GKN1-miR-185-DNMT1 axis suppresses gastric carcinogenesis through regulation of epigenetic alteration and cell cycle

Clinical Cancer Research

Volumn 19, Issue 17, 2013, Pages 4599-4610

  Yoon, Jung Hwan ^a   Choi, Yoo Jin ^a   Choi, Won Suk ^a   Ashktorab, Hassan ^b   Smoot, Duane T ^b   Nam, Suk Woo ^a   Lee, Jung Young ^a   Park, Won Sang ^a  

^a The Catholic University of Korea   (South Korea)

^b HOWARD UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DNA METHYLTRANSFERASE 1; FLUOROURACIL; GASTROKINE 1; MICRORNA; MICRORNA185; PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER GROWTH; CANCER TISSUE; CARCINOGENESIS; CELL CYCLE; CELL PROLIFERATION; CELL VIABILITY; COLONY FORMATION; DNA MODIFICATION; EPIGENETICS; EPITHELIUM CELL; G1 PHASE CELL CYCLE CHECKPOINT; G2 PHASE CELL CYCLE CHECKPOINT; GENE SEQUENCE; HUMAN; HUMAN CELL; HUMAN TISSUE; M PHASE CELL CYCLE CHECKPOINT; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; STOMACH ANTRUM; STOMACH CANCER; UPREGULATION;

CARCINOGENESIS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HELICOBACTER PYLORI; HISTONE DEACETYLASE 1; HUMANS; MICRORNAS; PEPTIDE HORMONES; STOMACH NEOPLASMS;

EID: 84883486821     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-12-3675     Document Type: Article

References (25)

1. Martin TE, Powell CT, Wang Z, Bhattacharyya S, Walsh-Reitz MM, Agarwal K, et al. A novel mitogenic protein that is highly expressed in cells of the gastric antrum mucosa. Am J Physiol Gastrointest Liver Physiol 2003;285:G332-43. (Pubitemid 36875205)
2. Xing R, Li W, Cui J, Zhang J, Kang B, Wang Y, et al. Gastrokine 1 induces senescence through p16/Rb pathway activation in gastric cancer cells. Gut 2012;61:43-52.
3. Toback FG, Walsh-Reitz MM, Musch MW, Chang EB, Del Valle J, Ren H, et al. Peptide fragments of AMP-18, a novel secreted gastric antrum mucosal protein, are mitogenic and motogenic. Am J Physiol Gastrointest Liver Physiol 2003;285:G344-53. (Pubitemid 36875206)
4. Nardone G, Rippa E, Martin G, Rocco A, Siciliano RA, Fiengo A, et al. Gastrokine 1 expression in patients with and without Helicobacter pylori infection. Dig Liver Dis 2007;39:122-9. (Pubitemid 46126745)
5. Shiozaki K, Nakamori S, Tsujie M, Okami J, Yamamoto H, Nagano H, et al. Human stomach-specific gene, CA11, is down-regulated in gastric cancer. Int J Oncol 2001;19:701-7.
6. Yoon JH, Kang YH, Choi YJ, Park IS, Nam SW, Lee JY, et al. Inactivation of the gastrokine 1 gene in gastric adenomas and carcinomas. J Pathol 2011;223:618-25.
7. Yoon JH, Cho ML, Choi YJ, Back JY, Park MK, Choi BJ, et al. Gastrokine 1 functions as a tumor suppressor by inhibition of epithelial-mesenchymal transition in gastric cancers. J Cancer Res Clin Oncol 2012;137:1697-704.
8. Yan GR, Xu SH, Tan ZL, Yin XF, He QY. Proteomics characterization of gastrokine 1-induced growth inhibition of gastric cancer cells. Proteomics 2011;11:3657-64.
9. Pfaffl MW. A new mathematical model for relative quantification in realtime RT-PCR. Nucleic Acids Res 2001;29:e45.
10. Kim H, Kim YH, Kim SE, Kim NG, Noh SH. Concerted promoter hypermethylation of hMLH1, p16INK4A, and E-cadherin in gastric carcinomas with microsatellite instability. J Pathol 2003;200: 23-31. (Pubitemid 36592632)
11. Bronner C. Control of DNMT1 abundance in epigenetic inheritance by acetylation, ubiquitylation, and the histone code. Sci Signal 2011; 4:pe3.
12. Lewis BP, Shih IH, Jones-Rhoades MW, Bartel DP, Burge CB. Prediction of mammalian microRNA targets. Cell 2003;115: 787-98. (Pubitemid 38058492)
13. Zhang Z, Tang H, Wang Z, Zhang B, Liu W, Lu H, et al. MiR-185 targets the DNAmethyltransferases 1 and regulates global DNAmethylation in human glioma. Mol. Cancer 2011;10:124.
14. Sun X, Shimizu H, Yamamoto K. Identification of a novel p53 promoter element involved in genotoxic stress-inducible p53 gene expression. Mol Cell Biol 1995;15:4489-96.
15. Seo JS, Kim TG, Hong YS, Chen JY, Lee SK. Contribution of Epstein-Barr virus infection to chemoresistance of gastric carcinoma cells to 5-fluorouracil. Arch Pharm Res 2011;34:635-43.
16. Graña X, Reddy EP. Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). Oncogene 1995;1:211-9.
17. Surani MA, Hayashi K, Hajkova P. Genetic and epigenetic regulators of pluripotency. Cell 2007;128:747-62. (Pubitemid 46273582)
18. Mutze K, Langer R, Schumacher F, Becker K, Ott K, Novotny A, et al. DNA methyltransferase 1 as a predictive biomarker and potential therapeutic target for chemotherapy in gastric cancer. Eur J Cancer 2011;47:1817-25.
19. Bracken AP, Dietrich N, Pasini D, Hansen KH, Helin K. Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev 2006;20:1123-36.
20. Chang CJ, Hung MC. The role of EZH2 in tumour progression. Br J Cancer 2011;106:243-7.
21. Simon JA, Lange CA. Roles of the EZH2 histone methyltransferase in cancer epigenetics. Mutat Res 2008;647:21-9.
22. Cao Q, Yu J, Dhanasekaran SM, Kim JH, Mani RS, Tomlins SA, et al. Repression of E-cadherin by the polycomb group protein EZH2 in cancer. Oncogene 2008;27:7274-84.
23. Lim SO, Gu JM, Kim MS, Kim HS, Park YN, Park CK, et al. Epigenetic changes induced by reactive oxygen species in hepatocellular carcinoma: methylation of E-cadherin promoter. Gastroenterology 2008; 135:2128-40.
24. Napieralski R, Ott K, Kremer M, Becker K, Boulesteix AL, Lordick F, et al. Methylation of tumor-related genes in neoadjuvant-treated gastric cancer: relation to therapy response and clinicopathologic and molecular features. Clin Cancer Res 2007;13:5095-102. (Pubitemid 47502076)
25. Okano M, Bell DW, Haber DA, Li E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 1999;99:247-57. (Pubitemid 29519904)