Lower CD28+ T cell proportions were associated with CMV-seropositivity in patients with Hashimoto's thyroiditis

BMC Endocrine Disorders

Volumn 13, Issue , 2013, Pages

  Prelog, Martina ^a,b   Schönlaub, Jörn ^a,b   Würzner, Reinhard ^b   Koppelstaetter, Christian ^c   Almanzar, Giovanni ^a   Brunner, Andrea ^d   Gasser, Martin ^a   Prommegger, Rupert ^b   Häusler, Gabriele ^e   Kapelari, Klaus ^b   Högler, Wolfgang ^f  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^c INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^d MEDICAL UNIVERSITY OF INNSBRUCK   (Austria)

^e MEDICAL UNIVERSITY OF VIENNA   (Austria)

^f BIRMINGHAM CHILDREN S HOSPITAL   (United Kingdom)

Author keywords

CD62L; Immunosenescence; Regulatory T cells; Telomere; TREC

Indexed keywords

CD28 ANTIGEN;

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; DISEASE DURATION; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; FLOW CYTOMETRY; HASHIMOTO DISEASE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LYMPHOCYTIC INFILTRATION; MALE; SEROLOGY; T LYMPHOCYTE;

EID: 84883463560     PISSN: None     EISSN: 14726823     Source Type: Journal    
DOI: 10.1186/1472-6823-13-34     Document Type: Article

References (40)

1. Hofer J, Hofer S, Zlamy M, Jeller V, Koppelstaetter C, Brandstätter A, Kern H, Köhle J, Zimmerhackl LB, Prelog M. Elevated proportions of recent thymic emigrants in children and adolescents with type 1 diabetes. Rejuv Res 2009, 12:311-320.
2. Prelog M, Schwarzenbrunner N, Sailer-Höck M, Kern H, Klein-Franke A, Ausserlechner MJ, Koppelstaetter C, Brunner A, Duftner C, Dejaco C, Strasak AM, Müller T, Zimmerhackl LB, Brunner J. Premature aging of the immune system in children with juvenile idiopathic arthritis. Arthritis Rheumat 2008, 58:2153-2162. 10.1002/art.23599, 18576332.
3. Prelog M. Aging of the immune system: a risk factor for autoimmunity?. Autoimm Rev 2006, 5:136-139.
4. Mayerl C, Prelog M. Immunosenescence and juvenile idiopathic arthritis. Autoimm Rev 2012, 11:297-300.
5. Hazenberg MD, Verschuren MC, Hamann D, Miedema F, van Dongen JJ. T cell receptor excision circles as markers for recent thymic emigrants: basic aspects, technical approach, and guidelines for interpretation. J Mol Med 2001, 79:631-640. 10.1007/s001090100271, 11715066.
6. Douek DC, McFarland RD, Keiser PH, Gage EA, Massey JM, Haynes BF, Polis MA, Haase AT, Feinberg MB, Sullivan JL, Jamieson BD, Zack JA, Picker LJ, Koup RA. Changes in thymic function with age and during the treatment of HIV infection. Nature 1998, 396:690-695. 10.1038/25374, 9872319.
7. Hohensinner PJ, Goronzy JJ, Weyand CM. Telomere dysfunction, autoimmunity and aging. Aging Dis 2011, 2:524-537. 3295061, 22396899.
8. Almanzar G, Schwaiger S, Jenewein B, Keller M, Herndler-Brandstetter D, Würzner R, Schönitzer D, Grubeck-Loebenstein B. Long-term cytomegalovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons. J Virol 2005, 79:3675-3683. 10.1128/JVI.79.6.3675-3683.2005, 1075718, 15731261.
9. Prelog M, Schwarzenbrunner N, Sailer-Hoeck M, Kern H, Koppelstaetter C, Wurzner R, Zimmerhackl LB, Brunner J. Indications for a disturbed peripheral T cell homeostasis in juvenile idiopathic arthritis (JIA): absent expansion of CD28- T cells and no decrease of naive T cells in cytomegalovirus-positive JIA patients. J Rheumatol 2008, 35:520-527.
10. Caturegli P, Kimura H, Rocchi R, Rose NR. Autoimmune thyroid disease. Curr Opin Rheumatol 2007, 19:44-48. 10.1097/BOR.0b013e3280113d1a, 17143095.
11. Gopalakrishnan S, Marwaha RK. Juvenile autoimmune thyroiditis. J Pediatr Endocrinol Metabol 2007, 20:961-970.
12. Ehlers M, Thiel A, Bernecker C, Porwol D, Papewalis C, Willenberg HS, Schinner S, Hautzel H, Scherbaum WA, Schott M. Evidence of a combined cytotoxic thyroglobulin and thyroperoxidase epitope-specific cellular immunity in Hashimoto's Thyroiditis. J Clin Endocrinol Metab 2012, 97:1347-1354. 10.1210/jc.2011-2178, 22259066.
13. Brown RS. Autoimmune thyroiditis in childhood. J Clin Res Pediatr Endocrinol 2013, 5:45-49. 3608006, 23154164.
14. Bossowski A, Urban M, Stasiak-Barmuta A. Analysis of changes in the percentages of B (CD19) and T (CD3) lymphocytes, subsets CD4, CD8 and their memory (CD45RO), and naive (CD45RA) T cells in children with immune and non-immune thyroid disease. J Pediatr Endocrinol Metabol 2003, 16:63-70.
15. Okajima M, Wada T, Nishida M, Yokoyama T, Nakayama Y, Hashida Y, Shibata F, Tone Y, Ishizaki A, Shimizu M, Saito T, Ohta K, Toma T, Yachie A. Analysis of T cell receptor Vb diversity in peripheral CD4+ and CD8+ T lymphocytes in patients with autoimmune thyroid diseases. Clin Exp Immunol 2008, 155:166-172. 2675246, 19040601.
16. Setoguchi R, Hori S, Takahashi T, Sakaguchi S. Homeostatic maintenance of natural Foxp3+ CD25 + CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J Exp Med 2005, 201:723-735. 10.1084/jem.20041982, 2212841, 15753206.
17. McLachlan SM, Nagayama Y, Pichurin PN, Mizutori Y, Chen CR, Misharin A, Aliesky HA, Rapoport B. The link between Graves' disease and Hashimoto's thyroiditis: a role for regulatory T cells. Endocrinol 2007, 148:5724-5733.
18. Ban Y, Tozaki T, Tobe T, Ban Y, Jacobson EM, Concepcion ES, Tomer Y. The regulatory T cell gene FOXP3 and genetic susceptibility to thyroid autoimmunity: An association analysis in Caucasian and Japanese cohort. J Autoimm 2007, 28:201-207.
19. Kong YM, Morris GP, Brown NK, Yan Y, Flynn JC, David CS. Autoimmune thyroiditis: A model uniquely suited to probe regulatory T cell function. J Autoimm 2009, 33:239-246.
20. Morris GP, Brown NK, Kong AM. Naturally-existing CD4 + CD25 + Foxp3+ regulatory T cells are required for tolerance to experimental autoimmune thyroiditis induced by either exogenous or endogenous autoantigen. J Autoimm 2009, 33:68-75.
21. Appay V, van Lier RAW, Sallusto F, Roederer M. Phenotype and function of human T lymphocyte subets: consensus and issues. Cytometry A 2008, 73A:975-983.
22. Harris JM, Hazenberg MD, Poulin JF, Higuera-Alhino D, Schmidt D, Gotway M, McCune JM. Multiparameter evaluation of human thymic function: interpretation and caveats. Clin Immunol 2005, 115:138-146. 10.1016/j.clim.2004.12.008, 15885636.
23. Cawthon RM. Telomere measurement by quantitative PCR. Nucleic Acids Res 2002, 30:e47. 10.1093/nar/30.10.e47, 115301, 12000852.
24. Koppelstaetter C, Jennings P, Hochegger K, Perco P, Ischia R, Karkoszka H, Mayer G. Effect of tissue fixatives on telomere length determination by quantitative PCR. Mech Ageing Develop 2005, 126:1331-1333.
25. Prelog M, Schönlaub J, Jeller V, Almanzar G, Höfner K, Gruber S, Eiwegger T, Würzner R. Reduced varicella-zoster-virus (VZV)-specific lymphocytes and IgG antibody avidity in solid organ transplant recipients. Vaccine 2013, in press.
26. Ben-Skowronek I, Szewczyk L, Ciechanek R, Korobowicz E. Interactions of lymphocytes, thyrocytes and fibroblasts in Hashimoto's thyroiditis: an immunohistochemical and ultrastructural study. Horm Res Paediatr 2011, 76:335-342.
27. Ben-Skowronek I, Szewczyk L, Kulik-Rechberger B, Korobowicz E. The differences in T and B cell subsets in thyroid of children with Graves' disease and Hashimoto's thyroiditis. World J Pediatr 2013, in press.
28. Zeppa P, Marino G, Lepore M, Troncone G, Lupoli GA, Biondi B, Picardi M, Pane F, Vetrani A, Palombini L. Flow cytometry phenotypization of thyroid lymphoid infiltrate and functional status in Hashimoto's tyhroiditis. Anal Quant Cytol Histol 2006, 28:148-1456.
29. Kucharska AM, Gorska E, Wasik M, Demkow U. Altered expression of T lymphocyte surface markers in children with chronic autoimmune thyroiditis. J Physiol Pharmacol 2008, 59:375-382.
30. Thewissen M, Somers V, Venken K, Linsen L, van Paassen P, Geusens P, Damoiseaux J, Stinissen P. Analyses of immunosenescence markers in patients with autoimmune disease. Clin Immunol 2007, 123:209-218. 10.1016/j.clim.2007.01.005, 17317320.
31. Prelog M. Immune aging and autoimmune diseases in children. Curr Immunnol Rev 2011, 7:116-123.
32. Effros RB. Loss of CD28 expression on T lymphocytes: a marker of replicative senescence. Develop Compend Immunol 1997, 21:471-478.
33. Ouyang Q, Wagner WM, Zheng W, Wikby A, Remarque EJ, Pawelec G. Dysfunctional CMV-specific CD8(+) T cells accumulate in the elderly. Exper Gerontol 2004, 39:607-613.
34. Al-Zarzour N, Monem F. Are human herpes viruses associated with autoimmune thyroid disease?. J Infect Dev Ctries 2011, 5:890-892.
35. Thomas D, Liakos V, Michou V, Kaltsas G, TSilivakos V, Tsatsoulis A. Detection of herpes virus DNA in post-operative thyroid tissue specimens of patients with autoimmune thyroid disease. Exp Clin Endocrinol Diabetes 2008, 116:35-39. 10.1055/s-2007-956171, 18240111.
36. Thomas D, Karachaliou F, Kallergi K, Vlachopapadopoulou E, Antonaki G, Chatzimarkou F, Fotinou A, Kaldrymides P, Michalacos S. Herpes virus antibodies seroprevalence in children with autoimmune thyroid disease. Endocr 2008, 33:171-175.
37. Mori K, Yoshida K. Viral infection in induction of Hashimoto's thyroiditis: a key player or just a bystander?. Curr Opin Endocrinol Diabetes Obesity 2010, 17:418-424.
38. Gessl A, Wilfing A, Agis H, Steiner G, Czernin S, Boltz-Nitulescu G, Vierhapper H, Waldhäusl W. Activated naive CD4+ peripheral blood T cells in autoimmune thyroid disease. Thyroid 1995, 5:117-125. 10.1089/thy.1995.5.117, 7647571.
39. Fountoulakis S, Vartholomatos G, Kolaitis N, Frillingos S, Philippou G, Tsatsoulis A. HLA-DR expressing peripheral T regulatory cells in newly diagnosed patients with different forms of autoimmune thyroid disease. Thyroid 2008, 18:1195-1200. 10.1089/thy.2008.0089, 18925837.
40. Thewissen M, Linsen L, Somers V, Geusens P, Raus J, Stinissen P. Premature immunosenescence in rheumatoid arthritis and multiple sclerosis patients. Ann N Y Acad Sci 2005, 1051:255-262. 10.1196/annals.1361.066, 16126966.