Activity guided isolation of anti-inflammatory compound/fraction from root of Ricinus communis Linn

International Journal of PharmTech Research

Volumn 5, Issue 3, 2013, Pages 1142-1149

  Singh, Varinder ^a   Sharma, Saurabh ^a   Dhar, K L ^a   Kalia, A N ^a  

^a ISF COLLEGE OF PHARMACY   (India)

Author keywords

Anti inflammatory; Isolation; Ricinine; Ricinus communis

Indexed keywords

DICLOFENAC; PLANT MEDICINAL PRODUCT; QUERCETIN; RICININE; RICINUS COMMUNIS EXTRACT; SBFR 5; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG ISOLATION; FRACTIONATION; INFLAMMATION; NONHUMAN; PAW EDEMA; PHYTOCHEMISTRY; PLANT ROOT; PLETHYSMOGRAPHY; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; RICINUS COMMUNIS; SOXHLET EXTRACTION; THIN LAYER CHROMATOGRAPHY; ULTRAVIOLET SPECTROSCOPY;

EID: 84883470126     PISSN: 09744304     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Barbosa-Filho J. M., Piuvezam M. R., Moura M. D., Moura M. S., Batista Lima K. V., da-Cunha E. V. L., Fechine I. M., Takemura, O. S. (2006). Anti-inflammatory activity of alkaloids: A twenty-century review. Brazilian Journal of Pharmacognosy. 16(1):109-139.
2. Rainsford K. D., (2007). Anti-inflammatory drugs in the 21st century. Sub-cellular Biochemistry. 42:3-27.
3. Nonato F. R., Barros T. A. A., Lucchese A. M., Oliveira C. E. C., Santosa R. R., Soares M. B. P., Villarreal C. F. (2009). Antiinflammatory and antinociceptive activities of Blechnum occidentale L. extract. Journal of Ethnopharmacology. 125:102-107.
4. Dogne J. M., Supuran C. T., Pratico D., (2005). Adverse cardiovascular effects of the coxibs. Journal of Medicinal Chemistry. 48:2251-2257.
5. Reinke P., Bevilacqua M., Tryon V., Cheronis J., Volk H. D., (2002). Immunemonitoring of glucocorticoid therapy. In: Ernst ScheringResearch FoundationWorkshop. 40:25-37.
6. Schacke H., Docke W. D., Asadullah K., (2002). Mechanisms involved in the side-effects of glucocorticoids. Pharmacology & Therapeutics. 96:23-43.
7. Lakshmamma P. and Prayaga L., (2006). Identifying the sources of tolerance for drought in Castor, Ricinus communis L. J. Oilseeds Res. 33:348-352.
8. Scarpa, A. and Guerci, A., (1982). Various uses of the castor oil plant (Ricinus communis L.): a review. Journal of Ethnopharmacology 5, 117-137.
9. Kirtikar K. R. and Basu B. D., 1991. Indian Medicinal Plants. 3:2274-2277.
10. Padmapriya B., Leema M. C. E., Kumar A. P., Ilyas M. H. M., Rajeswari T., (2012). Antihepatotoxicity of Ricinus communis (L.) Against Ketoconazole Induced Hepatic Damage. Advances in Biological Research. 6(1):30-36.
11. Shanmugapriya R. and Ramanathan T., (2012). Antifilarial activity of seed extracts of Ricinus communis against Brugia malayi. Journal of Pharmacy Research. 5:1448-1450.
12. Singh, P. P. and Ambika Chauhan, S. M. S., (2009). Activity guided isolation of antioxidants from the leaves of Ricinus communis L. Food Chemistry. 114: 1069-1072.
13. Taur D. and Patil R. Y., (2011). Antiasthmatic activity of Ricinus communis L. roots. Asian Pacific Journal of Tropical Biomedicine. S13-S16.
14. Jombo G. T. A. and Enenebeaku M. N. O., (2008). Antibacterial profile of fermented seed extracts of Ricinus communis: findings from a preliminary analysis. Nigerian Journal of Physiological Sciences. 23:55-59.
15. Nandkarni K. M. (1954). Indian Materia Medica, third ed. Bombay: The Popular Book Depot.
16. Ilavarasan R., Mallika M., Venkataraman S., (2006). Anti-inflammatory and free radical scavenging activity of Ricinus communis root extract. Journal of Ethnopharmacology. 103:478-480.
17. Sandhyakumary K. and Bobby, R. G. M., (2003). Antifertility effects of Ricinus communis (Linn) on rats. Phytotherapy Research. 17:508-511.
18. Shokeen P., Anand P. Y., Murali K., Tandon V., (2008). Antidiabetic activity of 50% ethanolic extract of Ricinus communis and its purified fractions. Food and Chemical Toxicology. 46(11):3458-3466.
19. Verma S. K., Yousuf S., Singh S. K., Prasad G. B. K. S., Dua V. K., (2011). Antimicrobial potential of roots of Riccinus Communis against pathogenic microorganisms. International Journal of Pharma and Bio Sciences. 2:545-548.
20. Kang S., Cordell G., Soejarto D., Fong H., (1985). Alkaloids and flavonoids from Ricinus communis. J. Nat. Prod. 48(1):155-156.
21. Kim K. B., (2001). Effects of oil milling steps on residual toxin and antigen activities of castor bean meal. Food Sci. Biotechnol. 10(3): 305-310.
22. Sun J., Pohl E. E, Krylova O. O., Krylova E., Krylova I. I., Krylova A. J., Pohl P., (2004). Membrane destabilization by ricin. Eur Biophys J. 33:572-579.
23. Hall S. M. and Medlow G. C., (1975). Identification of IAA in phloem and root pressure saps of Ricinus communis by mass spectrometry. Plant Physiology. 56:177.
24. Alam P and Ali M, (2008). Phytochemical investigation of the root bark of Ricinus communis L. J. Saudi Chem. Soc. 12(4):523-530.
25. Cannel, R. J. P. (1998). Natural Products Isolation (Methods in Biotechnology). Humana Press, Totowa, New Jersey, USA vol. 4: pp-343-358.
26. Evans W. C. (2002). Trease and Evans Pharmacognosy, fifteenth ed. W. B. Saunders, New York. pp-156-200.
27. Winter C. A., Risley E. A., Nuss G. W., (1962). Carrageenan-induced edema in hind paws of the rat as an assay for anti-inflammatory drugs. Proc Soc Exp Biol Med. 111:544-547.
28. Ghasemzadeh A., Jaafar H. Z. E., Rahmat A., (2010). Antioxidant Activities, Total Phenolics and Flavonoids Content in Two Varieties of Malaysia Young Ginger (Zingiber officinale Roscoe). Molecules. 15:4324-4333.
29. Guvenc A., Okada Y., Akkol E. K., Duman H., Okuyama T., Calis I., (2010). Investigations of antiinflammatory, antinociceptive, antioxidant and aldose reductase inhibitory activities of phenolic compounds from Sideritis brevibracteata. Food Chemistry. 118:686-692.
30. Kang J., Xie C., Li Z., Nagarajan S., Schauss A. G., Wu T., Wu X., (2011). Flavonoids from acai (Euterpe oleracea Mart.) pulp and their antioxidant and anti-inflammatory activities. Food Chemistry. 128:152-157.
31. Bullangpoti V., Khumrungsee N., Pluempanupat W., Kainoh Y., Saguanpong U., (2011). Toxicity of ethyl acetate extract and ricinine from Jatropha gossypifolia senescent leaves against Spodoptera exigua Hübner (Lepidoptera: Noctuidae). J. Pestic. Sci. 36(2):260-263.
32. Park J. C, Park J. G., Hur J. S., Choi M. R., Yoo E. J., Kim SH., Son J. C., Kim M. S., (2004). Inhibitory effects of methanol extract, phenolic acids, and flavonoids from the leaves of Eucalyptus darylmpleana against 1, 1-Diphenyl-2-picrylhydrazyl radical. Natural product sciences. 10(5):244-247.
33. Susidarti R. A., Wahyono Yamin., (2011). Isolation and Identification of Antibacterial Compound from the leaves of Muehlenbeckia platyclada Meissn. International Journal of Advances in Pharmaceutical Sciences. 2:40-44.
34. Rotelli A. E., Guardia T., Juarez A. O., Rocha N. E., Pelzer L. E., (2003). Comparative study of flavonoids in experimental models of inflammation. Pharmacological Research. 48:601-606.
35. Vinegar R., Schreiber W., Hugo R., (1969). Biphasic development of carrageenan oedema in rats. Journal of Pharmacology and Experimental Therapeutics. 166:96-103.
36. Di Rosa M., Giroud J. P., Willoughby D. A., (1971). Studies of the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine. Journal of Pathology. 104:15-29.
37. Crunkhorn P. and Meacock S. C. R., (1971). Mediators of the inflammation induced in the rat paw by carrageenin. Br J Pharmacol. 42:392.
38. Garcia Leme J., Hamamura L., Leite M. P., Rocha E., Silva M., (1973). Pharmacological analysis of the acute inflammatory response induced in the rat's paw by local injection of carrageenan and by heating. British Journal of Pharmacology. 48:88-96.
39. Salvemini D., Wang Z. Q., Wyatt P. S., Bourdon D. M., Marino M. H., Manning P. T., Currie M. G., (1996). Nitric oxide: a key mediator in the early and late phase of carrageenan-induced rat paw inflammation. British Journal of Pharmacology. 118:829-838.
40. Flower R. J., Gryglewski R. J., Herbaczynska-Cedro K., Vane J. R., (1972). Effects of anti-inflammatory drugs on prostaglandin biosynthesis. Nature. 238:104-106.
41. Vane J. R. and Botting, R. M., (1998). Anti-inflammatory drugs and their mechanism of action. Inflammation Research. 47:S78-S87.
42. Vane J. R., Bakhle Y. S., Botting R. M., (1998). Cyclooxygenase 1 and 2. Annual Review of Pharmacology and Toxicology. 38:97-120.