Analysis of T cell receptor Vβ diversity in peripheral CD4+ and CD8+ T lymphocytes in patients with autoimmune thyroid diseases

Clinical and Experimental Immunology

Volumn 155, Issue 2, 2009, Pages 166-172

  Okajima, M ^a   Wada, T ^a   Nishida, M ^a   Yokoyama, T ^a   Nakayama, Y ^a   Hashida, Y ^a   Shibata, F ^a   Tone, Y ^a   Ishizaki, A ^a   Shimizu, M ^a   Saito, T ^a   Ohta, K ^a   Toma, T ^a   Yachie, A ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

Autoimmune; Graves' disease; Hashimoto's thyroiditis; Spectratyping; TCR V repertoire

Indexed keywords

T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR V BETA CHAIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; BLOOD; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL ISOLATION; CLINICAL ARTICLE; COMPARATIVE STUDY; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GENE; GRAVES DISEASE; HASHIMOTO DISEASE; HORMONE SUBSTITUTION; HUMAN; LYMPHOCYTE FUNCTION; LYMPHOCYTIC INFILTRATION; MALE; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE RECEPTOR V BETA GENE; THYROID DISEASE; THYROID GLAND;

ADOLESCENT; ADULT; ANTIBODIES, MONOCLONAL; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CHILD; COMPLEMENTARITY DETERMINING REGIONS; FEMALE; FLOW CYTOMETRY; GENETIC VARIATION; GRAVES DISEASE; HASHIMOTO DISEASE; HUMANS; MALE; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; THYROID GLAND; TIME FACTORS; YOUNG ADULT;

EID: 58149305874     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2008.03842.x     Document Type: Article

References (27)

1. Caturegli P, Kimura H, Rocchi R, Rose NR. Autoimmune thyroid diseases. Curr Opin Rheumatol 2007 19 : 44 8.
2. Canonica GW, Bagnasco M, Cosulich ME, Torre G, McLachlan SM, Smith BR. Why thyroid is major site of thyroid autoantibody synthesis in autoimmune thyroid disease. Lancet 1983 1 : 1163.
3. Utiger RD. The pathogenesis of autoimmune thyroid disease. N Engl J Med 1991 325 : 278 9.
4. MacKenzie WA, Schwartz AE, Friedman EW, Davies TF. Intrathyroidal T cell clones from patients with autoimmune thyroid disease. J Clin Endocrinol Metab 1987 64 : 818 24.
5. Davies TF, Martin A, Concepcion ES, Graves P, Cohen L, Ben-Nun A. Evidence of limited variability of antigen receptors on intrathyroidal T cells in autoimmune thyroid disease. N Engl J Med 1991 325 : 238 44.
6. Davies TF, Martin A, Concepcion ES et al. Evidence for selective accumulation of intrathyroidal T lymphocytes in human autoimmune thyroid disease based on T cell receptor V gene usage. J Clin Invest 1992 89 : 157 62.
7. + T cells in the absence of CD4+ T cell restriction. J Clin Endocrinol Metab 1997 82 : 1140 6.
8. Nikolich-Zugich J, Slifka MK, Messaoudi I. The many important facets of T-cell repertoire diversity. Nat Rev Immunol 2004 4 : 123 32.
9. - natural killer cells in a case of X-SCID with Omenn syndrome-like manifestations. Eur J Haematol 2007 79 : 81 5.
10. Wada T, Schurman SH, Otsu M et al. Somatic mosaicism in Wiskott-Aldrich syndrome suggests in vivo reversion by a DNA slippage mechanism. Proc Natl Acad Sci USA 2001 98 : 8697 702.
11. Okamoto H, Arii C, Shibata F et al. Clonotypic analysis of T cell reconstitution after haematopoietic stem cell transplantation (HSCT) in patients with severe combined immunodeficiency. Clin Exp Immunol 2007 148 : 450 60.
12. + hematopoietic progenitors. Blood 1998 91 : 2588 600.
13. Wada T, Schurman SH, Garabedian EK, Yachie A, Candotti F. Analysis of T-cell repertoire diversity in Wiskott-Aldrich syndrome. Blood 2005 106 : 3895 7.
14. + T cells with killer/effector phenotypes in juvenile dermatomyositis syndrome. Clin Exp Immunol 2004 137 : 187 94.
15. Yawalkar N, Ferenczi K, Jones DA et al. Profound loss of T-cell receptor repertoire complexity in cutaneous T-cell lymphoma. Blood 2003 102 : 4059 66.
16. + and CD8+ T cell clones in elderly humans. J Immunol 1997 158 : 4493 9.
17. Heufelder AE, Wenzel BE, Scriba PC. Antigen receptor variable region repertoires expressed by T cells infiltrating thyroid, retroorbital, and pretibial tissue in Graves' disease. J Clin Endocrinol Metab 1996 81 : 3733 9.
18. McIntosh RS, Tandon N, Pickerill AP, Davies R, Barnett D, Weetman AP. IL-2 receptor-positive intrathyroidal lymphocytes in Graves' disease. Analysis of V alpha transcript microheterogeneity. J Immunol 1993 151 : 3884 93.
19. McIntosh RS, Watson PF, Pickerill AP, Davies R, Weetman AP. No restriction of intrathyroidal T cell receptor V alpha families in the thyroid of Graves' disease. Clin Exp Immunol 1993 91 : 147 52.
20. Caso-Pelaez E, McGregor AM, Banga JP. A polyclonal T cell repertoire of V-alpha and V-beta T cell receptor gene families in intrathyroidal T lymphocytes of Graves' disease patients. Scand J Immunol 1995 41 : 141 7.
21. Matsumoto Y, Matsuo H, Sakuma H et al. CDR3 spectratyping analysis of the TCR repertoire in myasthenia gravis. J Immunol 2006 176 : 5100 7.
22. + T cells from patients with Hashimoto's thyroiditis. Eur J Endocrinol 2003 148 : 383 8.
23. Davies TF, Concepcion ES, Ben-Nun A, Graves PN, Tarjan G. T-cell receptor V gene use in autoimmune thyroid disease: direct assessment by thyroid aspiration. J Clin Endocrinol Metab 1993 76 : 660 6.
24. Rotondi M, Chiovato L, Romagnani S, Serio M, Romagnani P. Role of chemokines in endocrine autoimmune diseases. Endocr Rev 2007 28 : 492 520.
25. Antonelli A, Rotondi M, Fallahi P et al. High levels of circulating CXC chemokine ligand 10 are associated with chronic autoimmune thyroiditis and hypothyroidism. J Clin Endocrinol Metab 2004 89 : 5496 9.
26. + clones associated with IFN-gamma-inducible protein 10 (CXC chemokine ligand 10) production but not cytokine expression, cytolytic activity, or homing characteristics. J Immunol 2005 174 : 2746 55.
27. Wilson R, McKillop JH, Chopra M, Thomson JA. The effect of antithyroid drugs on B and T cell activity in vitro. Clin Endocrinol (Oxf) 1988 28 : 389 97.