Decreased 5-hydroxymethylcytosine (5-hmC) is an independent poor prognostic factor in gastric cancer patients

Journal of Biomedical Nanotechnology

Volumn 9, Issue 9, 2013, Pages 1607-1616

  Yang, Qi ^a   Wu, Kexia ^a   Ji, Meiju ^a   Jin, Weilin ^b   He, Nongyue ^c   Shi, Bingyin ^a   Hou, Peng ^a  

^a THE FIRST AFFILIATED HOSPITAL OF XI AN JIAOTONG UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

^c SOUTHEAST UNIVERSITY   (China)

Author keywords

5 Hydroxymethylcytosine (5 hmC); DNA methylation; Gastric cancer; Poor prognosis; TET1

Indexed keywords

5-HYDROXYMETHYLCYTOSINE; DNA METHYLATION; GASTRIC CANCERS; POOR PROGNOSIS; TET1;

DIAGNOSIS; GENE EXPRESSION; PATHOLOGY; TUMORS;

DISEASES;

5 HYDROXYMETHYLCYTOSINE;

ADULT; AGED; ARTICLE; CANCER DIAGNOSIS; CANCER PATIENT; CANCER PROGNOSIS; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PROTEIN EXPRESSION; STOMACH CANCER;

ADULT; AGED; AGED, 80 AND OVER; CHINA; CYTOSINE; FEMALE; HUMANS; INCIDENCE; MALE; MIDDLE AGED; PROGNOSIS; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; STOMACH NEOPLASMS; SURVIVAL ANALYSIS; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL;

EID: 84883443686     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2013.1713     Document Type: Article

References (41)

1. A. Jemal, R. Siegel, E. Ward, T. Murray, J. Xu, and M. J. Thun, Cancer statistics, 2007. CA. Cancer J. Clin. 57, 43 (2007).
2. H. J. Kim and M. S. Karpeh, Surgical approaches and outcomes in the treatment of gastric cancer. Semin. Radiat. Oncol. 12, 162 (2002).
3. H. Allgayer, M. M. Heiss, and F. W. Schildberg, Prognostic factors in gastric cancer. Br. J. Surg. 84, 1651 (1997).
4. H. Zhao, X. Ma, M. Li, D. Zhou, P. Xiao, and Z. Lu, Analysis of CpG island methylation using rolling circle amplification (RCA) product microarray. J. Biomed. Nanotechnol. 7, 292 (2011).
5. Q. Yu, X. Wang, J. Luo, S. Wang, X. Fang, J. Yu, and Z. Ling, CDH1 methylation in preoperative peritoneal washes is an independent prognostic factor for gastric cancer. J. Surg. Oncol. 106, 765 (2012).
6. S. Rafiq, W. Tapper, A. Collins, S. Khan, I. Politopoulos, S. Gerty, C. Blomqvist, F. J. Couch, H. Nevanlinna, J. Liu, and D. Eccles, Identification of inherited genetic variations influencing prognosis in early-onset breast cancer. Cancer Res. 73, 1883 (2013).
7. A. Hettiaratchi, N. J. Hawkins, G. McKenzie, R. L. Ward, J. E. Hunt, D. Wakefield, and N. Di. Girolamo, The collagenase-1 (MMP-1) gene promoter polymorphism-1607/2G is associated with favourable prognosis in patients with colorectal cancer. Br. J. Cancer 96, 783 (2007).
8. V. J. Bailey, B. P. Keeley, C. R. Razavi, E. Griffiths, H. E. Carraway, and T. H. Wang, DNA methylation detection using MS-qFRET, a quantum dot-based nanoassay. Methods 52, 237 (2010).
9. S. Li, H. Liu, Y. Jia, X. Mou, Y. Deng, L. Lin, and N. He, An automatic high-throughput SNP genotyping approach based on universal tagged arrays and magnetic nanoparticles. J. Biomed. Nanotechnol. 9, 689 (2013).
10. F. Wang, C. Ma, X. Zeng, C. Li, Y. Deng, and N. He, Chemiluminescence molecular detection of sequence-specific HBV-DNA using magnetic nanoparticles. J. Biomed. Nanotechnol. 8, 786 (2012).
11. B. Liu, Z. Li, H. Chen, Y. Deng, N. He, S. Elingarami, and J. Huang, Development of a total temperature micro-volume blended incubating and hybridizing apparatus for DNA hybridization on nanoparticles. J. Biomed. Nanotechnol. 8, 938 (2012).
12. G. Xia, W. Gao, K. Ji, S. Liu, B. Wan, J. Luo, and Y. Bai, Single nucleotide polymorphisms analysis of noise-Induced hearing loss using three-dimensional polyacrylamide gel-based microarray method. J. Biomed. Nanotechnol. 7, 807 (2011).
13. Y. Bai, D. Lin, Q. Han, Y. Jia, J. Tu, J. Luo, Q. Ge, D. Zhang, and Z. Lu, Discrimination of single nucleotide mutation by using a new class of immobilized shared-stem double-stranded DNA probes. J. Biomed. Nanotechnol. 7, 640 (2011).
14. P. A. Jones and S. B. Baylin, The fundamental role of epigenetic events in cancer. Nat. Rev. Genet. 3, 415 (2002).
15. T. Ushijima and M. Sasako, Focus on gastric cancer. Cancer Cell 5, 121 (2004).
16. H. Tomita, A. Hirata, Y. Yamada, K. Hata, T. Oyama, H. Mori, S. Yamashita, T. Ushijima, and A. Hara, Suppressive effect of global DNA hypomethylation on gastric carcinogenesis. Carcinogenesis 31, 1627 (2010).
17. H. Yokozaki, W. Yasui, and E. Tahara, Genetic and epigenetic changes in stomach cancer. Int. Rev. Cytol. 204, 49 (2001).
18. W. Yasui, N. Oue, P. P. Aung, S. Matsumura, M. Shutoh, and H. Nakayama, Molecular-pathological prognostic factors of gastric cancer: A review. Gastric Cancer 8, 86 (2005).
19. M. Tahiliani, K. P. Koh, Y. Shen, W. A. Pastor, H. Bandukwala, Y. Brudno, S. Agarwal, L. M. Iyer, D. R. Liu, L. Aravind, and A. Rao, Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 324, 930 (2009).
20. P. Hajkova, S. J. Jeffries, C. Lee, N. Miller, S. P. Jackson, and M. A. Surani, Genome-wide reprogramming in the mouse germ line entails the base excision repair pathway. Science 329, 78 (2010).
21. S. Ito, A. C. D'Alessio, O. V. Taranova, K. Hong, L. C. Sowers, and Y. Zhang, Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature 466, 1129 (2010).
22. S. C. Wu and Y. Zhang, Active DNA demethylation: Many roads lead to Rome. Nat. Rev. Mol. Cell Biol. 11, 607 (2010).
23. H. Wu and Y. Zhang, Mechanisms and functions of Tet proteinmediated 5-methylcytosine oxidation. Genes Dev. 25, 2436 (2011).
24. C. H. Hsu, K. L. Peng, M. L. Kang, Y. R. Chen, Y. C. Yang, C. H. Tsai, C. S. Chu, Y. M. Jeng, Y. T. Chen, F. M. Lin, H. D. Huang, Y. Y. Lu, Y. C. Teng, S. T. Lin, R. K. Lin, F. M. Tang, S. B. Lee, H. M. Hsu, J. C. Yu, P. W. Hsiao, and L. J. Juan, TET1 suppresses cancer invasion by activating the tissue inhibitors of metalloproteinases. Cell Rep. 2, 568 (2012).
25. C. G. Lian, Y. Xu, C. Ceol, F. Wu, A. Larson, K. Dresser, W. Xu, L. Tan, Y. Hu, Q. Zhan, C. W. Lee, D. Hu, B. Q. Lian, S. Kleffel, Y. Yang, J. Neiswender, A. J. Khorasani, R. Fang, C. Lezcano, L. M. Duncan, R. A. Scolyer, J. F. Thompson, H. Kakavand, Y. Houvras, L. I. Zon, M. C Jr. Mihm, U. B. Kaiser, T. Schatton, B. A. Woda, G. F. Murphy, and Y. G. Shi, Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma. Cell 150, 1135 (2012).
26. Y. Kudo, K. Tateishi, K. Yamamoto, S. Yamamoto, Y. Asaoka, H. Ijichi, G. Nagae, H. Yoshida, H. Aburatani, and K. Koike, Loss of 5-hydroxymethylcytosine is accompanied with malignant cellular transformation. Cancer Sci. 103, 670 (2012).
27. H. Yang, Y. Liu, F. Bai, J. Y. Zhang, S. H. Ma, J. Liu, Z. D. Xu, H. G. Zhu, Z. Q. Ling, D. Ye, K. L. Guan, and Y. Xiong, Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation. Oncogene 32, 663 (2013).
28. S. G. Jin, Y. Jiang, R. Qiu, T. A. Rauch, Y. Wang, G. Schackert, D. Krex, Q. Lu, and G. P. Pfeifer, 5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutations. Cancer Res. 71, 7360 (2011).
29. M. C. Haffner, A. Chaux, A. K. Meeker, D. M. Esopi, J. Gerber, L. G. Pellakuru, A. Toubaji, P. Argani, C. Iacobuzio-Donahue, W. G. Nelson, G. J. Netto, A. M. De Marzo, and S. Yegnasubramanian, Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers. Oncotarget 2, 627 (2011).
30. J. Shi, D. Yao, W. Liu, N. Wang, H. Lv, G. Zhang, M. Ji, L. Xu, N. He, B. Shi, and P. Hou, Highly frequent PIK3CA amplification is associated with poor prognosis in gastric cancer. BMC Cancer 12, 50 (2012).
31. W. Xu, H. Yang, Y. Liu, Y. Yang, P. Wang, S. H. Kim, S. Ito, C. Yang, P. Wang, M. T. Xiao, L. X. Liu, W. Q. Jiang, J. Liu, J. Y. Zhang, B. Wang, S. Frye, Y. Zhang, Y. H. Xu, Q. Y. Lei, K. L. Guan, S. M. Zhao, and Y. Xiong, Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell 19, 17 (2011).
32. B. J. Dicken, D. L. Bigam, C. Cass, J. R. Mackey, A. A. Joy, and S. M. Hamilton, Gastric adenocarcinoma. Ann. Surg. 241, 27 (2005).
33. F. Delhommeau, S. Dupont, V. Della Valle, C. James, S. Trannoy, A. Massé, O. Kosmider, J. P. Le Couedic, F. Robert, A. Alberdi, Y. Lécluse, I. Plo, F. J. Dreyfus, C. Marzac, N. Casadevall, C. Lacombe, S. P. Romana, P. Dessen, J. Soulier, F. Viguié, M. Fontenay, W. Vainchenker, and OA. Bernard, Mutation in TET2 in myeloid cancers. N. Engl. J. Med. 360, 2289 (2009).
34. M. Ko, Y. Huang, A. M. Jankowska, U. J. Pape, M. Tahiliani, H. S. Bandukwala, J. An, E. D. Lamperti, K. P. Koh, R. Ganetzky, X. S. Liu, L. Aravind, S. Agarwal, J. P. Maciejewski, and A. Rao, Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature 468, 839 (2010).
35. H. Zhang, X. Zhang, E. Clark, M. Mulcahey, S. Huang, and Y. G. Shi, TET1 is a DNA-binding protein that modulates DNA methylation and gene transcription via hydroxylation of 5-methylcytosine. Cell Res. 20, 1390 (2010).
36. Y. Xu, C. Xu, A. Kato, W. Tempel, J. G. Abreu, C. Bian, Y. Hu, D. Hu, B. Zhao, T. Cerovina, J. Diao, F. Wu, H. H. He, Q. Cui, E. Clark, C. Ma, A. Barbara, G. J. Veenstra, G. Xu, U. B. Kaiser, X. S. Liu, S. P. Sugrue, X. He, J. Min, Y. Kato, and Y. G. Shi, TET3 CXXC domain and dioxygenase activity cooperatively regulate key genes for Xenopus eye and neural development. Cell 151, 1200 (2012).
37. A. Inoue, S. Matoba, and Y. Zhang, Transcriptional activation of transposable elements in mouse zygotes is independent of TET3- mediated 5-methylcytosine oxidation. Cell Res. 22, 1640 (2012).
38. G. Ficz, M. R. Branco, S. Seisenberger, F. Santos, F. Krueger, T. A. Hore, C. J. Marques, S. Andrews, and W. Reik, Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation. Nature 473, 398 (2011).
39. H. Wu, A. C. D'Alessio, S. Ito, K. Xia, Z. Wang, K. Cui, K. Zhao, Y. E. Sun, and Y. Zhang, Dual functions of TET1 in transcriptional regulation in mouse embryonic stem cells. Nature 473, 389 (2011).
40. J. U. Guo, Y. Su, C. Zhong, G. L. Ming, and H. Song, Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell 145, 423 (2011).
41. C. X. Song, K. E. Szulwach, Y. Fu, Q. Dai, C. Yi, X. Li, Y. Li, C. H. Chen, W. Zhang, X. Jian, J. Wang, L. Zhang, T. J. Looney, B. Zhang, L. A. Godley, L. M. Hicks, B. T. Lahn, P. Jin, and C. He, Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat. Biotechnol. 29, 68 (2011).