Loss of BDNF or its receptors in three mouse models has unpredictable consequences for anxiety and fear acquisition

Learning and Memory

Volumn 20, Issue 9, 2013, Pages 499-504

  Olsen, Ditte ^a   Kaas, Mathias ^a   Schwartz, Ole ^a   Nykjaer, Anders ^a   Glerup, Simon ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR;

ANIMAL EXPERIMENT; ANXIETY; ARTICLE; EXPLORATORY BEHAVIOR; FEAR; GENOTYPE; HIGH RISK BEHAVIOR; MAZE TEST; MEMORY; MOUSE; NONHUMAN; OPEN FIELD TEST; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STARTLE REFLEX;

EID: 84883407668     PISSN: 10720502     EISSN: 15495485     Source Type: Journal    
DOI: 10.1101/lm.032045.113     Document Type: Article

References (47)

1. Alcantara S, Frisen J, del Rio JA, Soriano E, Barbacid M, Silos-Santiago I. 1997. TrkB signaling is required for postnatal survival of CNS neurons and protects hippocampal and motor neurons from axotomy-induced cell death. J Neurosci 17: 3623-3633.
2. Autry AE, Adachi M, Cheng P, Monteggia LM. 2009. Gender-specific impact of brain-derived neurotrophic factor signaling on stress-induced depression-like behavior. Biol Psychiatry 66: 84-90.
3. Barrett GL, Reid CA, Tsafoulis C, Zhu W, Williams DA, Paolini AG, Trieu J, Murphy M. 2010. Enhanced spatial memory and hippocampal long-term potentiation in p75 neurotrophin receptor knockout mice. Hippocampus 20: 145-152.
4. Catts VS, Al-Menhali N, Burne TH, Colditz MJ, Coulson EJ. 2008. The p75 neurotrophin receptor regulates hippocampal neurogenesis and related behaviours. Eur J Neurosci 28: 883-892.
5. Chao MV. 2003. Neurotrophins and their receptors: A convergence point for many signalling pathways. Nat Rev Neurosci 4: 299-309.
6. Chen ZY, Jing D, Bath KG, Ieraci A, Khan T, Siao CJ, Herrera DG, Toth M, Yang C, McEwen BS, et al. 2006. Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science 314: 140-143.
7. Chourbaji S, Hellweg R, Brandis D, Zorner B, Zacher C, Lang UE, Henn FA, Hortnagl H, Gass P. 2004. Mice with reduced brain-derived neurotrophic factor expression show decreased choline acetyltransferase activity, but regular brain monoamine levels and unaltered emotional behavior. Brain Res Mol Brain Res 121: 28-36.
8. Chourbaji S, Brandwein C, Vogt MA, Dormann C, Hellweg R, Gass P. 2008. Nature vs. nurture: Can enrichment rescue the behavioural phenotype of BDNF heterozygous mice? Behav Brain Res 192: 254-258.
9. Chourbaji S, Brandwein C, Gass P. 2011. Altering BDNF expression by genetics and/or environment: Impact for emotional and depressionlike behaviour in laboratory mice. Neurosci Biobehav Rev 35: 599-611.
10. Chourbaji S, Hortnagl H, Molteni R, Riva MA, Gass P, Hellweg R. 2012. The impact of environmental enrichment on sex-specific neurochemical circuitries-effects on brain-derived neurotrophic factor and the serotonergic system. Neuroscience 220: 267-276.
11. Croll SD, Suri C, Compton DL, Simmons MV, Yancopoulos GD, Lindsay RM, Wiegand SJ, Rudge JS, Scharfman HE. 1999. Brainderived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex. Neuroscience 93: 1491-1506.
12. Ernfors P, Lee KF, Jaenisch R. 1994. Mice lacking brain-derived neurotrophic factor develop with sensory deficits. Nature 368: 147-150.
13. Fadok JP, Dickerson TM, Palmiter RD. 2009. Dopamine is necessary for cue-dependent fear conditioning. J Neurosci 29: 11089-11097.
14. Holderbach R, Clark K, Moreau JL, Bischofberger J, Normann C. 2007. Enhanced long-term synaptic depression in an animal model of depression. Biol Psychiatry 62: 92-100.
15. Huang EJ, Reichardt LF. 2003. Trk receptors: Roles in neuronal signal transduction. Annu Rev Biochem 72: 609-642.
16. Juhasz G, Dunham JS, McKie S, Thomas E, Downey D, Chase D, Lloyd-Williams K, Toth ZG, Platt H, Mekli K, et al. 2011. The CREB1-BDNF-NTRK2 pathway in depression: Multiple gene-cognition-environment interactions. Biol Psychiatry 69: 762-771.
17. Kernie SG, Liebl DJ, Parada LF. 2000. BDNF regulates eating behavior and locomotor activity in mice. EMBO J 19: 1290-1300.
18. Klein R, Smeyne RJ, Wurst W, Long LK, Auerbach BA, Joyner AL, Barbacid M. 1993. Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death. Cell 75: 113-122.
19. Koizumi H, Hashimoto K, Iyo M. 2006. Dietary restriction changes behaviours in brain-derived neurotrophic factor heterozygous mice: Role of serotonergic system. Eur J Neurosci 24: 2335-2344.
20. Lee KF, Li E, Huber LJ, Landis SC, Sharpe AH, Chao MV, Jaenisch R. 1992. Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system. Cell 69: 737-749.
21. Linnarsson S, Bjorklund A, Ernfors P. 1997. Learning deficit in BDNF mutant mice. Eur J Neurosci 9: 2581-2587.
22. Liu IY, Lyons WE, Mamounas LA, Thompson RF. 2004. Brain-derived neurotrophic factor plays a critical role in contextual fear conditioning. J Neurosci 24: 7958-7963.
23. MacQueen GM, Ramakrishnan K, Croll SD, Siuciak JA, Yu G, Young LT, Fahnestock M. 2001. Performance of heterozygous brain-derived neurotrophic factor knockout mice on behavioral analogues of anxiety, nociception, and depression. Behav Neurosci 115: 1145-1153.
24. Martinez A, Alcantara S, Borrell V, Del Rio JA, Blasi J, Otal R, Campos N, Boronat A, Barbacid M, Silos-Santiago I, et al. 1998. TrkB and TrkC signaling are required for maturation and synaptogenesis of hippocampal connections. J Neurosci 18: 7336-7350.
25. Martinowich K, Schloesser RJ, Lu Y, Jimenez DV, Paredes D, Greene JS, Greig NH, Manji HK, Lu B. 2012. Roles of p75NTR, long-term depression, and cholinergic transmission in anxiety and acute stress coping. Biol Psychiatry 71: 75-83.
26. Minichiello L. 2009. TrkB signalling pathways in LTP and learning. Nat Rev Neurosci 10: 850-860.
27. Minichiello L, Korte M, Wolfer D, Kuhn R, Unsicker K, Cestari V, Rossi-Arnaud C, Lipp HP, Bonhoeffer T, Klein R. 1999. Essential role for TrkB receptors in hippocampus-mediated learning. Neuron 24: 401-414.
28. Monteggia LM, Barrot M, Powell CM, Berton O, Galanis V, Gemelli T, Meuth S, Nagy A, Greene RW, Nestler EJ. 2004. Essential role of brain-derived neurotrophic factor in adult hippocampal function. Proc Natl Acad Sci 101: 10827-10832.
29. Montkowski A, Holsboer F. 1997. Intact spatial learning and memory in transgenic mice with reduced BDNF. Neuroreport 8: 779-782.
30. Musumeci G, Minichiello L. 2011. BDNF-TrkB signalling in fear learning: From genetics to neural networks. Rev Neurosci 22: 303-315.
31. Nykjaer A, Lee R, Teng KK, Jansen P, Madsen P, Nielsen MS, Jacobsen C, Kliemannel M, Schwarz E, Willnow TE, et al. 2004. Sortilin is essential for proNGF-induced neuronal cell death. Nature 427: 843-848.
32. Pang PT, Teng HK, Zaitsev E, Woo NT, Sakata K, Zhen S, Teng KK, Yung WH, Hempstead BL, Lu B. 2004. Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity. Science 306: 487-491.
33. Park H, Poo MM. 2013. Neurotrophin regulation of neural circuit development and function. Nat Rev Neurosci 14: 7-23.
34. Peterson DA, Dickinson-Anson HA, Leppert JT, Lee KF, Gage FH. 1999. Central neuronal loss and behavioral impairment in mice lacking neurotrophin receptor p75. J Comp Neurol 404: 1-20.
35. Puehringer D, Orel N, Luningschror P, Subramanian N, Herrmann T, Chao MV, Sendtner M. 2013. EGF transactivation of Trk receptors regulates the migration of newborn cortical neurons. Nat Neurosci. 16: 407-415.
36. Rakofsky JJ, Ressler KJ, Dunlop BW. 2012. BDNF function as a potential mediator of bipolar disorder and post-traumatic stress disorder comorbidity. Mol Psychiatry 17: 22-35.
37. Rosch H, Schweigreiter R, Bonhoeffer T, Barde YA, Korte M. 2005. The neurotrophin receptor p75NTR modulates long-term depression and regulates the expression of AMPA receptor subunits in the hippocampus. Proc Natl Acad Sci 102: 7362-7367.
38. Silos-Santiago I, Fagan AM, Garber M, Fritzsch B, Barbacid M. 1997. Severe sensory deficits but normal CNS development in newborn mice lacking TrkB and TrkC tyrosine protein kinase receptors. Eur J Neurosci 9: 2045-2056.
39. Sun Y, Lim Y, Li F, Liu S, Lu JJ, Haberberger R, Zhong JH, Zhou XF. 2012. ProBDNF collapses neurite outgrowth of primary neurons by activating RhoA. PloS One 7: e35883.
40. Teng HK, Teng KK, Lee R, Wright S, Tevar S, Almeida RD, Kermani P, Torkin R, Chen ZY, Lee FS, et al. 2005. ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. J Neurosci 25: 5455-5463.
41. Vaegter CB, Jansen P, Fjorback AW, Glerup S, Skeldal S, Kjolby M, Richner M, Erdmann B, Nyengaard JR, Tessarollo L, et al. 2011. Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling. Nat Neurosci 14: 54-61.
42. Woo NH, Teng HK, Siao CJ, Chiaruttini C, Pang PT, Milner TA, Hempstead BL, Lu B. 2005. Activation of p75NTR by proBDNF facilitates hippocampal long-term depression. Nat Neurosci 8: 1069-1077.
43. Xie CW, Sayah D, Chen QS, Wei WZ, Smith D, Liu X. 2000. Deficient long-term memory and long-lasting long-term potentiation in mice with a targeted deletion of neurotrophin-4 gene. Proc Natl Acad Sci 97: 8116-8121.
44. Xu L, Anwyl R, Rowan MJ. 1997. Behavioural stress facilitates the induction of long-term depression in the hippocampus. Nature 387: 497-500.
45. Yang J, Siao CJ, Nagappan G, Marinic T, Jing D, McGrath K, Chen ZY, MarkW, Tessarollo L, Lee FS, et al. 2009. Neuronal release of proBDNF. Nat Neurosci 12: 113-115.
46. Zhu SW, Codita A, Bogdanovic N, Hjerling-Leffler J, Ernfors P, Winblad B, Dickins DW, Mohammed AH. 2009. Influence of environmental manipulation on exploratory behaviour in male BDNF knockout mice. Behav Brain Res 197: 339-346.
47. Zorner B, Wolfer DP, Brandis D, Kretz O, Zacher C, Madani R, Grunwald I, Lipp HP, Klein R, Henn FA, et al. 2003. Forebrain-specific trkB-receptor knockout mice: Behaviorally more hyperactive than "depressive." Biol Psychiatry 54: 972-982.