Ex vivo expansion of human outgrowth endothelial cells leads to IL-8-mediated replicative senescence and impaired vasoreparative function

Stem Cells

Volumn 31, Issue 8, 2013, Pages 1657-1668

  Medina, Reinhold J ^a   O'neill, Christina L ^a   O'doherty, T Michelle ^a   Chambers, Sarah E J ^a   Guduric Fuchs, Jasenka ^a   Neisen, Jessica ^a   Waugh, David J ^a   Simpson, David A ^a   Stitt, Alan W ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Angiogenesis; Cell therapy; Endothelial progenitor; IL8; Senescence

Indexed keywords

BETA GALACTOSIDASE; INTERLEUKIN 8; TELOMERASE; TRANSCRIPTOME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CYCLE ARREST; CELL EXPANSION; CELL FUNCTION; CELL PROLIFERATION; CELL REGENERATION; CELL SIZE; CELL STRUCTURE; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; ENDOTHELIAL PROGENITOR CELL; ENDOTHELIUM CELL; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; OUTGROWTH ENDOTHELIAL CELL; SENESCENCE; SIGNAL TRANSDUCTION; TELOMERE SHORTENING;

ANGIOGENESIS; CELL THERAPY; ENDOTHELIAL PROGENITOR; IL8; SENESCENCE;

ADULT; ANIMALS; CELL AGING; CELL- AND TISSUE-BASED THERAPY; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; EYE; FETAL BLOOD; GENE KNOCKDOWN TECHNIQUES; HUMANS; INTERLEUKIN-8; ISCHEMIA; MICE; MICE, INBRED C57BL; REGENERATION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; YOUNG ADULT;

EID: 84883435384     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1414     Document Type: Article

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