LRRK2 and RIPK2 Variants in the NOD 2-Mediated Signaling Pathway Are Associated with Susceptibility to Mycobacterium leprae in Indian Populations

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Marcinek, Patrick ^a   Jha, Aditya Nath ^b   Shinde, Vidyagouri ^c   Sundaramoorthy, Arun ^d   Rajkumar, Raja ^b   Suryadevara, Naveen Chandra ^c   Neela, Sanjeev Kumar ^c   van Tong, Hoang ^a   Balachander, Vellingiri ^d   Valluri, Vijaya Lakshmi ^c   Thangaraj, Kumarasamy ^b   Velavan, Thirumalaisamy P ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

^c Blue Peter Public Health and Research Centre   (India)

^d BHARATHIAR UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; LEUCINE RICH REPEAT KINASE 2; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE 2;

ADULT; ALLELE; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; IMMUNE RESPONSE; INDIAN; INFECTION RISK; INFECTION SENSITIVITY; LEPROSY; LRRK2 GENE; MAJOR CLINICAL STUDY; MALE; MYCOBACTERIUM LEPRAE; PATHOGENESIS; PAUCIBACILLARY LEPROSY; POLYMERASE CHAIN REACTION; PROGNOSIS; RIPK2 GENE; SIGNAL TRANSDUCTION;

ALLELES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; INDIA; LEPROSY; MALE; MYCOBACTERIUM LEPRAE; NOD2 SIGNALING ADAPTOR PROTEIN; POLYMORPHISM, GENETIC; PROTEIN-SERINE-THREONINE KINASES; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASE 2; SIGNAL TRANSDUCTION; TH1 CELLS;

EID: 84883366350     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0073103     Document Type: Article

References (40)

1. Leprosy update, 2011 (2011) Wkly Epidemiol Rec. 86: 389-399.
2. Monot M, Honore N, Garnier T, Zidane N, Sherafi D, et al. (2009) Comparative genomic and phylogeographic analysis of Mycobacterium leprae. Nat Genet 41: 1282-1289.
3. Ridley DS, (1974) Histological classification and the immunological spectrum of leprosy. Bull World Health Organ 51: 451-465.
4. de Messias-Reason IJ, Boldt AB, Moraes Braga AC, Von Rosen Seeling SE, Dornelles L, et al. (2007) The association between mannan-binding lectin gene polymorphism and clinical leprosy: new insight into an old paradigm. J Infect Dis 196: 1379-1385.
5. Schurr E, Gros P, (2009) A common genetic fingerprint in leprosy and Crohn's disease? N Engl J Med 361: 2666-2668.
6. Vannberg FO, Chapman SJ, Hill AV, (2011) Human genetic susceptibility to intracellular pathogens. Immunol Rev 240: 105-116.
7. Zhang FR, Huang W, Chen SM, Sun LD, Liu H, et al. (2009) Genomewide association study of leprosy. N Engl J Med 361: 2609-2618.
8. Ridley DS, Jopling WH, (1966) Classification of leprosy according to immunity. A five-group system. Int J Lepr Other Mycobact Dis 34: 255-273.
9. Velavan TP, Buyukyazici B, Kremsner PG, Kun JF, (2012) Combined promoter haplotypes of the IL10R genes are associated with protection against severe malaria in Gabonese children. Immunogenetics 64: 87-95.
10. Borzutzky A, Fried A, Chou J, Bonilla FA, Kim S, et al. (2010) NOD2-associated diseases: Bridging innate immunity and autoinflammation. Clin Immunol 134: 251-261.
11. Sun Y, Liu H, Yu G, Chen X, Liu H, et al. (2011) Gene expression analysis of leprosy by using a multiplex branched DNA assay. Exp Dermatol 20: 520-522.
12. Jeong YJ, Kim CH, Song EJ, Kang MJ, Kim JC, et al. (2012) Nucleotide-binding oligomerization domain 2 (Nod2) is dispensable for the innate immune responses of macrophages against Yersinia enterocolitica. J Microbiol 50: 489-495.
13. Tigno-Aranjuez JT, Abbott DW. (2012) Ubiquitination and phosphorylation in the regulation of NOD2 signaling and NOD2-mediated disease. Biochim Biophys Acta.
14. Schenk M, Krutzik SR, Sieling PA, Lee DJ, Teles RM, et al. (2012) NOD2 triggers an interleukin-32-dependent human dendritic cell program in leprosy. Nat Med 18: 555-563.
15. Madrigal AG, Barth K, Papadopoulos G, Genco CA, (2012) Pathogen-Mediated Proteolysis of the Cell Death Regulator RIPK1 and the Host Defense Modulator RIPK2 in Human Aortic Endothelial Cells. PLoS Pathog 8: e1002723.
16. Kim BC, Kang TJ, Jin SH, Kim SK, Lee SB, et al. (2004) Tissue-specific down-regulation of RIPK 2 in Mycobacterium leprae-infected nu/nu mice. Mediators Inflamm 13: 51-52.
17. Ogura Y, Inohara N, Benito A, Chen FF, Yamaoka S, et al. (2001) Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. J Biol Chem 276: 4812-4818.
18. Lee BD, Dawson VL, Dawson TM, (2012) Leucine-rich repeat kinase 2 (LRRK2) as a potential therapeutic target in Parkinson's disease. Trends Pharmacol Sci 33: 365-373.
19. Liu Z, Lenardo MJ, (2012) The role of LRRK2 in inflammatory bowel disease. Cell Res 22: 1092-1094.
20. Gardet A, Benita Y, Li C, Sands BE, Ballester I, et al. (2010) LRRK2 is involved in the IFN-gamma response and host response to pathogens. J Immunol 185: 5577-5585.
21. Hakimi M, Selvanantham T, Swinton E, Padmore RF, Tong Y, et al. (2011) Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures. J Neural Transm 118: 795-808.
22. Hitotsumatsu O, Ahmad RC, Tavares R, Wang M, Philpott D, et al. (2008) The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals. Immunity 28: 381-390.
23. Shinde V, Marcinek P, Rani DS, Sunder SR, Arun S, et al. (2013) Genetic evidence of TAP1 gene variant as a susceptibility factor in Indian leprosy patients. Hum Immunol 74: 803-807.
24. Shinde V, Marcinek P, Rani DS, Sunder SR, Arun S, et al. (2013) Genetic evidence of TAP1 gene variant as a susceptibility factor in Indian leprosy patients. Hum Immunol 74: 803-807.
25. Ferwerda G, Girardin SE, Kullberg BJ, Le BL, de Jong DJ, et al. (2005) NOD2 and toll-like receptors are nonredundant recognition systems of Mycobacterium tuberculosis. PLoS Pathog 1: 279-285.
26. Hugot JP, Chamaillard M, Zouali H, Lesage S, Cezard JP, et al. (2001) Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411: 599-603.
27. Johannsen U, (1968) [Studies of infectious enteritis (panleukopenia) in felines. I. Clinical aspects and pathological anatomy of the disease]. Arch Exp Veterinarmed 22: 233-246.
28. Okafuji I, Nishikomori R, Kanazawa N, Kambe N, Fujisawa A, et al. (2009) Role of the NOD2 genotype in the clinical phenotype of Blau syndrome and early-onset sarcoidosis. Arthritis Rheum 60: 242-250.
29. Pan H, Dai Y, Tang S, Wang J, (2012) Polymorphisms of NOD2 and the risk of tuberculosis: a validation study in the Chinese population. Int J Immunogenet 39: 233-240.
30. Grant AV, Alter A, Huong NT, Orlova M, Van TN, et al. (2012) Crohn's disease susceptibility genes are associated with leprosy in the Vietnamese population. J Infect Dis 206: 1763-1767.
31. Kang TJ, Chae GT, (2011) The Role of Intracellular Receptor NODs for Cytokine Production by Macrophages Infected with Mycobacterium leprae. Immune Netw 11: 424-427.
32. Moreira LO, El Kasmi KC, Smith AM, Finkelstein D, Fillon S, et al. (2008) The TLR2-MyD88-NOD2-RIPK2 signalling axis regulates a balanced pro-inflammatory and IL-10-mediated anti-inflammatory cytokine response to Gram-positive cell walls. Cell Microbiol 10: 2067-2077.
33. Lewis PA, Manzoni C, (2012) LRRK2 and human disease: a complicated question or a question of complexes? Sci Signal 5: e2.
34. Umeno J, Asano K, Matsushita T, Matsumoto T, Kiyohara Y, et al. (2011) Meta-analysis of published studies identified eight additional common susceptibility loci for Crohn's disease and ulcerative colitis. Inflamm Bowel Dis 17: 2407-2415.
35. Kaiser S, Di MP, Murphy ME, Sies H, (1990) Quenching of singlet molecular oxygen by tocopherols. Adv Exp Med Biol 264: 117-124.
36. Assaf A, Hoang TV, Faik I, Aebischer T, Kremsner PG, et al. (2012) Genetic evidence of functional ficolin-2 haplotype as susceptibility factor in cutaneous leishmaniasis. PLoS One 7: e34113.
37. Hoang TV, Toan NL, Song lH, Ouf EA, Bock CT, et al. (2011) Ficolin-2 levels and FCN2 haplotypes influence hepatitis B infection outcome in Vietnamese patients. PLoS One 6: e28113.
38. Ouf EA, Ojurongbe O, Akindele AA, Sina-Agbaje OR, Van TH, et al. (2012) Ficolin-2 Levels and FCN2 Genetic Polymorphisms as a Susceptibility Factor in Schistosomiasis. J Infect Dis.
39. Reich D, Thangaraj K, Patterson N, Price AL, Singh L, (2009) Reconstructing Indian population history. Nature 461: 489-494.
40. Zhang F, Liu H, Chen S, Low H, Sun L, et al. (2011) Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy. Nat Genet 43: 1247-1251.