Combination treatment of PD98059 and DAPT in gastric cancer through induction of apoptosis and downregulation of WNT/β-catenin

Cancer Biology and Therapy

Volumn 14, Issue 9, 2013, Pages 833-839

  Yao, Jun ^a   Qian, Cuijuan ^b   Shu, Ting ^a   Zhang, Xin ^c   Zhao, Zhiqiang ^a   Liang, Yong ^a  

^a TAIZHOU UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

^c TAIZHOU MUNICIPAL HOSPITAL   (China)

Author keywords

catenin; Apoptosis; DAPT; ERK; Gastric cancer; Notch1; PD98059

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ANTINEOPLASTIC AGENT; BETA CATENIN; ESTER DERIVATIVE; GAMMA SECRETASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N[N(3,5 DIFLUOROPHENACETYL)L ANANYL]S PHENYGLYCINE TERT BUTYL ESTER; NOTCH1 RECEPTOR; UNCLASSIFIED DRUG; WNT PROTEIN; 2-(2-AMINO-3-METHOXYPHENYL)-4H-1-BENZOPYRAN-4-ONE; DIPEPTIDE; FLAVONOID; N-(N-(3,5-DIFLUOROPHENACETYL)ALANYL)PHENYLGLYCINE TERT-BUTYL ESTER;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER COMBINATION CHEMOTHERAPY; CANCER MODEL; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; PROTEIN DOMAIN; STOMACH CANCER; TUMOR XENOGRAFT; ANIMAL; DRUG EFFECTS; METABOLISM; MIDDLE AGED; NUDE MOUSE; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS; TUMOR CELL LINE; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; BETA CATENIN; CELL LINE, TUMOR; DIPEPTIDES; DOWN-REGULATION; FEMALE; FLAVONOIDS; HUMANS; MALE; MAP KINASE SIGNALING SYSTEM; MICE, NUDE; MIDDLE AGED; RECEPTOR, NOTCH1; STOMACH NEOPLASMS; WNT PROTEINS;

EID: 84883386183     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.25332     Document Type: Article

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