Gastrokine 1 functions as a tumor suppressor by inhibition of epithelial-mesenchymal transition in gastric cancers

Journal of Cancer Research and Clinical Oncology

Volumn 137, Issue 11, 2011, Pages 1697-1704

  Yoon, Jung Hwan ^a   Kang, Young Hwi ^a   Choi, Yoo Jin ^a   Park, In Soo ^a   Nam, Suk Woo ^a   Lee, Jung Young ^a   Lee, Yun Sil ^b   Park, Won Sang ^a  

^a The Catholic University of Korea   (South Korea)

^b Ewha Womans University   (South Korea)

Author keywords

EMT; Gastric cancer; GKN1; Progression; Tumor suppressor

Indexed keywords

BETA CATENIN; FIBRONECTIN; GASTROKINE 1 PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; RECOMBINANT PROTEIN; RECOMBINANT PROTEIN GASTROKINE 1; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN;

ARTICLE; CANCER CELL; CANCER GROWTH; CANCER INHIBITION; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; DRUG MECHANISM; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION; GENE FUNCTION; GENETIC TRANSFECTION; GKN1 GENE; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; STOMACH CANCER; TREATMENT RESPONSE; TUMOR SUPPRESSOR GENE; WOUND HEALING;

CELL LINE, TUMOR; CELL MOVEMENT; EPITHELIAL-MESENCHYMAL TRANSITION; HUMANS; PEPTIDE HORMONES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE NITROGEN SPECIES; STOMACH NEOPLASMS;

EID: 80054769444     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-011-1051-8     Document Type: Article

References (25)

1. KL Ang DL Shi WW Keong RJ Epstein 2005 Upregulated Akt signaling adjacent to gastric cancers: implications for screening and chemoprevention Cancer Lett 225 53 59 15922857 10.1016/j.canlet.2004.11.021 1:CAS:528:DC%2BD2MXks1Ggsbw%3D (Pubitemid 40732768)
2. MW Babyatsky M deBeaumont L Thim DK Podolsky 1996 Oral trefoil peptides protect against ethanol- and indomethacin-induced gastric injury in rats Gastroenterology 110 489 497 8566596 10.1053/gast.1996.v110.pm8566596 1:CAS:528:DyaK28XhsV2ls78%3D (Pubitemid 26043882)
3. U Cavallaro G Christofori 2004 Multitasking in tumor progression: signaling functions of cell adhesion molecules Ann N Y Acad Sci 1014 58 66 15153420 10.1196/annals.1294.006 1:CAS:528:DC%2BD2cXkvVehsL4%3D (Pubitemid 38594791)
4. UH Frixen J Behrens M Sachs G Eberle B Voss A Warda D Löchner W Birchmeier 1991 E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells J Cell Biol 113 173 185 2007622 10.1083/jcb.113.1.173 1:CAS:528:DyaK3MXhvVejur8%3D (Pubitemid 21909684)
5. A Jemal T Murray E Ward A Samuels RC Tiwari A Ghafoor EJ Feuer MJ Thun 2005 Cancer statistics, 2005 CA Cancer J Clin 55 10 30 15661684 10.3322/canjclin.55.1.10 (Pubitemid 40310185)
6. M Jücker K Südel S Horn M Sickel W Wegner W Fiedler RA Feldman 2002 Expression of a mutated form of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase in a Hodgkin's lymphoma-derived cell line (CO) Leukemia 16 894 901 11986952 10.1038/sj.leu.2402484 (Pubitemid 34537563)
7. R Kalluri EG Neilson 2003 Epithelial-mesenchymal transition and its implications for fibrosis J Clin Invest 112 1776 1784 14679171 1:CAS:528:DC%2BD3sXhtVSmtLrL (Pubitemid 38063698)
8. R Kalluri RA Weinberg 2009 The basics of epithelial-mesenchymal transition J Clin Invest 119 1420 1428 19487818 10.1172/JCI39104 1:CAS:528:DC%2BD1MXntVCjtr0%3D
9. L Larue A Bellacosa 2005 Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3′ kinase/AKT pathways Oncogene 24 7443 7454 16288291 10.1038/sj.onc.1209091 1:CAS:528:DC%2BD2MXht1Wis7vE (Pubitemid 41637984)
10. TE Martin CT Powell Z Wang S Bhattacharyya MM Walsh-Reitz K Agarwal FG Toback 2003 A novel mitogenic protein that is highly expressed in cells of the gastric antrum mucosa Am J Physiol Gastrointest Liver Physiol 285 G332 G343 12851218 1:CAS:528:DC%2BD3sXmsVaht70%3D (Pubitemid 36875205)
11. G Nardone E Rippa G Martin A Rocco RA Siciliano A Fiengo G Cacace A Malorni G Budillon P Arcari 2007 Gastrokine 1 expression in patients with and without Helicobacter pylori infection Dig Liver Dis 39 122 129 17092786 10.1016/j.dld.2006.09.017 1:CAS:528:DC%2BD2sXktFWgsrw%3D (Pubitemid 46126745)
12. KA Oien F McGregor S Butler RK Ferrier I Downie S Bryce S Burns WN Keith 2004 Gastrokine 1 is abundantly and specifically expressed in superficial gastric epithelium, down-regulated in gastric carcinoma, and shows high evolutionary conservation J Pathol 203 789 797 15221938 10.1002/path.1583 1:CAS:528:DC%2BD2cXmtFSmtL8%3D (Pubitemid 38961565)
13. E Oki H Baba E Tokunaga T Nakamura N Ueda M Futatsugi K Mashino M Yamamoto M Ikebe Y Kakeji Y Maehara 2005 Akt phosphorylation associates with LOH of PTEN and leads to chemoresistance for gastric cancer Int J Cancer 117 376 380 15900596 10.1002/ijc.21170 1:CAS:528:DC%2BD2MXhtFant7rJ (Pubitemid 41429560)
14. DC Radisky DD Levy LE Littlepage H Liu CM Nelson JE Fata D Leake EL Godden DG Albertson MA Nieto Z Werb MJ Bissell 2005 Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability Nature 436 123 127 16001073 10.1038/nature03688 1:CAS:528:DC%2BD2MXlvVGiurk%3D (Pubitemid 40966197)
15. HR Shin KW Jung YJ Won JG Park 2004 139 KCCR-affiliated hospitals. 2002 annual report of the Korea central cancer registry: based on registered data from 139 hospitals J Korean Cancer Assoc 36 103 114
16. K Shiozaki S Nakamori M Tsujie J Okami H Yamamoto H Nagano K Dono K Umeshita M Sakon H Furukawa M Hiratsuka T Kasugai S Ishiguro M Monden 2001 Human stomach-specific gene, CA11, is down-regulated in gastric cancer Int J Oncol 19 701 707 11562744 1:CAS:528:DC%2BD3MXnsFSmtbk%3D
17. FG Toback MM Walsh-Reitz MW Musch EB Chang J Del Valle H Ren E Huang TE Martin 2003 Peptide fragments of AMP-18, a novel secreted gastric antrum mucosal protein, are mitogenic and motogenic Am J Physiol Gastrointest Liver Physiol 285 G344 G353 12851219 1:CAS:528:DC%2BD3sXmsVaht7o%3D (Pubitemid 36875206)
18. I Vivanco CL Sawyers 2002 The phosphatidylinositol 3-kinase AKT pathway in human cancer Nat Rev Cancer 2 489 501 12094235 10.1038/nrc839 1:CAS:528:DC%2BD38XkvFKltLs%3D (Pubitemid 37328931)
19. MM Walsh-Reitz EF Huang MW Musch EB Chang TE Martin S Kartha FG Toback 2005 AMP-18 protects barrier function of colonic epithelial cells: role of tight junction proteins Am J Physiol Gastrointest Liver Physiol 289 G163 G171 15961882 10.1152/ajpgi.00013.2005 1:CAS:528:DC%2BD2MXmvVeqs7o%3D (Pubitemid 40944235)
20. Z Wang Y Li FH Sarkar 2010 Signaling mechanism(s) of reactive oxygen species in epithelial-mesenchymal transition reminiscent of cancer stem cells in tumor progression Curr Stem Cell Res Ther 5 74 80 19951255 10.2174/ 157488810790442813
21. B Willipinski-Stapelfeldt S Riethdorf V Assmann U Woelfle T Rau G Sauter J Heukeshoven K Pantel 2005 Changes in cytoskeletal protein composition indicative of an epithelial-mesenchymal transition in human micrometastatic and primary breast carcinoma cells Clin Cancer Res 11 8006 8014 16299229 10.1158/1078-0432.CCR-05-0632 1:CAS:528:DC%2BD2MXht1entr7K (Pubitemid 41698741)
22. WS Wu 2006 The signaling mechanism of ROS in tumor progression Cancer Metastasis Rev 25 659 705
23. Xing R, Li W, Cui J, Zhang J, Kang B, Wang Y, Wang Z, Liu S, Lu Y (2011) Gastrokine 1 induces senescence through p16/Rb pathway activation in gastric cancer cells. Gut (in press)
24. JH Yoon JH Song C Zhang M Jin YH Kang SW Nam JY Lee WS Park 2011 Inactivation of the Gastrokine 1 gene in gastric adenomas and carcinomas J Pathol 223 618 625 21341273 10.1002/path.2838 1:CAS:528:DC%2BC3MXlvFCqtbw%3D
25. KH Zhang HY Tian X Gao WW Lei Y Hu DM Wang XC Pan ML Yu GJ Xu FK Zhao JG Song 2009 Ferritin heavy chain-mediated iron homeostasis and subsequent increased reactive oxygen species production are essential for epithelial-mesenchymal transition Cancer Res 69 5340 5348 19531652 10.1158/0008-5472.CAN-09-0112 1:CAS:528:DC%2BD1MXnvFWqu7o%3D