Synthesis and antitumor activities of novel α-aminophosphonates dehydroabietic acid derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 19, 2013, Pages 5283-5289

  Huang, Xiao Chao ^a   Wang, Meng ^a   Pan, Ying Ming ^a   Tian, Xiao Yan ^a   Wang, Heng Shan ^a   Zhang, Ye ^a,b  

^a GUANGXI NORMAL UNIVERSITY   (China)

^b GUILIN NORMAL COLLEGE   (China)

Author keywords

Aminophosphonate; Apoptosis; Cell cycle; Cytotoxicity; Dehydroabietic acid

Indexed keywords

ALPHA AMINOPHOSPHONATE DERIVATIVE; ANTINEOPLASTIC AGENT; DEHYDROABIETIC ACID; FLUOROURACIL; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE ARREST; CELL VIABILITY; CONTROLLED STUDY; DRUG DESIGN; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CANCER; LUNG ADENOCARCINOMA; MITOCHONDRIAL MEMBRANE POTENTIAL; OVARY CANCER;

AMINOPHOSPHONATE; APOPTOSIS; CELL CYCLE; CYTOTOXICITY; DEHYDROABIETIC ACID;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; DITERPENES, ABIETANE; DRUG EVALUATION, PRECLINICAL; FLOW CYTOMETRY; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; ORGANOPHOSPHONATES;

EID: 84883490385     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.08.005     Document Type: Article

References (26)

1. M.A. Jordan, and L. Wilson Nat. Rev. Cancer 4 2004 253
2. R. Vennila, S. Kamalraj, and J. Muthumary Biomed. Aging Pathol. 2 2012 16
3. R.L. Noble, C.T. Beer, and J.H. Cutts Ann. N.Y. Acad. Sci. 76 1958 882
4. J.W. Moncrief, and W.N. Lipscomb J. Am. Chem. Soc. 87 1965 4963
5. N. Neuss, and M.N. Neuss A. Brossi, M. Suffness, The Alkaloids Vol. 37 1990 Academic San Diego 229
6. D.J. Newman, G.M. Cragg, and K.M. Snader J. Nat. Prod. 66 2003 1022
7. Lin, C. -H.; Chuang, H. -S. U.S. Patent 5, 2003, 248, 696.
8. Y.-M. Cui, E. Yasutomi, Y. Otani, T. Yoshinaga, K. Ido, K. Sawada, and T. Ohwada Bioorg. Med. Chem. Lett. 18 2008 5201
9. X. Rao, Z. Song, L. He, and W. Jia Chem. Pharm. Bull. 56 2008 1575
10. R. Tanaka, H. Tokuda, and Y. Ezaki Phytomedicine 15 2008 985
11. F. Li, L. He, Z.-Q. Song, J.-C. Yao, X.-P. Rao, and H.-T. Li J. Pharm. Pharmacol. 60 2008 205
12. M. Gnant, and P. Clézardin Cancer Treat. Rev. 38 2012 407
13. P. Clézardin Bone 48 2011 71
14. L. Ning, W. Wang, Y.-J. Liang, H. Peng, L.-W. Fu, and H.-W. He Eur. J. Med. Chem. 48 2012 379
15. N.S. Ali, S. Zakir, M. Patel, and M. Farooqui Eur. J. Med. Chem. 50 2012 39
16. L. Gu, and C. Jin Org. Biomol. Chem. 10 2012 7098
17. P. Kafarski, and B. Lejczak V.P. Kukhar, H.R. Hudson, Aminophosphonic and Aminophosphinic Acids. Chemistry and Biological Activity Vol. 12 2000 John Wiley & Sons Chichester 407 442
18. F.R. Atherton, C.H. Hassal, and R.W. Lambert J. Med. Chem. 29 1986 29
19. S. Du, H. Faiger, V. Belakhov, and T. Baasov Bioorg. Med. Chem. 7 1999 2671
20. S. Sobhani, and Z. Tashrifi Synth. Commun. 39 2008 120
21. Z.-F. Chen, Y.-Q. Gu, X.-Y. Song, Y.-C. Liu, Y. Peng, and H. Liang Eur. J. Med. Chem. 59 2013 194
22. G. Tong, M. Poot, D. Hu, and D. Oda Oral Oncol. 36 2 2000 236
23. P. Wang, S. Ownby, Z. Zhang, W. Yuan, and S.Y. Li Bioorg. Med. Chem. Lett. 20 2010 2790
24. A. Mucha, M. Drag, J.P. Dalton, and P. Kafarski Biochimie 92 2010 1509
25. A. Mucha, P. Kafarski, and Ł. Berlicki J. Med. Chem. 54 2011 5955
26. M. Culcasi, G. Casano, C. Lucchesi, A. Mercier, J.L. Clement, V. Pique, L. Michelet, A. Krieger-Liszkay, M. Robin, and S. Pietri J. Med. Chem. 56 2013 2487