas SC. Birth and death of bone cells: basic regulatory, mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr Rev. 2000;21:115-37.
    • (2000) Endocr Rev , vol.21 , pp. 115-137
    • Manolagas, S.C.1
  • 35
    • 0033611467 scopus 로고    scopus 로고
    • OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
    • Kong YY, Yoshida H, Sarosi I, Tan HL, Timms E, Capparelli C, et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature. 1999;397:315-22.
    • (1999) Nature , vol.397 , pp. 315-322
    • Kong, Y.Y.1    Yoshida, H.2    Sarosi, I.3    Tan, H.L.4    Timms, E.5    Capparelli, C.6
  • 36
    • 58149112825 scopus 로고    scopus 로고
    • Vitamin K2, a gamma-carboxylating factor of gla-proteins, normalizes the bone crystal nucleation impaired by Mg-insufficiency
    • Amizuka N, Li M, Kobayashi M, Hara K, Akahane S, Takeuchi K, et al. Vitamin K2, a gamma-carboxylating factor of gla-proteins, normalizes the bone crystal nucleation impaired by Mg-insufficiency. Histol Hispathol. 2008;23:1353-66.
    • (2008) Histol Hispathol , vol.23 , pp. 1353-1366
    • Amizuka, N.1    Li, M.2    Kobayashi, M.3    Hara, K.4    Akahane, S.5    Takeuchi, K.6
  • 38
    • 58149459512 scopus 로고    scopus 로고
    • Osteoimmunology - The hidden imune regulation of bone
    • Caetano-Lopes J, Canhão H, Fonseca JE. Osteoimmunology - the hidden imune regulation of bone. Autoimmun Rev. 2009;8:250-5.
    • (2009) Autoimmun Rev , vol.8 , pp. 250-255
    • Caetano-Lopes, J.1    Canhão, H.2    Fonseca, J.E.3
  • 39
    • 84873546947 scopus 로고    scopus 로고
    • Osteoimmunology and the influence of proinflamatory cytokines on osteoclast
    • Zupan J, Matjaz J, Marc J. Osteoimmunology and the influence of proinflamatory cytokines on osteoclast. Biochem Med. 2013;1:43-65.
    • (2013) Biochem Med , vol.1 , pp. 43-65
    • Zupan, J.1    Matjaz, J.2    Marc, J.3
  • 43
    • 80051546618 scopus 로고    scopus 로고
    • Effects of increased hypothalamic leptin gene expression on ovariectomy-induced bone loss in rats
    • Jackson MA, Iwaniec UT, Turner RT, Wronski TJ, Kalra SP. Effects of increased hypothalamic leptin gene expression on ovariectomy-induced bone loss in rats. Peptides. 2011;32:1575-80.
    • (2011) Peptides , vol.32 , pp. 1575-1580
    • Jackson, M.A.1    Iwaniec, U.T.2    Turner, R.T.3    Wronski, T.J.4    Kalra, S.P.5
  • 44
    • 23944517324 scopus 로고    scopus 로고
    • Adiponectin stimulates human osteoblasts proliferation and differentiation via the MAPK signaling pathway
    • Luo XH, Guo LJ, Yuan LQ, Xie H, Zhou HD, Wu XP, et al. Adiponectin stimulates human osteoblasts proliferation and differentiation via the MAPK signaling pathway. Exp Cell Res. 2005;309:99-109.
    • (2005) Exp Cell Res , vol.309 , pp. 99-109
    • Luo, X.H.1    Guo, L.J.2    Yuan, L.Q.3    Xie, H.4    Zhou, H.D.5    Wu, X.P.6
  • 45
    • 33749244468 scopus 로고    scopus 로고
    • Adiponectin stimulates RANKL and inhibits OPG expression in human osteoblasts through the MAPK signaling pathway
    • Luo XH, Guo LJ, Xie H, Yuan LQ, Wu XP, Zhou HD, et al. Adiponectin stimulates RANKL and inhibits OPG expression in human osteoblasts through the MAPK signaling pathway. J Bone Miner Res. 2006;21:1648-56.
    • (2006) J Bone Miner Res , vol.21 , pp. 1648-1656
    • Luo, X.H.1    Guo, L.J.2    Xie, H.3    Yuan, L.Q.4    Wu, X.P.5    Zhou, H.D.6
  • 46
    • 84863655029 scopus 로고    scopus 로고
    • Peptide YY regulates bone remodeling in mice: A link between gut and skeletal biology
    • Wong I, Driessler F, Khor EC, Shi Y, Nguyen AD, Enriquez RF, et al. Peptide YY regulates bone remodeling in mice: a link between gut and skeletal biology. PlosONE. 2012;7:e40038.
    • (2012) PlosONE , vol.7
    • Wong, I.1    Driessler, F.2    Khor, E.C.3    Shi, Y.4    Nguyen, A.D.5    Enriquez, R.F.6
  • 47
    • 84879192082 scopus 로고    scopus 로고
    • Ghrelin is an osteoblast mitogen and increases osteoclastic bone resorption in vitro
    • 2011
    • Costa JL, Naot D, Lin JM, Watson M, Callon KE, Reid IR, et al. Ghrelin is an osteoblast mitogen and increases osteoclastic bone resorption in vitro. Int J Pept. 2011;2011:605193.
    • (2011) Int J Pept , pp. 605193
    • Costa, J.L.1    Naot, D.2    Lin, J.M.3    Watson, M.4    Callon, K.E.5    Reid, I.R.6
  • 48
    • 25444468833 scopus 로고    scopus 로고
    • Hypothalamic control of bone formation: Distinct actions of leptin and Y2 receptor pathways
    • Baldock PA, Sainsbury A, Allison S, Lin EJ, Couzens M, Boey D, et al. Hypothalamic control of bone formation: distinct actions of leptin and Y2 receptor pathways. J Bone Miner Res. 2005;20:1851-7.
    • (2005) J Bone Miner Res , vol.20 , pp. 1851-1857
    • Baldock, P.A.1    Sainsbury, A.2    Allison, S.3    Lin, E.J.4    Couzens, M.5    Boey, D.6
  • 49
    • 50949118377 scopus 로고    scopus 로고
    • Regulation of bone remodeling by the central and peripheral nervous system
    • Florent E. Regulation of bone remodeling by the central and peripheral nervous system. Arch Biochem Biophys. 2008;473:231-6.
    • (2008) Arch Biochem Biophys , vol.473 , pp. 231-236
    • Florent, E.1
  • 50
    • 84864304634 scopus 로고    scopus 로고
    • Microarchitecture, the key to bone quality
    • iv3-iv8
    • Brandi ML. Microarchitecture, the key to bone quality. Rheumatology. 2009;48:iv3-8.
    • (2009) Rheumatology , vol.48
    • Brandi, M.L.1
  • 51
    • 79960966080 scopus 로고    scopus 로고
    • High-resolution computed tomography for clinical imaging of bone microarchitecture
    • Burghardt AJ, Link TM, Majumdar S. High-resolution computed tomography for clinical imaging of bone microarchitecture. Clin Orthop Relat Res. 2011;469:2179-93.
    • (2011) Clin Orthop Relat Res , vol.469 , pp. 2179-2193
    • Burghardt, A.J.1    Link, T.M.2    Majumdar, S.3
  • 52
    • 84870429565 scopus 로고    scopus 로고
    • Sex and age-related differences in bone microarchitecture in men relative to women assessed by high-resolution peripheral quantitative computed tomography
    • 2012
    • Amin S, Khosla S. Sex and age-related differences in bone microarchitecture in men relative to women assessed by high-resolution peripheral quantitative computed tomography. J Osteoporos. 2012;2012:129760.
    • (2012) J Osteoporos , pp. 129760
    • Amin, S.1    Khosla, S.2
  • 53
    • 67349103852 scopus 로고    scopus 로고
    • Bone turnover markers: Understanding their value in clinical trials and clinical practice
    • Civitelli R, Armamento-Villareal R, Napoli N. Bone turnover markers: understanding their value in clinical trials and clinical practice. Osteoporos Int. 2009;20:843-51.
    • (2009) Osteoporos Int , vol.20 , pp. 843-851
    • Civitelli, R.1    Armamento-Villareal, R.2    Napoli, N.3
  • 54
    • 0343517092 scopus 로고    scopus 로고
    • Biochemical markers of bone turnover, endogenous hormones and the risk of fractures in postmenopausal women: The OFELY study
    • Garnero P, Sornay-Rendu E, Claustrat B, Delmas PD. Biochemical markers of bone turnover, endogenous hormones and the risk of fractures in postmenopausal women: the OFELY study. J Bone Miner Res. 2000;15:1526-36.
    • (2000) J Bone Miner Res , vol.15 , pp. 1526-1536
    • Garnero, P.1    Sornay-Rendu, E.2    Claustrat, B.3    Delmas, P.D.4
  • 55
    • 0033926478 scopus 로고    scopus 로고
    • Serum type I collagen breakdown product (Serum CTX) predicts hip fracture risk in elderly women: The EPIDOS study
    • Chapurlat RD, Garnero P, BreArt G, Meunier PJ, Delmas PD. Serum type I collagen breakdown product (Serum CTX) predicts hip fracture risk in elderly women: the EPIDOS study. Bone. 2000;27:283-6.
    • (2000) Bone , vol.27 , pp. 283-286
    • Chapurlat, R.D.1    Garnero, P.2    Breart, G.3    Meunier, P.J.4    Delmas, P.D.5
  • 56
    • 15344343455 scopus 로고    scopus 로고
    • Bone resorption and osteoporotic fractures in elderly men: The Dubbo Osteoporosis Epidemiology Study
    • Meier C, Nguyen TV, Center JR, Seibel MJ, Eisman JA. Bone resorption and osteoporotic fractures in elderly men: the Dubbo Osteoporosis Epidemiology Study. J Bone Miner Res. 2005;20:579-87.
    • (2005) J Bone Miner Res , vol.20 , pp. 579-587
    • Meier, C.1    Nguyen, T.V.2    Center, J.R.3    Seibel, M.J.4    Eisman, J.A.5
  • 59
    • 34250632807 scopus 로고    scopus 로고
    • Recomendações para o diagnóstico e terapêutica da osteoporose, Sociedade Portuguesa de Reumatologia e Sociedade Portuguesa de Doenças Ósseas Metabólicas
    • Tavares V, Canhão H, Melo-Gomes JA, Simões E, Romeu JC, Coelho P, et al. Recomendações para o diagnóstico e terapêutica da osteoporose, Sociedade Portuguesa de Reumatologia e Sociedade Portuguesa de Doenças Ósseas Metabólicas. Acta Reumatol Port. 2007;32:49-59.
    • (2007) Acta Reumatol Port , vol.32 , pp. 49-59
    • Tavares, V.1    Canhão, H.2    Melo-Gomes, J.A.3    Simões, E.4    Romeu, J.C.5    Coelho, P.6
  • 60
    • 51249116239 scopus 로고    scopus 로고
    • Case finding for the management of osteoporosis with FRAX®-assessment and intervention thresholds for the UK
    • Kanis JA, McCloskey EV, Johansson H, Strom O, Borgstrom F, Oden A. Case finding for the management of osteoporosis with FRAX®-assessment and intervention thresholds for the UK. Osteoporos Int. 2008;19:1395-408.
    • (2008) Osteoporos Int , vol.19 , pp. 1395-1408
    • Kanis, J.A.1    McCloskey, E.V.2    Johansson, H.3    Strom, O.4    Borgstrom, F.5    Oden, A.6
  • 62
    • 84883543987 scopus 로고    scopus 로고
    • Tratamento Farmacológico da Osteoporose Pós-menopáusica, Norma da direcção geral de saúde. 027/2011. [Accessed 2013 Jun 02]. Disponível em
    • Branco JC, Tavares V, Vaz AF, Simões E, Canhão H, George F. Tratamento Farmacológico da Osteoporose Pós-menopáusica, Norma da direcção geral de saúde. 027/2011. [Accessed 2013 Jun 02]. Disponível em: http://www.dgs.pt/?cr=21174.
    • Branco, J.C.1    Tavares, V.2    Vaz, A.F.3    Simões, E.4    Canhão, H.5    George, F.6
  • 64
    • 84876510489 scopus 로고    scopus 로고
    • Bone mineral density and body composition of adult premenopausal women with three levels of physical activity
    • 2013
    • Saraví FD, Sayegh F. Bone mineral density and body composition of adult premenopausal women with three levels of physical activity. J Osteoporos. 2013;2013:953271.
    • (2013) J Osteoporos , pp. 953271
    • Saraví, F.D.1    Sayegh, F.2
  • 65
    • 38949143249 scopus 로고    scopus 로고
    • Shifting the focus in fracture prevention from osteoporosis to falls
    • Järvinen TN, Sievänen H, Khan KM, Heinonen A, Kannus P. Shifting the focus in fracture prevention from osteoporosis to falls. BMJ. 2008;336:124-6.
    • (2008) BMJ , vol.336 , pp. 124-126
    • Järvinen, T.N.1    Sievänen, H.2    Khan, K.M.3    Heinonen, A.4    Kannus, P.5
  • 66
  • 67
    • 0028851590 scopus 로고
    • Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis
    • The Alendronate Phase III Osteoporosis Treatment Study Group
    • Liberman UA, Weiss SR, Bröll J, Minne HW, Quan H, Bell NH, et al. Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. The Alendronate Phase III Osteoporosis Treatment Study Group. N Engl J Med. 1995;333:1437-43.
    • (1995) N Engl J Med , vol.333 , pp. 1437-1443
    • Liberman, U.A.1    Weiss, S.R.2    Bröll, J.3    Minne, H.W.4    Quan, H.5    Bell, N.H.6
  • 68
    • 0033552255 scopus 로고    scopus 로고
    • Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: A randomized controlled trial
    • Harris ST, Watts NB, Genant HK, McKeever CD, Hangartner TN, Keller M, et al. Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: A randomized controlled trial. JAMA. 1999;282:1344-52.
    • (1999) JAMA , vol.282 , pp. 1344-1352
    • Harris, S.T.1    Watts, N.B.2    Genant, H.K.3    McKeever, C.D.4    Hangartner, T.N.5    Keller, M.6
  • 70
    • 4544262219 scopus 로고    scopus 로고
    • Effects of oral ibandronate administered daily or intermittently on fracture risk in postmenopausal osteoporosis
    • Chesnut III CH, Skag A, Christiansen C, Recker R, Stakkestad JA, Hoiseth A, et al. Effects of oral ibandronate administered daily or intermittently on fracture risk in postmenopausal osteoporosis. J Bone Miner Res. 2004;19:1241-9.
    • (2004) J Bone Miner Res , vol.19 , pp. 1241-1249
    • Chesnut III, C.H.1    Skag, A.2    Christiansen, C.3    Recker, R.4    Stakkestad, J.A.5    Hoiseth, A.6
  • 71
  • 72
    • 84856184102 scopus 로고    scopus 로고
    • The effects of 3 versus 6 years if zoledronic Acid treatment of osteoporosis: A randomized extension to HORIZON-pivotal fracture trial (PFT)
    • Black DM, Reid IR, Boonen S, Bucci-Rechtweg C, Cauley JA, Cosman F, et al. The effects of 3 versus 6 years if zoledronic Acid treatment of osteoporosis: a randomized extension to HORIZON-pivotal fracture trial (PFT). J Bone Miner Res. 2012;27:243-54.
    • (2012) J Bone Miner Res , vol.27 , pp. 243-254
    • Black, D.M.1    Reid, I.R.2    Boonen, S.3    Bucci-Rechtweg, C.4    Cauley, J.A.5    Cosman, F.6
  • 73
    • 84861668653 scopus 로고    scopus 로고
    • Continuing bisphosphonate treatment for osteoporosis-For whom and for how long?
    • Black DM, Bauer DC, Schwartz AV, Cummings SR, Rosen CJ. Continuing bisphosphonate treatment for osteoporosis-For whom and for how long? N Engl J Med. 2012;366:2051-3.
    • (2012) N Engl J Med , vol.366 , pp. 2051-2053
    • Black, D.M.1    Bauer, D.C.2    Schwartz, A.V.3    Cummings, S.R.4    Rosen, C.J.5
  • 74
    • 77952314262 scopus 로고    scopus 로고
    • Bisphosphonates and fractures of the subtrochanteric or diaphyseal femur
    • Black DM, Kelly MP, Genant HK, Palermo L, Eastell R. Bisphosphonates and fractures of the subtrochanteric or diaphyseal femur. N Engl J Med. 2010;362:1761-71.
    • (2010) N Engl J Med , vol.362 , pp. 1761-1771
    • Black, D.M.1    Kelly, M.P.2    Genant, H.K.3    Palermo, L.4    Eastell, R.5
  • 75
    • 21444449880 scopus 로고    scopus 로고
    • Osteonecrosis of the jaw and bisphosphonates
    • Durie BG, Katz M, Crowley J. Osteonecrosis of the jaw and bisphosphonates. N Engl J Med. 2005;353:99-102.
    • (2005) N Engl J Med , vol.353 , pp. 99-102
    • Durie, B.G.1    Katz, M.2    Crowley, J.3
  • 76
    • 84873649934 scopus 로고    scopus 로고
    • Exposure to bisphosphonates and risk of gastrointestinal cancers: Series of nested case-control studies with QResearch and CPRD data
    • Vinogradova Y, Coupland C, Hippisley-Cox J. Exposure to bisphosphonates and risk of gastrointestinal cancers: series of nested case-control studies with QResearch and CPRD data. BMJ. 2013;346:f114.
    • (2013) BMJ , vol.346
    • Vinogradova, Y.1    Coupland, C.2    Hippisley-Cox, J.3
  • 77
    • 79959993170 scopus 로고    scopus 로고
    • How strontium ranelate, via opposite effects on bone resorption and formation, prevents osteoporosis
    • Marie PJ, Felsenberg D, Brandi ML. How strontium ranelate, via opposite effects on bone resorption and formation, prevents osteoporosis. Osteoporos Int. 2011;22:1659-67.
    • (2011) Osteoporos Int , vol.22 , pp. 1659-1667
    • Marie, P.J.1    Felsenberg, D.2    Brandi, M.L.3
  • 78
    • 21044447888 scopus 로고    scopus 로고
    • Strontium ranelate reduces the risk of non-vertebral fractures in postmenopausal women with osteoporosis
    • Treatment of peripheral osteoporosis (TROPOS) study
    • Reginster JY, Seeman E, de Vernejoul MC, Adami S, Compston J, Phenekos C, et al. Strontium ranelate reduces the risk of non-vertebral fractures in postmenopausal women with osteoporosis. Treatment of peripheral osteoporosis (TROPOS) study. J Clin Endocrinol Metab. 2005;90:2816-22.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 2816-2822
    • Reginster, J.Y.1    Seeman, E.2    de Vernejoul, M.C.3    Adami, S.4    Compston, J.5    Phenekos, C.6
  • 79
    • 9144233479 scopus 로고    scopus 로고
    • The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis
    • Meunier PJ, Roux C, Seeman E, Ortolani S, Badurski JE, Spector TD, et al. The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N Engl J Med. 2004;350:459-68.
    • (2004) N Engl J Med , vol.350 , pp. 459-468
    • Meunier, P.J.1    Roux, C.2    Seeman, E.3    Ortolani, S.4    Badurski, J.E.5    Spector, T.D.6
  • 80
    • 79960225337 scopus 로고    scopus 로고
    • A meta-analysis of the effect of strontium ranelate on the risk of vertebral and non-vertebral fracture in postmenopausal osteoporosis and the interaction with FRAX
    • Kanis JA, Johansson H, Oden A, McCloskey EV. A meta-analysis of the effect of strontium ranelate on the risk of vertebral and non-vertebral fracture in postmenopausal osteoporosis and the interaction with FRAX. Osteoporos Int. 2011;22:2347-55.
    • (2011) Osteoporos Int , vol.22 , pp. 2347-2355
    • Kanis, J.A.1    Johansson, H.2    Oden, A.3    McCloskey, E.V.4
  • 81
    • 84883532919 scopus 로고    scopus 로고
    • European Medicines Agency confirms positive benefit-risk balance of Protelos/Osseor, but recommends new contraindications and revised warnings, EMA/CHMP/185175/2012 (March 2012). [Accessed 2013 Jun 02]. Disponível em
    • European Medicines Agency confirms positive benefit-risk balance of Protelos/Osseor, but recommends new contraindications and revised warnings, EMA/CHMP/185175/2012 (March 2012). [Accessed 2013 Jun 02]. Disponível em: http://www.ema.europa.eu/docs/en_GB/document_library/Press_release/2012/03/WC500124206.pdf.
  • 82
    • 84883514937 scopus 로고    scopus 로고
    • Pharmacovigilance Risk Assessment Committee (PRAC) recommends restriction in the use of Protelos/Osseor, EMA/220628/2013 (April 2013). [Accessed 2013 Jun 02]. Disponível em
    • Pharmacovigilance Risk Assessment Committee (PRAC) recommends restriction in the use of Protelos/Osseor, EMA/220628/2013 (April 2013). [Accessed 2013 Jun 02]. Disponível em: http://www.ema.europa.eu/docs/en_GB/document_library/Medicine_QA/human/000560/WC500142021.pdf.
  • 83
    • 39749159923 scopus 로고    scopus 로고
    • Teriparatide in the management of osteoporosis
    • Bodenner D, Redman D, Riggs A. Teriparatide in the management of osteoporosis. Clin Interv Aging. 2007;2:499-507.
    • (2007) Clin Interv Aging , vol.2 , pp. 499-507
    • Bodenner, D.1    Redman, D.2    Riggs, A.3
  • 85
    • 77953454405 scopus 로고    scopus 로고
    • Effects of denosumab on bone mineral density and bone turnover in postmenopausal women transitioning from alendronate therapy
    • Kendler DL, Roux C, Benhamou CL, Brown JP, Lillestol M, Siddhanti S, et al. Effects of denosumab on bone mineral density and bone turnover in postmenopausal women transitioning from alendronate therapy. J Bone Miner Res. 2010;25:72-81.
    • (2010) J Bone Miner Res , vol.25 , pp. 72-81
    • Kendler, D.L.1    Roux, C.2    Benhamou, C.L.3    Brown, J.P.4    Lillestol, M.5    Siddhanti, S.6
  • 86
    • 84857493658 scopus 로고    scopus 로고
    • A review of the efficacy and safety of denosumab in postmenopausal women with osteoporosis
    • Miller PD. A review of the efficacy and safety of denosumab in postmenopausal women with osteoporosis. Ther Adv Musculoskelet Dis. 2011;3:271-82.
    • (2011) Ther Adv Musculoskelet Dis , vol.3 , pp. 271-282
    • Miller, P.D.1
  • 88
    • 10344259093 scopus 로고    scopus 로고
    • Raloxifene modulates interleukin-6 and tumor necrosis factor-α synthesis in vivo: Results from a pilot clinical study
    • Gianni W, Ricci A, Gazzaniga P, Brama M, Pietropaolo M, Votano S, et al. Raloxifene modulates interleukin-6 and tumor necrosis factor-α synthesis in vivo: results from a pilot clinical study. J Clin Endocrinol Metab. 2004;89:6097-9.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 6097-6099
    • Gianni, W.1    Ricci, A.2    Gazzaniga, P.3    Brama, M.4    Pietropaolo, M.5    Votano, S.6
  • 89
    • 0036171788 scopus 로고    scopus 로고
    • The selective estrogen receptor modulator raloxifene regulates osteoblast and osteoclast activity in vitro
    • Taranta A, Brama M, Teti A, DeLuca V, Scandurra R, Spera G, et al. The selective estrogen receptor modulator raloxifene regulates osteoblast and osteoclast activity in vitro. Bone. 2002;30:368-76.
    • (2002) Bone , vol.30 , pp. 368-376
    • Taranta, A.1    Brama, M.2    Teti, A.3    Deluca, V.4    Scandurra, R.5    Spera, G.6
  • 90
    • 0033581212 scopus 로고    scopus 로고
    • Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: Results from a 3-year randomized clinical trial. Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators
    • Ettinger B, Black DM, Mitlak BH, Knickerbocker RK, Nickelsen T, Genant HK, et al. Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators. JAMA. 1999;282:637-45.
    • (1999) JAMA , vol.282 , pp. 637-645
    • Ettinger, B.1    Black, D.M.2    Mitlak, B.H.3    Knickerbocker, R.K.4    Nickelsen, T.5    Genant, H.K.6
  • 91
    • 56549092475 scopus 로고    scopus 로고
    • Efficacy of bazedoxifene in reducing new vertebral fracture risk in postmenopausal women with osteoporosis: Results from a 3-year, randomized, placebo-, and active-controlled clinical trial
    • Silverman SL, Christiansen C, Genant HK, Vukicevic S, Zanchetta JR, de Villiers TJ. Efficacy of bazedoxifene in reducing new vertebral fracture risk in postmenopausal women with osteoporosis: results from a 3-year, randomized, placebo-, and active-controlled clinical trial. J Bone Miner Res. 2008;23:1923-34.
    • (2008) J Bone Miner Res , vol.23 , pp. 1923-1934
    • Silverman, S.L.1    Christiansen, C.2    Genant, H.K.3    Vukicevic, S.4    Zanchetta, J.R.5    de Villiers, T.J.6
  • 92
    • 0037125379 scopus 로고    scopus 로고
    • Risks and benefits of estrogen and progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial
    • Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML. Risks and benefits of estrogen and progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial. JAMA. 2002;288:321.
    • (2002) JAMA , vol.288 , pp. 321
    • Rossouw, J.E.1    Anderson, G.L.2    Prentice, R.L.3    Lacroix, A.Z.4    Kooperberg, C.5    Stefanick, M.L.6
  • 93
    • 0036951194 scopus 로고    scopus 로고
    • Calcitonin and bone formation: A knockout full of surprises
    • Zaidi M, Moonga BS, Abe E. Calcitonin and bone formation: a knockout full of surprises. J Clin Invest. 2002;110:1769-71.
    • (2002) J Clin Invest , vol.110 , pp. 1769-1771
    • Zaidi, M.1    Moonga, B.S.2    Abe, E.3
  • 94
    • 84883506637 scopus 로고    scopus 로고
    • Questions and answers on the review of calcitonin-containing medicines, EMA/731082/2012, EMEA/H/A-31/1291 (November 2012). [Accessed 2013 Jun 02]. Disponível em
    • Questions and answers on the review of calcitonin-containing medicines, EMA/731082/2012, EMEA/H/A-31/1291 (November 2012). [Accessed 2013 Jun 02]. Disponível em: http://www.emea.europa.eu/docs/en_GB/document_library/Referrals_document/Calcitonin_31/WC500134838.pdf.
  • 95
    • 37349075476 scopus 로고    scopus 로고
    • The cost-effectiveness of alendronate in the management of osteoporosis
    • Kanis JA, Adams J, Borgstrom F, Cooper C, Jonsson B, Preedy D, et al. The cost-effectiveness of alendronate in the management of osteoporosis. Bone. 2008;42:4-15.
    • (2008) Bone , vol.42 , pp. 4-15
    • Kanis, J.A.1    Adams, J.2    Borgstrom, F.3    Cooper, C.4    Jonsson, B.5    Preedy, D.6
  • 97
    • 84867896789 scopus 로고    scopus 로고
    • The cost effectiveness of teriparatide as a first-line treatment for glucocorticoid-induced and postmenopausalosteoporosis patients in Sweden
    • Murphy DR, Smolen LJ, Klein TM, Klein RW. The cost effectiveness of teriparatide as a first-line treatment for glucocorticoid-induced and postmenopausalosteoporosis patients in Sweden. BMC Musculoskelet Disord. 2012;30:213.
    • (2012) BMC Musculoskelet Disord , vol.30 , pp. 213
    • Murphy, D.R.1    Smolen, L.J.2    Klein, T.M.3    Klein, R.W.4
  • 101
    • 84867336111 scopus 로고    scopus 로고
    • New therapeutics target for osteoporosis: Beyond denosumab
    • Vivien L, Clarke BL. New therapeutics target for osteoporosis: beyond denosumab. Maturitas. 2012;73:269-72.
    • (2012) Maturitas , vol.73 , pp. 269-272
    • Vivien, L.1    Clarke, B.L.2
  • 102
    • 80052058754 scopus 로고    scopus 로고
    • JTT-305, an orally active calcium-sensing receptor antagonist, stimulates transient parathyroid hormone release and bone formation in ovariectomized rats
    • Kimura S, Nakagawa T, Matsuo Y, Ishida Y, Okamoto Y, Hayashi M. JTT-305, an orally active calcium-sensing receptor antagonist, stimulates transient parathyroid hormone release and bone formation in ovariectomized rats. Eur J Pharmacol. 2011;668:331-6.
    • (2011) Eur J Pharmacol , vol.668 , pp. 331-336
    • Kimura, S.1    Nakagawa, T.2    Matsuo, Y.3    Ishida, Y.4    Okamoto, Y.5    Hayashi, M.6
  • 103
    • 79953323645 scopus 로고    scopus 로고
    • Prevalence of osteoporosis and fractures among women prescribed osteoporosis medication in five European countries: The POSSIBLE EU® study
    • Roux C, Cooper C, Díez-Pérez A, Martinez L, Ortolani S, Gitlin M. Prevalence of osteoporosis and fractures among women prescribed osteoporosis medication in five European countries: the POSSIBLE EU® study. Osteoporos Int. 2011;22:1227-36.
    • (2011) Osteoporos Int , vol.22 , pp. 1227-1236
    • Roux, C.1    Cooper, C.2    Díez-Pérez, A.3    Martinez, L.4    Ortolani, S.5    Gitlin, M.6


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