The effects of different hormone treatment on endothelial function in healthy postmenopausal women

Gynecological Endocrinology

Volumn 29, Issue 9, 2013, Pages 867-872

  Akman, Levent ^a   Duygu, Hamza ^b   Akercan, Fuat ^a   Ulukus, Murat ^a   Ozerkan, Filiz ^a   Akin, Mustafa ^a  

^a EGE UNIVERSITY   (Turkey)

^b ATATURK TRAINING AND RESEARCH HOSPITAL   (Turkey)

Author keywords

Estrogen; Hormone therapy; Postmenopause; Progesterone; Raloxifene; Tibolone

Indexed keywords

CONJUGATED ESTROGEN; MEDROXYPROGESTERONE ACETATE; RALOXIFENE; TIBOLONE;

ADULT; ARTERY BLOOD FLOW; ARTERY DILATATION; ARTICLE; BRACHIAL ARTERY; CONTROLLED STUDY; DRUG EFFICACY; DRUG RESPONSE; ENDOTHELIAL DYSFUNCTION; FEMALE; HORMONAL THERAPY; HUMAN; MAJOR CLINICAL STUDY; POSTMENOPAUSE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; BRACHIAL ARTERY; DRUG COMBINATIONS; ENDOTHELIUM, VASCULAR; ESTROGEN REPLACEMENT THERAPY; ESTROGENS, CONJUGATED (USP); FEMALE; HEALTH; HUMANS; MEDROXYPROGESTERONE ACETATE; MIDDLE AGED; NORPREGNENES; POSTMENOPAUSE; RALOXIFENE; VASODILATION;

EID: 84883353848     PISSN: 09513590     EISSN: 14730766     Source Type: Journal    
DOI: 10.3109/09513590.2013.813471     Document Type: Article

References (39)

1. Colditz GA, WillettWC, Stampfer MJ, et al. Menopause and the risk of coronary heart disease in women. N Engl J Med 1987;316: 1105-10
2. Herrington DM, Espeland MA, Crouse 3rd JR, et al. Estrogen replacement and brachial artery flow-mediated vasodilation in older women. Arterioscler Thromb Vasc Biol 2001;21:1955-61
3. Vita JA, Keany JF. Hormone replacement therapy and endothelial function. The exception that proves the rule? Arterioscler Thromb Vasc Biol 2001;21:1867-9
4. Ross R. Atherosclerosis-An inflammatory disease. N Engl J Med 1999;340:115-26
5. Schachinger V, Britten MB, Zeiher AM. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation 2000;101:1899-906
6. Henderson A. Endothelial dysfunction: A reversible clinical measure of atherogenic susceptibility and cardiovascular inefficiency. Int J Cardiol 1997;62:43-8
7. Celermajer DS, Sorenson KE, Gooch VM, et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992;340:1111-5
8. Anderson TJ, Uehata A, Gerhard MD, et al. Close relation of endothelial function in the human coronary and peripheral circulations. J Am Coll Cardiol 1995;26:1235-41
9. Corretti MC, Anderson TJ, Benjamin EJ, et al. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery. A report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol 2002;39: 257-65
10. Kalantaridou SN, Naka KK, Papanikolaou E, et al. Impaired endothelial function in young women with premature ovarian failure: Normalization with hormone therapy. J Clin Endocrinol Metab 2004;89:3907-13
11. Rossouw JE, Anderson GL, Prentice RL, et al. Writing Group for the Women's Health Initative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial. JAMA 2002;288:321-33
12. Hulley S, Grady D, Bush T, et al. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. JAMA 1998;280:605-13
13. Davignon J, Ganz P. Role of endothelial dysfunction in atherosclerosis. Circulation 2004;109:27-32
14. Celermajer DS. Endothelial dysfunction: Does it matter? Is it reversible? J Am Coll Cardiol 1997;303:25-53
15. Koh KK, Jin DK, Yang SH, et al. Vascular effects of synthetic or natural progestagen combined with conjugated equine estrogen in healthy postmenopausal woman. Circulation 2001;103: 1961-6
16. Wakatsuki A, Okatani Y, Ikenoue N, Fukaya T. Effect of medroxyprogesterone asetate on endotehelium-dependent vasodilation in postmenopausal woman receiving estrogen. Circulation 2001; 104:1773-8
17. Gisclard V, Miller VM, Vanhoutte P. Effect of 17alfa-estradiol on endothelium-dependent responses in the rabbit. J Pharmacol Exp Ther 1988;244:19-22
18. Arnal JF, Clamens S, Pechet C, et al. Ethinylestradiol does not enhance the expression of nitric oxide synthase in bovine aortic endothelial cells but increases the release of bioactive nitric oxide by inhibiting superoxide anion production. Proc Natl Acad Sci USA 1996;93:4108-13
19. Mendelsohn ME. Mechanisms of estrogen action in the cardiovascular system. J Steroid Biochem Mol Biol 2000;74:337-43
20. Reslan OM, Khalil RA. Vascular effects of estrogenic menopausal hormone therapy. Rev Recent Clin Trials 2012;7:47-70
21. Denti L. The hormone replacement therapy (HRT) of menopause: Focus on cardiovascular implications. Acta Biomed 2010;81:73-6
22. McCrohon JA, Adams MR, McCredie RJ, et al. Hormone replacement therapy is associated with improved arterial physiology in healty post-menopausal woman. Clin Endocrinol 1996;45: 435-41
23. Gerhard M, Walsh BW, Tawakol A, et al. Estrodiol therapy combined with progesterone and endothelium-dependent vasodilation in postmenopausal woman. Circulation 1998;98: 1158-63
24. L'Hermite M, Simoncini T, Fuller S, Genazzani AR. Could transdermal estradiol-progesterone be a safer postmenopausal HRT? A review. Maturitas 2008;60:185-201
25. Simoncini T, Caruso A, Giretti MS, et al. Effects of dydrogesterone and of its stable metabolite, 20-Alpha-dihydrodydrogesterone, on nitric oxide synthesis in human endothelial cells. Fertil Steril 2006; 86:1235-42
26. Simoncini T, Mannella P, Fornari L, et al. Differential signal transduction of progesterone andmedroxyprogesterone acetate in human endothelial cells. Endocrinology 2004;145:5745-56
27. Simoncini T, Mannella P, Fornari L, et al. Tibolone activates nitric oxide synthesis in human endothelial cells. J Clin Endocrinol Metab 2004;89:4594-600
28. Seeger H, Kloosterboer HJ, Studen M, et al. In vitro effects of tibolone and its metabolites on human vascular coronary cells. Maturitas 2007;58:42-9
29. Koh KK, Ahn JY, Jin DK, et al. Significant differential effects of hormone therapy or tibolone onmarkers of cardiovascular disease in postmenopausal women: A randomized, double-blind, placebocontrolled, crossover study. Arterioscler Thromb Vasc Biol 2003;23: 1889-94
30. Koh KK, Han SH, Shin MS, et al. Significant differential effects of lower doses of hormone therapy or tibolone on markers ofcardiovascular disease in post-menopausal women: A randomized, double-blind, crossover study. Eur Heart J 2005;26: 1362-8
31. de Kleijn MJ, Wilmink HW, Bots ML, et al. Hormone replacement therapy and endothelial function. Results of a randomized controlled trial in healthy postmenopausal women. Atherosclerosis 2001;159: 357-65
32. Silvestri A, Gambacciani M, Vitale C, et al. Different effect of hormone replacementtherapy, DHEAS and tibolone on endothelial function in postmenopausal women with increased cardiovascular risk. Maturitas 2005;50:305-11
33. Sarrel PM, Haq N, Wendy C, et al. Raloxifene and endothelial function in healthy postmenopausal woman. Am J Obstet Gynecol 2002;188:304-9
34. Saitta A, Altavilla D, Cucinotta D, et al. Randomized, double-blind, placebo-controlled study on effects of raloxifenee and hormone replacement therapy on plasma NO concentratations, endothelin-1 levels, and endothelium-dependent vasodilation in postmenopausal woman. Arterioscler Thromb Vasc Biol 2001;21:1512-9
35. Simoncini T, Genazzani AR. Raloxifene acutely stimulates nitric oxide release from human endothelial cells via an activation of endothelial nitric oxide synthase. J Clin Endocrinol Metab 2000;85: 2966-669
36. Simoncini T, Genazzani AR, Liao JK. Nongenomic mechanisms of endothelialnitric oxide synthase activation by the selective estrogen receptor modulator raloxifene. Circulation 2002;105: 1368-73
37. Dushek EJJ, Stehouwer CDA, De Valk-De Roo GW, et al. Raloxifene, conjugated oestrogen and endotheilial function in postmenopausal woman. J Intern Med 2003;254:85-94
38. Bechlioulis A, Naka KK, Kalantaridou SN, et al. Short-term hormone therapy improves sCD40L and endothelial function in early menopausal women: Potential role of estrogen receptor polymorphisms. Maturitas 2012;71:389-395
39. Henmi N, Takahashi K, Amita M, et al. Effect of dienogest on estrogen-induced nitric oxide production in human umbilical vein endothelial cells and endothelium-dependent vasodilatation in postmenopausal women. Menopause 2010;17:615-21