Hormone replacement therapy is associated with improved arterial physiology in healthy post-menopausal women

Clinical Endocrinology

Volumn 45, Issue 4, 1996, Pages 435-441

  McCrohon, Jane A ^a   Adams, Mark R ^a   McCredie, Robyn J ^a,b   Robinson, Jacqui ^a,b   Pike, Anne ^a   Abbey, Mavis ^c   Keech, Anthony C ^a,d   Celermajer, David S ^a,b  

^a ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^b HEART RESEARCH INSTITUTE   (Australia)

^c CSIRO   (Australia)

^d UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CONJUGATED ESTROGEN; DYDROGESTERONE; ESTRADIOL; ESTRONE; MEDROXYPROGESTERONE; NORETHISTERONE; PROGESTERONE;

ADOLESCENT; ADULT; AGED; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN EXPERIMENT; MENOPAUSE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; TRANSDERMAL DRUG ADMINISTRATION;

EID: 0029827353     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.1996.8070816.x     Document Type: Article

References (45)

1. Adams, M.R., Kaplan, J.R., Manuck, S.B., Koritnik, D.R., Parks, J.S., Wolfe, M.S. & Clarkson, T.B. (1990) Inhibition of coronary artery atherosclerosis by 17-beta estradiol in ovariectomized monkeys: lack of an effect of added progesterone. Arteriosclerosis, 10, 1051-1057.
2. Anderson, T.J., Uehata, A., Gerhard, M. D., Meredith, I.T., Knab, S., Delagrange, D., Leiberman, E.H., Ganz, P., Creager, M.A., Yeung, A.C. & Selwyn, A.P. (1995) Close relationship of endothelial function in the human coronary and peripheral circulations. Journal of the American College of Cardiology, 26, 1235-1241.
3. Barrett-Conner, E.L. (1989) The risks and benefits of long term estrogen replacement therapy. Public Health Report, 104(Suppl), 62-65.
4. Barrett-Conner, E.L. & Bush, T.L. (1991) Estrogen and coronary heart disease in women. Journal of American Medical Association, 265, 1861-1867.
5. Belchetz, P.E. (1994) Hormonal treatment of post-menopausal women. New England Journal of Medicine, 330, 1062-1071.
6. Bush, T.L., Barrett-Conner, E.L., Cowan, L.D., Criqui, M.N., Wallace, R.B., Suchindran, C.M., Tyroler, H.A. & Rifkind, B.M. (1987) Cardiovascular mortality and non-contraceptive use of estrogen in women; results from the Lipid Research Clinic Program Follow-up Study. Circulation, 75, 1102-1109.
7. Celermajer, D.S., Sorensen, K.E., Gooch, V.M., Spiegelhalter, D.J., Miller, O.I., Sullivan, I.D., Lloyd, J.K. & Deanfield, J.E. (1992) Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet, 340, 1111-1115.
8. Celermajer, D.S., Sorensen, K.E., Georgakopoulos, D., Bull, C., Thomas, O., Robinson, J. & Deanfield, J.E. (1993) Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults. Circulation, 88, 2149-2155.
9. Celemajer, D.S., Sorensen, K.E., Spiegelhalter, D.J., Georgakopoulos, D., Robinson, J. & Deanfield, J.E. (1994) Aging is associated with endothelial dysfunction in men years before the age-related decline in women. Journal of the American College of Cardiology, 24, 471-476.
10. Celermajer, D.S., Adams, M.R., Clarkson, P., Robinson, J., McCredie, R., Donald, A. & Deanfield, J.E. (1996) Passive smoking and impaired endothelium-dependent dilatation in healthy young adults. New England Journal of Medicine, 334, 150-154.
11. Cheng, D.Y. & Gruelter, C.A. (1992) Chronic estrogen alters responsiveness to angiotensin II and norepinephrine in female rat aorta. European Journal of Pharmacology, 215, 171-176.
12. Cooke, J.P. & Tsao, P.S. (1994) Is NO an anti-atherogenic molecule? Arteriosclerosis and Thrombosis, 14, 653-655.
13. Davidson, N.E. (1995) Hormone replacement therapy - breast versus heart versus bone. New England Journal of Medicine, 331, 1638-1639.
14. Fogelberg, M., Vesterquist, O., Diczfalusy, V. & Henriksson, P. (1990) Experimental atherosclerosis; effects of estrogen and atherosclerosis on thromboxane and prostacyclin formation. European Journal of Clinical Investigation, 20, 105-110.
15. Friedewald, W.J., Levy, R.I. & Fredrickson, D.S. (1988) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry, 34, 920-924.
16. Gilligan, D.M., Badar, D.M., Panza, J.A., Quyyumi, A.A. & Cannon, R O. (1994a) Acute vascular effects of estrogen in postmenopausal women. Circulation, 90, 786-791.
17. Gilligan, D.M., Quyyumi, A.A. & Cannon, R.O. (1994b) Effects of physiological levels of estrogen on coronary vasomotor function in postmenopausal women. Circulation, 89, 2545-2551.
18. Grady, D., Rubin, S.M., Petitti, D.B., Fox, C.S., Black, D., Ettinger, B., Ernster, V.L. & Cummings, S.R. (1992) Hormone therapy to prevent disease and prolong life in postmenopausal women. Annals of Internal Medicine, 117, 1016-1037.
19. Haarbo, J., Leth-Espensen, P., Stender, S. & Christiansen, C. (1991) Estrogen monotherapy and combined estrogen-progestogen replacement therapy attenuate aortic accumulation of cholesterol in ovariectomised cholesterol-fed rabbits. Journal of Clinical Investigation, 87, 1274-1279.
20. Harrison, D.G., Armstrong, M.L., Freiman, P.C. & Heistad, D.D. (1987) Restoration of Endothelium-dependent relaxation by dietary treatment of atherosclerosis. Journal of Clinical Investigation, 80, 1808-1811.
21. Hochberg, Y. (1988) A sharper Bonferroni procedure for multiple tests of significance. Biometrika, 75, 800-802.
22. Hunt, K., Vessey, M., McPherson, K. & Coleman, M. (1987) Long-term surveillance of mortality and cancer incidence in women receiving hormone replacement therapy. British Journal of Obstetrics and Gynaecology, 94, 620-635.
23. Jiang, C., Sarrel, P.M., Lindsay, D.C., Poole-Wilson, P.A. & Collins, P. (1991) Endothelium-independent relaxation of rabbit coronary artery by 17 beta-oestradiol in vitro. British Journal of Pharmacology, 104, 1033-1037.
24. Jiang, C., Sarrel, P.M., Poole-Wilson, P.A. & Collins, P. (1992) Acute effects of 17 beta-oestradiol on rabbit coronary artery contractile response to endothelin. American Journal of Physiology, 262, H271-275.
25. Joannides, R., Haefeli, W.E., Linder, L., Richard, V., Bakkali, E. L., Thuillez, C. & Lüscher, T.F. (1995) Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation, 91, 1314-1319.
26. Karas, R.W., Patterson, B.L. & Mendelsohn, M.E. (1994) Human vascular smooth muscle cells contain functional estrogen receptor. Circulation, 89, 1943-1950.
27. Keaney, J.F. Jr, Shwaeny, G.T., Xu, A., Nicolosi, R.J., Loscalzo, J., Foxall, T.L. & Vita, J.A. (1994) 17 beta-estradiol preserves endothelial vasodilator function and limits low-density lipoprotein oxidation in hypercholesterolemic swine. Circulation, 89, 2251-2259.
28. Kushwaha, R.S. (1992) Female sex steroid hormones and lipoprotein metabolism. Current Opinion in Lipidology, 3, 167-172.
29. Lieberman, E.H., Gerhard, M.D., Uehata, A., Walsh, B.W., Selwyn, A.P., Ganz, P., Yeung, A.C. & Creager. M.A. (1994a) Estrogen improves endothelium-dependent flow mediated vasodilation in postmenopausal women. Annals of Internal Medicine, 121, 936-941.
30. Lieberman, E.H., Knab, S.T. & Creager, M.A. (1994b) Nitric oxide mediates the vasodilator response to flow in humans (abstract). Circulation, 90 (Suppl), 1-38.
31. Moore, S. (1973) Thromboatherosclerosis in normolipaemic rabbits, a result of continued endothelial damage. Laboratory Investigation, 29, 478-487.
32. Nabulsi, A.A., Folsom, M.D., White, A., Patsch, W., Heiss, G., Wu, K.K. & Szklo, M. (1993) Association of hormone replacement therapy with various cardiovascular risk factors in postmenopausal women. New England Journal of Medicine, 328, 1069-1075.
33. Notelovitz, M., Kitchens, C.S. & Ware, M.D. (1984) Coagulation and Fibrinolysis in estrogen-treated surgically menopausal women. Obstetrics and Gynecology, 63, 621-625.
34. PEPI investigators (1995) Effects of estrogen or estrogen progestin regimens on heart disease risk factors in post-menopausal women. Journal of the American Medical Association, 273, 199-208.
35. Ramsey, B., Johnson, M.R., Leone, A.M. & Steer, D.J. (1995) The effects of exogenous estrogen on nitric oxide production in women: a placebo controlled crossover study. British Journal of Obstetrics and Gynaecology, 102, 417-419.
36. Reis, S.E., Gloth, S.T., Blumenthal, R.S., Resar, J.R., Zacur, H.A., Gerstenblith, G. & Brinker, J.A. (1994) Ethinyl estradiol acutely attenuates abnormal coronary vasomotor responses to acetylcholine in post-menopausal women. Circulation, 89, 52-60.
37. Rosano, G.M.C., Sarrel, P.M., Poole-Wilson, P.A. & Collins, P. (1993) Beneficial effect of estrogen on exercise induced myocardial ischaemia in women with coronary artery disease. Lancet, 342, 133-136.
38. Ross, R. (1993) The pathogenesis of atherosclerosis; a perspective for the 1990's. Nature, 362, 801-809.
39. Sorensen, K.E., Celermajer, D.S., Spiegelhalter, D.J., Georgakopoulos, D., Robinson, J., Thomas, O. & Deanfield, J.E. (1995) Non-invasive measurement of endothelium-dependent arterial responses in man; accuracy and reproducibility. British Heart Journal 74, 247-253.
40. Stampfer, M.J., Willett, W.C., Colditz, G.A., Speizer, F.E. & Hennekens, C.H. (1990) Past use of oral contraceptives and cardiovascular disease: a meta-analysis in the context of the Nurses' Health Study. American Journal of Obstetrics and Gynecology, 163, 285-291.
41. Tikkanen, M.J., Kuusi, T., Nikkila, E.A. & Sipinen, S. (1986) Postmenopausal hormone replacement therapy: effects of progestogens on serum lipids and lipoproteins: a review. Maturitas, 8, 7-17.
42. Treasure, C.B., Klein, J.L., Weintraub, W.S., Talley, D., Stillabower, M.E., Kosinski, A., Zhang, J., Bioccuzzi, S.J., Cedarholm, C.J. & Alexander, W. (1995) Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease. New England Journal of Medicine, 332, 481-487.
43. Vita, J. A., Treasure, C. B., Nabel, E. G., McLenachan, J. M., Fish, R. A., Yeung, A. C., Vekshtein, V. I., Selwyn, A. P. & Ganz, P. (1990) Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease. Circulation, 81, 491-497.
44. Williams, J.K., Honore, E.K., Washburn, S.A. & Clarkson, T.B. (1994) Effects of hormone replacement therapy on reactivity of atherosclerotic coronary arteries in cynomolgus monkeys. Journal of the American College of Cardiology, 24, 1757-1761.
45. Yasue, H., Matsuyama, K., Matsuyama, K., Okumura, K., Morikami, Y., & Ogawa, H. (1990) Responses of angiographically normal human coronary arteries of intracoronary injection of acetylcholine by age and segment: possible role of early atherosclerosis. Circulation, 81, 482-490.